General Information of the Protein
Protein ID
PT06352
Protein Name
Taste receptor type 2 member 31
Secondarily
Protein Name
Taste receptor type 2 member 44
Taste receptor type 2 member 53
Gene Name
TAS2R31
Secondarily
Gene Name
TAS2R44
Sequence
MTTFIPIIFSSVVVVLFVIGNFANGFIALVNSIERVKRQKISFADQILTALAVSRVGLLWVLLLNWYSTVFNPAFYSVEVRTTAYNVWAVTGHFSNWLATSLSIFYLLKIANFSNLIFLHLKRRVKSVILVMLLGPLLFLACQLFVINMKEIVRTKEYEGNLTWKIKLRSAVYLSDATVTTLGNLVPFTLTLLCFLLLICSLCKHLKKMQLHGKGSQDPSTKVHIKALQTVIFFLLLCAVYFLSIMISVWSFGSLENKPVFMFCKAIRFSYPSIHPFILIWGNKKLKQTFLSVLRQVRYWVKGEKPSSP
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Organism
Homo sapiens, Human
Protein Classification
Membrane receptor
>
Taste family G protein-coupled receptor
>
Taste receptor (taste family GPCR)
Function
Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity). Activated by the sulfonyl amide sweeteners saccharin and acesulfame K.
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Uniprot ID
Primary ID:
P59538

Secondarily ID:
P59547
Q17R84
Q645X5
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HGNC ID
HGNC:19113
Subcellular Location
Membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000025 , HEK-293T
Compound ID Compound Name Compound Formula
CP0850084
3-Betahydroxy dihydro costunolide
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C15H22O3
 1
1
EC50 = 31500 nM
   TI
   LI
   LO
   TS
CP0866307
3-beta-hydroxy dihydro costunolide
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C15H22O3
 1
1
EC50 = 31500 nM
   TI
   LI
   LO
   TS
Similar Protein(s) and Bioactivity Statistics
50% Identity
Protein ID Protein Name Protein Organism
PT06350 Taste receptor type 2 member 46 Homo sapiens, Human