Protein Information

General Information of the Protein

Protein ID	PT06318
Protein Name	Sphingomyelin phosphodiesterase 3
Secondarily Protein Name	Neutral sphingomyelinase 2 Neutral sphingomyelinase II
Gene Name	SMPD3
Sequence	MVLYTTPFPNSCLSALHCVSWALIFPCYWLVDRLAASFIPTTYEKRQRADDPCCLQLLCTALFTPIYLALLVASLPFAFLGFLFWSPLQSARRPYIYSRLEDKGLAGGAALLSEWKGTGPGKSFCFATANVCLLPDSLARVNNLFNTQARAKEIGQRIRNGAARPQIKIYIDSPTNTSISAASFSSLVSPQGGDGVARAVPGSIKRTASVEYKGDGGRHPGDEAANGPASGDPVDSSSPEDACIVRIGGEEGGRPPEADDPVPGGQARNGAGGGPRGQTPNHNQQDGDSGSLGSPSASRESLVKGRAGPDTSASGEPGANSKLLYKASVVKKAAARRRRHPDEAFDHEVSAFFPANLDFLCLQEVFDKRAATKLKEQLHGYFEYILYDVGVYGCQGCCSFKCLNSGLLFASRYPIMDVAYHCYPNKCNDDALASKGALFLKVQVGSTPQDQRIVGYIACTHLHAPQEDSAIRCGQLDLLQDWLADFRKSTSSSSAANPEELVAFDVVCGDFNFDNCSSDDKLEQQHSLFTHYRDPCRLGPGEEKPWAIGTLLDTNGLYDEDVCTPDNLQKVLESEEGRREYLAFPTSKSSGQKGRKELLKGNGRRIDYMLHAEEGLCPDWKAEVEEFSFITQLSGLTDHLPVAMRLMVSSGEEEA Show/Hide
Organism	Homo sapiens, Human
Protein Classification	Enzyme > Hydrolase
Function	Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Regulates the cell cycle by acting as a growth suppressor in confluent cells. Probably acts as a regulator of postnatal development and participates in bone and dentin mineralization (PubMed:10823942, PubMed:14741383, PubMed:15051724). Binds to anionic phospholipids (APLs) such as phosphatidylserine (PS) and phosphatidic acid (PA) that modulate enzymatic activity and subcellular location. May be involved in IL-1-beta-induced JNK activation in hepatocytes (By similarity). May act as a mediator in transcriptional regulation of NOS2/iNOS via the NF-kappa-B activation under inflammatory conditions (By similarity). Show/Hide
Uniprot ID	Primary ID: Q9NY59 Secondarily ID: B7ZL82 Q2M1S8 Show/Hide
Ensembl ID	ENSG00000103056
HGNC ID	HGNC:14240
Subcellular Location	Golgi apparatus membrane Cell membrane

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000006 , HEK293

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0551167 Compound Info	2,6-diethoxy-4-(4-phenyl-5-thiophen-2-yl-1H-imidazol-2-yl)phenol Show/Hide	C23H22N2O3S	1
1	IC50 = 10 nM Bioactivity Info	TI LI LO TS
CP0121109 Compound Info	4-(4,5-diphenyl-1,3-dihydroimidazol-2-ylidene)-2,6-dimethoxy-1-cyclohexa-2,5-dienone Show/Hide	C23H20N2O3	1
1	IC50 = 20 nM Bioactivity Info	TI LI LO TS
CP0542335 Compound Info	2,6-dimethoxy-4-(5-methyl-4-thiophen-2-yl-1H-imidazol-2-yl)phenol Show/Hide	C16H16N2O3S	1
1	IC50 = 20 nM Bioactivity Info	TI LI LO TS
CP0542336 Compound Info	2,6-dimethoxy-4-(5-methyl-4-phenyl-1H-imidazol-2-yl)phenol Show/Hide	C18H18N2O3	1
1	IC50 = 20 nM Bioactivity Info	TI LI LO TS
CP0562121 Compound Info	4-(4,5-dithiophen-2-yl-1H-imidazol-2-yl)-2,6-dimethoxyphenol Show/Hide	C19H16N2O3S2	1
1	IC50 = 20 nM Bioactivity Info	TI LI LO TS
CP0573115 Compound Info	4-[4,5-bis(4-methoxyphenyl)-1H-imidazol-2-yl]-2,6-dimethoxyphenol Show/Hide	C25H24N2O5	1
1	IC50 = 20 nM Bioactivity Info	TI LI LO TS
CP0143496 Compound Info	2,6-dimethoxy-4-(4-phenyl-5-thiophen-2-yl-1H-imidazol-2-yl)phenol Show/Hide	C21H18N2O3S	1
1	IC50 = 30 nM Bioactivity Info	TI LI LO TS
CP0517615 Compound Info	4-(4-phenyl-5-thiophen-2-yl-1H-imidazol-2-yl)-2,6-di(propan-2-yloxy)phenol Show/Hide	C25H26N2O3S	1
1	IC50 = 40 nM Bioactivity Info	TI LI LO TS
CP0560789 Compound Info	4-[4,5-bis(furan-2-yl)-1H-imidazol-2-yl]-2,6-dimethoxyphenol Show/Hide	C19H16N2O5	1
1	IC50 = 40 nM Bioactivity Info	TI LI LO TS
CP0560790 Compound Info	4-(4-butyl-5-methyl-1H-imidazol-2-yl)-2,6-dimethoxyphenol Show/Hide	C16H22N2O3	1
1	IC50 = 60 nM Bioactivity Info	TI LI LO TS
CP0486080 Compound Info	2,6-dimethoxy-4-(4-phenyl-5-propan-2-yl-1H-imidazol-2-yl)phenol Show/Hide	C20H22N2O3	1
1	IC50 = 70 nM Bioactivity Info	TI LI LO TS
CP0536357 Compound Info	2,6-dimethoxy-4-(5-phenyl-1H-imidazol-2-yl)phenol Show/Hide	C17H16N2O3	1
1	IC50 = 70 nM Bioactivity Info	TI LI LO TS
CP0542337 Compound Info	4-[4,5-bis(4-methylphenyl)-1H-imidazol-2-yl]-2,6-dimethoxyphenol Show/Hide	C25H24N2O3	1
1	IC50 = 70 nM Bioactivity Info	TI LI LO TS
CP0564813 Compound Info	4-(4-phenyl-5-thiophen-2-yl-1H-imidazol-2-yl)-2,6-bis(2,2,2-trifluoroethoxy)phenol Show/Hide	C23H16F6N2O3S	1
1	IC50 = 70 nM Bioactivity Info	TI LI LO TS
CP0565368 Compound Info	3-(3,4-dimethoxyphenyl)-2,6-dimethyl-8-pyrrolidin-1-ylimidazo[1,2-b]pyridazine Show/Hide	C20H24N4O2	1
1	IC50 = 70 nM Bioactivity Info	TI LI LO TS
CP0551166 Compound Info	4-[4,5-di(propan-2-yl)-1H-imidazol-2-yl]-2,6-dimethoxyphenol Show/Hide	C17H24N2O3	1
1	IC50 = 90 nM Bioactivity Info	TI LI LO TS
CP0576202 Compound Info	N-[(3R)-1-[3-(3,4-dimethoxyphenyl)-2,6-dimethylimidazo[1,2-b]pyridazin-8-yl]pyrrolidin-3-yl]-4-methylbenzenesulfonamide Show/Hide	C27H31N5O4S	1
1	IC50 = 90 nM Bioactivity Info	TI LI LO TS
CP0472668 Compound Info	N-[(3R)-1-[3-(3,4-dimethoxyphenyl)-2,6-dimethylimidazo[1,2-b]pyridazin-8-yl]pyrrolidin-3-yl]hexanamide Show/Hide	C26H35N5O3	1
1	IC50 = 100 nM Bioactivity Info	TI LI LO TS
CP0479690 Compound Info	N-[(3R)-1-[3-(3,4-dimethoxyphenyl)-2,6-dimethylimidazo[1,2-b]pyridazin-8-yl]pyrrolidin-3-yl]cyclopropanesulfonamide Show/Hide	C23H29N5O4S	1
1	IC50 = 100 nM Bioactivity Info	TI LI LO TS
CP0525810 Compound Info	N-[(3R)-1-[3-(3,4-dimethoxyphenyl)-2,6-dimethylimidazo[1,2-b]pyridazin-8-yl]pyrrolidin-3-yl]-2,2-difluoro-2-phenylacetamide Show/Hide	C28H29F2N5O3	1
1	IC50 = 100 nM Bioactivity Info	TI LI LO TS
CP0570790 Compound Info	N-[(3R)-1-[3-(3,4-dimethoxyphenyl)-2,6-dimethylimidazo[1,2-b]pyridazin-8-yl]pyrrolidin-3-yl]thiophene-2-sulfonamide Show/Hide	C24H27N5O4S2	1
1	IC50 = 100 nM Bioactivity Info	TI LI LO TS
CP0491829 Compound Info	4-(4,5-diethyl-1H-imidazol-2-yl)-2,6-dimethoxyphenol Show/Hide	C15H20N2O3	1
1	IC50 = 120 nM Bioactivity Info	TI LI LO TS
CP0526058 Compound Info	2,6-dicyclopentyloxy-4-(4-phenyl-5-thiophen-2-yl-1H-imidazol-2-yl)phenol Show/Hide	C29H30N2O3S	1
1	IC50 = 120 nM Bioactivity Info	TI LI LO TS
CP0573116 Compound Info	2,6-dimethoxy-4-[5-(4-methylphenyl)-1H-imidazol-2-yl]phenol Show/Hide	C18H18N2O3	1
1	IC50 = 130 nM Bioactivity Info	TI LI LO TS
CP0520932 Compound Info	N-[(3R)-1-[2,6-dimethyl-3-(4-methylsulfanylphenyl)imidazo[1,2-b]pyridazin-8-yl]pyrrolidin-3-yl]acetamide Show/Hide	C21H25N5OS	1
1	IC50 = 200 nM Bioactivity Info	TI LI LO TS
CP0520933 Compound Info	1-[(3R)-1-[3-(3,4-dimethoxyphenyl)-2,6-dimethylimidazo[1,2-b]pyridazin-8-yl]pyrrolidin-3-yl]-3-phenylurea Show/Hide	C27H30N6O3	1
1	IC50 = 200 nM Bioactivity Info	TI LI LO TS
CP0539776 Compound Info	(3-methylphenyl) N-[(3R)-1-[3-(3,4-dimethoxyphenyl)-2,6-dimethylimidazo[1,2-b]pyridazin-8-yl]pyrrolidin-3-yl]carbamate Show/Hide	C28H31N5O4	1
1	IC50 = 200 nM Bioactivity Info	TI LI LO TS
CP0539777 Compound Info	N-[(3R)-1-[3-(3,4-dimethoxyphenyl)-2,6-dimethylimidazo[1,2-b]pyridazin-8-yl]pyrrolidin-3-yl]-4-(trifluoromethyl)benzenesulfonamide Show/Hide	C27H28F3N5O4S	1
1	IC50 = 200 nM Bioactivity Info	TI LI LO TS
CP0554295 Compound Info	4-acetyl-N-[(3R)-1-[3-(3,4-dimethoxyphenyl)-2,6-dimethylimidazo[1,2-b]pyridazin-8-yl]pyrrolidin-3-yl]benzenesulfonamide Show/Hide	C28H31N5O5S	1
1	IC50 = 200 nM Bioactivity Info	TI LI LO TS
CP0565367 Compound Info	4-cyano-N-[(3R)-1-[3-(3,4-dimethoxyphenyl)-2,6-dimethylimidazo[1,2-b]pyridazin-8-yl]pyrrolidin-3-yl]benzenesulfonamide Show/Hide	C27H28N6O4S	1
1	IC50 = 200 nM Bioactivity Info	TI LI LO TS
CP0570787 Compound Info	N-[(3R)-1-[2,6-dimethyl-3-[4-(trifluoromethoxy)phenyl]imidazo[1,2-b]pyridazin-8-yl]pyrrolidin-3-yl]acetamide Show/Hide	C21H22F3N5O2	1
1	IC50 = 200 nM Bioactivity Info	TI LI LO TS
CP0575999 Compound Info	N-[(3R)-1-[3-(3,4-dimethoxyphenyl)-2,6-dimethylimidazo[1,2-b]pyridazin-8-yl]pyrrolidin-3-yl]-2-phenoxyacetamide Show/Hide	C28H31N5O4	1
1	IC50 = 200 nM Bioactivity Info	TI LI LO TS
CP0526057 Compound Info	2,6-dimethoxy-4-(5-methyl-1H-imidazol-2-yl)phenol Show/Hide	C12H14N2O3	1
1	IC50 = 220 nM Bioactivity Info	TI LI LO TS
CP0525430 Compound Info	N-[(3R)-1-(2,6-dimethyl-3-thiophen-2-ylimidazo[1,2-b]pyridazin-8-yl)pyrrolidin-3-yl]acetamide Show/Hide	C18H21N5OS	1
1	IC50 = 300 nM Bioactivity Info	TI LI LO TS
CP0525814 Compound Info	S-[(3R)-1-[3-(3,4-dimethoxyphenyl)-2,6-dimethylimidazo[1,2-b]pyridazin-8-yl]pyrrolidin-3-yl] ethanethioate Show/Hide	C22H26N4O3S	1
1	IC50 = 300 nM Bioactivity Info	TI LI LO TS
CP0538387 Compound Info	phenyl N-[(3R)-1-[3-(3,4-dimethoxyphenyl)-2,6-dimethylimidazo[1,2-b]pyridazin-8-yl]pyrrolidin-3-yl]carbamate Show/Hide	C27H29N5O4	1
1	IC50 = 300 nM Bioactivity Info	TI LI LO TS
CP0539171 Compound Info	3-(3,4-dimethoxyphenyl)-2,6-dimethyl-8-[(3R)-3-(4-phenyltriazol-1-yl)pyrrolidin-1-yl]imidazo[1,2-b]pyridazine Show/Hide	C28H29N7O2	1
1	IC50 = 300 nM Bioactivity Info	TI LI LO TS
CP0554294 Compound Info	benzyl N-[(3R)-1-[3-(3,4-dimethoxyphenyl)-2,6-dimethylimidazo[1,2-b]pyridazin-8-yl]pyrrolidin-3-yl]carbamate Show/Hide	C28H31N5O4	1
1	IC50 = 300 nM Bioactivity Info	TI LI LO TS
CP0569957 Compound Info	phenyl N-[(3S)-1-[3-(3,4-dimethoxyphenyl)-2,6-dimethylimidazo[1,2-b]pyridazin-8-yl]pyrrolidin-3-yl]carbamate Show/Hide	C27H29N5O4	1
1	IC50 = 300 nM Bioactivity Info	TI LI LO TS
CP0569958 Compound Info	cyclohexyl N-[(3R)-1-[3-(3,4-dimethoxyphenyl)-2,6-dimethylimidazo[1,2-b]pyridazin-8-yl]pyrrolidin-3-yl]carbamate Show/Hide	C27H35N5O4	1
1	IC50 = 300 nM Bioactivity Info	TI LI LO TS
CP0570789 Compound Info	naphthalen-2-yl N-[(3R)-1-[3-(3,4-dimethoxyphenyl)-2,6-dimethylimidazo[1,2-b]pyridazin-8-yl]pyrrolidin-3-yl]carbamate Show/Hide	C31H31N5O4	1
1	IC50 = 300 nM Bioactivity Info	TI LI LO TS
CP0570791 Compound Info	3-(3,4-dimethoxyphenyl)-2,6-dimethyl-8-[(3R)-3-(sulfamoylamino)pyrrolidin-1-yl]imidazo[1,2-b]pyridazine Show/Hide	C20H26N6O4S	1
1	IC50 = 300 nM Bioactivity Info	TI LI LO TS
CP0574968 Compound Info	N-[(3R)-1-[3-(3,4-dimethoxyphenyl)-2,6-dimethylimidazo[1,2-b]pyridazin-8-yl]pyrrolidin-3-yl]propane-2-sulfonamide Show/Hide	C23H31N5O4S	1
1	IC50 = 300 nM Bioactivity Info	TI LI LO TS
CP0486081 Compound Info	2-methoxy-4-(4-phenyl-5-thiophen-2-yl-1H-imidazol-2-yl)phenol Show/Hide	C20H16N2O2S	1
1	IC50 = 320 nM Bioactivity Info	TI LI LO TS
CP0525815 Compound Info	[(3R)-1-[3-(3,4-dimethoxyphenyl)-2,6-dimethylimidazo[1,2-b]pyridazin-8-yl]pyrrolidin-3-yl] acetate Show/Hide	C22H26N4O4	1
1	IC50 = 400 nM Bioactivity Info	TI LI LO TS
CP0539170 Compound Info	N-[(3R)-1-[3-(3,4-dimethoxyphenyl)-2,6-dimethylimidazo[1,2-b]pyridazin-8-yl]pyrrolidin-3-yl]-2-phenylacetamide Show/Hide	C28H31N5O3	1
1	IC50 = 400 nM Bioactivity Info	TI LI LO TS
CP0554293 Compound Info	(2S)-N-[(3R)-1-[3-(3,4-dimethoxyphenyl)-2,6-dimethylimidazo[1,2-b]pyridazin-8-yl]pyrrolidin-3-yl]-2-methoxy-2-phenylacetamide Show/Hide	C29H33N5O4	1
1	IC50 = 400 nM Bioactivity Info	TI LI LO TS
CP0565366 Compound Info	4-chloro-N-[(3R)-1-[3-(3,4-dimethoxyphenyl)-2,6-dimethylimidazo[1,2-b]pyridazin-8-yl]pyrrolidin-3-yl]benzenesulfonamide Show/Hide	C26H28ClN5O4S	1
1	IC50 = 400 nM Bioactivity Info	TI LI LO TS
CP0542338 Compound Info	2,6-dimethoxy-4-(4,5,6,7-tetrahydro-1H-benzimidazol-2-yl)phenol Show/Hide	C15H18N2O3	1
1	IC50 = 420 nM Bioactivity Info	TI LI LO TS
CP0560791 Compound Info	4-(1H-imidazol-2-yl)-2,6-dimethoxyphenol Show/Hide	C11H12N2O3	1
1	IC50 = 420 nM Bioactivity Info	TI LI LO TS
CP0472664 Compound Info	N-[(3R)-1-[3-(6-methoxypyridin-3-yl)-2,6-dimethylimidazo[1,2-b]pyridazin-8-yl]pyrrolidin-3-yl]acetamide Show/Hide	C20H24N6O2	1
1	IC50 = 500 nM Bioactivity Info	TI LI LO TS
CP0479691 Compound Info	N-[(3R)-1-[3-(3,4-dimethoxyphenyl)-2,6-dimethylimidazo[1,2-b]pyridazin-8-yl]pyrrolidin-3-yl]benzenesulfonamide Show/Hide	C26H29N5O4S	1
1	IC50 = 500 nM Bioactivity Info	TI LI LO TS
CP0565370 Compound Info	(3S)-1-[3-(3,4-dimethoxyphenyl)-2,6-dimethylimidazo[1,2-b]pyridazin-8-yl]pyrrolidin-3-ol Show/Hide	C20H24N4O3	1
1	IC50 = 500 nM Bioactivity Info	TI LI LO TS
CP0570786 Compound Info	N-[(3R)-1-[3-[3-(dimethylsulfamoyl)phenyl]-2,6-dimethylimidazo[1,2-b]pyridazin-8-yl]pyrrolidin-3-yl]acetamide Show/Hide	C22H28N6O3S	1
1	IC50 = 500 nM Bioactivity Info	TI LI LO TS
CP0383081 Compound Info	4-(4,5-dimethyl-1H-imidazol-2-yl)-2,6-dimethoxyphenol Show/Hide	C13H16N2O3	1
1	IC50 = 520 nM Bioactivity Info	TI LI LO TS
CP0491830 Compound Info	2,6-bis[(2-methylpropan-2-yl)oxy]-4-(4-phenyl-5-thiophen-2-yl-1H-imidazol-2-yl)phenol Show/Hide	C27H30N2O3S	1
1	IC50 = 520 nM Bioactivity Info	TI LI LO TS
CP0536375 Compound Info	3-methoxy-5-(4-phenyl-5-thiophen-2-yl-1H-imidazol-2-yl)benzene-1,2-diol Show/Hide	C20H16N2O3S	1
1	IC50 = 560 nM Bioactivity Info	TI LI LO TS
CP0487349 Compound Info	N-[(3R)-1-[3-(3,4-dimethoxyphenyl)-2,6-dimethylimidazo[1,2-b]pyridazin-8-yl]pyrrolidin-3-yl]benzamide Show/Hide	C27H29N5O3	1
1	IC50 = 600 nM Bioactivity Info	TI LI LO TS
CP0525809 Compound Info	N-[(3R)-1-[3-(3-fluoro-4-methoxyphenyl)-2,6-dimethylimidazo[1,2-b]pyridazin-8-yl]pyrrolidin-3-yl]acetamide Show/Hide	C21H24FN5O2	1
1	IC50 = 600 nM Bioactivity Info	TI LI LO TS
CP0525813 Compound Info	(3R)-1-[3-(3,4-dimethoxyphenyl)-2,6-dimethylimidazo[1,2-b]pyridazin-8-yl]pyrrolidin-3-ol Show/Hide	C20H24N4O3	1
1	IC50 = 600 nM Bioactivity Info	TI LI LO TS
CP0472671 Compound Info	3-(3,4-dimethoxyphenyl)-8-[(3R)-3-fluoropyrrolidin-1-yl]-2,6-dimethylimidazo[1,2-b]pyridazine Show/Hide	C20H23FN4O2	1
1	IC50 = 700 nM Bioactivity Info	TI LI LO TS
CP0472672 Compound Info	8-[(3R)-3-azidopyrrolidin-1-yl]-3-(3,4-dimethoxyphenyl)-2,6-dimethylimidazo[1,2-b]pyridazine Show/Hide	C20H23N7O2	1
1	IC50 = 700 nM Bioactivity Info	TI LI LO TS
CP0570792 Compound Info	4-[(3R)-1-[3-(3,4-dimethoxyphenyl)-2,6-dimethylimidazo[1,2-b]pyridazin-8-yl]pyrrolidin-3-yl]morpholine Show/Hide	C24H31N5O3	1
1	IC50 = 700 nM Bioactivity Info	TI LI LO TS
CP0578249 Compound Info	N-[(3R)-1-[2,6-dimethyl-3-[4-(trifluoromethyl)phenyl]imidazo[1,2-b]pyridazin-8-yl]pyrrolidin-3-yl]acetamide Show/Hide	C21H22F3N5O	1
1	IC50 = 700 nM Bioactivity Info	TI LI LO TS
CP0938652 Compound Info	(R)-N-(1-(3-(1H-Indol-6-yl)-2,6-dimethylimidazo[1,2-b]pyridazin-8-yl)pyrrolidin-3-yl)acetamide Show/Hide	C22H24N6O	1
1	IC50 = 700 nM Bioactivity Info	TI LI LO TS
CP0554292 Compound Info	N-[(3R)-1-[2,6-dimethyl-3-(3-morpholin-4-ylphenyl)imidazo[1,2-b]pyridazin-8-yl]pyrrolidin-3-yl]acetamide Show/Hide	C24H30N6O2	1
1	IC50 = 800 nM Bioactivity Info	TI LI LO TS
CP0574967 Compound Info	1-[(3R)-1-[3-(3,4-dimethoxyphenyl)-2,6-dimethylimidazo[1,2-b]pyridazin-8-yl]pyrrolidin-3-yl]-3-propan-2-ylurea Show/Hide	C24H32N6O3	1
1	IC50 = 800 nM Bioactivity Info	TI LI LO TS
CP0491831 Compound Info	5-(4-phenyl-5-thiophen-2-yl-1H-imidazol-2-yl)benzene-1,2,3-triol Show/Hide	C19H14N2O3S	1
1	IC50 = 840 nM Bioactivity Info	TI LI LO TS
CP0437457 Compound Info	tert-butyl 3-[3-(3,4-dimethoxyphenyl)-2,6-dimethylimidazo[1,2-b]pyridazin-8-yl]imidazolidine-1-carboxylate Show/Hide	C24H31N5O4	1
1	IC50 = 900 nM Bioactivity Info	TI LI LO TS
CP0472665 Compound Info	N-[(3R)-1-[3-(furan-2-yl)-2,6-dimethylimidazo[1,2-b]pyridazin-8-yl]pyrrolidin-3-yl]acetamide Show/Hide	C18H21N5O2	1
1	IC50 = 900 nM Bioactivity Info	TI LI LO TS
CP0525434 Compound Info	N-[(3R)-1-[3-(3,4-dimethoxyphenyl)-6-methylimidazo[1,2-b]pyridazin-8-yl]pyrrolidin-3-yl]acetamide Show/Hide	C21H25N5O3	1
1	IC50 = 900 nM Bioactivity Info	TI LI LO TS
CP0539169 Compound Info	N-[(3R)-1-[3-(3,4-dimethoxyphenyl)-2,6-dimethylimidazo[1,2-b]pyridazin-8-yl]pyrrolidin-3-yl]-2,2,2-trifluoroacetamide Show/Hide	C22H24F3N5O3	1
1	IC50 = 900 nM Bioactivity Info	TI LI LO TS
CP0341590 Compound Info	N-[(3R)-1-[3-(3,4-dimethoxyphenyl)-2,6-dimethylimidazo[1,2-b]pyridazin-8-yl]pyrrolidin-3-yl]acetamide Show/Hide	C22H27N5O3	1
1	IC50 = 1000 nM Bioactivity Info	TI LI LO TS
CP0525812 Compound Info	8-(3,3-difluoropyrrolidin-1-yl)-3-(3,4-dimethoxyphenyl)-2,6-dimethylimidazo[1,2-b]pyridazine Show/Hide	C20H22F2N4O2	1
1	IC50 = 1000 nM Bioactivity Info	TI LI LO TS
CP0525811 Compound Info	8-(2,5-dihydropyrrol-1-yl)-3-(3,4-dimethoxyphenyl)-2,6-dimethylimidazo[1,2-b]pyridazine Show/Hide	C20H22N4O2	1
1	IC50 = 1100 nM Bioactivity Info	TI LI LO TS
CP0525432 Compound Info	N-[(3R)-1-[3-(3,4-dimethoxyphenyl)-2,6-dimethylimidazo[1,2-b]pyridazin-8-yl]pyrrolidin-3-yl]methanesulfonamide Show/Hide	C21H27N5O4S	1
1	IC50 = 1200 nM Bioactivity Info	TI LI LO TS
CP0539168 Compound Info	N-[(3R)-1-[2,6-dimethyl-3-(1,3-thiazol-2-yl)imidazo[1,2-b]pyridazin-8-yl]pyrrolidin-3-yl]acetamide Show/Hide	C17H20N6OS	1
1	IC50 = 1200 nM Bioactivity Info	TI LI LO TS
CP0578248 Compound Info	N-[(3R)-1-[2,6-dimethyl-3-(3,4,5-trimethoxyphenyl)imidazo[1,2-b]pyridazin-8-yl]pyrrolidin-3-yl]acetamide Show/Hide	C23H29N5O4	1
1	IC50 = 1400 nM Bioactivity Info	TI LI LO TS
CP0565365 Compound Info	N-[(3R)-1-(2,6-dimethyl-3-phenylimidazo[1,2-b]pyridazin-8-yl)pyrrolidin-3-yl]acetamide Show/Hide	C20H23N5O	1
1	IC50 = 1500 nM Bioactivity Info	TI LI LO TS
CP0068865 Compound Info	N-[(3S)-1-[3-(3,4-dimethoxyphenyl)-2,6-dimethylimidazo[1,2-b]pyridazin-8-yl]pyrrolidin-3-yl]acetamide Show/Hide	C22H27N5O3	1
1	IC50 = 2000 nM Bioactivity Info	TI LI LO TS
CP0539811 Compound Info	N-[(3R)-1-[3-(4-fluoro-3-methoxyphenyl)-2,6-dimethylimidazo[1,2-b]pyridazin-8-yl]pyrrolidin-3-yl]acetamide Show/Hide	C21H24FN5O2	1
1	IC50 = 2000 nM Bioactivity Info	TI LI LO TS
CP0570788 Compound Info	(3R)-1-[3-(3,4-dimethoxyphenyl)-2,6-dimethylimidazo[1,2-b]pyridazin-8-yl]pyrrolidin-3-amine;hydrochloride Show/Hide	C20H26ClN5O2	1
1	IC50 = 2000 nM Bioactivity Info	TI LI LO TS
CP0536376 Compound Info	4-(4-phenyl-5-thiophen-2-yl-1H-imidazol-2-yl)phenol Show/Hide	C19H14N2OS	1
1	IC50 = 2100 nM Bioactivity Info	TI LI LO TS
CP0570793 Compound Info	tert-butyl 4-[3-(3,4-dimethoxyphenyl)-2,6-dimethylimidazo[1,2-b]pyridazin-8-yl]piperazine-1-carboxylate Show/Hide	C25H33N5O4	1
1	IC50 = 2100 nM Bioactivity Info	TI LI LO TS
CP0570794 Compound Info	cyclohexyl-[4-[3-(3,4-dimethoxyphenyl)-2,6-dimethylimidazo[1,2-b]pyridazin-8-yl]piperazin-1-yl]methanone Show/Hide	C27H35N5O3	1
1	IC50 = 2400 nM Bioactivity Info	TI LI LO TS
CP0575998 Compound Info	N-[(3R)-1-[3-(4-cyanophenyl)-2,6-dimethylimidazo[1,2-b]pyridazin-8-yl]pyrrolidin-3-yl]acetamide Show/Hide	C21H22N6O	1
1	IC50 = 2500 nM Bioactivity Info	TI LI LO TS
CP0038142 Compound Info	cambinol Show/Hide	C21H16N2O2S	2
1	IC50 = 5000 nM Bioactivity Info	TI LI LO TS
2	IC50 > 1000 nM Bioactivity Info	TI LI LO TS
CP0437456 Compound Info	N-[4-[[(3R)-1-[3-(3,4-dimethoxyphenyl)-2,6-dimethylimidazo[1,2-b]pyridazin-8-yl]pyrrolidin-3-yl]sulfamoyl]phenyl]acetamide Show/Hide	C28H32N6O5S	1
1	IC50 = 5000 nM Bioactivity Info	TI LI LO TS
CP0525433 Compound Info	N-[2-[[3-(3,4-dimethoxyphenyl)-2,6-dimethylimidazo[1,2-b]pyridazin-8-yl]-ethylamino]ethyl]acetamide Show/Hide	C22H29N5O3	1
1	IC50 = 5300 nM Bioactivity Info	TI LI LO TS
CP0525437 Compound Info	N-[(3R)-1-[3-(3,4-dimethoxyphenyl)imidazo[1,2-b]pyridazin-8-yl]pyrrolidin-3-yl]acetamide Show/Hide	C20H23N5O3	1
1	IC50 = 5700 nM Bioactivity Info	TI LI LO TS
CP0570795 Compound Info	N-[(3R)-1-[3-(3,4-dimethoxyphenyl)-2-methylimidazo[1,2-b]pyridazin-8-yl]pyrrolidin-3-yl]acetamide Show/Hide	C21H25N5O3	1
1	IC50 = 7200 nM Bioactivity Info	TI LI LO TS
CP0577357 Compound Info	N-[(3R)-1-(2,6-dimethylimidazo[1,2-b]pyridazin-8-yl)pyrrolidin-3-yl]acetamide Show/Hide	C14H19N5O	1
1	IC50 = 7500 nM Bioactivity Info	TI LI LO TS
CP0487350 Compound Info	4-[3-(3,4-dimethoxyphenyl)-2,6-dimethylimidazo[1,2-b]pyridazin-8-yl]morpholine Show/Hide	C20H24N4O3	1
1	IC50 = 8400 nM Bioactivity Info	TI LI LO TS
CP0231837 Compound Info	N-[2-[[3-(3,4-dimethoxyphenyl)-2,6-dimethylimidazo[1,2-b]pyridazin-8-yl]amino]ethyl]acetamide Show/Hide	C20H25N5O3	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0479692 Compound Info	1-[4-[3-(3,4-dimethoxyphenyl)-2,6-dimethylimidazo[1,2-b]pyridazin-8-yl]piperazin-1-yl]ethanone Show/Hide	C22H27N5O3	1
1	IC50 = 11300 nM Bioactivity Info	TI LI LO TS
CP0564812 Compound Info	2,6-dimethoxy-4-(1,3-thiazol-2-yl)phenol Show/Hide	C11H11NO3S	1
1	IC50 = 20000 nM Bioactivity Info	TI LI LO TS
CP0574965 Compound Info	(Z)-3-[4-[(Z)-3-(4,5-dihydro-1H-imidazol-2-ylamino)-3-oxoprop-1-enyl]phenyl]-N-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]prop-2-enamide;dihydrochloride Show/Hide	C24H26Cl2N6O2	1
1	IC50 = 20000 nM Bioactivity Info	TI LI LO TS
CP0103996 Compound Info	4-phenyl-5-thiophen-2-yl-2-(3,4,5-trimethoxyphenyl)-1H-imidazole Show/Hide	C22H20N2O3S	1
1	IC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0517616 Compound Info	2,6-dichloro-4-(4-phenyl-5-thiophen-2-yl-1H-imidazol-2-yl)phenol Show/Hide	C19H12Cl2N2OS	1
1	IC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0526059 Compound Info	3-(4-phenyl-5-thiophen-2-yl-1H-imidazol-2-yl)phenol Show/Hide	C19H14N2OS	1
1	IC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0560792 Compound Info	2-(4-phenyl-5-thiophen-2-yl-1H-imidazol-2-yl)phenol Show/Hide	C19H14N2OS	1
1	IC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0560793 Compound Info	2-(3,5-dimethoxyphenyl)-4-phenyl-5-thiophen-2-yl-1H-imidazole Show/Hide	C21H18N2O2S	1
1	IC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0562148 Compound Info	4-(4,5-dihydro-1H-imidazol-2-yl)-2,6-dimethoxyphenol Show/Hide	C11H14N2O3	1
1	IC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0573117 Compound Info	2,4-diphenyl-5-thiophen-2-yl-1H-imidazole Show/Hide	C19H14N2S	1
1	IC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0524388 Compound Info	N-[(3R)-1-[7-(3,4-dimethoxyphenyl)-2-methylthieno[3,4-d]pyrimidin-4-yl]pyrrolidin-3-yl]acetamide Show/Hide	C21H24N4O3S	1
1	IC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0554296 Compound Info	N-[(3R)-1-[6-chloro-3-(3,4-dimethoxyphenyl)-2-methylimidazo[1,2-b]pyridazin-8-yl]pyrrolidin-3-yl]acetamide Show/Hide	C21H24ClN5O3	1
1	IC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0570784 Compound Info	N-[(3R)-1-[9-(3,4-dimethoxyphenyl)-2,8-dimethylpurin-6-yl]pyrrolidin-3-yl]acetamide Show/Hide	C21H26N6O3	1
1	IC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0570785 Compound Info	N-[(3R)-1-[3-(3,4-dimethoxyphenyl)-2,5-dimethylfuro[3,2-b]pyridin-7-yl]pyrrolidin-3-yl]acetamide Show/Hide	C23H27N3O4	1
1	IC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0578247 Compound Info	N-[(3R)-1-[7-(3,4-dimethoxyphenyl)-2,6-dimethylthieno[3,2-d]pyrimidin-4-yl]pyrrolidin-3-yl]acetamide Show/Hide	C22H26N4O3S	1
1	IC50 > 100000 nM Bioactivity Info	TI LI LO TS

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About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han