General Information of the Protein
Protein ID
PT05986
Protein Name
Mas-related G-protein coupled receptor member X1
Secondarily
Protein Name
Sensory neuron-specific G-protein coupled receptor 1
Gene Name
MRGPRX1
Secondarily
Gene Name
Mrgc
Mrgprc
Mrgprc11
Snsr
Snsr1
Sequence
MDPTISSLSTESTTLNKTGHPSCRPILTLSFLVPIITLLGLAGNTIVLWLLGFRMRRKAISVYVLNLSLADSFFLCCHFIDSLMRIMNFYGIYAHKLSKEILGNAAIIPYISGLSILSAISTERCLSVLWPIWYHCHRPRNMSAIICVLIWVLSFLMGILDWFFSGFLGETHHHLWKNVDFIVTAFLIFLFMLLFGSSLALLVRILCGSRRKPLSRLYVTISLTVMVYLICGLPLGLYLFLLYWFGIHLHYPFCHIYQVTVLLSCVNSSANPIIYFLVGSFRHRKKHRSLKMVLKRALEETPEEDEYTDSHVQKPTEISERRC
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Organism
Rattus norvegicus, Rat
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Peptide receptor (family A GPCR)
>
Short peptide receptor (family A GPCR)
>
Neuropeptide receptor
Function
Orphan receptor activated by neuropeptides terminating in Arg-Phe or Arg-Phe-amide. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. May regulate the function of nociceptive neurons by modulation of pain perception (By similarity).
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Uniprot ID
Primary ID:
Q8R4G1

Secondarily ID:
Q7TN42
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Subcellular Location
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0719182
 Compound Info 
(5S,8S,11S,14S,17S,20S,23S,26S,29S,32S)-26,29-bis((1H-indol-3-yl)methyl)-32-((S)-1-((S)-2-(2-((S)-2-amino-3-methylbutanamido)acetamido)-5-guanidinopentanoyl)pyrrolidine-2-carboxamido)-14-(3-amino-3-oxopropyl)-11-(4-aminobutyl)-20-(carboxymethyl)-8-(3-guanidinopropyl)-5,17-bis(4-hydroxybenzyl)-23-(2-(methylthio)ethyl)-4,7,10,13,16,19,22,25,28,31-decaoxo-3,6,9,12,15,18,21,24,27,30-decaazapentatriacontane-1,35-dioic acid
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C91H127N25O23S
  1
1
EC50 = 316.23 nM
 Bioactivity Info 
   TI
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CP0536802
 Compound Info 
(2R)-2-amino-N-[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]-3-[4-(diaminomethylideneamino)phenyl]propanamide
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C19H24N6O2
  1
1
EC50 = 630.96 nM
 Bioactivity Info 
   TI
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   LO
   TS
CP0551488
 Compound Info 
(2S)-2-[[2-amino-2-(1-carbamimidoylpiperidin-4-yl)acetyl]amino]-3-phenylpropanamide
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C17H26N6O2
  1
1
EC50 = 3981.07 nM
 Bioactivity Info 
   TI
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   LO
   TS
CP0179651
 Compound Info 
Adamantane-1-carboxylic acid [(S)-1-((S)-1-carbamoyl-2-phenyl-ethylcarbamoyl)-4-guanidino-butyl]-amide
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C26H38N6O3
  1
1
EC50 = 6309.57 nM
 Bioactivity Info 
   TI
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CP0455916
 Compound Info 
(2S)-2-amino-N-[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]-5-(diaminomethylideneamino)pentanamide
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C15H24N6O2
  1
1
EC50 = 6309.57 nM
 Bioactivity Info 
   TI
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CP0379135
 Compound Info 
(2S)-2-amino-N-[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]-3-[4-(diaminomethylideneamino)phenyl]propanamide
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C19H24N6O2
  1
1
EC50 = 50118.72 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0379134
 Compound Info 
(2S)-2-[[2-amino-2-[3-(diaminomethylideneamino)phenyl]acetyl]amino]-3-phenylpropanamide
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C18H22N6O2
  1
1
EC50 > 100000 nM
 Bioactivity Info 
   TI
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CP0379754
 Compound Info 
(2S,4S)-N-[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]-4-[(diaminomethylideneamino)methyl]pyrrolidine-2-carboxamide
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C16H24N6O2
  1
1
EC50 > 100000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0520596
 Compound Info 
(2S,4S)-N-[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]-4-(diaminomethylideneamino)pyrrolidine-2-carboxamide
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C15H22N6O2
  1
1
EC50 > 100000 nM
 Bioactivity Info 
   TI
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   TS
CP0071244
 Compound Info 
4-(6-methoxypyridin-3-yl)-N-[2-methyl-3-[(6-oxo-4-piperazin-1-ylpyridazin-1-yl)methyl]phenyl]benzamide
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C29H30N6O3
  1
1
EC50 > 1995.26 nM
 Bioactivity Info 
   TI
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   TS
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0719182
 Compound Info 
(5S,8S,11S,14S,17S,20S,23S,26S,29S,32S)-26,29-bis((1H-indol-3-yl)methyl)-32-((S)-1-((S)-2-(2-((S)-2-amino-3-methylbutanamido)acetamido)-5-guanidinopentanoyl)pyrrolidine-2-carboxamido)-14-(3-amino-3-oxopropyl)-11-(4-aminobutyl)-20-(carboxymethyl)-8-(3-guanidinopropyl)-5,17-bis(4-hydroxybenzyl)-23-(2-(methylthio)ethyl)-4,7,10,13,16,19,22,25,28,31-decaoxo-3,6,9,12,15,18,21,24,27,30-decaazapentatriacontane-1,35-dioic acid
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C91H127N25O23S
  1
1 EC50 = 300 nM
Similar Protein(s) and Bioactivity Statistics
50% Identity
Protein ID Protein Name Protein Organism
PT05083 Mas-related G-protein coupled receptor member X1 Mus musculus, Mouse
 Protein Info