General Information of the Protein
Protein ID
PT06106
Protein Name
Low-density lipoprotein receptor
Gene Name
LDLR
Sequence
MGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTEAEAAVATQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGATPGLTTVEIVTMSHQALGDVAGRGNEKKPSSVRALSIVLPIVLLVFLCLGVFLLWKNWRLKNINSINFDNPVYQKTTEDEVHICHNQDGYSYPSRQMVSLEDDVA
    Show/Hide
Organism
Homo sapiens, Human
Protein Classification
Membrane receptor
Function
Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits.
    Show/Hide
Uniprot ID
Primary ID:
P01130

Secondarily ID:
B4DII3
B4DJZ8
B4DR00
B4DTQ3
C0JYY8
H0YLU8
H0YNT7
Q53ZD9
Q59FQ1
Q9UDH7
    Show/Hide
Ensembl ID
ENSG00000130164
HGNC ID
HGNC:6547
Subcellular Location
Cell membrane
Membrane
Clathrin-coated pit
Golgi apparatus
Early endosome
Late endosome
Lysosome
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000063 , Hep-G2
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0489983
 Compound Info 
N-[3-(1,3-benzodioxol-5-ylmethylamino)-4-methylphenyl]-3-cyclohexylpropanamide
   Show/Hide
C24H30N2O3
  1
1
EC50 = 600 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0392671
 Compound Info 
N-[3-[(Z)-2-(1,3-benzodioxol-5-yl)-2-cyanoethenyl]-4-methylphenyl]-3-cyclohexylpropanamide
   Show/Hide
C26H28N2O3
  1
1
EC50 = 700 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0437043
 Compound Info 
3-Cyclohexyl-N-[3-(5-hydroxy-1H-benzoimidazol-2-yl)-4-methyl-phenyl]-propionamide
   Show/Hide
C23H27N3O2
  1
1
EC50 = 700 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0526745
 Compound Info 
N-[3-[(Z)-2-cyano-2-pyridin-3-ylethenyl]-4-methylphenyl]-3-cyclohexylpropanamide
   Show/Hide
C24H27N3O
  1
1
EC50 = 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0432288
 Compound Info 
N-[5-(3-cyclohexylpropanoylamino)-2-methylphenyl]pyridine-3-carboxamide
   Show/Hide
C22H27N3O2
  1
1
EC50 = 1200 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0381986
 Compound Info 
3-Cyclohexyl-N-[4-methyl-3-(5-methyl-1H-benzoimidazol-2-yl)-phenyl]-propionamide
   Show/Hide
C24H29N3O
  1
1
EC50 = 1300 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0535742
 Compound Info 
N-[3-(1H-benzimidazol-2-yl)-4-methylphenyl]-3-cyclohexylpropanamide
   Show/Hide
C23H27N3O
  1
1
EC50 = 1300 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0505648
 Compound Info 
N-[5-(3-cyclohexylpropanoylamino)-2-methylphenyl]-4-hydroxybenzamide
   Show/Hide
C23H28N2O3
  1
1
EC50 = 1700 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0437750
 Compound Info 
N-[5-(3-cyclohexylpropanoylamino)-2-methylphenyl]benzamide
   Show/Hide
C23H28N2O2
  1
1
EC50 = 2000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0511199
 Compound Info 
N-(2-cyclohexylethyl)-3-[(4-hydroxybenzoyl)amino]-4-methylbenzamide
   Show/Hide
C23H28N2O3
  1
1
EC50 = 2000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0511268
 Compound Info 
N-[5-(3-cyclohexylpropanoylamino)-2-methylphenyl]-3-hydroxybenzamide
   Show/Hide
C23H28N2O3
  1
1
EC50 = 2000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0509503
 Compound Info 
N-[5-(4-cyclohexylbutanoyl)-2-methylphenyl]pyridine-3-carboxamide
   Show/Hide
C23H28N2O2
  1
1
EC50 = 2000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0509217
 Compound Info 
Acetic acid 4-[5-(3-cyclohexyl-propionylamino)-2-methyl-phenylcarbamoyl]-phenyl ester
   Show/Hide
C25H30N2O4
  1
1
EC50 = 2500 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0530263
 Compound Info 
4-Amino-N-[5-(3-cyclohexyl-propionylamino)-2-methyl-phenyl]-benzamide
   Show/Hide
C23H29N3O2
  1
1
EC50 = 3800 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0508533
 Compound Info 
N-[5-(4-cyclohexylbutanoylamino)-2-methylphenyl]-4-hydroxybenzamide
   Show/Hide
C24H30N2O3
  1
1
EC50 = 4000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0392683
 Compound Info 
5-(3-Cyclohexyl-propionylamino)-N-(4-hydroxy-phenyl)-2-methyl-benzamide
   Show/Hide
C23H28N2O3
  1
1
EC50 = 7000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0378375
 Compound Info 
N-[5-(3-cyclohexylpropanoylamino)-2-methylphenyl]-4-(hydroxymethyl)benzamide
   Show/Hide
C24H30N2O3
  1
1
EC50 = 7600 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Clinical Information about the Protein
Target 1 ( Low-density lipoprotein receptor (LDL-R) )
Target Type Successful Target