General Information of the Protein
Protein ID
PT06316
Protein Name
Lysophosphatidylserine lipase ABHD12
Secondarily
Protein Name
2-arachidonoylglycerol hydrolase ABHD12
Abhydrolase domain-containing protein 12
Monoacylglycerol lipase ABHD12
Oxidized phosphatidylserine lipase ABHD12
Gene Name
ABHD12
Secondarily
Gene Name
C20orf22
Sequence
MRKRTEPVALEHERCAAAGSSSSGSAAAALDADCRLKQNLRLTGPAAAEPRCAADAGMKRALGRRKGVWLRLRKILFCVLGLYIAIPFLIKLCPGIQAKLIFLNFVRVPYFIDLKKPQDQGLNHTCNYYLQPEEDVTIGVWHTVPAVWWKNAQGKDQMWYEDALASSHPIILYLHGNAGTRGGDHRVELYKVLSSLGYHVVTFDYRGWGDSVGTPSERGMTYDALHVFDWIKARSGDNPVYIWGHSLGTGVATNLVRRLCERETPPDALILESPFTNIREEAKSHPFSVIYRYFPGFDWFFLDPITSSGIKFANDENVKHISCPLLILHAEDDPVVPFQLGRKLYSIAAPARSFRDFKVQFVPFHSDLGYRHKYIYKSPELPRILREFLGKSEPEHQH
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
Function
Lysophosphatidylserine (LPS) lipase that mediates the hydrolysis of lysophosphatidylserine, a class of signaling lipids that regulates immunological and neurological processes (PubMed:25290914, PubMed:30237167, PubMed:30420694, PubMed:30720278, PubMed:30643283). Represents a major lysophosphatidylserine lipase in the brain, thereby playing a key role in the central nervous system (By similarity). Also able to hydrolyze oxidized phosphatidylserine; oxidized phosphatidylserine is produced in response to severe inflammatory stress and constitutes a proapoptotic 'eat me' signal (PubMed:30643283). Also has monoacylglycerol (MAG) lipase activity: hydrolyzes 2-arachidonoylglycerol (2-AG), thereby acting as a regulator of endocannabinoid signaling pathways (PubMed:22969151, PubMed:24027063). Has a strong preference for very-long-chain lipid substrates; substrate specificity is likely due to improved catalysis and not improved substrate binding (PubMed:30237167).
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Uniprot ID
Primary ID:
Q8N2K0

Secondarily ID:
A6NED4
A6NJ90
A8K450
B4DE71
Q5T710
Q5T711
Q96CR1
Q9BX05
Q9NPX7
Q9UFV6
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Ensembl ID
ENSG00000100997
HGNC ID
HGNC:15868
Subcellular Location
Endoplasmic reticulum membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0424584
 Compound Info 
N-cycloheptyl-5-(4-fluorophenyl)-1-[(4-fluorophenyl)methyl]-6-methyl-2-oxopyridine-3-carboxamide
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C27H28F2N2O2
  1
1
IC50 = 600 nM
 Bioactivity Info 
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CP0396315
 Compound Info 
5-bromo-N-cycloheptyl-1-[(4-fluorophenyl)methyl]-4-methyl-2-oxopyridine-3-carboxamide
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C21H24BrFN2O2
  1
1
IC50 = 2100 nM
 Bioactivity Info 
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CP0421363
 Compound Info 
5-bromo-N-cycloheptyl-2-[(4-fluorophenyl)methoxy]-6-methylpyridine-3-carboxamide
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C21H24BrFN2O2
  1
1
IC50 = 2100 nM
 Bioactivity Info 
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CP0396312
 Compound Info 
N-cycloheptyl-1-[(4-fluorophenyl)methyl]-4-methyl-2-oxo-5-phenylpyridine-3-carboxamide
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C27H29FN2O2
  1
1
IC50 = 2500 nM
 Bioactivity Info 
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CP0392103
 Compound Info 
N-cycloheptyl-1-[(4-fluorophenyl)methyl]-4-methyl-2-oxopyridine-3-carboxamide
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C21H25FN2O2
  1
1
IC50 > 10000 nM
 Bioactivity Info 
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CP0392104
 Compound Info 
N-cycloheptyl-1-[(4-fluorophenyl)methyl]-5-(4-methoxyphenyl)-4-methyl-2-oxopyridine-3-carboxamide
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C28H31FN2O3
  1
1
IC50 > 10000 nM
 Bioactivity Info 
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CP0392105
 Compound Info 
5-bromo-N-cycloheptyl-1-[(4-fluorophenyl)methyl]-2-oxo-4-phenylpyridine-3-carboxamide
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C26H26BrFN2O2
  1
1
IC50 > 10000 nM
 Bioactivity Info 
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CP0392106
 Compound Info 
N-cycloheptyl-1-[(4-fluorophenyl)methyl]-4-(4-methoxyphenyl)-2-oxopyridine-3-carboxamide
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C27H29FN2O3
  1
1
IC50 > 10000 nM
 Bioactivity Info 
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CP0396313
 Compound Info 
N-cycloheptyl-1-[(4-fluorophenyl)methyl]-2-oxo-4-phenylpyridine-3-carboxamide
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C26H27FN2O2
  1
1
IC50 > 10000 nM
 Bioactivity Info 
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CP0396314
 Compound Info 
N-cycloheptyl-1-[(4-fluorophenyl)methyl]-2-oxo-4,5-diphenylpyridine-3-carboxamide
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C32H31FN2O2
  1
1
IC50 > 10000 nM
 Bioactivity Info 
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CP0396316
 Compound Info 
5-bromo-N-cycloheptyl-1-[(4-fluorophenyl)methyl]-4-(4-methoxyphenyl)-2-oxopyridine-3-carboxamide
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C27H28BrFN2O3
  1
1
IC50 > 10000 nM
 Bioactivity Info 
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CP0396317
 Compound Info 
N-cycloheptyl-2-[(4-fluorophenyl)methoxy]-4-methylpyridine-3-carboxamide
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C21H25FN2O2
  1
1
IC50 > 10000 nM
 Bioactivity Info 
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CP0408593
 Compound Info 
5-bromo-N-cycloheptyl-2-[(4-fluorophenyl)methoxy]-4-methylpyridine-3-carboxamide
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C21H24BrFN2O2
  1
1
IC50 > 10000 nM
 Bioactivity Info 
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CP0429740
 Compound Info 
N-cycloheptyl-1-[(4-fluorophenyl)methyl]-5-(4-methoxyphenyl)-2-oxo-4-phenylpyridine-3-carboxamide
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C33H33FN2O3
  1
1
IC50 > 10000 nM
 Bioactivity Info 
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CP0424563
 Compound Info 
5-bromo-N-cycloheptyl-1-[(4-fluorophenyl)methyl]-6-methyl-2-oxopyridine-3-carboxamide
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C21H24BrFN2O2
  1
1
IC50 > 10000 nM
 Bioactivity Info 
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CP0424583
 Compound Info 
N-cycloheptyl-5-(4-fluorophenyl)-2-[(4-fluorophenyl)methoxy]-6-methylpyridine-3-carboxamide
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C27H28F2N2O2
  1
1
IC50 > 10000 nM
 Bioactivity Info 
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CP0424585
 Compound Info 
5-bromo-1-[(4-fluorophenyl)methyl]-6-methyl-2-oxo-N-[[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-methoxyoxan-2-yl]methyl]pyridine-3-carboxamide
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C21H24BrFN2O7
  1
1
IC50 > 10000 nM
 Bioactivity Info 
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CP0466162
 Compound Info 
5-chloro-N-cycloheptyl-1-[(4-fluorophenyl)methyl]-6-methyl-2-oxopyridine-3-carboxamide
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C21H24ClFN2O2
  1
1
IC50 > 10000 nM
 Bioactivity Info 
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CP0466163
 Compound Info 
5-bromo-1-[(4-fluorophenyl)methyl]-6-methyl-2-oxo-N-piperidin-4-ylpyridine-3-carboxamide
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C19H21BrFN3O2
  1
1
IC50 > 10000 nM
 Bioactivity Info 
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CP0466164
 Compound Info 
N-cycloheptyl-5-fluoro-1-[(4-fluorophenyl)methyl]-6-methyl-2-oxopyridine-3-carboxamide
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C21H24F2N2O2
  1
1
IC50 > 10000 nM
 Bioactivity Info 
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CP0507466
 Compound Info 
N-cycloheptyl-1-[(4-fluorophenyl)methyl]-5-(4-methoxyphenyl)-6-methyl-2-oxopyridine-3-carboxamide
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C28H31FN2O3
  1
1
IC50 > 10000 nM
 Bioactivity Info 
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CP0507468
 Compound Info 
N-cycloheptyl-2-[(4-fluorophenyl)methoxy]-6-methylpyridine-3-carboxamide
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C21H25FN2O2
  1
1
IC50 > 10000 nM
 Bioactivity Info 
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CP0517326
 Compound Info 
N-cycloheptyl-2-[(4-fluorophenyl)methoxy]-5-(4-methoxyphenyl)-6-methylpyridine-3-carboxamide
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C28H31FN2O3
  1
1
IC50 > 10000 nM
 Bioactivity Info 
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CP0546086
 Compound Info 
N-cycloheptyl-1-[(4-fluorophenyl)methyl]-6-methyl-2-oxopyridine-3-carboxamide
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C21H25FN2O2
  1
1
IC50 > 10000 nM
 Bioactivity Info 
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CP0553145
 Compound Info 
N-[(2R,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]-5-bromo-1-[(4-fluorophenyl)methyl]-6-methyl-2-oxopyridine-3-carboxamide
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C22H25BrFN3O7
  1
1
IC50 > 10000 nM
 Bioactivity Info 
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CP0553271
 Compound Info 
N-cycloheptyl-1-[(4-fluorophenyl)methyl]-6-methyl-2-oxo-5-phenylpyridine-3-carboxamide
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C27H29FN2O2
  1
1
IC50 > 10000 nM
 Bioactivity Info 
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