General Information of the Protein
Protein ID
PT06208
Protein Name
Sodium-dependent neutral amino acid transporter B(0)AT2
Secondarily
Protein Name
Sodium- and chloride-dependent neurotransmitter transporter NTT73
Sodium-coupled branched-chain amino-acid transporter 1
Solute carrier family 6 member 15
Transporter v7-3
Gene Name
SLC6A15
Secondarily
Gene Name
B0AT2
NTT73
SBAT1
Sequence
MPKNSKVVKRELDDDVTESVKDLLSNEDAADDAFKTSELIVDGQEEKDTDVEEGSEVEDERPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLLPYLILLMVIGIPLFFLELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFYFSQSFQQPLPWDQCPLVKNASHTFVEPECEQSSATTYYWYREALNISSSISESGGLNWKMTICLLAAWVMVCLAMIKGIQSSGKIIYFSSLFPYVVLICFLIRAFLLNGSIDGIRHMFTPKLEIMLEPKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFINFFTSVLATLVVFAVLGFKANVINEKCITQNSETIMKFLKMGNISQDIIPHHINLSTVTAEDYHLVYDIIQKVKEEEFPALHLNSCKIEEELNKAVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLVNLGLGSMFGTIEGIVTPIVDTFKVRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDDYSATLPLLIVVILENIAVCFVYGIDKFMEDLKDMLGFAPSRYYYYMWKYISPLMLLSLLIASVVNMGLSPPGYNAWIEDKASEEFLSYPTWGLVVCVSLVVFAILPVPVVFIVRRFNLIDDSSGNLASVTYKRGRVLKEPVNLEGDDTSLIHGKIPSEMPSPNFGKNIYRKQSGSPTLDTAPNGRYGIGYLMADIMPDMPESDL
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Organism
Homo sapiens, Human
Protein Classification
Transporter
>
Electrochemical transporter
>
SLC superfamily of solute carriers
>
SLC06 neurotransmitter transporter family
Function
Functions as a sodium-dependent neutral amino acid transporter. Exhibits preference for the branched-chain amino acids, particularly leucine, valine and isoleucine and methionine. Can also transport low-affinity substrates such as alanine, phenylalanine, glutamine and pipecolic acid. Mediates the saturable, pH-sensitive and electrogenic cotransport of proline and sodium ions with a stoichiometry of 1:1. May have a role as transporter for neurotransmitter precursors into neurons. In contrast to other members of the neurotransmitter transporter family, does not appear to be chloride-dependent.
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Uniprot ID
Primary ID:
Q9H2J7

Secondarily ID:
A8K592
B7Z2P7
E7ESJ5
Q9H9F5
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Ensembl ID
ENSG00000072041
HGNC ID
HGNC:13621
Subcellular Location
Membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0411297
 Compound Info 
1-[4-(13-chloro-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene)piperidin-1-yl]pentan-1-one
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C24H27ClN2O
  1
1
IC50 = 3400 nM
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CP0068895
 Compound Info 
ethyl 4-(13-chloro-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene)piperidine-1-carboxylate
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C22H23ClN2O2
  1
1
IC50 = 4000 nM
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CP0386698
 Compound Info 
ethyl 4-(13-chloro-6-methoxy-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene)piperidine-1-carboxylate
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C23H25ClN2O3
  1
1
IC50 = 4500 nM
 Bioactivity Info 
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CP0411480
 Compound Info 
propyl 4-(13-chloro-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene)piperidine-1-carboxylate
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C23H25ClN2O2
  1
1
IC50 = 4600 nM
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CP0386804
 Compound Info 
1-[4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidin-1-yl]-butan-1-one
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C23H25ClN2O
  1
1
IC50 = 4900 nM
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CP0535279
 Compound Info 
prop-2-enyl 4-(13-chloro-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene)piperidine-1-carboxylate
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C23H23ClN2O2
  1
1
IC50 = 4900 nM
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CP0504705
 Compound Info 
(E)-1-[4-(13-chloro-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene)piperidin-1-yl]but-2-en-1-one
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C23H23ClN2O
  1
1
IC50 = 5000 nM
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CP0518714
 Compound Info 
1-[4-(13-chloro-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene)piperidin-1-yl]hexan-1-one
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C25H29ClN2O
  1
1
IC50 = 5200 nM
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CP0379350
 Compound Info 
S-ethyl 4-(13-chloro-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene)piperidine-1-carbothioate
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C22H23ClN2OS
  1
1
IC50 = 5300 nM
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CP0398237
 Compound Info 
1-[4-(13-chloro-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene)piperidin-1-yl]-2-cyclohexylethanone
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C27H31ClN2O
  1
1
IC50 = 5700 nM
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CP0386697
 Compound Info 
(2R)-2-amino-1-[4-(13-chloro-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene)piperidin-1-yl]-4-methylpentan-1-one
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C25H30ClN3O
  1
1
IC50 = 7700 nM
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CP0386876
 Compound Info 
2-methylpropyl 4-(13-chloro-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene)piperidine-1-carboxylate
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C24H27ClN2O2
  1
1
IC50 = 7800 nM
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CP0398417
 Compound Info 
1-[4-(13-chloro-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene)piperidin-1-yl]-3-methylbutan-1-one
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C24H27ClN2O
  1
1
IC50 = 10800 nM
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CP0554028
 Compound Info 
methyl 13-chloro-2-(1-ethoxycarbonylpiperidin-4-ylidene)-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaene-5-carboxylate
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C24H25ClN2O4
  1
1
IC50 = 12400 nM
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CP0498170
 Compound Info 
ethyl 4-(13-chloro-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-yl)-3,6-dihydro-2H-pyridine-1-carboxylate
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C22H23ClN2O2
  1
1
IC50 = 14800 nM
 Bioactivity Info 
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CP0017055
 Compound Info 
1-[4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidin-1-yl]-2-phenyl-ethanone
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C27H25ClN2O
  1
1
IC50 = 16100 nM
 Bioactivity Info 
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CP0398485
 Compound Info 
propan-2-yl 4-(13-chloro-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene)piperidine-1-carboxylate
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C23H25ClN2O2
  1
1
IC50 = 16800 nM
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CP0535281
 Compound Info 
ethyl 4-(13-chloro-6-hydroxy-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene)piperidine-1-carboxylate
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C22H23ClN2O3
  1
1
IC50 = 17600 nM
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CP0504706
 Compound Info 
ethyl 4-[13-chloro-7-(hydroxymethyl)-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3,5,7,12,14-hexaen-2-ylidene]piperidine-1-carboxylate
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C23H25ClN2O3
  1
1
IC50 = 18300 nM
 Bioactivity Info 
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CP0411296
 Compound Info 
3-amino-1-[4-(13-chloro-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene)piperidin-1-yl]propan-1-one
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C22H24ClN3O
  1
1
IC50 = 18700 nM
 Bioactivity Info 
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CP0398240
 Compound Info 
methyl 4-(13-chloro-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene)piperidine-1-carboxylate
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C21H21ClN2O2
  1
1
IC50 = 19600 nM
 Bioactivity Info 
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CP0025634
 Compound Info 
2-Amino-1-[4-(8-chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidin-1-yl]-ethanone
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C21H22ClN3O
  1
1
IC50 = 22900 nM
 Bioactivity Info 
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CP0398482
 Compound Info 
1-[4-(13-chloro-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene)piperidin-1-yl]-2-methoxyethanone
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C22H23ClN2O2
  1
1
IC50 = 26400 nM
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CP0535280
 Compound Info 
4-(13-chloro-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene)-N-ethylpiperidine-1-carboxamide
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C22H24ClN3O
  1
1
IC50 = 35000 nM
 Bioactivity Info 
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CP0398484
 Compound Info 
1-[4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidin-1-yl]-propan-1-one
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C22H23ClN2O
  1
1
IC50 = 36000 nM
 Bioactivity Info 
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CP0386802
 Compound Info 
(2R)-2-amino-1-[4-(13-chloro-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene)piperidin-1-yl]-3-methylbutan-1-one
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C24H28ClN3O
  1
1
IC50 = 39100 nM
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CP0264804
 Compound Info 
8-Chloro-11-[1-(5-methyl-pyridin-3-ylmethyl)-piperidin-4-ylidene]-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine
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C26H26ClN3
  1
1
IC50 > 40000 nM
 Bioactivity Info 
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CP0498705
 Compound Info 
1-[4-(13-chloro-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene)piperidin-1-yl]-2-methylpropan-1-one
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C23H25ClN2O
  1
1
IC50 = 41500 nM
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CP0024186
 Compound Info 
1-[4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidin-1-yl]-ethanone
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C21H21ClN2O
  1
1
IC50 = 54800 nM
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CP0386699
 Compound Info 
13-chloro-2-(1-propylsulfonylpiperidin-4-ylidene)-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaene
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C22H25ClN2O2S
  1
1
IC50 > 80000 nM
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CP0386803
 Compound Info 
13-chloro-2-(1-methylpiperidin-4-ylidene)-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaene
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C20H21ClN2
  1
1
IC50 > 80000 nM
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CP0398238
 Compound Info 
tert-butyl 4-(13-chloro-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene)piperidine-1-carboxylate
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C24H27ClN2O2
  1
1
IC50 > 80000 nM
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CP0398242
 Compound Info 
ethyl 4-(13-chloro-7-cyano-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3,5,7,12,14-hexaen-2-ylidene)piperidine-1-carboxylate
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C23H22ClN3O2
  1
1
IC50 > 80000 nM
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CP0418690
 Compound Info 
ethyl 4-[13-chloro-5-(hydroxymethyl)-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene]piperidine-1-carboxylate
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C23H25ClN2O3
  1
1
IC50 > 80000 nM
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CP0513036
 Compound Info 
ethyl 4-(13-chloro-5-cyano-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene)piperidine-1-carboxylate
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C23H22ClN3O2
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1
IC50 > 80000 nM
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CP0515781
 Compound Info 
benzyl 4-(13-chloro-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene)piperidine-1-carboxylate
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C27H25ClN2O2
  1
1
IC50 > 80000 nM
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CP0554029
 Compound Info 
phenyl 4-(13-chloro-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene)piperidine-1-carboxylate
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C26H23ClN2O2
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1
IC50 > 80000 nM
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Clinical Information about the Protein
Target 1 ( HUMAN solute carrier family 6 member 15 (SLC6A15) )
Target Type Unknown Type Target