Protein Information

General Information of the Protein

Protein ID	PT06087
Protein Name	ATP-binding cassette sub-family C member 9
Secondarily Protein Name	Sulfonylurea receptor 2
Gene Name	ABCC9
Secondarily Gene Name	SUR2
Sequence	MSLSFCGNNISSYNINDGVLQNSCFVDALNLVPHVFLLFITFPILFIGWGSQSSKVQIHHNTWLHFPGHNLRWILTFALLFVHVCEIAEGIVSDSRRESRHLHLFMPAVMGFVATTTSIVYYHNIETSNFPKLLLALFLYWVMAFITKTIKLVKYCQSGLDISNLRFCITGMMVILNGLLMAVEINVIRVRRYVFFMNPQKVKPPEDLQDLGVRFLQPFVNLLSKATYWWMNTLIISAHKKPIDLKAIGKLPIAMRAVTNYVCLKDAYEEQKKKVADHPNRTPSIWLAMYRAFGRPILLSSTFRYLADLLGFAGPLCISGIVQRVNETQNGTNNTTGISETLSSKEFLENAYVLAVLLFLALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSIFMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSLFHILVTPLFLLSTVVRFAVKAIISVQKLNEFLLSDEIGDDSWRTGESSLPFESCKKHTGVQPKTINRKQPGRYHLDSYEQSTRRLRPAETEDIAIKVTNGYFSWGSGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFNKQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKDVELYEHWKTLMNRQDQELEKDMEADQTTLERKTLRRAMYSREAKAQMEDEDEEEEEEEDEDDNMSTVMRLRTKMPWKTCWRYLTSGGFFLLILMIFSKLLKHSVIVAIDYWLATWTSEYSINNTGKADQTYYVAGFSILCGAGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLVALLPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASIASISGSSNSGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKNGLFSTLVMTNK Show/Hide
Organism	Homo sapiens, Human
Protein Classification	Transporter > Primary active transporter > ATP-binding cassette > ABCC subfamily
Function	Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with KCNJ11. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation. Show/Hide
Uniprot ID	Primary ID: O60706 Secondarily ID: O60707 Show/Hide
Ensembl ID	ENSG00000069431
HGNC ID	HGNC:60
Subcellular Location	Membrane

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000005 , TE 671

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0434933 Compound Info	(-)-3-chlorophenyl (3S,4R)-6-cyano-3-hydroxy-2,2-dimethylchroman-4-ylcarbamate Show/Hide	C19H17ClN2O3	1
1	EC50 = 70 nM Bioactivity Info	TI LI LO TS
CP0434938 Compound Info	(+/-)-3-chlorophenyl 6-cyano-3-hydroxy-2,2-dimethylchroman-4-ylcarbamate Show/Hide	C19H17ClN2O3	1
1	EC50 = 120 nM Bioactivity Info	TI LI LO TS
CP0009138 Compound Info	CAS_60559-98-0 Show/Hide	C12H17N5	1
1	EC50 = 230 nM Bioactivity Info	TI LI LO TS
CP0462312 Compound Info	(+/-)-3-chlorophenyl 6-cyano-3-hydroxy-2,2-dimethylchroman-4-yl carbonate Show/Hide	C19H16ClNO4	1
1	EC50 = 310 nM Bioactivity Info	TI LI LO TS
CP0422815 Compound Info	4-chloro-N-((3S,4R)-6-cyano-3-hydroxy-2,2-dimethylchroman-4-yl)nicotinamide Show/Hide	C18H16ClN3O3	1
1	EC50 = 560 nM Bioactivity Info	TI LI LO TS
CP0422795 Compound Info	(3S,4R)-4-(6-chloro-3-oxo-3H-benzo[d]isoxazol-2-yl)-3-hydroxy-2,2-dimethyl-chroman-6-carbonitrile Show/Hide	C19H15ClN2O4	1
1	EC50 = 670 nM Bioactivity Info	TI LI LO TS
CP0523014 Compound Info	(3S,4R)-2-(6-Benzenesulfonyl-3-hydroxy-2,2-dimethylchroman-4-yl)-6-chloro-benzo[d]isoxazol-3-one Show/Hide	C24H20ClNO6S	1
1	EC50 = 750 nM Bioactivity Info	TI LI LO TS
CP0374095 Compound Info	(+/-)-4-chlorophenyl 6-cyano-3-hydroxy-2,2-dimethylchroman-4-ylcarbamate Show/Hide	C19H17ClN2O3	1
1	EC50 = 780 nM Bioactivity Info	TI LI LO TS
CP0526204 Compound Info	N-[(3S,4R)-6-cyano-3-hydroxy-2,2-dimethyl-3,4-dihydrochromen-4-yl]-1,3-benzodioxole-5-carboxamide Show/Hide	C20H18N2O5	1
1	EC50 = 810 nM Bioactivity Info	TI LI LO TS
CP0467669 Compound Info	(3S,4R)-(5-Chloro-3-oxo-3H-benzo[d]isoxazol-2-yl)-3-hydroxy-2,2-dimethyl-chroman-6-sulfonic acid diethylamide Show/Hide	C22H25ClN2O6S	1
1	EC50 = 820 nM Bioactivity Info	TI LI LO TS
CP0463809 Compound Info	(3S,4R)-6-Chloro-2-[3-hydroxy-2,2-dimethyl-6-(piperidine-1-sulfonyl)-chroman-4-yl]-benzo[d] isoxazol-3-one Show/Hide	C23H25ClN2O6S	1
1	EC50 = 1080 nM Bioactivity Info	TI LI LO TS
CP0022488 Compound Info	CAS_94535-50-9 Show/Hide	C16H18N2O3	1
1	EC50 = 1250 nM Bioactivity Info	TI LI LO TS
CP0422810 Compound Info	(3S,4R)-6-Benzenesulfonyl-4-(5-chloro-benzo[d]-isoxazol-3-ylamino)-chroman-3-ol Show/Hide	C24H21ClN2O5S	1
1	EC50 = 1370 nM Bioactivity Info	TI LI LO TS
CP0374104 Compound Info	(3S,4R)-4-[5-(4-Chloro-phenyl)-pyrazol-1-yl]-3-hydroxy-2,2-dimethyl-chroman-6-carbonitrile Show/Hide	C21H18ClN3O2	1
1	EC50 = 1500 nM Bioactivity Info	TI LI LO TS
CP0374103 Compound Info	3-chloro-N-((3S,4R)-6-cyano-3-hydroxy-2,2-dimethylchroman-4-yl)benzenesulfonamide Show/Hide	C18H17ClN2O4S	1
1	EC50 = 1540 nM Bioactivity Info	TI LI LO TS
CP0422804 Compound Info	(3S,4R)-2-(6-Benzenesulfonyl-3-hydroxy-2,2-dimethylchroman-4-yl)-5-chloro-4-benzo[d] isoxazol-3-one Show/Hide	C24H20ClNO6S	1
1	EC50 = 1560 nM Bioactivity Info	TI LI LO TS
CP0519219 Compound Info	(3S,4R)-4-[5-(4-Chloro-phenyl)-pyrazol-1-yl]-2,2-dimethyl-3,4-dihydro-2H-pyrano[3,2-c]pyridin-3-ol Show/Hide	C19H18ClN3O2	1
1	EC50 = 1640 nM Bioactivity Info	TI LI LO TS
CP0422800 Compound Info	(3S,4R)-6-Chloro-2-[6-(3-fluoro-benzenesulfonyl)-3-hydroxy-2,2-dimethyl-chroman-4-yl]-benzo[d]isoxazol-3-one Show/Hide	C24H19ClFNO6S	1
1	EC50 = 1710 nM Bioactivity Info	TI LI LO TS
CP0444597 Compound Info	(+)-3-chlorophenyl (3R,4S)-6-cyano-3-hydroxy-2,2-dimethylchroman-4-ylcarbamate Show/Hide	C19H17ClN2O3	1
1	EC50 = 2070 nM Bioactivity Info	TI LI LO TS
CP0444596 Compound Info	(3S,4R)-4-(6-Chloro-4-oxo-1,4-dihydro-quinazolin-2-ylamino)-3-hydroxy-2,2-dimethyl-chroman-6-carbonitrile Show/Hide	C20H17ClN4O3	1
1	EC50 = 2290 nM Bioactivity Info	TI LI LO TS
CP0453661 Compound Info	(3S,4R)-4-(5-chloro-3-oxobenzo[d]isoxazol-2(3H)-yl)-3-hydroxy-2,2-dimethylchroman-6-carbonitrile Show/Hide	C19H15ClN2O4	1
1	EC50 = 2440 nM Bioactivity Info	TI LI LO TS
CP0463808 Compound Info	(3S,4R)-4-(5-Ethoxy-benzothiazol-2-ylamino)-3-hydroxy-2,2-dimethyl-chroman-6-carbonitrile Show/Hide	C21H21N3O3S	1
1	EC50 = 2600 nM Bioactivity Info	TI LI LO TS
CP0493444 Compound Info	(3S,4R)-4-[2-(4-Chloro-phenyl)-imidazol-1-yl]-3-hydroxy-2,2-dimethyl-chroman-6-carbonitrile Show/Hide	C21H18ClN3O2	1
1	EC50 = 2750 nM Bioactivity Info	TI LI LO TS
CP0374094 Compound Info	(3S,4R)-3-Hydroxy-2,2-dimethyl-4-(5-nitrobenzothiazol-2-ylamino)-chroman-6-carbonitrile Show/Hide	C19H16N4O4S	1
1	EC50 = 3090 nM Bioactivity Info	TI LI LO TS
CP0422802 Compound Info	(3S,4R)-4-(5-Chloro-1,3-dioxo-1,3-dihydro-isoindol-2-yl)-3-hydroxy-2,2-dimethyl-chroman-6-carbonitrile Show/Hide	C20H15ClN2O4	1
1	EC50 = 3160 nM Bioactivity Info	TI LI LO TS
CP0021671 Compound Info	CAS_85371-64-8 Show/Hide	C13H19N5	1
1	EC50 = 3540 nM Bioactivity Info	TI LI LO TS
CP0422811 Compound Info	(3S,4R)-3-Hydroxy-2,2-dimethyl-4-(4-oxo-1,4-dihydroquinazolin-2-ylamino)-chroman-6-carbonitrile Show/Hide	C20H18N4O3	1
1	EC50 = 3710 nM Bioactivity Info	TI LI LO TS
CP0481597 Compound Info	(3S,4R)-3-Hydroxy-2,2-dimethyl-4-(6-nitro-3-oxo-3Hbenzo[d]isothiazol-2-yl)-chroman-6-carbonitrile Show/Hide	C19H15N3O5S	1
1	EC50 = 4100 nM Bioactivity Info	TI LI LO TS
CP0434937 Compound Info	(3S,4R)-4-[2-(4-Chloro-phenyl)-imidazol-1-yl]-2,2-dimethyl-3,4-dihydro-2H-pyrano[3,2-c] pyridin-3-ol Show/Hide	C19H18ClN3O2	1
1	EC50 = 4330 nM Bioactivity Info	TI LI LO TS
CP0481596 Compound Info	(3S,4R)-4-(1,3-Dioxo-1,3-dihydro-pyrrolo[3,4-c]pyridin-2-yl)-3-hydroxy-2,2-dimethyl-chroman-6-carbonitrile Show/Hide	C19H15N3O4	1
1	EC50 = 6040 nM Bioactivity Info	TI LI LO TS
CP0433784 Compound Info	(3S,4R)-4-(6-Chloro-benzo[d]isoxazol-3-ylamino)-3-hydroxy-2,2-dimethyl-chroman-6-carbonitrile Show/Hide	C19H16ClN3O3	1
1	EC50 = 6180 nM Bioactivity Info	TI LI LO TS
CP0422799 Compound Info	(3S,4R)-2-(6-Benzoyl-3-hydroxy-2,2-dimethyl-chroman-4-yl)-6-chloro-4-benzo[d]isoxazol-3-one Show/Hide	C25H20ClNO5	1
1	EC50 = 6450 nM Bioactivity Info	TI LI LO TS
CP0422793 Compound Info	(3S,4R)-4-(5-Chloro-1H-indazol-3-ylamino)-3-hydroxy-2,2-dimethyl-chroman-6-carbonitrile Show/Hide	C19H17ClN4O2	1
1	EC50 = 6850 nM Bioactivity Info	TI LI LO TS
CP0422805 Compound Info	(3S,4R)-3-Hydroxy-2,2-dimethyl-4-(3-oxo-3H-benzo[d]-isoxazol-2-yl)-chroman-6-carbonitrile Show/Hide	C19H16N2O4	1
1	EC50 = 6940 nM Bioactivity Info	TI LI LO TS
CP0434934 Compound Info	3,4-dichloro-N-((3S,4R)-6-cyano-3-hydroxy-2,2-dimethylchroman-4-yl)benzamide Show/Hide	C19H16Cl2N2O3	1
1	EC50 = 7060 nM Bioactivity Info	TI LI LO TS
CP0422803 Compound Info	(3S,4R)-6-Chloro-[2-hydroxy-6-(4-methoxy-benzenesulfonyl)-2,2-dimethyl-chroman-4-yl]-benzo[d]isoxazol-3-one Show/Hide	C25H22ClNO7S	1
1	EC50 = 7330 nM Bioactivity Info	TI LI LO TS
CP0415592 Compound Info	(3S,4R)-4-[5-(4-Chloro-phenyl)-imidazol-1-yl]-3-hydroxy-2,2-dimethyl-chroman-6-carbonitrile Show/Hide	C21H18ClN3O2	1
1	EC50 = 7450 nM Bioactivity Info	TI LI LO TS
CP0422808 Compound Info	(3S,4R)-4-(5-Chloro-benzo[d]isoxazol-3-ylamino)-6-(3-fluoro-benzenesulfonyl)-2,2-dimethyl-chroman-3-ol Show/Hide	C24H20ClFN2O5S	1
1	EC50 = 7770 nM Bioactivity Info	TI LI LO TS
CP0433783 Compound Info	(3S,4R)-4-(6-Chloro-benzo[d]isoxazol-3-yloxy)-3-hydroxy-2,2-dimethyl-chroman-6-carbonitrile Show/Hide	C19H15ClN2O4	1
1	EC50 = 7850 nM Bioactivity Info	TI LI LO TS
CP0515751 Compound Info	(3S,4R)-6-Chloro-2-[6-(4-chloro-benzenesulfonyl)-3-hydroxy-2,2-dimethyl-chroman-4-yl]-benzo[d]isoxazol-3-one Show/Hide	C24H19Cl2NO6S	1
1	EC50 = 7990 nM Bioactivity Info	TI LI LO TS
CP0462311 Compound Info	(3S,4R)-4-(5-Fluoro-benzothiazol-2-ylamino)-3-hydroxy-2,2-dimethyl-chroman-6-carbonitrile Show/Hide	C19H16FN3O2S	1
1	EC50 = 8440 nM Bioactivity Info	TI LI LO TS
CP0422797 Compound Info	(3S,4R)-6-Chloro-2-(6,7-dichloro-3-hydroxy-2,2-dimethyl-chroman-4-yl)-benzo[d]isoxazol-3-one Show/Hide	C18H14Cl3NO4	1
1	EC50 = 10300 nM Bioactivity Info	TI LI LO TS
CP0422812 Compound Info	(3S,4R)-2,2-Dimethyl-4-(2-phenyl-imidazol-1-yl)-3,4-dihydro-2H-pyrano[3,2-c]pyridin-3-ol Show/Hide	C19H19N3O2	1
1	EC50 = 12900 nM Bioactivity Info	TI LI LO TS
CP0453659 Compound Info	(3S,4R)-3-Hydroxy-2,2-dimethyl-4-(2-phenyl-imidazol-1-yl)-chroman-6-carbonitrile Show/Hide	C21H19N3O2	1
1	EC50 = 13000 nM Bioactivity Info	TI LI LO TS
CP0384666 Compound Info	(3S,4R) 4-[5-(4-Chloro-phenyl)-imidazol-1-yl]-2,2-dimethyl-3,4-dihydro-2H-pyrano[3,2-c]pyridin-3-ol Show/Hide	C19H18ClN3O2	1
1	EC50 = 13800 nM Bioactivity Info	TI LI LO TS
CP0433785 Compound Info	(3S,4R)-3-hydroxy-2,2-dimethyl-4-(3-oxobenzo[d]isothiazol-2(3H)-yl)chroman-6-carbonitrile Show/Hide	C19H16N2O3S	1
1	EC50 = 14100 nM Bioactivity Info	TI LI LO TS
CP0433782 Compound Info	(3S,4R)-4-(5-Chloro-1H-benzoimidazol-2-ylsulfanyl)-3-hydroxy-2,2-dimethyl-chroman-6-carbonitrile Show/Hide	C19H16ClN3O2S	1
1	EC50 = 14700 nM Bioactivity Info	TI LI LO TS
CP0374093 Compound Info	(3S,4R)-4-(Benzo[d]isothiazol-3-yloxy)-3-hydroxy-2,2-dimethyl-chroman-6-carbonitrile Show/Hide	C19H16N2O3S	1
1	EC50 = 16100 nM Bioactivity Info	TI LI LO TS
CP0453660 Compound Info	(3S,4R)-4-(5-Chloro-benzooxazol-2-ylamino)-3-hydroxy-2,2-dimethyl-chroman-6-carbonitrile Show/Hide	C19H16ClN3O3	1
1	EC50 = 16500 nM Bioactivity Info	TI LI LO TS
CP0434936 Compound Info	(3S,4R)-3-hydroxy-2,2-dimethyl-4-[[methyl(phenyl)phosphoryl]amino]-3,4-dihydrochromene-6-carbonitrile Show/Hide	C19H21N2O3P	1
1	EC50 = 18600 nM Bioactivity Info	TI LI LO TS
CP0422806 Compound Info	(3S,4R)-4-(5-Chloro-benzo[d]isoxazol-3-ylamino)-3Shydroxy-2,2-dimethyl-chroman-6-yl-phenyl-methanone Show/Hide	C25H21ClN2O4	1
1	EC50 = 20400 nM Bioactivity Info	TI LI LO TS
CP0422816 Compound Info	(+/-)-4-cyanophenyl 6-cyano-3-hydroxy-2,2-dimethylchroman-4-ylcarbamate Show/Hide	C20H17N3O3	1
1	EC50 = 21100 nM Bioactivity Info	TI LI LO TS
CP0374092 Compound Info	(3S,4R)-6,7-Dichloro-4-(5-chloro-benzo[d]isoxazol-3-ylamino)-2,2-dimethyl-chroman-3-ol Show/Hide	C18H15Cl3N2O3	1
1	EC50 = 24800 nM Bioactivity Info	TI LI LO TS
CP0422792 Compound Info	(3S,4R)-3-Hydroxy-2,2-dimethyl-4-(4-methyl-2-phenylimidazol-1-yl)-chroman-6-carbonitrile Show/Hide	C22H21N3O2	1
1	EC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0422807 Compound Info	(3S,4R)-4-(5-Chloro-benzo[d]isoxazol-3-ylamino)-3-hydroxy-2,2-dimethyl-chroman-6-sulfonic acid diethylamide Show/Hide	C22H26ClN3O5S	1
1	EC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0422814 Compound Info	(3S,4R)-6-Chloro-2,2-dimethyl-4-(2-phenyl-imidazol-1-yl)-chroman-3-ol Show/Hide	C20H19ClN2O2	1
1	EC50 > 30000 nM Bioactivity Info	TI LI LO TS

Clinical Information about the Protein

Target 1 ( ATP-binding cassette transporter C9 (ABCC9) )

Target Type	Successful Target
Disease	4 Target-related Diseases				4
1	Diabetic complication [ICD-11: 5A2Y]
2	Angina pectoris [ICD-11: BA40]
3	Non-insulin dependent diabetes [ICD-11: 5A11]
4	Multiple sclerosis [ICD-11: 8A40]
Approved Drug(s)	4 Approved Drugs				4
1	Glimepiride	Drug Info	Approved	Diabetic complication
2	Nicorandil	Drug Info	Approved	Angina pectoris
3	Repaglinide	Drug Info	Approved	Diabetic complication
4	Tolbutamide	Drug Info	Approved	Non-insulin dependent diabetes
Discontinued Drug(s)	2 Discontinued Drugs				2
1	BMS-191095	Drug Info	Discontinued in Phase 1	Angina pectoris
2	CCX915	Drug Info	Discontinued in Phase 1	Multiple sclerosis

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han