General Information of the Protein
Protein ID
PT06365
Protein Name
Beta-1 adrenergic receptor
Secondarily
Protein Name
Beta-1 adrenoreceptor
Gene Name
ADRB1
Secondarily
Gene Name
Adrb1r
Sequence
MGAGALALGASEPCNLSSAAPLPDGAATAARLLVLASPPASLLPPASEGSAPLSQQWTAGMGLLLALIVLLIVVGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARALVCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPEPSPSPGPPRPADSLANGRSSKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRDLVPDRLFVFFNWLGYANSAFNPIIYCRSPDFRKAFQRLLCCARRAACRRRAAHGDRPRASGCLARAGPPPSPGAPSDDDDDDAGTTPPARLLEPWTGCNGGTTTVDSDSSLDEPGRQGFSSESKV
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Organism
Mus musculus, Mouse
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Monoamine receptor
>
Adrenergic receptor
Function
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling (By similarity). Involved in the regulation of sleep/wake behaviors (PubMed:31473062).
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Uniprot ID
Primary ID:
P34971

Secondarily ID:
B2RVY4
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Ensembl ID
ENSG00000043591
Subcellular Location
Cell membrane
Early endosome
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0401112
 Compound Info 
5-hydroxy-8-[(1R)-1-hydroxy-2-[2-[3-methoxy-4-(3-phenylpropoxy)phenyl]ethylamino]ethyl]-4H-1,4-benzoxazin-3-one
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C28H32N2O6
  1
1
Ki = 5.1 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0399132
 Compound Info 
8-hydroxy-5-[(1R)-1-hydroxy-2-[2-[3-methoxy-4-(3-phenylpropoxy)phenyl]ethylamino]ethyl]-1H-quinolin-2-one
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C29H32N2O5
  1
1
Ki = 5.8 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0401110
 Compound Info 
5-hydroxy-8-[2-[2-[3-methoxy-4-(3-phenylpropoxy)phenyl]ethylamino]ethyl]-4H-1,4-benzoxazin-3-one
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C28H32N2O5
  1
1
Ki = 79 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0384600
 Compound Info 
4-[(1R)-1-hydroxy-2-[2-[3-methoxy-4-(3-phenylpropoxy)phenyl]ethylamino]ethyl]benzene-1,2-diol
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C26H31NO5
  1
1
Ki = 85 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0401111
 Compound Info 
8-hydroxy-5-[2-[2-[3-methoxy-4-(3-phenylpropoxy)phenyl]ethylamino]ethyl]-1H-quinolin-2-one
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C29H32N2O4
  1
1
Ki = 150 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0384609
 Compound Info 
4-[(1R)-1-hydroxy-2-[2-(2-methoxyphenoxy)ethylamino]ethyl]benzene-1,2-diol
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C17H21NO5
  1
1
Ki = 160 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0419868
 Compound Info 
5-hydroxy-8-[(1S)-1-hydroxy-2-[2-[3-methoxy-4-(3-phenylpropoxy)phenyl]ethylamino]ethyl]-4H-1,4-benzoxazin-3-one
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C28H32N2O6
  1
1
Ki = 180 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0068209
 Compound Info 
4-[1-hydroxy-2-(isopropylamino)ethyl]pyrocatechol;hydrochloride
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C11H17NO3
  1
1
Ki = 220 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0399136
 Compound Info 
8-hydroxy-5-[(1S)-1-hydroxy-2-[2-[3-methoxy-4-(3-phenylpropoxy)phenyl]ethylamino]ethyl]-1H-quinolin-2-one
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C29H32N2O5
  1
1
Ki = 300 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0399131
 Compound Info 
4-[(1S)-1-hydroxy-2-[2-[3-methoxy-4-(3-phenylpropoxy)phenyl]ethylamino]ethyl]benzene-1,2-diol
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C26H31NO5
  1
1
Ki = 530 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0399134
 Compound Info 
4-[(1S)-1-hydroxy-2-[2-(2-methoxyphenoxy)ethylamino]ethyl]benzene-1,2-diol
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C17H21NO5
  1
1
Ki = 1500 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0399133
 Compound Info 
4-[2-[2-[3-methoxy-4-(3-phenylpropoxy)phenyl]ethylamino]ethyl]benzene-1,2-diol
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C26H31NO4
  1
1
Ki = 2300 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0399135
 Compound Info 
4-[2-[2-(2-methoxyphenoxy)ethylamino]ethyl]benzene-1,2-diol
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C17H21NO4
  1
1
Ki = 5000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Line ID: CL000025 , HEK-293T
 Cell Line Info 
Similar Protein(s) and Bioactivity Statistics
90% Identity
Protein ID Protein Name Protein Organism
PT01179 Beta-1 adrenergic receptor Homo sapiens, Human
 Protein Info 
PT02505 Beta-1 adrenergic receptor Rattus norvegicus, Rat
 Protein Info