General Information of the Protein
Protein ID
PT06210
Protein Name
Krueppel-like factor 5
Secondarily
Protein Name
Basic transcription element-binding protein 2
Colon krueppel-like factor
GC-box-binding protein 2
Intestinal-enriched krueppel-like factor
Transcription factor BTEB2
Gene Name
KLF5
Secondarily
Gene Name
BTEB2
CKLF
IKLF
Sequence
MATRVLSMSARLGPVPQPPAPQDEPVFAQLKPVLGAANPARDAALFPGEELKHAHHRPQAQPAPAQAPQPAQPPATGPRLPPEDLVQTRCEMEKYLTPQLPPVPIIPEHKKYRRDSASVVDQFFTDTEGLPYSINMNVFLPDITHLRTGLYKSQRPCVTHIKTEPVAIFSHQSETTAPPPAPTQALPEFTSIFSSHQTAAPEVNNIFIKQELPTPDLHLSVPTQQGHLYQLLNTPDLDMPSSTNQTAAMDTLNVSMSAAMAGLNTHTSAVPQTAVKQFQGMPPCTYTMPSQFLPQQATYFPPSPPSSEPGSPDRQAEMLQNLTPPPSYAATIASKLAIHNPNLPTTLPVNSQNIQPVRYNRRSNPDLEKRRIHYCDYPGCTKVYTKSSHLKAHLRTHTGEKPYKCTWEGCDWRFARSDELTRHYRKHTGAKPFQCGVCNRSFSRSDHLALHMKRHQN
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Organism
Homo sapiens, Human
Protein Classification
Transcription factor
Function
Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes.
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Uniprot ID
Primary ID:
Q13887

Secondarily ID:
A2TJX0
L0R3U5
L0R4T9
Q9UHP8
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Ensembl ID
ENSG00000102554
HGNC ID
HGNC:6349
Subcellular Location
Nucleus
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000134 , DLD-1
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0961810
 Compound Info 
(E)-3-(3-chlorophenyl)-N-(2-((1,1-dioxidotetrahydro-2H-thiopyran-4-yl)(methyl)amino)-2-oxoethyl)acrylamide
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C17H21ClN2O4S
  1
1
IC50 = 54 nM
 Bioactivity Info 
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CP0904102
 Compound Info 
3-(3-chlorophenyl)-N-[2-[(1,1-dioxothian-4-yl)-ethyl-amino]-2-oxo-ethyl]prop-2-enamide
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C18H23ClN2O4S
  1
1
IC50 = 72 nM
 Bioactivity Info 
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CP0417378
 Compound Info 
(E)-3-(3-nitrophenyl)-2-propenoic acid [2-[(1,1-dioxo-3-thiolanyl)-methylamino]-2-oxoethyl] ester
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C16H18N2O7S
  1
1
IC50 = 270 nM
 Bioactivity Info 
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CP0904100
 Compound Info 
N-[2-[(1,1-dioxothiolan-3-yl)-methyl-amino]-2-oxo-ethyl]-3-(3-nitrophenyl)prop-2-enamide
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C16H19N3O6S
  1
1
IC50 = 3100 nM
 Bioactivity Info 
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CP0887782
 Compound Info 
3-(3-chlorophenyl)-N-[2-[(1,1-dioxothiolan-3-yl)-methyl-amino]-2-oxo-ethyl]prop-2-enamide
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C16H19ClN2O4S
  1
1
IC50 = 5300 nM
 Bioactivity Info 
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CP0887784
 Compound Info 
N-[2-[[2-[(1,1-dioxothian-4-yl)-methyl-amino]-2-oxo-ethyl]amino]-2-oxo-ethyl]benzamide
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C17H23N3O5S
  1
1
IC50 = 20490 nM
 Bioactivity Info 
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CP0952931
 Compound Info 
3-[3-(dimethylsulfamoyl)phenyl]-N-[2-[(1,1-dioxothian-4-yl)-methyl-amino]-2-oxo-ethyl]prop-2-enamide
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C19H27N3O6S2
  1
1
IC50 = 59000 nM
 Bioactivity Info 
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CP0853190
 Compound Info 
(2R)-2-[[3-(3-chlorophenyl)prop-2-enoyl]amino]-N-(1,1-dioxothiolan-3-yl)propanamide
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C16H19ClN2O4S
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0853191
 Compound Info 
(2R)-2-[[3-(3-chlorophenyl)prop-2-enoyl]amino]-N-(1,1-dioxothiolan-3-yl)-N-methyl-propanamide
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C17H21ClN2O4S
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0853192
 Compound Info 
N-[2-[(1,1-dioxothian-4-yl)-methyl-amino]-2-oxo-ethyl]-1H-indole-6-carboxamide
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C17H21N3O4S
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0853193
 Compound Info 
6-chloro-N-[2-[(1,1-dioxothian-4-yl)-methyl-amino]-2-oxo-ethyl]quinoline-3-carboxamide
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C18H20ClN3O4S
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0853259
 Compound Info 
3-[[3-(3-chlorophenyl)prop-2-enoyl]amino]-N-(1,1-dioxothiolan-3-yl)propanamide
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C16H19ClN2O4S
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0874614
 Compound Info 
2-[(2,4-dibromophenyl)carbamoylamino]-N-(1,1-dioxothian-4-yl)-N-methyl-acetamide
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C15H19Br2N3O4S
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0874615
 Compound Info 
N-[2-[(1,1-dioxothian-4-yl)-methyl-amino]-2-oxo-ethyl]-2-(4-methoxyphenyl)acetamide
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C17H24N2O5S
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0887786
 Compound Info 
N-(1,1-dioxothian-4-yl)-2-[(3-methoxyphenyl)methylcarbamoylamino]-N-methyl-acetamide
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C17H25N3O5S
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0904101
 Compound Info 
N-[2-[(1,1-dioxothian-4-yl)-methyl-amino]-2-oxo-ethyl]-1-(p-tolyl)cyclopropanecarboxamide
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C19H26N2O4S
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0947234
 Compound Info 
3-(3-chlorophenyl)-N-[2-[(1,1-dioxothian-4-yl)amino]-2-oxo-ethyl]prop-2-enamide
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C16H19ClN2O4S
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0947235
 Compound Info 
2-[(2-benzyloxyacetyl)amino]-N-(1,1-dioxothian-4-yl)-N-methyl-acetamide
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C17H24N2O5S
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0951404
 Compound Info 
3-[3-(dimethylsulfamoyl)phenyl]-N-[2-[(1,1-dioxothiolan-3-yl)-methyl-amino]-2-oxo-ethyl]prop-2-enamide
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C18H25N3O6S2
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0951405
 Compound Info 
2-(1,3-benzodioxol-5-yl)-N-[2-[(1,1-dioxothian-4-yl)-methyl-amino]-2-oxo-ethyl]acetamide
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C17H22N2O6S
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0953864
 Compound Info 
N-[2-[(1,1-dioxothian-4-yl)-methyl-amino]-2-oxo-ethyl]thiophene-3-carboxamide
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C13H18N2O4S2
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0954621
 Compound Info 
N-[2-[(1,1-dioxothian-4-yl)-methyl-amino]-2-oxo-ethyl]benzofuran-2-carboxamide
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C17H20N2O5S
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0954622
 Compound Info 
N-[2-[(1,1-dioxothian-4-yl)-methyl-amino]-2-oxo-ethyl]chromane-2-carboxamide
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C18H24N2O5S
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0954623
 Compound Info 
N-[2-[(1,1-dioxothian-4-yl)-methyl-amino]-2-oxo-ethyl]-1,3-benzothiazole-6-carboxamide
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C16H19N3O4S2
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0958100
 Compound Info 
(2R)-2-[[3-(3-chlorophenyl)prop-2-enoyl]amino]-N-(1,1-dioxothian-4-yl)propanamide
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C17H21ClN2O4S
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0958101
 Compound Info 
5-chloro-N-[2-[(1,1-dioxothian-4-yl)-methyl-amino]-2-oxo-ethyl]-1H-indole-2-carboxamide
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C17H20ClN3O4S
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0958103
 Compound Info 
N-[2-[(1,1-dioxothian-4-yl)-methyl-amino]-2-oxo-ethyl]quinoline-2-carboxamide
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C18H21N3O4S
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0960320
 Compound Info 
N-[2-[(1,1-dioxothian-4-yl)-methyl-amino]-2-oxo-ethyl]-2-phenyl-pyrazole-3-carboxamide
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C18H22N4O4S
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0961811
 Compound Info 
N-[2-[(1,1-dioxothian-4-yl)-methyl-amino]-2-oxo-ethyl]-2,3-dihydro-1,4-benzodioxine-5-carboxamide
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C17H22N2O6S
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0964031
 Compound Info 
(2R)-2-[[3-(3-chlorophenyl)prop-2-enoyl]amino]-N-(1,1-dioxothian-4-yl)-N-methyl-propanamide
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C18H23ClN2O4S
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0964032
 Compound Info 
N-[2-[(1,1-dioxothian-4-yl)-methyl-amino]-2-oxo-ethyl]-4-oxo-chromene-3-carboxamide
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C18H20N2O6S
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0970137
 Compound Info 
3-[[3-(3-chlorophenyl)prop-2-enoyl]amino]-N-(1,1-dioxothiolan-3-yl)-N-methyl-propanamide
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C17H21ClN2O4S
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0970138
 Compound Info 
N-(1,1-dioxothian-4-yl)-N-methyl-2-(1-naphthylsulfonylamino)acetamide
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C18H22N2O5S2
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0946472
 Compound Info 
3-(3-chlorophenyl)-N-[2-[cyclopropyl-(1,1-dioxothian-4-yl)amino]-2-oxo-ethyl]prop-2-enamide
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C19H23ClN2O4S
  1
1
IC50 >= 7800 nM
 Bioactivity Info 
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