General Information of the Protein
Protein ID
PT06207
Protein Name
Vasopressin V1a receptor
Secondarily
Protein Name
AVPR V1a
Antidiuretic hormone receptor 1a
Vascular/hepatic-type arginine vasopressin receptor
Gene Name
AVPR1A
Sequence
MSFPRGSHDLPAGNSSPWWPLTTEGANSSREAAGLGEGGSPPGDVRNEELAKLEVTVLAVIFVVAVLGNSSVLLALHRTPRKTSRMHLFIRHLSLADLAVAFFQVLPQLCWDITYRFRGPDWLCRVVKHLQVFAMFASSYMLVVMTADRYIAVCHPLKTLQQPARRSRLMIAASWGLSFVLSIPQYFIFSVIEFEVNNGTKAQDCWATFIPPWGTRAYVTWMTSGVFVVPVIILGTCYGFICYHIWRNVRGKTASRQSKGGKGSGEAAGPFHKGLLVTPCVSSVKSISRAKIRTVKMTFVIVSAYILCWTPFFIVQMWSVWDTNFVWTDSENPSTTITALLASLNSCCNPWIYMFFSGHLLQDCVQSFPCCQSIAQKFAKDDSDSMSRRQTSYSNNRSPTNSTGTWKDSPKSSKSIRFIPVST
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Organism
Mus musculus, Mouse
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Peptide receptor (family A GPCR)
>
Short peptide receptor (family A GPCR)
>
Vasopressin and oxytocin receptor
Function
Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. Involved in social memory formation.
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Uniprot ID
Primary ID:
Q62463

Secondarily ID:
Q62464
Q9QYH2
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Subcellular Location
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0379178
 Compound Info 
[6-chloro-1-(1-methylpiperidin-4-yl)indol-3-yl]-spiro[1H-2-benzofuran-3,4'-piperidine]-1'-ylmethanone
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C27H30ClN3O2
  1
1
Ki = 11 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0441648
 Compound Info 
[6-chloro-1-[[(2S)-1-methylpyrrolidin-2-yl]methyl]indol-3-yl]-spiro[1H-2-benzofuran-3,4'-piperidine]-1'-ylmethanone
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C27H30ClN3O2
  1
1
Ki = 13 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0419751
 Compound Info 
2-[6-chloro-3-(spiro[1H-2-benzofuran-3,4'-piperidine]-1'-carbonyl)indol-1-yl]-N,N-dimethylacetamide
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C25H26ClN3O3
  1
1
Ki = 14 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0244529
 Compound Info 
[6-chloro-1-[2-(dimethylamino)ethyl]indol-3-yl]-spiro[1H-2-benzofuran-3,4'-piperidine]-1'-ylmethanone
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C25H28ClN3O2
  1
1
Ki = 39 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0379184
 Compound Info 
2-[6-chloro-3-(spiro[1H-2-benzofuran-3,4'-piperidine]-1'-carbonyl)indol-1-yl]-1-(4-methylpiperazin-1-yl)ethanone
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C28H31ClN4O3
  1
1
Ki = 41 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0379185
 Compound Info 
[6-chloro-1-[[(2S)-pyrrolidin-2-yl]methyl]indol-3-yl]-spiro[1H-2-benzofuran-3,4'-piperidine]-1'-ylmethanone
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C26H28ClN3O2
  1
1
Ki = 125 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0379179
 Compound Info 
2-[6-chloro-3-(spiro[1H-2-benzofuran-3,4'-piperidine]-1'-carbonyl)indol-1-yl]-N-[2-(dimethylamino)ethyl]acetamide
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C27H31ClN4O3
  1
1
Ki = 177 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0246508
 Compound Info 
(1-benzyl-2-methylindol-3-yl)-spiro[1H-2-benzofuran-3,4'-piperidine]-1'-ylmethanone
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C29H28N2O2
  1
1
Ki = 210 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0441646
 Compound Info 
(6-chloro-1H-indol-3-yl)-spiro[1H-2-benzofuran-3,4'-piperidine]-1'-ylmethanone
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C21H19ClN2O2
  1
1
Ki = 1012 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0379183
 Compound Info 
(6-chloro-1H-indol-3-yl)-spiro[5H-furo[3,4-b]pyridine-7,4'-piperidine]-1'-ylmethanone
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C20H18ClN3O2
  1
1
Ki = 1018 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0498957
 Compound Info 
(6-chloro-1H-indol-3-yl)-(4-phenylpiperidin-1-yl)methanone
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C20H19ClN2O
  1
1
Ki = 1491 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0433526
 Compound Info 
(6-chloro-1H-indol-3-yl)-[4-(2-chlorophenyl)piperazin-1-yl]methanone
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C19H17Cl2N3O
  1
1
Ki = 1972 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0379180
 Compound Info 
3-[1-(6-chloro-1H-indole-3-carbonyl)piperidin-4-yl]-1H-benzimidazol-2-one
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C21H19ClN4O2
  1
1
Ki = 2395 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0499768
 Compound Info 
(6-chloro-1H-indol-3-yl)-spiro[1H-furo[3,4-c]pyridine-3,4'-piperidine]-1'-ylmethanone
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C20H18ClN3O2
  1
1
Ki = 2980 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0379182
 Compound Info 
(6-chloro-1H-indol-3-yl)-spiro[7H-furo[3,4-b]pyridine-5,4'-piperidine]-1'-ylmethanone
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C20H18ClN3O2
  1
1
Ki = 4816 nM
 Bioactivity Info 
   TI
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   LO
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CP0398079
 Compound Info 
(6-chloro-1H-indol-3-yl)-(2,2-dioxospiro[1H-2-benzothiophene-3,4'-piperidine]-1'-yl)methanone
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C21H19ClN2O3S
  1
1
Ki = 5886 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0379181
 Compound Info 
(6-chloro-1H-indol-3-yl)-spiro[1,2-dihydroindole-3,4'-piperidine]-1'-ylmethanone
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C21H20ClN3O
  1
1
Ki = 5890 nM
 Bioactivity Info 
   TI
   LI
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   TS
CP0419752
 Compound Info 
1H-indol-3-yl(spiro[1H-2-benzofuran-3,4'-piperidine]-1'-yl)methanone
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C21H20N2O2
  1
1
Ki = 6620 nM
 Bioactivity Info 
   TI
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   TS
Similar Protein(s) and Bioactivity Statistics
90% Identity
Protein ID Protein Name Protein Organism
PT02139 Vasopressin V1a receptor Rattus norvegicus, Rat
 Protein Info