Protein Information

General Information of the Protein

Protein ID	PT06121
Protein Name	1-acyl-sn-glycerol-3-phosphate acyltransferase beta
Secondarily Protein Name	1-acylglycerol-3-phosphate O-acyltransferase 2 Lysophosphatidic acid acyltransferase beta
Gene Name	AGPAT2
Sequence	MELWPCLAAALLLLLLLVQLSRAAEFYAKVALYCALCFTVSAVASLVCLLRHGGRTVENMSIIGWFVRSFKYFYGLRFEVRDPRRLQEARPCVIVSNHQSILDMMGLMEVLPERCVQIAKRELLFLGPVGLIMYLGGVFFINRQRSSTAMTVMADLGERMVRENLKVWIYPEGTRNDNGDLLPFKKGAFYLAVQAQVPIVPVVYSSFSSFYNTKKKFFTSGTVTVQVLEAIPTSGLTAADVPALVDTCHRAMRTTFLHISKTPQENGATAGSGVQPAQ Show/Hide
Organism	Homo sapiens, Human
Protein Classification	Enzyme > Transferase
Function	Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Show/Hide
Uniprot ID	Primary ID: O15120 Secondarily ID: O00516 O15106 Q5VUD3 Q5VUD4 Q9BSV7 Q9BWR7 Show/Hide
Ensembl ID	ENSG00000169692
HGNC ID	HGNC:325
Subcellular Location	Endoplasmic reticulum membrane

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000013 , Sf9

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0457111 Compound Info	prop-2-ynyl N-[4-chloro-3-(5-chloro-1,3-benzothiazol-2-yl)phenyl]carbamate Show/Hide	C17H10Cl2N2O2S	1
1	IC50 = 6 nM Bioactivity Info	TI LI LO TS
CP0510045 Compound Info	6-(5-Chloro-2-ethoxy-phenyl)-N4-(4-nitro-phenyl)-pyrimidine-2,4-diamine Show/Hide	C18H16ClN5O3	1
1	IC50 = 10 nM Bioactivity Info	TI LI LO TS
CP0389841 Compound Info	prop-2-ynyl N-[3-(5-chloro-1,3-benzothiazol-2-yl)-4-methylphenyl]carbamate Show/Hide	C18H13ClN2O2S	1
1	IC50 = 15 nM Bioactivity Info	TI LI LO TS
CP0407013 Compound Info	N-[4-chloro-3-(5-chloro-1,3-benzothiazol-2-yl)phenyl]-2-cyanoacetamide Show/Hide	C16H9Cl2N3OS	1
1	IC50 = 15 nM Bioactivity Info	TI LI LO TS
CP0477084 Compound Info	prop-2-ynyl N-[4-chloro-3-[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]phenyl]carbamate Show/Hide	C18H10ClF3N2O2S	1
1	IC50 = 15 nM Bioactivity Info	TI LI LO TS
CP0106219 Compound Info	6-(5-Bromo-2-ethoxy-phenyl)-N4-(4-chloro-phenyl)-pyrimidine-2,4-diamine Show/Hide	C18H16BrClN4O	1
1	IC50 = 16 nM Bioactivity Info	TI LI LO TS
CP0438955 Compound Info	6-(5-Chloro-2-ethoxy-phenyl)-N4-(4-chloro-phenyl)-pyrimidine-2,4-diamine Show/Hide	C18H16Cl2N4O	1
1	IC50 = 17 nM Bioactivity Info	TI LI LO TS
CP0530109 Compound Info	4-[2-Amino-6-(5-bromo-2-ethoxy-phenyl)-pyrimidin-4-ylamino]-benzonitrile Show/Hide	C19H16BrN5O	1
1	IC50 = 17 nM Bioactivity Info	TI LI LO TS
CP0397775 Compound Info	6-(5-Bromo-2-methyl-phenyl)-N4-(4-bromo-phenyl)-pyrimidine-2,4-diamine Show/Hide	C17H14Br2N4	1
1	IC50 = 18 nM Bioactivity Info	TI LI LO TS
CP0430530 Compound Info	4-N-(4-chlorophenyl)-6-(2,5-dichlorophenyl)pyrimidine-2,4-diamine Show/Hide	C16H11Cl3N4	1
1	IC50 = 20 nM Bioactivity Info	TI LI LO TS
CP0538748 Compound Info	6-(5-Chloro-2-methyl-phenyl)-N4-(4-chloro-phenyl)-pyrimidine-2,4-diamine Show/Hide	C17H14Cl2N4	1
1	IC50 = 22 nM Bioactivity Info	TI LI LO TS
CP0518082 Compound Info	6-(5-Chloro-2-ethoxy-phenyl)-N4-(1H-indazol-6-yl)-pyrimidine-2,4-diamine Show/Hide	C19H17ClN6O	1
1	IC50 = 24 nM Bioactivity Info	TI LI LO TS
CP0452943 Compound Info	N-[4-chloro-3-(5-chloro-1,3-benzoxazol-2-yl)phenyl]-2-cyanoacetamide Show/Hide	C16H9Cl2N3O2	1
1	IC50 = 27 nM Bioactivity Info	TI LI LO TS
CP0446117 Compound Info	2-{4-[2-Amino-6-(5-chloro-2-ethoxy-phenyl)-pyrimidin-4-ylamino]-phenyl}-ethanol Show/Hide	C20H21ClN4O2	1
1	IC50 = 28 nM Bioactivity Info	TI LI LO TS
CP0495053 Compound Info	4-N-(4-bromophenyl)-6-(5-chloro-2-methoxyphenyl)pyrimidine-2,4-diamine Show/Hide	C17H14BrClN4O	1
1	IC50 = 28 nM Bioactivity Info	TI LI LO TS
CP0528844 Compound Info	6-(5-Bromo-2-methyl-phenyl)-N4-(4-chloro-phenyl)-pyrimidine-2,4-diamine Show/Hide	C17H14BrClN4	1
1	IC50 = 31 nM Bioactivity Info	TI LI LO TS
CP0531427 Compound Info	1-{4-[2-Amino-6-(5-bromo-2-ethoxy-phenyl)-pyrimidin-4-ylamino]-phenyl}-ethanone Show/Hide	C20H19BrN4O2	1
1	IC50 = 34 nM Bioactivity Info	TI LI LO TS
CP0534872 Compound Info	4-N-(4-bromophenyl)-6-(5-chloro-2-methylphenyl)pyrimidine-2,4-diamine Show/Hide	C17H14BrClN4	1
1	IC50 = 34 nM Bioactivity Info	TI LI LO TS
CP0438412 Compound Info	prop-2-ynyl N-[4-chloro-3-(5-chloro-1,3-benzoxazol-2-yl)phenyl]carbamate Show/Hide	C17H10Cl2N2O3	1
1	IC50 = 35 nM Bioactivity Info	TI LI LO TS
CP0476078 Compound Info	4-(5-Chloro-2-methoxy-phenyl)-N-(4-chloro-phenyl)-pyridine-2,6-diamine Show/Hide	C18H15Cl2N3O	1
1	IC50 = 40 nM Bioactivity Info	TI LI LO TS
CP0375450 Compound Info	methyl N-[4-chloro-3-(5-chloro-1,3-benzothiazol-2-yl)phenyl]carbamate Show/Hide	C15H10Cl2N2O2S	1
1	IC50 = 40 nM Bioactivity Info	TI LI LO TS
CP0405166 Compound Info	4-(5-Chloro-2-ethoxy-phenyl)-N-(4-chloro-phenyl)-pyridine-2,6-diamine Show/Hide	C19H17Cl2N3O	1
1	IC50 = 50 nM Bioactivity Info	TI LI LO TS
CP0483481 Compound Info	4-[6-Amino-4-(5-chloro-2-ethoxy-phenyl)-pyridin-2-ylamino]-benzaldehyde Show/Hide	C20H18ClN3O2	1
1	IC50 = 50 nM Bioactivity Info	TI LI LO TS
CP0377773 Compound Info	(3-Benzooxazol-2-yl-4-chloro-phenyl)-carbamic acid prop-2-ynyl ester Show/Hide	C17H11ClN2O3	1
1	IC50 = 50 nM Bioactivity Info	TI LI LO TS
CP0448401 Compound Info	N-[4-chloro-3-[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]phenyl]-2-cyanoacetamide Show/Hide	C17H9ClF3N3OS	1
1	IC50 = 50 nM Bioactivity Info	TI LI LO TS
CP0436063 Compound Info	6-(5-Chloro-2-methoxy-phenyl)-N4-(4-chloro-phenyl)-pyrimidine-2,4-diamine Show/Hide	C17H14Cl2N4O	1
1	IC50 = 54 nM Bioactivity Info	TI LI LO TS
CP0407198 Compound Info	prop-2-ynyl N-[4-chloro-3-(5-chloro-1-methylbenzimidazol-2-yl)phenyl]carbamate Show/Hide	C18H13Cl2N3O2	1
1	IC50 = 60 nM Bioactivity Info	TI LI LO TS
CP0530980 Compound Info	5TT4A4MBLR Show/Hide	C16H13BrClN5	1
1	IC50 = 60 nM Bioactivity Info	TI LI LO TS
CP0448416 Compound Info	N-[3-(1,3-benzothiazol-2-yl)-4-methylphenyl]-2-cyanoacetamide Show/Hide	C17H13N3OS	1
1	IC50 = 70 nM Bioactivity Info	TI LI LO TS
CP0438823 Compound Info	but-3-ynyl N-[4-chloro-3-(5-chloro-1,3-benzoxazol-2-yl)phenyl]carbamate Show/Hide	C18H12Cl2N2O3	1
1	IC50 = 75 nM Bioactivity Info	TI LI LO TS
CP0453453 Compound Info	but-2-ynyl N-[4-chloro-3-(5-chloro-1,3-benzoxazol-2-yl)phenyl]carbamate Show/Hide	C18H12Cl2N2O3	1
1	IC50 = 75 nM Bioactivity Info	TI LI LO TS
CP0538227 Compound Info	[4-[[2-amino-6-(5-chloro-2-ethoxyphenyl)pyrimidin-4-yl]amino]phenyl]methanol Show/Hide	C19H19ClN4O2	1
1	IC50 = 75 nM Bioactivity Info	TI LI LO TS
CP0534514 Compound Info	6-(5-Chloro-2-methoxy-phenyl)-N4-(1H-indazol-6-yl)-pyrimidine-2,4-diamine Show/Hide	C18H15ClN6O	1
1	IC50 = 80 nM Bioactivity Info	TI LI LO TS
CP0916822 Compound Info	1-{4-[2-Amino-6-(5-bromo-2-ethoxy-phenyl)-pyrimidin-4-ylamino]-phenyl}-ethanone oxime Show/Hide	C20H20BrN5O2	1
1	IC50 = 84 nM Bioactivity Info	TI LI LO TS
CP0410128 Compound Info	4-[2-Amino-6-(5-bromo-2-ethoxy-phenyl)-pyrimidin-4-ylamino]-N-hydroxy-benzamide Show/Hide	C19H18BrN5O3	1
1	IC50 = 88 nM Bioactivity Info	TI LI LO TS
CP0520322 Compound Info	6-(5-Bromo-2-ethoxy-phenyl)-N4-(4-dihydroxyboron-phenyl)-pyrimidine-2,4-diamine Show/Hide	C18H18BBrN4O3	1
1	IC50 = 91 nM Bioactivity Info	TI LI LO TS
CP0541628 Compound Info	[4-[[6-amino-4-(5-chloro-2-ethoxyphenyl)pyridin-2-yl]amino]phenyl]methanol Show/Hide	C20H20ClN3O2	1
1	IC50 = 99 nM Bioactivity Info	TI LI LO TS
CP0395167 Compound Info	prop-2-ynyl N-[3-(5-chloro-1,3-benzoxazol-2-yl)-4-methylphenyl]carbamate Show/Hide	C18H13ClN2O3	1
1	IC50 = 100 nM Bioactivity Info	TI LI LO TS
CP0395232 Compound Info	N-[4-chloro-3-(5-methyl-1,3-benzoxazol-2-yl)phenyl]-2-cyanoacetamide Show/Hide	C17H12ClN3O2	1
1	IC50 = 100 nM Bioactivity Info	TI LI LO TS
CP0402882 Compound Info	1-[4-Chloro-3-(5-chloro-benzooxazol-2-yl)-phenyl]-3-prop-2-ynyl-urea Show/Hide	C17H11Cl2N3O2	1
1	IC50 = 100 nM Bioactivity Info	TI LI LO TS
CP0471143 Compound Info	N-[4-chloro-3-(5-chloro-1,3-benzoxazol-2-yl)phenyl]pent-4-ynamide Show/Hide	C18H12Cl2N2O2	1
1	IC50 = 100 nM Bioactivity Info	TI LI LO TS
CP0432604 Compound Info	prop-2-ynyl N-[4-chloro-3-[1-methyl-5-(trifluoromethyl)benzimidazol-2-yl]phenyl]carbamate Show/Hide	C19H13ClF3N3O2	1
1	IC50 = 120 nM Bioactivity Info	TI LI LO TS
CP0404282 Compound Info	6-(5-Bromo-2-ethoxy-phenyl)-N4-phenyl-pyrimidine-2,4-diamine Show/Hide	C18H17BrN4O	1
1	IC50 = 120 nM Bioactivity Info	TI LI LO TS
CP0383365 Compound Info	prop-2-ynyl N-[4-chloro-3-[5-(trifluoromethyl)-1,3-benzoxazol-2-yl]phenyl]carbamate Show/Hide	C18H10ClF3N2O3	1
1	IC50 = 140 nM Bioactivity Info	TI LI LO TS
CP0492495 Compound Info	6-(5-Chloro-2-methyl-phenyl)-N4-(4-trifluoromethyl-phenyl)-pyrimidine-2,4-diamine Show/Hide	C18H14ClF3N4	1
1	IC50 = 140 nM Bioactivity Info	TI LI LO TS
CP0523973 Compound Info	4-N-(4-chlorophenyl)-6-(5-fluoro-2-methylphenyl)pyrimidine-2,4-diamine Show/Hide	C17H14ClFN4	1
1	IC50 = 150 nM Bioactivity Info	TI LI LO TS
CP0384040 Compound Info	prop-2-ynyl N-[4-chloro-3-(4-methyl-1,3-benzoxazol-2-yl)phenyl]carbamate Show/Hide	C18H13ClN2O3	1
1	IC50 = 160 nM Bioactivity Info	TI LI LO TS
CP0453057 Compound Info	2-Azido-N-[4-chloro-3-(5-chloro-benzooxazol-2-yl)-phenyl]-acetamide Show/Hide	C15H9Cl2N5O2	1
1	IC50 = 170 nM Bioactivity Info	TI LI LO TS
CP0467992 Compound Info	prop-2-ynyl N-[4-chloro-3-(5-methyl-1,3-benzoxazol-2-yl)phenyl]carbamate Show/Hide	C18H13ClN2O3	1
1	IC50 = 190 nM Bioactivity Info	TI LI LO TS
CP0449001 Compound Info	methyl N-[4-chloro-3-[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]phenyl]carbamate Show/Hide	C16H10ClF3N2O2S	1
1	IC50 = 200 nM Bioactivity Info	TI LI LO TS
CP0545112 Compound Info	2-[4-[[2-amino-6-(5-bromo-2-ethoxyphenyl)pyrimidin-4-yl]amino]phenyl]acetic acid Show/Hide	C20H19BrN4O3	1
1	IC50 = 210 nM Bioactivity Info	TI LI LO TS
CP0507604 Compound Info	3-{4-[2-Amino-6-(5-chloro-2-ethoxy-phenyl)-pyrimidin-4-ylamino]-phenyl}-propan-1-ol Show/Hide	C21H23ClN4O2	1
1	IC50 = 230 nM Bioactivity Info	TI LI LO TS
CP0483478 Compound Info	4-(5-Chloro-2-methoxy-phenyl)-N-p-tolyl-pyridine-2,6-diamine Show/Hide	C19H18ClN3O	1
1	IC50 = 240 nM Bioactivity Info	TI LI LO TS
CP0483479 Compound Info	4-[6-Amino-4-(5-chloro-2-methoxy-phenyl)-pyridin-2-ylamino]-benzaldehyde Show/Hide	C19H16ClN3O2	1
1	IC50 = 260 nM Bioactivity Info	TI LI LO TS
CP0448368 Compound Info	N-[4-chloro-3-(5-chloro-1-methylbenzimidazol-2-yl)phenyl]-2-cyanoacetamide Show/Hide	C17H12Cl2N4O	1
1	IC50 = 300 nM Bioactivity Info	TI LI LO TS
CP0476690 Compound Info	methyl N-[4-chloro-3-(5-chloro-1,3-benzoxazol-2-yl)phenyl]carbamate Show/Hide	C15H10Cl2N2O3	1
1	IC50 = 300 nM Bioactivity Info	TI LI LO TS
CP0383364 Compound Info	methyl N-[4-chloro-3-(6-methyl-1,3-benzoxazol-2-yl)phenyl]carbamate Show/Hide	C16H13ClN2O3	1
1	IC50 = 400 nM Bioactivity Info	TI LI LO TS
CP0505086 Compound Info	2-{4-[2-Amino-6-(5-bromo-2-ethoxy-phenyl)-pyrimidin-4-ylamino]-phenyl}-N-hydroxy-acetamide Show/Hide	C20H20BrN5O3	1
1	IC50 = 400 nM Bioactivity Info	TI LI LO TS
CP0534937 Compound Info	2-[2-Amino-6-(4-chloro-phenylamino)-pyrimidin-4-yl]-4-bromo-phenol Show/Hide	C16H12BrClN4O	1
1	IC50 = 450 nM Bioactivity Info	TI LI LO TS
CP0483480 Compound Info	4-(5-Chloro-2-ethoxy-phenyl)-N-p-tolyl-pyridine-2,6-diamine Show/Hide	C20H20ClN3O	1
1	IC50 = 490 nM Bioactivity Info	TI LI LO TS
CP0438528 Compound Info	N-[4-chloro-3-(5-methyl-1,3-benzoxazol-2-yl)phenyl]pent-4-ynamide Show/Hide	C19H15ClN2O2	1
1	IC50 = 500 nM Bioactivity Info	TI LI LO TS
CP0452984 Compound Info	(3-Benzooxazol-2-yl-4-chloro-phenyl)-carbamic acid methyl ester Show/Hide	C15H11ClN2O3	1
1	IC50 = 500 nM Bioactivity Info	TI LI LO TS
CP0461124 Compound Info	methyl N-[4-chloro-3-(4-methyl-1,3-benzoxazol-2-yl)phenyl]carbamate Show/Hide	C16H13ClN2O3	1
1	IC50 = 500 nM Bioactivity Info	TI LI LO TS
CP0438524 Compound Info	methyl N-[3-(5-chloro-1,3-benzoxazol-2-yl)-4-methylphenyl]carbamate Show/Hide	C16H13ClN2O3	1
1	IC50 = 550 nM Bioactivity Info	TI LI LO TS
CP0531426 Compound Info	2-[4-[[2-amino-6-(5-chloro-2-ethoxyphenyl)pyrimidin-4-yl]amino]phenyl]acetic acid Show/Hide	C20H19ClN4O3	1
1	IC50 = 580 nM Bioactivity Info	TI LI LO TS
CP0452983 Compound Info	2-Azido-N-[4-chloro-3-(5-methyl-benzooxazol-2-yl)-phenyl]-acetamide Show/Hide	C16H12ClN5O2	1
1	IC50 = 600 nM Bioactivity Info	TI LI LO TS
CP0544976 Compound Info	4-N-(3-bromophenyl)-6-(5-chloro-2-methylphenyl)pyrimidine-2,4-diamine Show/Hide	C17H14BrClN4	1
1	IC50 = 610 nM Bioactivity Info	TI LI LO TS
CP0425306 Compound Info	6-(5-Chloro-2-ethoxy-phenyl)-N4-(3-nitro-phenyl)-pyrimidine-2,4-diamine Show/Hide	C18H16ClN5O3	1
1	IC50 = 640 nM Bioactivity Info	TI LI LO TS
CP0452944 Compound Info	methyl N-[4-chloro-3-(5-chloro-1-methylbenzimidazol-2-yl)phenyl]carbamate Show/Hide	C16H13Cl2N3O2	1
1	IC50 = 650 nM Bioactivity Info	TI LI LO TS
CP0392228 Compound Info	3-[2-Amino-6-(5-bromo-2-ethoxy-phenyl)-pyrimidin-4-ylamino]-benzonitrile Show/Hide	C19H16BrN5O	1
1	IC50 = 720 nM Bioactivity Info	TI LI LO TS
CP0449863 Compound Info	4-[2-Amino-6-(5-bromo-2-ethoxy-phenyl)-pyrimidin-4-ylamino]-benzamide Show/Hide	C19H18BrN5O2	1
1	IC50 = 750 nM Bioactivity Info	TI LI LO TS
CP0384038 Compound Info	methyl N-[4-chloro-3-[5-(trifluoromethyl)-1,3-benzoxazol-2-yl]phenyl]carbamate Show/Hide	C16H10ClF3N2O3	1
1	IC50 = 800 nM Bioactivity Info	TI LI LO TS
CP0520200 Compound Info	6-(5-Chloro-2-methoxy-phenyl)-N2-(1H-indazol-6-yl)-pyrimidine-2,4-diamine Show/Hide	C18H15ClN6O	1
1	IC50 = 800 nM Bioactivity Info	TI LI LO TS
CP0448359 Compound Info	1-[4-Chloro-3-(5-chloro-benzooxazol-2-yl)-phenyl]-3-methyl-urea Show/Hide	C15H11Cl2N3O2	1
1	IC50 = 950 nM Bioactivity Info	TI LI LO TS
CP0530111 Compound Info	1-{4-[2-Amino-6-(5-bromo-2-ethoxy-phenyl)-pyrimidin-4-ylamino]-phenyl}-ethanone O-methyl-oxime Show/Hide	C21H22BrN5O2	1
1	IC50 = 970 nM Bioactivity Info	TI LI LO TS
CP0508026 Compound Info	methyl N-[4-chloro-3-(5-methyl-1,3-benzoxazol-2-yl)phenyl]carbamate Show/Hide	C16H13ClN2O3	1
1	IC50 = 1000 nM Bioactivity Info	TI LI LO TS
CP0392227 Compound Info	4-N-(4-chlorophenyl)-6-phenylpyrimidine-2,4-diamine Show/Hide	C16H13ClN4	1
1	IC50 = 1100 nM Bioactivity Info	TI LI LO TS
CP0440404 Compound Info	prop-2-enyl N-[4-chloro-3-(5-methyl-1,3-benzoxazol-2-yl)phenyl]carbamate Show/Hide	C18H15ClN2O3	1
1	IC50 = 1400 nM Bioactivity Info	TI LI LO TS
CP0401684 Compound Info	methyl N-[4-methyl-3-(5-methyl-1,3-benzoxazol-2-yl)phenyl]carbamate Show/Hide	C17H16N2O3	1
1	IC50 = 1500 nM Bioactivity Info	TI LI LO TS
CP0461095 Compound Info	N-[4-chloro-3-(5-methyl-1,3-benzoxazol-2-yl)phenyl]propanamide Show/Hide	C17H15ClN2O2	1
1	IC50 = 1500 nM Bioactivity Info	TI LI LO TS
CP0463903 Compound Info	ethyl N-[4-chloro-3-(5-methyl-1,3-benzoxazol-2-yl)phenyl]carbamate Show/Hide	C17H15ClN2O3	1
1	IC50 = 1500 nM Bioactivity Info	TI LI LO TS
CP0438523 Compound Info	prop-2-ynyl N-[4-chloro-3-(5-hydroxy-1,3-benzoxazol-2-yl)phenyl]carbamate Show/Hide	C17H11ClN2O4	1
1	IC50 = 2000 nM Bioactivity Info	TI LI LO TS
CP0529884 Compound Info	2-(5-Chloro-2-methoxy-phenyl)-N-(1H-indazol-6-yl)-pyrimidine-4,6-diamine Show/Hide	C18H15ClN6O	1
1	IC50 = 2100 nM Bioactivity Info	TI LI LO TS
CP0573211 Compound Info	2-N-(4-bromophenyl)-6-(5-chloro-2-methoxyphenyl)pyrimidine-2,4-diamine Show/Hide	C17H14BrClN4O	1
1	IC50 = 2300 nM Bioactivity Info	TI LI LO TS
CP0453393 Compound Info	N-[4-chloro-3-(5-methyl-1,3-benzoxazol-2-yl)phenyl]acetamide Show/Hide	C16H13ClN2O2	1
1	IC50 = 2500 nM Bioactivity Info	TI LI LO TS
CP0470970 Compound Info	N-[4-chloro-3-(5-methyl-1,3-benzoxazol-2-yl)phenyl]butanamide Show/Hide	C18H17ClN2O2	1
1	IC50 = 2500 nM Bioactivity Info	TI LI LO TS
CP0541143 Compound Info	4-[2-Amino-6-(5-bromo-2-ethoxy-phenyl)-pyrimidin-4-ylamino]-benzoic acid Show/Hide	C19H17BrN4O3	1
1	IC50 = 2700 nM Bioactivity Info	TI LI LO TS
CP0439059 Compound Info	6-(5-Chloro-2-ethoxy-phenyl)-N4-(2-chloro-phenyl)-pyrimidine-2,4-diamine Show/Hide	C18H16Cl2N4O	1
1	IC50 = 4900 nM Bioactivity Info	TI LI LO TS
CP0507565 Compound Info	prop-2-ynyl N-[4-chloro-3-[6-(trifluoromethyl)-1H-benzimidazol-2-yl]phenyl]carbamate Show/Hide	C18H11ClF3N3O2	1
1	IC50 = 5200 nM Bioactivity Info	TI LI LO TS
CP0436064 Compound Info	6-(5-Chloro-2-methoxy-phenyl)-N2-(4-chloro-phenyl)-pyridine-2,4-diamine Show/Hide	C18H15Cl2N3O	1
1	IC50 = 6500 nM Bioactivity Info	TI LI LO TS
CP0404158 Compound Info	2-(5-Chloro-2-methoxy-phenyl)-N-(4-chloro-phenyl)-pyrimidine-4,6-diamine Show/Hide	C17H14Cl2N4O	1
1	IC50 = 7000 nM Bioactivity Info	TI LI LO TS
CP0380904 Compound Info	6-(5-Chloro-2-methoxy-phenyl)-N2-(4-chloro-phenyl)-pyrimidine-2,4-diamine Show/Hide	C17H14Cl2N4O	1
1	IC50 = 7000 nM Bioactivity Info	TI LI LO TS
CP0502814 Compound Info	4-N-(4-bromophenyl)-2-(5-chloro-2-methoxyphenyl)pyrimidine-4,6-diamine Show/Hide	C17H14BrClN4O	1
1	IC50 = 8000 nM Bioactivity Info	TI LI LO TS
CP0525968 Compound Info	3-[2-Amino-6-(4-chloro-phenylamino)-pyrimidin-4-yl]-4-methyl-phenol Show/Hide	C17H15ClN4O	1
1	IC50 = 8300 nM Bioactivity Info	TI LI LO TS
CP0464338 Compound Info	methyl N-[4-chloro-3-(4-methyl-1,3-benzothiazol-2-yl)phenyl]carbamate Show/Hide	C16H13ClN2O2S	1
1	IC50 = 9000 nM Bioactivity Info	TI LI LO TS
CP0543939 Compound Info	2-[2-Amino-6-(4-chloro-phenylamino)-pyrimidin-4-yl]-4-chloro-phenol Show/Hide	C16H12Cl2N4O	1
1	IC50 = 10000 nM Bioactivity Info	TI LI LO TS
CP0463819 Compound Info	methyl N-[4-chloro-3-(1,5-dimethylbenzimidazol-2-yl)phenyl]carbamate Show/Hide	C17H16ClN3O2	1
1	IC50 = 11000 nM Bioactivity Info	TI LI LO TS
CP0438241 Compound Info	N-[4-chloro-3-(5-methyl-1,3-benzoxazol-2-yl)phenyl]-N-methylpropanamide Show/Hide	C18H17ClN2O2	1
1	IC50 = 12000 nM Bioactivity Info	TI LI LO TS
CP0453045 Compound Info	propyl N-[4-chloro-3-(5-methyl-1,3-benzoxazol-2-yl)phenyl]carbamate Show/Hide	C18H17ClN2O3	1
1	IC50 = 12000 nM Bioactivity Info	TI LI LO TS
CP0466800 Compound Info	propan-2-yl N-[4-chloro-3-(5-methyl-1,3-benzoxazol-2-yl)phenyl]carbamate Show/Hide	C18H17ClN2O3	1
1	IC50 = 16000 nM Bioactivity Info	TI LI LO TS
CP0496086 Compound Info	6-(5-Chloro-2-methoxy-phenyl)-N4-(4-chloro-phenyl)-pyridine-2,4-diamine Show/Hide	C18H15Cl2N3O	1
1	IC50 = 18000 nM Bioactivity Info	TI LI LO TS
CP0407011 Compound Info	But-2-ynoic acid [4-chloro-3-(5-chloro-benzooxazol-2-yl)-phenyl]-amide Show/Hide	C17H10Cl2N2O2	1
1	IC50 > 20000 nM Bioactivity Info	TI LI LO TS
CP0410621 Compound Info	But-2-ynoic acid [4-chloro-3-(5-methyl-benzooxazol-2-yl)-phenyl]-amide Show/Hide	C18H13ClN2O2	1
1	IC50 > 20000 nM Bioactivity Info	TI LI LO TS
CP0448369 Compound Info	methyl N-[4-chloro-3-(1,6-dimethylbenzimidazol-2-yl)phenyl]carbamate Show/Hide	C17H16ClN3O2	1
1	IC50 > 20000 nM Bioactivity Info	TI LI LO TS
CP0454592 Compound Info	methyl N-[4-chloro-3-(5-hydroxy-1,3-benzoxazol-2-yl)phenyl]carbamate Show/Hide	C15H11ClN2O4	1
1	IC50 > 20000 nM Bioactivity Info	TI LI LO TS
CP0479775 Compound Info	2-(2-Chloro-5-methoxycarbonylamino-phenyl)-benzooxazole-5-carboxylic acid Show/Hide	C16H11ClN2O5	1
1	IC50 > 20000 nM Bioactivity Info	TI LI LO TS
CP0486665 Compound Info	6-(5-Chloro-2-methoxy-phenyl)-N2-p-tolyl-pyridine-2,4-diamine Show/Hide	C19H18ClN3O	1
1	IC50 = 29000 nM Bioactivity Info	TI LI LO TS
CP0463518 Compound Info	N-[4-chloro-3-(5-methyl-1,3-benzoxazol-2-yl)phenyl]-2-hydroxyacetamide Show/Hide	C16H13ClN2O3	1
1	IC50 = 31000 nM Bioactivity Info	TI LI LO TS
CP0377596 Compound Info	N-[4-chloro-3-(5-methyl-1,3-benzoxazol-2-yl)phenyl]benzamide Show/Hide	C21H15ClN2O2	1
1	IC50 = 40000 nM Bioactivity Info	TI LI LO TS
CP0513162 Compound Info	2-(4-Amino-3-methylphenyl)benzothiazole Show/Hide	C14H12N2S	1
1	IC50 > 40000 nM Bioactivity Info	TI LI LO TS
CP0377373 Compound Info	methyl N-[4-fluoro-3-(5-methyl-1,3-benzoxazol-2-yl)phenyl]carbamate Show/Hide	C16H13FN2O3	1
1	IC50 > 64000 nM Bioactivity Info	TI LI LO TS
CP0384128 Compound Info	methyl N-[4-chloro-3-(6-methyl-1,3-benzothiazol-2-yl)phenyl]carbamate Show/Hide	C16H13ClN2O2S	1
1	IC50 > 64000 nM Bioactivity Info	TI LI LO TS
CP0407012 Compound Info	methyl N-[4-chloro-3-(5-phenyl-1,3-benzoxazol-2-yl)phenyl]carbamate Show/Hide	C21H15ClN2O3	1
1	IC50 = 64000 nM Bioactivity Info	TI LI LO TS
CP0453432 Compound Info	methyl N-[3-(5-methyl-1,3-benzoxazol-2-yl)phenyl]carbamate Show/Hide	C16H14N2O3	1
1	IC50 > 64000 nM Bioactivity Info	TI LI LO TS
CP0463744 Compound Info	methyl N-[4-methoxy-3-(5-methyl-1,3-benzoxazol-2-yl)phenyl]carbamate Show/Hide	C17H16N2O4	1
1	IC50 = 64000 nM Bioactivity Info	TI LI LO TS
CP0384037 Compound Info	N-[4-chloro-3-(5-chloro-1,3-benzoxazol-2-yl)phenyl]-2-(dimethylamino)acetamide Show/Hide	C17H15Cl2N3O2	1
1	IC50 > 5000 nM Bioactivity Info	TI LI LO TS
CP0407062 Compound Info	N-[4-chloro-3-(5-methyl-1,3-benzoxazol-2-yl)phenyl]formamide Show/Hide	C15H11ClN2O2	1
1	IC50 > 5000 nM Bioactivity Info	TI LI LO TS
CP0449004 Compound Info	4-[4-Chloro-3-(5-methyl-benzooxazol-2-yl)-phenylamino]-butyronitrile Show/Hide	C18H16ClN3O	1
1	IC50 > 5000 nM Bioactivity Info	TI LI LO TS
CP0453452 Compound Info	N-[4-chloro-3-(5-chloro-1,3-benzoxazol-2-yl)phenyl]-2-(methylamino)acetamide Show/Hide	C16H13Cl2N3O2	1
1	IC50 > 5000 nM Bioactivity Info	TI LI LO TS
CP0496600 Compound Info	4-[2-Amino-6-(5-bromo-2-ethoxy-phenyl)-pyrimidin-4-ylamino]-benzamidine Show/Hide	C19H19BrN6O	1
1	IC50 > 5000 nM Bioactivity Info	TI LI LO TS

Biochemical Assays

Compound ID	Compound Name	Compound Formula
CP0530980 Compound Info	5TT4A4MBLR Show/Hide	C16H13BrClN5	1
1	IC50 = 60 nM

Clinical Information about the Protein

Target 1 ( Lysophosphatidic acid acyltransferase beta (LPAATB) )

Target Type	Literature-reported Target

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han