Protein Information

General Information of the Protein

Protein ID	PT06356
Protein Name	Adenylate cyclase type 1
Secondarily Protein Name	ATP pyrophosphate-lyase 1 Adenylate cyclase type I Adenylyl cyclase 1 Ca(2+)/calmodulin-activated adenylyl cyclase
Gene Name	ADCY1
Sequence	MAGAPRGGGGGGGGAGEPGGAERAAGTSRRRGLRACDEEFACPELEALFRGYTLRLEQAATLKALAVLSLLAGALALAELLGAPGPAPGLAKGSHPVHCVLFLALLVVTNVRSLQVPQLQQVGQLALLFSLTFALLCCPFALGGPARGSAGAAGGPATAEQGVWQLLLVTFVSYALLPVRSLLAIGFGLVVAASHLLVTATLVPAKRPRLWRTLGANALLFVGVNMYGVFVRILTERSQRKAFLQARSCIEDRLRLEDENEKQERLLMSLLPRNVAMEMKEDFLKPPERIFHKIYIQRHDNVSILFADIVGFTGLASQCTAQELVKLLNELFGKFDELATENHCRRIKILGDCYYCVSGLTQPKTDHAHCCVEMGLDMIDTITSVAEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANVMEAAGLPGKVHITKTTLACLNGDYEVEPGYGHERNSFLKTHNIETFFIVPSHRRKIFPGLILSDIKPAKRMKFKTVCYLLVQLMHCRKMFKAEIPFSNVMTCEDDDKRRALRTASEKLRNRSSFSTNVVYTTPGTRVNRYISRLLEARQTELEMADLNFFTLKYKHVEREQKYHQLQDEYFTSAVVLTLILAALFGLVYLLIFPQSVVVLLLLVFCICFLVACVLYLHITRVQCFPGCLTIQIRTVLCIFIVVLIYSVAQGCVVGCLPWAWSSKPNSSLVVLSSGGQRTALPTLPCESTHHALLCCLVGTLPLAIFFRVSSLPKMILLSGLTTSYILVLELSGYTRTGGGAVSGRSYEPIVAILLFSCALALHARQVDIRLRLDYLWAAQAEEEREDMEKVKLDNRRILFNLLPAHVAQHFLMSNPRNMDLYYQSYSQVGVMFASIPNFNDFYIELDGNNMGVECLRLLNEIIADFDELMEKDFYKDIEKIKTIGSTYMAAVGLAPTSGTKAKKSISSHLSTLADFAIEMFDVLDEINYQSYNDFVLRVGINVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGRIQVTEEVHRLLRRCPYHFVCRGKVSVKGKGEMLTYFLEGRTDGNGSQIRSLGLDRKMCPFGRAGLQGRRPPVCPMPGVSVRAGLPPHSPGQYLPSAAAGKEA Show/Hide
Organism	Homo sapiens, Human
Protein Classification	Enzyme
Function	Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates responses to increased cellular Ca(2+)/calmodulin levels (By similarity). May be involved in regulatory processes in the central nervous system. May play a role in memory and learning. Plays a role in the regulation of the circadian rhythm of daytime contrast sensitivity probably by modulating the rhythmic synthesis of cyclic AMP in the retina (By similarity). Show/Hide
Uniprot ID	Primary ID: Q08828 Secondarily ID: A4D2L8 Q75MI1 Show/Hide
Ensembl ID	ENSG00000164742
HGNC ID	HGNC:232
Subcellular Location	Membrane Cell membrane Cytoplasm Membrane raft

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000006 , HEK293

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0574273 Compound Info	N-[2-(4-ethyl-6-oxo-1H-pyrimidin-2-yl)-5-methylpyrazol-3-yl]-3-phenylbenzamide Show/Hide	C23H21N5O2	1
1	IC50 = 250 nM Bioactivity Info	TI LI LO TS
CP0550106 Compound Info	N-[2-(4-ethyl-6-oxo-1H-pyrimidin-2-yl)-5-methylpyrazol-3-yl]-3,4-dimethylbenzamide Show/Hide	C19H21N5O2	1
1	IC50 = 290 nM Bioactivity Info	TI LI LO TS
CP0574272 Compound Info	4-chloro-N-[2-(4-ethyl-6-oxo-1H-pyrimidin-2-yl)-5-methylpyrazol-3-yl]benzamide Show/Hide	C17H16ClN5O2	1
1	IC50 = 360 nM Bioactivity Info	TI LI LO TS
CP0574576 Compound Info	N-[2-(4-ethyl-6-oxo-1H-pyrimidin-2-yl)-5-methylpyrazol-3-yl]-3-propan-2-ylbenzamide Show/Hide	C20H23N5O2	1
1	IC50 = 360 nM Bioactivity Info	TI LI LO TS
CP0543599 Compound Info	4-ethyl-N-[2-(4-ethyl-6-oxo-1H-pyrimidin-2-yl)-5-methylpyrazol-3-yl]benzamide Show/Hide	C19H21N5O2	1
1	IC50 = 390 nM Bioactivity Info	TI LI LO TS
CP0543598 Compound Info	N-[2-(4-ethyl-6-oxo-1H-pyrimidin-2-yl)-5-methylpyrazol-3-yl]-3-methylbenzamide Show/Hide	C18H19N5O2	1
1	IC50 = 410 nM Bioactivity Info	TI LI LO TS
CP0543322 Compound Info	3-ethyl-N-[2-(4-ethyl-6-oxo-1H-pyrimidin-2-yl)-5-methylpyrazol-3-yl]benzamide Show/Hide	C19H21N5O2	1
1	IC50 = 440 nM Bioactivity Info	TI LI LO TS
CP0571830 Compound Info	3-chloro-N-[2-(4-ethyl-6-oxo-1H-pyrimidin-2-yl)-5-methylpyrazol-3-yl]benzamide Show/Hide	C17H16ClN5O2	1
1	IC50 = 470 nM Bioactivity Info	TI LI LO TS
CP0550105 Compound Info	N-[2-(4-ethyl-6-oxo-1H-pyrimidin-2-yl)-5-methylpyrazol-3-yl]-3,5-dimethylbenzamide Show/Hide	C19H21N5O2	1
1	IC50 = 520 nM Bioactivity Info	TI LI LO TS
CP0568332 Compound Info	N-[2-(4-ethyl-6-oxo-1H-pyrimidin-2-yl)-5-methylpyrazol-3-yl]-2-fluoro-5-methylbenzamide Show/Hide	C18H18FN5O2	1
1	IC50 = 540 nM Bioactivity Info	TI LI LO TS
CP0568888 Compound Info	N-[2-(4-ethyl-6-oxo-1H-pyrimidin-2-yl)-5-methylpyrazol-3-yl]-2-fluoro-3-methylbenzamide Show/Hide	C18H18FN5O2	1
1	IC50 = 570 nM Bioactivity Info	TI LI LO TS
CP0550356 Compound Info	3-bromo-N-[2-(4-ethyl-6-oxo-1H-pyrimidin-2-yl)-5-methylpyrazol-3-yl]benzamide Show/Hide	C17H16BrN5O2	1
1	IC50 = 610 nM Bioactivity Info	TI LI LO TS
CP0577394 Compound Info	N-[2-(4-ethyl-6-oxo-1H-pyrimidin-2-yl)-5-methylpyrazol-3-yl]-3-methylsulfanylbenzamide Show/Hide	C18H19N5O2S	1
1	IC50 = 630 nM Bioactivity Info	TI LI LO TS
CP0550355 Compound Info	N-[2-(4-ethyl-6-oxo-1H-pyrimidin-2-yl)-5-methylpyrazol-3-yl]-4-methylbenzamide Show/Hide	C18H19N5O2	1
1	IC50 = 670 nM Bioactivity Info	TI LI LO TS
CP0574575 Compound Info	N-[2-(4-ethyl-6-oxo-1H-pyrimidin-2-yl)-5-methylpyrazol-3-yl]-3-(trifluoromethyl)benzamide Show/Hide	C18H16F3N5O2	1
1	IC50 = 680 nM Bioactivity Info	TI LI LO TS
CP0574274 Compound Info	N-[2-(4-ethyl-6-oxo-1H-pyrimidin-2-yl)-5-methylpyrazol-3-yl]-4-phenylbenzamide Show/Hide	C23H21N5O2	1
1	IC50 = 770 nM Bioactivity Info	TI LI LO TS
CP0570413 Compound Info	N-[2-(4-ethyl-6-oxo-1H-pyrimidin-2-yl)-5-methylpyrazol-3-yl]-4-fluorobenzamide Show/Hide	C17H16FN5O2	1
1	IC50 = 790 nM Bioactivity Info	TI LI LO TS
CP0577921 Compound Info	3-cyclopropyl-N-[2-(4-ethyl-6-oxo-1H-pyrimidin-2-yl)-5-methylpyrazol-3-yl]benzamide Show/Hide	C20H21N5O2	1
1	IC50 = 810 nM Bioactivity Info	TI LI LO TS
CP0568886 Compound Info	3-tert-butyl-N-[2-(4-ethyl-6-oxo-1H-pyrimidin-2-yl)-5-methylpyrazol-3-yl]benzamide Show/Hide	C21H25N5O2	1
1	IC50 = 880 nM Bioactivity Info	TI LI LO TS
CP0571256 Compound Info	N-[2-(4-ethyl-6-oxo-1H-pyrimidin-2-yl)-5-methylpyrazol-3-yl]-4-methoxybenzamide Show/Hide	C18H19N5O3	1
1	IC50 = 900 nM Bioactivity Info	TI LI LO TS
CP0579380 Compound Info	3-ethoxy-N-[2-(4-ethyl-6-oxo-1H-pyrimidin-2-yl)-5-methylpyrazol-3-yl]benzamide Show/Hide	C19H21N5O3	1
1	IC50 = 900 nM Bioactivity Info	TI LI LO TS
CP0568329 Compound Info	4-tert-butyl-N-[2-(4-ethyl-6-oxo-1H-pyrimidin-2-yl)-5-methylpyrazol-3-yl]benzamide Show/Hide	C21H25N5O2	1
1	IC50 = 970 nM Bioactivity Info	TI LI LO TS
CP0554070 Compound Info	3-fluoro-N-[5-(5,6,7,8-tetrahydronaphthalen-2-yl)-1,3,4-oxadiazol-2-yl]benzamide Show/Hide	C19H16FN3O2	1
1	IC50 = 1000 nM Bioactivity Info	TI LI LO TS
CP0562875 Compound Info	4-ethyl-N-[5-(5,6,7,8-tetrahydronaphthalen-2-yl)-1,3,4-oxadiazol-2-yl]benzamide Show/Hide	C21H21N3O2	1
1	IC50 = 1200 nM Bioactivity Info	TI LI LO TS
CP0574684 Compound Info	N-[2-(4-ethyl-6-oxo-1H-pyrimidin-2-yl)-5-methylpyrazol-3-yl]pyridine-2-carboxamide Show/Hide	C16H16N6O2	1
1	IC50 = 1200 nM Bioactivity Info	TI LI LO TS
CP0413058 Compound Info	N-(5-cyclohexyl-1,3,4-oxadiazol-2-yl)-3-phenylbenzamide Show/Hide	C21H21N3O2	1
1	IC50 = 1400 nM Bioactivity Info	TI LI LO TS
CP0559325 Compound Info	N-[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]-3-methyl-5-(trifluoromethyl)benzamide Show/Hide	C17H11F4N3O2	1
1	IC50 = 1400 nM Bioactivity Info	TI LI LO TS
CP0550354 Compound Info	N-[2-(4-ethyl-6-oxo-1H-pyrimidin-2-yl)-5-methylpyrazol-3-yl]-3-fluorobenzamide Show/Hide	C17H16FN5O2	1
1	IC50 = 1400 nM Bioactivity Info	TI LI LO TS
CP0569784 Compound Info	N-[2-(4-ethyl-6-oxo-1H-pyrimidin-2-yl)-5-methylpyrazol-3-yl]-2-fluorobenzamide Show/Hide	C17H16FN5O2	1
1	IC50 = 1400 nM Bioactivity Info	TI LI LO TS
CP0577920 Compound Info	N-[2-(4-ethyl-6-oxo-1H-pyrimidin-2-yl)-5-methylpyrazol-3-yl]-3-methoxybenzamide Show/Hide	C18H19N5O3	1
1	IC50 = 1420 nM Bioactivity Info	TI LI LO TS
CP0413061 Compound Info	4-chloro-N-[5-(5,6,7,8-tetrahydronaphthalen-2-yl)-1,3,4-oxadiazol-2-yl]benzamide Show/Hide	C19H16ClN3O2	1
1	IC50 = 1500 nM Bioactivity Info	TI LI LO TS
CP0521385 Compound Info	N-[5-(5,6,7,8-tetrahydronaphthalen-2-yl)-1,3,4-oxadiazol-2-yl]-3-(trifluoromethyl)benzamide Show/Hide	C20H16F3N3O2	1
1	IC50 = 1600 nM Bioactivity Info	TI LI LO TS
CP0384246 Compound Info	3-methylsulfanyl-N-[5-(5,6,7,8-tetrahydronaphthalen-2-yl)-1,3,4-oxadiazol-2-yl]benzamide Show/Hide	C20H19N3O2S	1
1	IC50 = 1700 nM Bioactivity Info	TI LI LO TS
CP0550107 Compound Info	N-[2-(4-ethyl-6-oxo-1H-pyrimidin-2-yl)-5-methylpyrazol-3-yl]-2-methylbenzamide Show/Hide	C18H19N5O2	1
1	IC50 = 2200 nM Bioactivity Info	TI LI LO TS
CP0416978 Compound Info	N-[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]-3-phenylbenzamide Show/Hide	C21H14FN3O2	1
1	IC50 = 2300 nM Bioactivity Info	TI LI LO TS
CP0531412 Compound Info	6-chloro-2-(trichloromethyl)chromen-4-one Show/Hide	C10H4Cl4O2	1
1	IC50 = 2300 nM Bioactivity Info	TI LI LO TS
CP0578568 Compound Info	4-(dimethylamino)-N-[2-(4-ethyl-6-oxo-1H-pyrimidin-2-yl)-5-methylpyrazol-3-yl]benzamide Show/Hide	C19H22N6O2	1
1	IC50 = 2300 nM Bioactivity Info	TI LI LO TS
CP0562876 Compound Info	N-[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]-4-phenylbenzamide Show/Hide	C21H14FN3O2	1
1	IC50 = 2800 nM Bioactivity Info	TI LI LO TS
CP0570412 Compound Info	N-[2-(4-ethyl-6-oxo-1H-pyrimidin-2-yl)-5-methylpyrazol-3-yl]benzamide Show/Hide	C17H17N5O2	1
1	IC50 = 2800 nM Bioactivity Info	TI LI LO TS
CP0554078 Compound Info	3-methoxy-N-[5-(5,6,7,8-tetrahydronaphthalen-2-yl)-1,3,4-oxadiazol-2-yl]benzamide Show/Hide	C20H19N3O3	1
1	IC50 = 3100 nM Bioactivity Info	TI LI LO TS
CP0545136 Compound Info	2-ethyl-N-[2-(4-ethyl-6-oxo-1H-pyrimidin-2-yl)-5-methylpyrazol-3-yl]benzamide Show/Hide	C19H21N5O2	1
1	IC50 = 3100 nM Bioactivity Info	TI LI LO TS
CP0252079 Compound Info	MLS000529919 Show/Hide	C19H17N3O2	1
1	IC50 = 3400 nM Bioactivity Info	TI LI LO TS
CP0384247 Compound Info	4-methyl-N-[5-(5,6,7,8-tetrahydronaphthalen-2-yl)-1,3,4-oxadiazol-2-yl]benzamide Show/Hide	C20H19N3O2	1
1	IC50 = 3400 nM Bioactivity Info	TI LI LO TS
CP0521364 Compound Info	4-bromo-N-[5-(2,3-dihydro-1,4-benzodioxin-6-yl)-1,3,4-oxadiazol-2-yl]benzamide Show/Hide	C17H12BrN3O4	1
1	IC50 = 3400 nM Bioactivity Info	TI LI LO TS
CP0416976 Compound Info	N-(5-cyclohexyl-1,3,4-oxadiazol-2-yl)-4-methyl-3-(trifluoromethyl)benzamide Show/Hide	C17H18F3N3O2	1
1	IC50 = 3700 nM Bioactivity Info	TI LI LO TS
CP0384244 Compound Info	4-bromo-N-[5-(5,6,7,8-tetrahydronaphthalen-2-yl)-1,3,4-oxadiazol-2-yl]benzamide Show/Hide	C19H16BrN3O2	1
1	IC50 = 4200 nM Bioactivity Info	TI LI LO TS
CP0570414 Compound Info	N-[2-(4-ethyl-6-oxo-1H-pyrimidin-2-yl)-5-methylpyrazol-3-yl]-4-(methoxymethoxy)benzamide Show/Hide	C19H21N5O4	1
1	IC50 = 4300 nM Bioactivity Info	TI LI LO TS
CP0384245 Compound Info	N-[5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl]-2-thiophen-2-ylquinoline-4-carboxamide Show/Hide	C23H16N4O3S	1
1	IC50 = 4600 nM Bioactivity Info	TI LI LO TS
CP0403046 Compound Info	N-[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]-4-methyl-3-(trifluoromethyl)benzamide Show/Hide	C17H11F4N3O2	1
1	IC50 = 4600 nM Bioactivity Info	TI LI LO TS
CP0521367 Compound Info	N-(5-cyclohexyl-1,3,4-oxadiazol-2-yl)-3-methoxy-5-(trifluoromethyl)benzamide Show/Hide	C17H18F3N3O3	1
1	IC50 = 4800 nM Bioactivity Info	TI LI LO TS
CP0554073 Compound Info	N-[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]-3-(trifluoromethyl)benzamide Show/Hide	C16H9F4N3O2	1
1	IC50 = 5000 nM Bioactivity Info	TI LI LO TS
CP0556655 Compound Info	N-[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]-3-methoxy-5-(trifluoromethyl)benzamide Show/Hide	C17H11F4N3O3	1
1	IC50 = 5000 nM Bioactivity Info	TI LI LO TS
CP0539579 Compound Info	N-[5-(2,3-dihydro-1,4-benzodioxin-6-yl)-1,3,4-oxadiazol-2-yl]-3-(trifluoromethyl)benzamide Show/Hide	C18H12F3N3O4	1
1	IC50 = 5100 nM Bioactivity Info	TI LI LO TS
CP0416977 Compound Info	N-[5-(2,3-dihydro-1,4-benzodioxin-6-yl)-1,3,4-oxadiazol-2-yl]-3,4-dimethylbenzamide Show/Hide	C19H17N3O4	1
1	IC50 = 5300 nM Bioactivity Info	TI LI LO TS
CP0554075 Compound Info	N-(5-phenyl-1,3,4-oxadiazol-2-yl)-4-propan-2-yloxybenzamide Show/Hide	C18H17N3O3	1
1	IC50 = 5400 nM Bioactivity Info	TI LI LO TS
CP0563335 Compound Info	4-fluoro-N-[5-(5,6,7,8-tetrahydronaphthalen-2-yl)-1,3,4-oxadiazol-2-yl]benzamide Show/Hide	C19H16FN3O2	1
1	IC50 = 5900 nM Bioactivity Info	TI LI LO TS
CP0562877 Compound Info	N-(5-cyclohexyl-1,3,4-oxadiazol-2-yl)-3-(trifluoromethyl)benzamide Show/Hide	C16H16F3N3O2	1
1	IC50 = 6000 nM Bioactivity Info	TI LI LO TS
CP0473327 Compound Info	4-methoxy-N-[5-(5,6,7,8-tetrahydronaphthalen-2-yl)-1,3,4-oxadiazol-2-yl]benzamide Show/Hide	C20H19N3O3	1
1	IC50 = 6400 nM Bioactivity Info	TI LI LO TS
CP0384249 Compound Info	N-[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]-3,4-dimethylbenzamide Show/Hide	C17H14FN3O2	1
1	IC50 = 6500 nM Bioactivity Info	TI LI LO TS
CP0403045 Compound Info	N-(5-cyclohexyl-1,3,4-oxadiazol-2-yl)-3-methylsulfanylbenzamide Show/Hide	C16H19N3O2S	1
1	IC50 = 6600 nM Bioactivity Info	TI LI LO TS
CP0543597 Compound Info	N-[2-(4-ethyl-6-oxo-1H-pyrimidin-2-yl)-5-methylpyrazol-3-yl]furan-2-carboxamide Show/Hide	C15H15N5O3	1
1	IC50 = 6700 nM Bioactivity Info	TI LI LO TS
CP0403075 Compound Info	N-(5-cyclohexyl-1,3,4-oxadiazol-2-yl)-4-ethylbenzamide Show/Hide	C17H21N3O2	1
1	IC50 = 7300 nM Bioactivity Info	TI LI LO TS
CP0528101 Compound Info	N-[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]-4-methylbenzamide Show/Hide	C16H12FN3O2	1
1	IC50 = 7300 nM Bioactivity Info	TI LI LO TS
CP0554071 Compound Info	N-[5-(2,3-dihydro-1,4-benzodioxin-6-yl)-1,3,4-oxadiazol-2-yl]-4-propan-2-yloxybenzamide Show/Hide	C20H19N3O5	1
1	IC50 = 7500 nM Bioactivity Info	TI LI LO TS
CP0416974 Compound Info	4-bromo-N-(5-thiophen-2-yl-1,3,4-oxadiazol-2-yl)benzamide Show/Hide	C13H8BrN3O2S	1
1	IC50 = 7700 nM Bioactivity Info	TI LI LO TS
CP0521362 Compound Info	N-(5-cyclohexyl-1,3,4-oxadiazol-2-yl)-3,4-dimethylbenzamide Show/Hide	C17H21N3O2	1
1	IC50 = 8100 nM Bioactivity Info	TI LI LO TS
CP0403047 Compound Info	4-ethyl-N-[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]benzamide Show/Hide	C17H14FN3O2	1
1	IC50 = 8200 nM Bioactivity Info	TI LI LO TS
CP0521361 Compound Info	4-bromo-N-(5-cyclohexyl-1,3,4-oxadiazol-2-yl)benzamide Show/Hide	C15H16BrN3O2	1
1	IC50 = 8600 nM Bioactivity Info	TI LI LO TS
CP0413056 Compound Info	4-chloro-N-[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]benzamide Show/Hide	C15H9ClFN3O2	1
1	IC50 = 8900 nM Bioactivity Info	TI LI LO TS
CP0556653 Compound Info	3-methyl-N-[5-(5,6,7,8-tetrahydronaphthalen-2-yl)-1,3,4-oxadiazol-2-yl]-5-(trifluoromethyl)benzamide Show/Hide	C21H18F3N3O2	1
1	IC50 = 9100 nM Bioactivity Info	TI LI LO TS
CP0571280 Compound Info	N-[2-(4-ethyl-6-oxo-1H-pyrimidin-2-yl)-5-methylpyrazol-3-yl]-2-(3-methylphenyl)acetamide Show/Hide	C19H21N5O2	1
1	IC50 = 9200 nM Bioactivity Info	TI LI LO TS
CP0403048 Compound Info	3-methoxy-N-[5-(5,6,7,8-tetrahydronaphthalen-2-yl)-1,3,4-oxadiazol-2-yl]-5-(trifluoromethyl)benzamide Show/Hide	C21H18F3N3O3	1
1	IC50 = 9400 nM Bioactivity Info	TI LI LO TS
CP0554080 Compound Info	N-[5-(2,3-dihydro-1,4-benzodioxin-6-yl)-1,3,4-oxadiazol-2-yl]-3-methylsulfanylbenzamide Show/Hide	C18H15N3O4S	1
1	IC50 = 9500 nM Bioactivity Info	TI LI LO TS
CP0416980 Compound Info	N-(5-cyclohexyl-1,3,4-oxadiazol-2-yl)-3-methyl-5-(trifluoromethyl)benzamide Show/Hide	C17H18F3N3O2	1
1	IC50 = 9600 nM Bioactivity Info	TI LI LO TS
CP0554072 Compound Info	N-[5-(2,3-dihydro-1,4-benzodioxin-6-yl)-1,3,4-oxadiazol-2-yl]-3-methoxybenzamide Show/Hide	C18H15N3O5	1
1	IC50 = 9600 nM Bioactivity Info	TI LI LO TS
CP0521386 Compound Info	4-propan-2-yloxy-N-(5-thiophen-2-yl-1,3,4-oxadiazol-2-yl)benzamide Show/Hide	C16H15N3O3S	1
1	IC50 = 9900 nM Bioactivity Info	TI LI LO TS
CP0521365 Compound Info	4-bromo-N-[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]benzamide Show/Hide	C15H9BrFN3O2	1
1	IC50 = 10000 nM Bioactivity Info	TI LI LO TS
CP0521366 Compound Info	N-(5-cyclohexyl-1,3,4-oxadiazol-2-yl)-4-propan-2-yloxybenzamide Show/Hide	C18H23N3O3	1
1	IC50 = 10000 nM Bioactivity Info	TI LI LO TS
CP0564564 Compound Info	4-propan-2-yloxy-N-[5-(5,6,7,8-tetrahydronaphthalen-2-yl)-1,3,4-oxadiazol-2-yl]benzamide Show/Hide	C22H23N3O3	1
1	IC50 = 10000 nM Bioactivity Info	TI LI LO TS
CP0561554 Compound Info	HTS-09836 Show/Hide	C12H20N6O	1
1	IC50 = 10000 nM Bioactivity Info	TI LI LO TS
CP0413065 Compound Info	3-methylsulfanyl-N-(5-thiophen-2-yl-1,3,4-oxadiazol-2-yl)benzamide Show/Hide	C14H11N3O2S2	1
1	IC50 = 11000 nM Bioactivity Info	TI LI LO TS
CP0521363 Compound Info	N-(5-cyclohexyl-1,3,4-oxadiazol-2-yl)-3-fluorobenzamide Show/Hide	C15H16FN3O2	1
1	IC50 = 11000 nM Bioactivity Info	TI LI LO TS
CP0539581 Compound Info	N-[5-(7-ethoxy-1-benzofuran-2-yl)-1,3,4-oxadiazol-2-yl]-2-methylsulfanylbenzamide Show/Hide	C20H17N3O4S	1
1	IC50 = 11000 nM Bioactivity Info	TI LI LO TS
CP0540930 Compound Info	3-fluoro-N-[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]benzamide Show/Hide	C15H9F2N3O2	1
1	IC50 = 11000 nM Bioactivity Info	TI LI LO TS
CP0540932 Compound Info	N-[5-(2,3-dihydro-1,4-benzodioxin-6-yl)-1,3,4-oxadiazol-2-yl]-4-methylbenzamide Show/Hide	C18H15N3O4	1
1	IC50 = 12000 nM Bioactivity Info	TI LI LO TS
CP0413057 Compound Info	N-(5-cyclohexyl-1,3,4-oxadiazol-2-yl)-4-fluorobenzamide Show/Hide	C15H16FN3O2	1
1	IC50 = 13000 nM Bioactivity Info	TI LI LO TS
CP0413059 Compound Info	N-(5-phenyl-1,3,4-oxadiazol-2-yl)-3-(trifluoromethyl)benzamide Show/Hide	C16H10F3N3O2	1
1	IC50 = 13000 nM Bioactivity Info	TI LI LO TS
CP0521368 Compound Info	N-[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]-4-methoxybenzamide Show/Hide	C16H12FN3O3	1
1	IC50 = 13000 nM Bioactivity Info	TI LI LO TS
CP0562878 Compound Info	4-chloro-N-(5-cyclohexyl-1,3,4-oxadiazol-2-yl)benzamide Show/Hide	C15H16ClN3O2	1
1	IC50 = 14000 nM Bioactivity Info	TI LI LO TS
CP0413055 Compound Info	N-[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]-3-methoxybenzamide Show/Hide	C16H12FN3O3	1
1	IC50 = 15000 nM Bioactivity Info	TI LI LO TS
CP0539580 Compound Info	4-methoxy-N-(5-thiophen-2-yl-1,3,4-oxadiazol-2-yl)benzamide Show/Hide	C14H11N3O3S	1
1	IC50 = 15000 nM Bioactivity Info	TI LI LO TS
CP0473329 Compound Info	N-[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]-4-piperidin-1-ylsulfonylbenzamide Show/Hide	C20H19FN4O4S	1
1	IC50 = 16000 nM Bioactivity Info	TI LI LO TS
CP0540931 Compound Info	N-(5-cyclohexyl-1,3,4-oxadiazol-2-yl)-4-methylbenzamide Show/Hide	C16H19N3O2	1
1	IC50 = 16000 nM Bioactivity Info	TI LI LO TS
CP0577923 Compound Info	N-[2-(4-ethyl-6-oxo-1H-pyrimidin-2-yl)-5-methylpyrazol-3-yl]-2-(2-fluorophenyl)acetamide Show/Hide	C18H18FN5O2	1
1	IC50 = 16300 nM Bioactivity Info	TI LI LO TS
CP0403049 Compound Info	4-fluoro-N-[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]benzamide Show/Hide	C15H9F2N3O2	1
1	IC50 = 17000 nM Bioactivity Info	TI LI LO TS
CP0473331 Compound Info	N-(5-cyclohexyl-1,3,4-oxadiazol-2-yl)-4-methoxybenzamide Show/Hide	C16H19N3O3	1
1	IC50 = 22000 nM Bioactivity Info	TI LI LO TS
CP0521360 Compound Info	N-(5-cyclohexyl-1,3,4-oxadiazol-2-yl)benzamide Show/Hide	C15H17N3O2	1
1	IC50 = 25000 nM Bioactivity Info	TI LI LO TS
CP0554074 Compound Info	4-methyl-N-[5-(5,6,7,8-tetrahydronaphthalen-2-yl)-1,3,4-oxadiazol-2-yl]-3-(trifluoromethyl)benzamide Show/Hide	C21H18F3N3O2	1
1	IC50 = 26000 nM Bioactivity Info	TI LI LO TS
CP0559323 Compound Info	N-(5-thiophen-2-yl-1,3,4-oxadiazol-2-yl)benzamide Show/Hide	C13H9N3O2S	1
1	IC50 = 28000 nM Bioactivity Info	TI LI LO TS
CP0413062 Compound Info	N-[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]benzamide Show/Hide	C15H10FN3O2	1
1	IC50 = 29000 nM Bioactivity Info	TI LI LO TS
CP0578747 Compound Info	N-[2-(4-ethyl-6-oxo-1H-pyrimidin-2-yl)-5-methylpyrazol-3-yl]acetamide Show/Hide	C12H15N5O2	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0473328 Compound Info	N-[5-(2,3-dihydro-1,4-benzodioxin-6-yl)-1,3,4-oxadiazol-2-yl]benzamide Show/Hide	C17H13N3O4	1
1	IC50 = 31000 nM Bioactivity Info	TI LI LO TS
CP0550357 Compound Info	N-[2-(4-ethyl-6-oxo-1H-pyrimidin-2-yl)-5-methylpyrazol-3-yl]-4-hydroxybenzamide Show/Hide	C17H17N5O3	1
1	IC50 > 60000 nM Bioactivity Info	TI LI LO TS

Clinical Information about the Protein

Target 1 ( Adenylate cyclase type 1 (ADCY1) )

Target Type	Successful Target
Disease	1 Target-related Disease				1
1	Malnutrition [ICD-11: 5B50-5B71]
Approved Drug(s)	1 Approved Drug				1
1	Adenosine monophosphate	Drug Info	Approved	Malnutrition

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han