General Information of the Protein
Protein ID
PT06357
Protein Name
Adenylate cyclase type 8
Secondarily
Protein Name
ATP pyrophosphate-lyase 8
Adenylate cyclase type VIII
Adenylyl cyclase 8
Ca(2+)/calmodulin-activated adenylyl cyclase
Gene Name
ADCY8
Sequence
MELSDVRCLTGSEELYTIHPTPPAGDGRSASRPQRLLWQTAVRHITEQRFIHGHRGGSGSGSGGSGKASDPAGGGPNHHAPQLSGDSALPLYSLGPGERAHSTCGTKVFPERSGSGSASGSGGGGDLGFLHLDCAPSNSDFFLNGGYSYRGVIFPTLRNSFKSRDLERLYQRYFLGQRRKSEVVMNVLDVLTKLTLLVLHLSLASAPMDPLKGILLGFFTGIEVVICALVVVRKDTTSHTYLQYSGVVTWVAMTTQILAAGLGYGLLGDGIGYVLFTLFATYSMLPLPLTWAILAGLGTSLLQVILQVVIPRLAVISINQVVAQAVLFMCMNTAGIFISYLSDRAQRQAFLETRRCVEARLRLETENQRQERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFADVKGFTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRQDHAHCCVEMGLSMIKTIRYVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISKATLDCLNGDYNVEEGHGKERNEFLRKHNIETYLIKQPEDSLLSLPEDIVKESVSSSDRRNSGATFTEGSWSPELPFDNIVGKQNTLAALTRNSINLLPNHLAQALHVQSGPEEINKRIEHTIDLRSGDKLRREHIKPFSLMFKDSSLEHKYSQMRDEVFKSNLVCAFIVLLFITAIQSLLPSSRVMPMTIQFSILIMLHSALVLITTAEDYKCLPLILRKTCCWINETYLARNVIIFASILINFLGAILNILWCDFDKSIPLKNLTFNSSAVFTDICSYPEYFVFTGVLAMVTCAVFLRLNSVLKLAVLLIMIAIYALLTETVYAGLFLRYDNLNHSGEDFLGTKEVSLLLMAMFLLAVFYHGQQLEYTARLDFLWRVQAKEEINEMKELREHNENMLRNILPSHVARHFLEKDRDNEELYSQSYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLGEDRFQDIEKIKTIGSTYMAVSGLSPEKQQCEDKWGHLCALADFSLALTESIQEINKHSFNNFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLILKDQGFAFDYRGEIYVKGISEQEGKIKTYFLLGRVQPNPFILPPRRLPGQYSLAAVVLGLVQSLNRQRQKQLLNENNNTGIIKGHYNRRTLLSPSGTEPGAQAEGTDKSDLP
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
>
Lyase
Function
Catalyzes the formation of cAMP in response to calcium entry leadings to cAMP signaling activation that affect processes suche as synaptic plasticity and insulin secretion. Plays a role in many brain functions, such as learning, memory, drug addiction, and anxiety modulation through regulation of synaptic plasticity by modulating long-term memory and long-term potentiation (LTP) through CREB transcription factor activity modulation. Plays a central role in insulin secretion by controlling glucose homeostasis through glucagon-like peptide 1 and glucose signaling pathway and maintains insulin secretion through calcium-dependent PKA activation leading to vesicle pool replenishment. Also, allows PTGER3 to induce potentiation of PTGER4-mediated PLA2 secretion by switching from a negative to a positive regulation, during the IL1B induced-dedifferentiation of smooth muscle cells.
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Uniprot ID
P40145
Ensembl ID
ENSG00000155897
HGNC ID
HGNC:239
Subcellular Location
Cell membrane
Basolateral cell membrane
Apical cell membrane
Synapse
Cell projection
Dendrite
Cell projection
Axon
Presynaptic cell membrane
Postsynaptic density
Membrane raft
Membrane
Coated pit
Cytoplasmic vesicle
Clathrin-coated vesicle membrane
Membrane
Caveola
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000006 , HEK293
Compound ID Compound Name Compound Formula
CP0568886
3-tert-butyl-N-[2-(4-ethyl-6-oxo-1H-pyrimidin-2-yl)-5-methylpyrazol-3-yl]benzamide
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C21H25N5O2
 1
1
IC50 = 380 nM
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CP0574273
N-[2-(4-ethyl-6-oxo-1H-pyrimidin-2-yl)-5-methylpyrazol-3-yl]-3-phenylbenzamide
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C23H21N5O2
 1
1
IC50 = 570 nM
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CP0574274
N-[2-(4-ethyl-6-oxo-1H-pyrimidin-2-yl)-5-methylpyrazol-3-yl]-4-phenylbenzamide
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C23H21N5O2
 1
1
IC50 = 700 nM
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CP0550106
N-[2-(4-ethyl-6-oxo-1H-pyrimidin-2-yl)-5-methylpyrazol-3-yl]-3,4-dimethylbenzamide
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C19H21N5O2
 1
1
IC50 = 710 nM
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CP0570413
N-[2-(4-ethyl-6-oxo-1H-pyrimidin-2-yl)-5-methylpyrazol-3-yl]-4-fluorobenzamide
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C17H16FN5O2
 1
1
IC50 = 780 nM
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CP0571830
3-chloro-N-[2-(4-ethyl-6-oxo-1H-pyrimidin-2-yl)-5-methylpyrazol-3-yl]benzamide
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C17H16ClN5O2
 1
1
IC50 = 1000 nM
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CP0578568
4-(dimethylamino)-N-[2-(4-ethyl-6-oxo-1H-pyrimidin-2-yl)-5-methylpyrazol-3-yl]benzamide
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C19H22N6O2
 1
1
IC50 = 1000 nM
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CP0568329
4-tert-butyl-N-[2-(4-ethyl-6-oxo-1H-pyrimidin-2-yl)-5-methylpyrazol-3-yl]benzamide
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C21H25N5O2
 1
1
IC50 = 1200 nM
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CP0574575
N-[2-(4-ethyl-6-oxo-1H-pyrimidin-2-yl)-5-methylpyrazol-3-yl]-3-(trifluoromethyl)benzamide
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C18H16F3N5O2
 1
1
IC50 = 1300 nM
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CP0577394
N-[2-(4-ethyl-6-oxo-1H-pyrimidin-2-yl)-5-methylpyrazol-3-yl]-3-methylsulfanylbenzamide
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C18H19N5O2S
 1
1
IC50 = 1300 nM
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CP0413058
N-(5-cyclohexyl-1,3,4-oxadiazol-2-yl)-3-phenylbenzamide
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C21H21N3O2
 1
1
IC50 = 1400 nM
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CP0550354
N-[2-(4-ethyl-6-oxo-1H-pyrimidin-2-yl)-5-methylpyrazol-3-yl]-3-fluorobenzamide
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C17H16FN5O2
 1
1
IC50 = 1600 nM
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CP0550105
N-[2-(4-ethyl-6-oxo-1H-pyrimidin-2-yl)-5-methylpyrazol-3-yl]-3,5-dimethylbenzamide
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C19H21N5O2
 1
1
IC50 = 1700 nM
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CP0569784
N-[2-(4-ethyl-6-oxo-1H-pyrimidin-2-yl)-5-methylpyrazol-3-yl]-2-fluorobenzamide
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C17H16FN5O2
 1
1
IC50 = 1900 nM
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CP0577921
3-cyclopropyl-N-[2-(4-ethyl-6-oxo-1H-pyrimidin-2-yl)-5-methylpyrazol-3-yl]benzamide
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C20H21N5O2
 1
1
IC50 = 1900 nM
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CP0562875
4-ethyl-N-[5-(5,6,7,8-tetrahydronaphthalen-2-yl)-1,3,4-oxadiazol-2-yl]benzamide
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C21H21N3O2
 1
1
IC50 = 2000 nM
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CP0550356
3-bromo-N-[2-(4-ethyl-6-oxo-1H-pyrimidin-2-yl)-5-methylpyrazol-3-yl]benzamide
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C17H16BrN5O2
 1
1
IC50 = 2100 nM
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CP0556653
3-methyl-N-[5-(5,6,7,8-tetrahydronaphthalen-2-yl)-1,3,4-oxadiazol-2-yl]-5-(trifluoromethyl)benzamide
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C21H18F3N3O2
 1
1
IC50 = 2400 nM
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CP0574272
4-chloro-N-[2-(4-ethyl-6-oxo-1H-pyrimidin-2-yl)-5-methylpyrazol-3-yl]benzamide
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C17H16ClN5O2
 1
1
IC50 = 2500 nM
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CP0574576
N-[2-(4-ethyl-6-oxo-1H-pyrimidin-2-yl)-5-methylpyrazol-3-yl]-3-propan-2-ylbenzamide
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C20H23N5O2
 1
1
IC50 = 2600 nM
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CP0543598
N-[2-(4-ethyl-6-oxo-1H-pyrimidin-2-yl)-5-methylpyrazol-3-yl]-3-methylbenzamide
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C18H19N5O2
 1
1
IC50 = 2700 nM
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CP0574684
N-[2-(4-ethyl-6-oxo-1H-pyrimidin-2-yl)-5-methylpyrazol-3-yl]pyridine-2-carboxamide
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C16H16N6O2
 1
1
IC50 = 2800 nM
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CP0568332
N-[2-(4-ethyl-6-oxo-1H-pyrimidin-2-yl)-5-methylpyrazol-3-yl]-2-fluoro-5-methylbenzamide
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C18H18FN5O2
 1
1
IC50 = 3400 nM
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CP0577923
N-[2-(4-ethyl-6-oxo-1H-pyrimidin-2-yl)-5-methylpyrazol-3-yl]-2-(2-fluorophenyl)acetamide
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C18H18FN5O2
 1
1
IC50 = 3400 nM
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CP0543322
3-ethyl-N-[2-(4-ethyl-6-oxo-1H-pyrimidin-2-yl)-5-methylpyrazol-3-yl]benzamide
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C19H21N5O2
 1
1
IC50 = 3500 nM
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CP0413061
4-chloro-N-[5-(5,6,7,8-tetrahydronaphthalen-2-yl)-1,3,4-oxadiazol-2-yl]benzamide
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C19H16ClN3O2
 1
1
IC50 = 3600 nM
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CP0559325
N-[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]-3-methyl-5-(trifluoromethyl)benzamide
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C17H11F4N3O2
 1
1
IC50 = 4100 nM
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CP0554070
3-fluoro-N-[5-(5,6,7,8-tetrahydronaphthalen-2-yl)-1,3,4-oxadiazol-2-yl]benzamide
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C19H16FN3O2
 1
1
IC50 = 4200 nM
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CP0579380
3-ethoxy-N-[2-(4-ethyl-6-oxo-1H-pyrimidin-2-yl)-5-methylpyrazol-3-yl]benzamide
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C19H21N5O3
 1
1
IC50 = 4400 nM
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CP0554078
3-methoxy-N-[5-(5,6,7,8-tetrahydronaphthalen-2-yl)-1,3,4-oxadiazol-2-yl]benzamide
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C20H19N3O3
 1
1
IC50 = 5300 nM
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CP0384245
N-[5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl]-2-thiophen-2-ylquinoline-4-carboxamide
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C23H16N4O3S
 1
1
IC50 = 5600 nM
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CP0543599
4-ethyl-N-[2-(4-ethyl-6-oxo-1H-pyrimidin-2-yl)-5-methylpyrazol-3-yl]benzamide
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C19H21N5O2
 1
1
IC50 = 6600 nM
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CP0416976
N-(5-cyclohexyl-1,3,4-oxadiazol-2-yl)-4-methyl-3-(trifluoromethyl)benzamide
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C17H18F3N3O2
 1
1
IC50 = 7000 nM
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CP0416978
N-[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]-3-phenylbenzamide
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C21H14FN3O2
 1
1
IC50 = 7000 nM
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CP0562876
N-[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]-4-phenylbenzamide
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C21H14FN3O2
 1
1
IC50 = 7500 nM
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CP0384247
4-methyl-N-[5-(5,6,7,8-tetrahydronaphthalen-2-yl)-1,3,4-oxadiazol-2-yl]benzamide
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C20H19N3O2
 1
1
IC50 = 7900 nM
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CP0521385
N-[5-(5,6,7,8-tetrahydronaphthalen-2-yl)-1,3,4-oxadiazol-2-yl]-3-(trifluoromethyl)benzamide
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C20H16F3N3O2
 1
1
IC50 = 7900 nM
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CP0403046
N-[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]-4-methyl-3-(trifluoromethyl)benzamide
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C17H11F4N3O2
 1
1
IC50 = 9000 nM
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CP0521367
N-(5-cyclohexyl-1,3,4-oxadiazol-2-yl)-3-methoxy-5-(trifluoromethyl)benzamide
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C17H18F3N3O3
 1
1
IC50 = 9000 nM
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CP0384246
3-methylsulfanyl-N-[5-(5,6,7,8-tetrahydronaphthalen-2-yl)-1,3,4-oxadiazol-2-yl]benzamide
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C20H19N3O2S
 1
1
IC50 = 9400 nM
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CP0577920
N-[2-(4-ethyl-6-oxo-1H-pyrimidin-2-yl)-5-methylpyrazol-3-yl]-3-methoxybenzamide
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C18H19N5O3
 1
1
IC50 = 9600 nM
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CP0403048
3-methoxy-N-[5-(5,6,7,8-tetrahydronaphthalen-2-yl)-1,3,4-oxadiazol-2-yl]-5-(trifluoromethyl)benzamide
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C21H18F3N3O3
 1
1
IC50 = 10000 nM
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CP0578747
N-[2-(4-ethyl-6-oxo-1H-pyrimidin-2-yl)-5-methylpyrazol-3-yl]acetamide
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C12H15N5O2
 1
1
IC50 = 10600 nM
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CP0252079
MLS000529919
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C19H17N3O2
 1
1
IC50 = 11000 nM
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CP0539581
N-[5-(7-ethoxy-1-benzofuran-2-yl)-1,3,4-oxadiazol-2-yl]-2-methylsulfanylbenzamide
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C20H17N3O4S
 1
1
IC50 = 11000 nM
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CP0564564
4-propan-2-yloxy-N-[5-(5,6,7,8-tetrahydronaphthalen-2-yl)-1,3,4-oxadiazol-2-yl]benzamide
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C22H23N3O3
 1
1
IC50 = 11000 nM
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CP0554074
4-methyl-N-[5-(5,6,7,8-tetrahydronaphthalen-2-yl)-1,3,4-oxadiazol-2-yl]-3-(trifluoromethyl)benzamide
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C21H18F3N3O2
 1
1
IC50 = 13000 nM
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CP0416977
N-[5-(2,3-dihydro-1,4-benzodioxin-6-yl)-1,3,4-oxadiazol-2-yl]-3,4-dimethylbenzamide
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C19H17N3O4
 1
1
IC50 = 14000 nM
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CP0416980
N-(5-cyclohexyl-1,3,4-oxadiazol-2-yl)-3-methyl-5-(trifluoromethyl)benzamide
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C17H18F3N3O2
 1
1
IC50 = 15000 nM
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CP0543597
N-[2-(4-ethyl-6-oxo-1H-pyrimidin-2-yl)-5-methylpyrazol-3-yl]furan-2-carboxamide
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C15H15N5O3
 1
1
IC50 = 15700 nM
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CP0550107
N-[2-(4-ethyl-6-oxo-1H-pyrimidin-2-yl)-5-methylpyrazol-3-yl]-2-methylbenzamide
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C18H19N5O2
 1
1
IC50 = 15700 nM
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CP0384244
4-bromo-N-[5-(5,6,7,8-tetrahydronaphthalen-2-yl)-1,3,4-oxadiazol-2-yl]benzamide
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C19H16BrN3O2
 1
1
IC50 = 19000 nM
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CP0563335
4-fluoro-N-[5-(5,6,7,8-tetrahydronaphthalen-2-yl)-1,3,4-oxadiazol-2-yl]benzamide
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C19H16FN3O2
 1
1
IC50 = 22000 nM
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CP0521364
4-bromo-N-[5-(2,3-dihydro-1,4-benzodioxin-6-yl)-1,3,4-oxadiazol-2-yl]benzamide
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C17H12BrN3O4
 1
1
IC50 = 23000 nM
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CP0521361
4-bromo-N-(5-cyclohexyl-1,3,4-oxadiazol-2-yl)benzamide
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C15H16BrN3O2
 1
1
IC50 = 25000 nM
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CP0554073
N-[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]-3-(trifluoromethyl)benzamide
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C16H9F4N3O2
 1
1
IC50 = 29000 nM
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CP0556655
N-[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]-3-methoxy-5-(trifluoromethyl)benzamide
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C17H11F4N3O3
 1
1
IC50 = 29000 nM
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CP0570414
N-[2-(4-ethyl-6-oxo-1H-pyrimidin-2-yl)-5-methylpyrazol-3-yl]-4-(methoxymethoxy)benzamide
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C19H21N5O4
 1
1
IC50 > 30000 nM
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CP0539579
N-[5-(2,3-dihydro-1,4-benzodioxin-6-yl)-1,3,4-oxadiazol-2-yl]-3-(trifluoromethyl)benzamide
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C18H12F3N3O4
 1
1
IC50 = 32000 nM
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CP0562877
N-(5-cyclohexyl-1,3,4-oxadiazol-2-yl)-3-(trifluoromethyl)benzamide
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C16H16F3N3O2
 1
1
IC50 = 33000 nM
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CP0570412
N-[2-(4-ethyl-6-oxo-1H-pyrimidin-2-yl)-5-methylpyrazol-3-yl]benzamide
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C17H17N5O2
 1
1
IC50 = 35900 nM
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CP0521362
N-(5-cyclohexyl-1,3,4-oxadiazol-2-yl)-3,4-dimethylbenzamide
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C17H21N3O2
 1
1
IC50 = 44000 nM
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CP0545136
2-ethyl-N-[2-(4-ethyl-6-oxo-1H-pyrimidin-2-yl)-5-methylpyrazol-3-yl]benzamide
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C19H21N5O2
 1
1
IC50 > 60000 nM
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CP0550355
N-[2-(4-ethyl-6-oxo-1H-pyrimidin-2-yl)-5-methylpyrazol-3-yl]-4-methylbenzamide
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C18H19N5O2
 1
1
IC50 > 60000 nM
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CP0550357
N-[2-(4-ethyl-6-oxo-1H-pyrimidin-2-yl)-5-methylpyrazol-3-yl]-4-hydroxybenzamide
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C17H17N5O3
 1
1
IC50 > 60000 nM
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CP0568888
N-[2-(4-ethyl-6-oxo-1H-pyrimidin-2-yl)-5-methylpyrazol-3-yl]-2-fluoro-3-methylbenzamide
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C18H18FN5O2
 1
1
IC50 > 60000 nM
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CP0571256
N-[2-(4-ethyl-6-oxo-1H-pyrimidin-2-yl)-5-methylpyrazol-3-yl]-4-methoxybenzamide
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C18H19N5O3
 1
1
IC50 > 60000 nM
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CP0571280
N-[2-(4-ethyl-6-oxo-1H-pyrimidin-2-yl)-5-methylpyrazol-3-yl]-2-(3-methylphenyl)acetamide
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C19H21N5O2
 1
1
IC50 > 60000 nM
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