General Information of the Protein
Protein ID
PT06058
Protein Name
Cyclic AMP-dependent transcription factor ATF-1
Secondarily
Protein Name
Activating transcription factor 1
Protein TREB36
Gene Name
ATF1
Sequence
MEDSHKSTTSETAPQPGSAVQGAHISHIAQQVSSLSESEESQDSSDSIGSSQKAHGILARRPSYRKILKDLSSEDTRGRKGDGENSGVSAAVTSMSVPTPIYQTSSGQYIAIAPNGALQLASPGTDGVQGLQTLTMTNSGSTQQGTTILQYAQTSDGQQILVPSNQVVVQTASGDMQTYQIRTTPSATSLPQTVVMTSPVTLTSQTTKTDDPQLKREIRLMKNREAARECRRKKKEYVKCLENRVAVLENQNKTLIEELKTLKDLYSNKSV
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Organism
Homo sapiens, Human
Protein Classification
Transcription factor
Function
This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation.
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Uniprot ID
Primary ID:
P18846

Secondarily ID:
B4DRF9
P25168
Q9H4A8
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Ensembl ID
ENSG00000123268
HGNC ID
HGNC:783
Subcellular Location
Nucleus
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000001 , Jurkat
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0383316
 Compound Info 
2-Chloro-4-trifluoromethyl-pyrimidine-5-carboxylic acid (3,5-bis-trifluoromethyl-phenyl)-amide
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C14H5ClF9N3O
  1
1
IC50 = 50 nM
 Bioactivity Info 
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CP0487583
 Compound Info 
3-[(2-Chloro-4-trifluoromethyl-pyrimidine-5-carbonyl)-amino]-5-trifluoromethyl-benzoic acid butyl ester
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C18H14ClF6N3O3
  1
1
IC50 = 120 nM
 Bioactivity Info 
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CP0502655
 Compound Info 
3-[(2-Chloro-4-trifluoromethyl-pyrimidine-5-carbonyl)-amino]-5-trifluoromethyl-benzoic acid ethyl ester
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C16H10ClF6N3O3
  1
1
IC50 = 150 nM
 Bioactivity Info 
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CP0480394
 Compound Info 
2-Chloro-4-trifluoromethyl-pyrimidine-5-carboxylic acid (4-trifluoromethyl-phenyl)-amide
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C13H6ClF6N3O
  1
1
IC50 = 490 nM
 Bioactivity Info 
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CP0404464
 Compound Info 
2-Chloro-4-trifluoromethyl-pyrimidine-5-carboxylic acid (2,6-dichloro-pyrimidin-4-yl)-amide
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C10H3Cl3F3N5O
  1
1
IC50 = 500 nM
 Bioactivity Info 
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CP0497922
 Compound Info 
2-Chloro-4-trifluoromethyl-pyrimidine-5-carboxylic acid (3,5-dichloro-phenyl)-amide
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C12H5Cl3F3N3O
  1
1
IC50 = 500 nM
 Bioactivity Info 
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CP0480389
 Compound Info 
3-[(2-Chloro-4-trifluoromethyl-pyrimidine-5-carbonyl)-amino]-5-trifluoromethyl-benzoic acid hexyl ester
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C20H18ClF6N3O3
  1
1
IC50 = 660 nM
 Bioactivity Info 
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CP0372902
 Compound Info 
2-Chloro-4-trifluoromethyl-pyrimidine-5-carboxylic acid (3,4,5-trichloro-phenyl)-amide
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C12H4Cl4F3N3O
  1
1
IC50 = 900 nM
 Bioactivity Info 
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CP0480472
 Compound Info 
3-[(2-Chloro-4-trifluoromethyl-pyrimidine-5-carbonyl)-amino]-5-trifluoromethyl-benzoic acid cyclohexyl ester
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C20H16ClF6N3O3
  1
1
IC50 = 1200 nM
 Bioactivity Info 
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CP0509862
 Compound Info 
3-[(2-Chloro-4-trifluoromethyl-pyrimidine-5-carbonyl)-amino]-5-trifluoromethyl-benzoic acid octyl ester
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C22H22ClF6N3O3
  1
1
IC50 = 1200 nM
 Bioactivity Info 
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CP0421119
 Compound Info 
2-Chloro-4-trifluoromethyl-pyrimidine-5-carboxylic acid (3,5-dimethoxy-phenyl)-amide
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C14H11ClF3N3O3
  1
1
IC50 = 1600 nM
 Bioactivity Info 
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CP0375890
 Compound Info 
2-Chloro-4-trifluoromethyl-pyrimidine-5-carboxylic acid benzyl-(3,5-dichloro-phenyl)-amide
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C19H11Cl3F3N3O
  1
1
IC50 = 2700 nM
 Bioactivity Info 
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CP0500182
 Compound Info 
2-Chloro-4-trifluoromethyl-pyrimidine-5-carboxylic acid (5-methyl-thiophen-2-yl)-amide
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C11H7ClF3N3OS
  1
1
IC50 = 2800 nM
 Bioactivity Info 
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CP0372941
 Compound Info 
3-[(2-Chloro-4-trifluoromethyl-pyrimidine-5-carbonyl)-amino]-5-trifluoromethyl-benzoic acid diethoxy-phosphorylmethyl ester
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C19H17ClF6N3O6P
  1
1
IC50 = 3000 nM
 Bioactivity Info 
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CP0399909
 Compound Info 
2-Chloro-4-trifluoromethyl-pyrimidine-5-carboxylic acid (3-carbamoyl-5-trifluoromethyl-phenyl)-amide
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C14H7ClF6N4O2
  1
1
IC50 = 3000 nM
 Bioactivity Info 
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CP0509861
 Compound Info 
2-Chloro-4-trifluoromethyl-pyrimidine-5-carboxylic acid (3,5-dichloro-phenyl)-methyl-amide
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C13H7Cl3F3N3O
  1
1
IC50 = 3000 nM
 Bioactivity Info 
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CP0376784
 Compound Info 
2-Chloro-4-trifluoromethyl-pyrimidine-5-carboxylic acid (3-methyl-isoxazol-5-yl)-amide
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C10H6ClF3N4O2
  1
1
IC50 = 3800 nM
 Bioactivity Info 
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CP0474633
 Compound Info 
2-Piperidin-1-yl-4-trifluoromethyl-pyrimidine-5-carboxylic acid (3,5-dichloro-phenyl)-amide
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C17H15Cl2F3N4O
  1
1
IC50 = 4000 nM
 Bioactivity Info 
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CP0399973
 Compound Info 
2-Amino-4-trifluoromethyl-pyrimidine-5-carboxylic acid (3,5-dichloro-phenyl)-amide
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C12H7Cl2F3N4O
  1
1
IC50 > 10000 nM
 Bioactivity Info 
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CP0410001
 Compound Info 
2-Dimethylamino-4-trifluoromethyl-pyrimidine-5-carboxylic acid (3,5-dichloro-phenyl)-amide
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C14H11Cl2F3N4O
  1
1
IC50 > 10000 nM
 Bioactivity Info 
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CP0425329
 Compound Info 
2-Chloro-4-trifluoromethyl-pyrimidine-5-carboxylic acid phenylamide
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C12H7ClF3N3O
  1
1
IC50 > 10000 nM
 Bioactivity Info 
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CP0463053
 Compound Info 
2-Chloro-4-trifluoromethyl-pyrimidine-5-carboxylic acid (2,6-dimethyl-phenyl)-amide
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C14H11ClF3N3O
  1
1
IC50 > 10000 nM
 Bioactivity Info 
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CP0464728
 Compound Info 
2-Cyclohexylamino-4-trifluoromethyl-pyrimidine-5-carboxylic acid (3,5-dichloro-phenyl)-amide
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C18H17Cl2F3N4O
  1
1
IC50 > 10000 nM
 Bioactivity Info 
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CP0480419
 Compound Info 
2-Butylamino-4-trifluoromethyl-pyrimidine-5-carboxylic acid (3,5-dichloro-phenyl)-amide
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C16H15Cl2F3N4O
  1
1
IC50 > 10000 nM
 Bioactivity Info 
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CP0483207
 Compound Info 
2-Benzylamino-4-trifluoromethyl-pyrimidine-5-carboxylic acid (3,5-dichloro-phenyl)-amide
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C19H13Cl2F3N4O
  1
1
IC50 > 10000 nM
 Bioactivity Info 
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CP0493693
 Compound Info 
2-Chloro-4-trifluoromethyl-pyrimidine-5-carboxylic acid butylamide
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C10H11ClF3N3O
  1
1
IC50 > 10000 nM
 Bioactivity Info 
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CP0494737
 Compound Info 
2-Hydroxy-4-trifluoromethyl-pyrimidine-5-carboxylic acid (3,5-dichloro-phenyl)-amide
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C12H6Cl2F3N3O2
  1
1
IC50 > 10000 nM
 Bioactivity Info 
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CP0495895
 Compound Info 
2-Phenylamino-4-trifluoromethyl-pyrimidine-5-carboxylic acid (3,5-dichloro-phenyl)-amide
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C18H11Cl2F3N4O
  1
1
IC50 > 10000 nM
 Bioactivity Info 
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CP0497646
 Compound Info 
4-Trifluoromethyl-pyrimidine-5-carboxylic acid (3,5-dichloro-phenyl)-amide
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C12H6Cl2F3N3O
  1
1
IC50 > 10000 nM
 Bioactivity Info 
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CP0506161
 Compound Info 
2-Chloro-4-trifluoromethyl-pyrimidine-5-carboxylic acid (3-butylcarbamoyl-5-trifluoromethyl-phenyl)-amide
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C18H15ClF6N4O2
  1
1
IC50 > 10000 nM
 Bioactivity Info 
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CP0508891
 Compound Info 
2-Methoxy-4-trifluoromethyl-pyrimidine-5-carboxylic acid (3,5-dichloro-phenyl)-amide
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C13H8Cl2F3N3O2
  1
1
IC50 > 10000 nM
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