General Information of the Protein
Protein ID
PT06377
Protein Name
C-C chemokine receptor type 10
Secondarily
Protein Name
Chemokine C-C receptor 9
G-protein coupled receptor 2
Gene Name
CCR10
Secondarily
Gene Name
Cmkbr9
Gpr2
Sequence
MGTKPTEQVSWGLYSGYDEEAYSVGPLPELCYKADVQAFSRAFQPSVSLMVAVLGLAGNGLVLATHLAARRTTRSPTSVHLLQLALADLLLALTLPFAAAGALQGWNLGSTTCRAISGLYSASFHAGFLFLACISADRYVAIARALPAGQRPSTPSRAHLVSVFVWLLSLFLALPALLFSRDGPREGQRRCRLIFPESLTQTVKGASAVAQVVLGFALPLGVMAACYALLGRTLLAARGPERRRALRVVVALVVAFVVLQLPYSLALLLDTADLLAARERSCSSSKRKDLALLVTGGLTLVRCSLNPVLYAFLGLRFRRDLRRLLQGGGCSPKPNPRGRCPRRLRLSSCSAPTETHSLSWDN
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Organism
Mus musculus, Mouse
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Peptide receptor (family A GPCR)
>
Chemokine receptor
>
CC chemokine receptor
Function
Receptor for chemokines SCYA27 and SCYA28. Subsequently transduces a signal by increasing the intracellular calcium ions level.
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Uniprot ID
Primary ID:
Q9JL21

Secondarily ID:
Q542A4
Q9JIP1
Q9JL20
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Ensembl ID
ENSG00000184451
Subcellular Location
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000026 , CHO-K1
Compound ID Compound Name Compound Formula
CP0445928
N-[4-(2-cyanopyrrol-1-yl)-1-(4-methylpiperidin-1-yl)-1-oxobutan-2-yl]-1H-indole-6-sulfonamide
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C23H27N5O3S
 1
1
IC50 = 1000 nM
   TI
   LI
   LO
   TS
CP0065780
4-amino-3,5-dichloro-N-[4-(2-cyanopyrrol-1-yl)-1-(4-methylpiperidin-1-yl)-1-oxobutan-2-yl]benzenesulfonamide
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C21H25Cl2N5O3S
 1
1
IC50 = 1584.89 nM
   TI
   LI
   LO
   TS
CP0534622
4-amino-3,5-dichloro-N-[4-(5-cyanopyrazol-1-yl)-1-(4-methylpiperidin-1-yl)-1-oxobutan-2-yl]benzenesulfonamide
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C20H24Cl2N6O3S
 1
1
IC50 = 3162.28 nM
   TI
   LI
   LO
   TS
CP0558400
N-[4-(2-cyanopyrrol-1-yl)-1-(4-methylpiperidin-1-yl)-1-oxobutan-2-yl]-1-methylindole-4-sulfonamide
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C24H29N5O3S
 1
1
IC50 = 6309.57 nM
   TI
   LI
   LO
   TS
CP0519198
N-[4-(2-cyanopyrrol-1-yl)-1-(4-methylpiperidin-1-yl)-1-oxobutan-2-yl]-1H-indole-7-sulfonamide
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C23H27N5O3S
 1
1
IC50 = 7943.28 nM
   TI
   LI
   LO
   TS
CP0427286
4-amino-3,5-dichloro-N-[(2R)-1-(4-methylpiperidin-1-yl)-1-oxo-4-phenylbutan-2-yl]benzenesulfonamide
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C22H27Cl2N3O3S
 1
1
IC50 = 10000 nM
   TI
   LI
   LO
   TS
CP0385314
N-[4-(2-cyanopyrrol-1-yl)-1-(4-methylpiperidin-1-yl)-1-oxobutan-2-yl]benzenesulfonamide
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C21H26N4O3S
 1
1
IC50 > 19952.62 nM
   TI
   LI
   LO
   TS
CP0419710
4-amino-3,5-dichloro-N-[1-(4-methylpiperidin-1-yl)-4-(2-nitroimidazol-1-yl)-1-oxobutan-2-yl]benzenesulfonamide
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C19H24Cl2N6O5S
 1
1
IC50 > 19952.62 nM
   TI
   LI
   LO
   TS
CP0534634
4-amino-3,5-dichloro-N-[4-(2-chloroimidazol-1-yl)-1-(4-methylpiperidin-1-yl)-1-oxobutan-2-yl]benzenesulfonamide
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C19H24Cl3N5O3S
 1
1
IC50 > 19952.62 nM
   TI
   LI
   LO
   TS