General Information of the Protein
Protein ID
PT05802
Protein Name
Sodium-dependent phosphate transport protein 2A
Secondarily
Protein Name
Na(+)-dependent phosphate cotransporter 2A
NaPi-3
Sodium/phosphate cotransporter 2A
Solute carrier family 34 member 1
Gene Name
SLC34A1
Secondarily
Gene Name
NPT2
SLC17A2
Sequence
MLSYGERLGSPAVSPLPVRGGHVMRGTAFAYVPSPQVLHRIPGTSAYAFPSLGPVALAEHTCPCGEVLERHEPLPAKLALEEEQKPESRLVPKLRQAGAMLLKVPLMLTFLYLFVCSLDMLSSAFQLAGGKVAGDIFKDNAILSNPVAGLVVGILVTVLVQSSSTSTSIIVSMVSSGLLEVSSAIPIIMGSNIGTSVTNTIVALMQAGDRTDFRRAFAGATVHDCFNWLSVLVLLPLEAATGYLHHITRLVVASFNIHGGRDAPDLLKIITEPFTKLIIQLDESVITSIATGDESLRNHSLIQIWCHPDSLQAPTSMSRAEANSSQTLGNATMEKCNHIFVDTGLPDLAVGLILLAGSLVLLCTCLILLVKMLNSLLKGQVAKVIQKVINTDFPAPFTWVTGYFAMVVGASMTFVVQSSSVFTSAITPLIGLGVISIERAYPLTLGSNIGTTTTAILAALASPREKLSSAFQIALCHFFFNISGILLWYPVPCTRLPIRMAKALGKRTAKYRWFAVLYLLVCFLLLPSLVFGISMAGWQVMVGVGTPFGALLAFVVLINVLQSRSPGHLPKWLQTWDFLPRWMHSLKPLDHLITRATLCCARPEPRSPPLPPRVFLEELPPATPSPRLALPAHHNATRL
    Show/Hide
Organism
Homo sapiens, Human
Protein Classification
Transporter
>
Electrochemical transporter
>
SLC superfamily of solute carriers
>
SLC34 family of sodium phosphate co-transporters
Function
Involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane (PubMed:26047794, PubMed:8327470, PubMed:12324554, PubMed:20335586). The cotransport has a Na(+):Pi stoichiometry of 3:1 and is electrogenic (By similarity).
    Show/Hide
Uniprot ID
Primary ID:
Q06495

Secondarily ID:
B4DPE3
    Show/Hide
Ensembl ID
ENSG00000131183
HGNC ID
HGNC:11019
Subcellular Location
Apical cell membrane
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000006 , HEK293
Compound ID Compound Name Compound Formula
CP0412052
3-chloro-2-methyl-7-(1-oxo-2,8-diazaspiro[4.5]decan-8-yl)-5-(trifluoromethyl)-1H-pyrrolo[3,2-b]pyridine-6-carbonitrile
   Show/Hide
C18H17ClF3N5O
 2
1
IC50 = 100 nM
   TI
   LI
   LO
   TS
2
Ki = 82 nM
   TI
   LI
   LO
   TS
CP0852935
3-chloro-2-methyl-7-(2-methyl-1-oxo-2,8-diazaspiro[4.5]decan-8-yl)-5-(trifluoromethyl)-1H-pyrrolo[3,2-b]pyridine-6-carbonitrile
   Show/Hide
C19H19ClF3N5O
 2
1
IC50 = 120 nM
   TI
   LI
   LO
   TS
2
Ki = 530 nM
   TI
   LI
   LO
   TS
CP0852936
3-chloro-7-(4-hydroxypiperidin-1-yl)-2-methyl-5-(trifluoromethyl)-1H-pyrrolo[3,2-b]pyridine-6-carbonitrile
   Show/Hide
C15H14ClF3N4O
 2
1
IC50 = 130 nM
   TI
   LI
   LO
   TS
2
Ki = 440 nM
   TI
   LI
   LO
   TS
CP0396537
4-amino-1-[3-chloro-6-cyano-2-methyl-5-(trifluoromethyl)-1H-pyrrolo[3,2-b]pyridin-7-yl]piperidine-4-carboxamide
   Show/Hide
C16H16ClF3N6O
 2
1
IC50 = 290 nM
   TI
   LI
   LO
   TS
2
Ki = 250 nM
   TI
   LI
   LO
   TS
CP0432155
3-chloro-7-[(2S)-2-(hydroxymethyl)morpholin-4-yl]-2-methyl-5-(trifluoromethyl)-1H-pyrrolo[3,2-b]pyridine-6-carbonitrile
   Show/Hide
C15H14ClF3N4O2
 2
1
IC50 = 380 nM
   TI
   LI
   LO
   TS
2
Ki = 750 nM
   TI
   LI
   LO
   TS
CP0538749
3-chloro-7-[(2R)-2-(hydroxymethyl)morpholin-4-yl]-2-methyl-5-(trifluoromethyl)-1H-pyrrolo[3,2-b]pyridine-6-carbonitrile
   Show/Hide
C15H14ClF3N4O2
 2
1
IC50 = 390 nM
   TI
   LI
   LO
   TS
2
Ki = 1300 nM
   TI
   LI
   LO
   TS
CP0875942
N-(4-chloro-2-(2-(3-fluorobenzylidene)hydrazinecarbonyl)phenyl)-3-((2,3-dihydroxypropylthio)methyl)benzamide
   Show/Hide
C25H23ClFN3O4S
 2
1
IC50 = 460 nM
   TI
   LI
   LO
   TS
2
Ki = 690 nM
   TI
   LI
   LO
   TS
CP0392939
2-methyl-7-(1-oxo-2,8-diazaspiro[4.5]decan-8-yl)-5-(trifluoromethyl)-1H-pyrrolo[3,2-b]pyridine-6-carbonitrile
   Show/Hide
C18H18F3N5O
 2
1
IC50 = 1500 nM
   TI
   LI
   LO
   TS
2
Ki = 2000 nM
   TI
   LI
   LO
   TS
CP0411999
7-(4-aminopiperidin-1-yl)-3-chloro-2-methyl-5-(trifluoromethyl)-1H-pyrrolo[3,2-b]pyridine-6-carbonitrile
   Show/Hide
C15H15ClF3N5
 2
1
IC50 = 2500 nM
   TI
   LI
   LO
   TS
2
Ki = 2300 nM
   TI
   LI
   LO
   TS
CP0412050
2-methyl-7-[4-(pyridin-2-ylamino)piperidin-1-yl]-5-(trifluoromethyl)-1H-pyrrolo[3,2-b]pyridine-6-carbonitrile
   Show/Hide
C20H19F3N6
 2
1
IC50 = 6500 nM
   TI
   LI
   LO
   TS
2
Ki = 14000 nM
   TI
   LI
   LO
   TS
CP0865069
7-(1-oxo-2,8-diazaspiro[4.5]decan-8-yl)-5-(trifluoromethyl)-1H-pyrrolo[3,2-b]pyridine-6-carbonitrile
   Show/Hide
C17H16F3N5O
 2
1
IC50 > 15000 nM
   TI
   LI
   LO
   TS
2
Ki = 10000 nM
   TI
   LI
   LO
   TS
CP0396536
N-(4-chlorophenyl)-5-methoxy-2-[[3-(trifluoromethyl)phenyl]sulfonylamino]benzamide
   Show/Hide
C21H16ClF3N2O4S
 2
1
IC50 > 7300 nM
   TI
   LI
   LO
   TS
2
Ki > 25000 nM
   TI
   LI
   LO
   TS