General Information of the Protein
Protein ID
PT05764
Protein Name
Protein-lysine 6-oxidase
Secondarily
Protein Name
Lysyl oxidase
Gene Name
LOX
Sequence
MRFAWTVLLLGPLQLCALVHCAPPAAGQQQPPREPPAAPGAWRQQIQWENNGQVFSLLSLGSQYQPQRRRDPGAAVPGAANASAQQPRTPILLIRDNRTAAARTRTAGSSGVTAGRPRPTARHWFQAGYSTSRAREAGASRAENQTAPGEVPALSNLRPPSRVDGMVGDDPYNPYKYSDDNPYYNYYDTYERPRPGGRYRPGYGTGYFQYGLPDLVADPYYIQASTYVQKMSMYNLRCAAEENCLASTAYRADVRDYDHRVLLRFPQRVKNQGTSDFLPSRPRYSWEWHSCHQHYHSMDEFSHYDLLDANTQRRVAEGHKASFCLEDTSCDYGYHRRFACTAHTQGLSPGCYDTYGADIDCQWIDITDVKPGNYILKVSVNPSYLVPESDYTNNVVRCDIRYTGHHAYASGCTISPY
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
>
Oxidoreductase
Function
Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin (PubMed:26838787). Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture (By similarity).
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Uniprot ID
Primary ID:
P28300

Secondarily ID:
B2R5Q3
Q5FWF0
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HGNC ID
HGNC:6664
Subcellular Location
Secreted
Secreted
Extracellular space
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0037451
 Compound Info 
1,1',1'',1'''-[disulfanediylbis(carbonothioylnitrilo)]tetraethane
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C10H20N2S4
  1
1
IC50 = 320 nM
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CP0326412
 Compound Info 
CHEBI:27413
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C3H6N2
  2
1
IC50 = 550 nM
 Bioactivity Info 
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2
IC50 > 100000 nM
 Bioactivity Info 
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CP0068761
 Compound Info 
MLS000069752
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C6H12N2S4
  1
1
IC50 = 1040 nM
 Bioactivity Info 
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CP0415598
 Compound Info 
6-methyl-3-[2-[(5-methyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylidene]hydrazinyl]-4H-1,2,4-triazin-5-one
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C15H15N7O2
  1
1
IC50 = 1600 nM
 Bioactivity Info 
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CP0901481
 Compound Info 
3-((4-(Aminomethyl)pyridin-2-yl)oxy)-N-(4-fluorophenyl)-benzamide Hydrochloride
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C19H17ClFN3O2
  1
1
IC50 = 1800 nM
 Bioactivity Info 
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CP0912863
 Compound Info 
3-((4-(Aminomethyl)pyridin-2-yl)oxy)-N-(4-methoxyphenyl)-benzamide Hydrochloride
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C20H20ClN3O3
  1
1
IC50 = 2400 nM
 Bioactivity Info 
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CP0390004
 Compound Info 
4,5-dimethyl-2-phenyl-4H-pyrazol-3-one
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C11H12N2O
  1
1
IC50 = 2600 nM
 Bioactivity Info 
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CP0468819
 Compound Info 
[3-[4-(aminomethyl)pyridin-2-yl]oxyphenyl]-(3,4-dihydro-1H-isoquinolin-2-yl)methanone
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C22H21N3O2
  1
1
IC50 = 2800 nM
 Bioactivity Info 
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CP0901482
 Compound Info 
3-((4-(Aminomethyl)pyridin-2-yl)oxy)-N-(benzo[b]thiophen-2-ylmethyl)benzamide Hydrochloride
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C22H20ClN3O2S
  1
1
IC50 = 2900 nM
 Bioactivity Info 
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CP0902471
 Compound Info 
3-((4-(Aminomethyl)pyridin-2-yl)oxy)-N-phenylbenzamide Hydrochloride
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C19H18ClN3O2
  1
1
IC50 = 3100 nM
 Bioactivity Info 
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CP0930294
 Compound Info 
3-((4-(Aminomethyl)pyridin-2-yl)oxy)-N-benzylbenzamide Hydrochloride
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C20H20ClN3O2
  1
1
IC50 = 3100 nM
 Bioactivity Info 
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CP0901483
 Compound Info 
3-((4-(Aminomethyl)pyridin-2-yl)oxy)-N-(3-carbamimidoylbenzyl)benzamide Dihydrochloride
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C21H23Cl2N5O2
  1
1
IC50 = 3500 nM
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CP0457811
 Compound Info 
diethyl 5-[(5-amino-3-oxo-2-phenyl-1H-pyrazol-4-yl)diazenyl]-3-methylthiophene-2,4-dicarboxylate
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C20H21N5O5S
  1
1
IC50 = 5000 nM
 Bioactivity Info 
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CP0930479
 Compound Info 
4-((4-(Aminomethyl)pyridin-2-yl)oxy)-N-phenylbenzamide Hydrochloride
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C19H18ClN3O2
  1
1
IC50 = 5500 nM
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CP0107701
 Compound Info 
(2-chloropyridin-4-yl)methanamine
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C6H7ClN2
  1
1
IC50 = 5910 nM
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CP0912862
 Compound Info 
3-((4-(Aminomethyl)pyridin-2-yl)oxy)-N-(2-methoxyethyl)-benzamide Hydrochloride
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C16H20ClN3O3
  1
1
IC50 = 7300 nM
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CP0903505
 Compound Info 
4-((4-(Aminomethyl)pyridin-2-yl)oxy)-N-(2-methoxyethyl)benzamide Hydrochloride
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C16H20ClN3O3
  1
1
IC50 = 8400 nM
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CP0902472
 Compound Info 
(2-Phenoxypyridin-4-yl)methanamine Hydrochloride
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C12H13ClN2O
  1
1
IC50 = 8700 nM
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CP0396640
 Compound Info 
(4Z)-4-(1-ethylquinolin-2-ylidene)-2-phenyl-5-phenyliminopyrazolidin-3-one
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C26H22N4O
  1
1
IC50 = 9200 nM
 Bioactivity Info 
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CP0756410
 Compound Info 
3-((4-(Aminomethyl)-6-(trifluoromethyl)pyridin-2-yl)oxy)-N-phenylbenzamide Hydrochloride
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C20H17ClF3N3O2
  1
1
IC50 = 11000 nM
 Bioactivity Info 
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CP0930024
 Compound Info 
3-((4-(Aminomethyl)-6-(trifluoromethyl)pyridin-2-yl)oxy)-N-(benzo[b]thiophen-2-ylmethyl)benzamide Hydrochloride
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C23H19ClF3N3O2S
  1
1
IC50 = 11000 nM
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CP0518797
 Compound Info 
(2-methoxypyridin-4-yl)methanamine
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C7H10N2O
  1
1
IC50 = 16000 nM
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CP0757384
 Compound Info 
N-(2-(1H-Tetrazol-1-yl)ethyl)-3-((4-(aminomethyl)-6-(trifluoromethyl)pyridin-2-yl)oxy)benzamide Hydrochloride
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C17H17ClF3N7O2
  1
1
IC50 = 16000 nM
 Bioactivity Info 
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CP0901484
 Compound Info 
4-(3-((4-(Aminomethyl)pyridin-2-yl)oxy)benzamido)benzoic Acid Hydrochloride
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C20H18ClN3O4
  1
1
IC50 = 16000 nM
 Bioactivity Info 
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CP0468821
 Compound Info 
(3S)-3-[4-(aminomethyl)-6-(trifluoromethyl)pyridin-2-yl]oxy-N-phenylpiperidine-1-carboxamide
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C19H21F3N4O2
  1
1
IC50 = 18000 nM
 Bioactivity Info 
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CP0430322
 Compound Info 
[3-[4-(aminomethyl)-6-(trifluoromethyl)pyridin-2-yl]oxyphenyl]-[(3R)-3-aminopyrrolidin-1-yl]methanone;dihydrochloride
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C18H21Cl2F3N4O2
  1
1
IC50 = 21000 nM
 Bioactivity Info 
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CP0261509
 Compound Info 
3-[4-(aminomethyl)-6-(trifluoromethyl)pyridin-2-yl]oxy-N-[(2R)-2,3-dihydroxypropyl]benzamide;hydrochloride
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C17H19ClF3N3O4
  1
1
IC50 = 22000 nM
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CP0775033
 Compound Info 
3-((4-(Aminomethyl)-6-(trifluoromethyl)pyridin-2-yl)oxy)-N-(2-sulfamoylethyl)benzamide Hydrochloride
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C16H18ClF3N4O4S
  1
1
IC50 = 23000 nM
 Bioactivity Info 
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CP0330327
 Compound Info 
[3-[4-(aminomethyl)-6-(trifluoromethyl)pyridin-2-yl]oxyphenyl]-[(3R)-3-hydroxypyrrolidin-1-yl]methanone;hydrochloride
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C18H19ClF3N3O3
  1
1
IC50 = 30000 nM
 Bioactivity Info 
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CP0415597
 Compound Info 
1-hydroxypyridine-2-thione
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C5H5NOS
  1
1
IC50 = 33000 nM
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CP0519353
 Compound Info 
(2-cyclohexyloxypyridin-4-yl)methanamine
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C12H18N2O
  1
1
IC50 = 34000 nM
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CP0327496
 Compound Info 
[3-[4-(aminomethyl)-6-(trifluoromethyl)pyridin-2-yl]oxyphenyl]-[(3R,4R)-3-fluoro-4-hydroxypyrrolidin-1-yl]methanone;hydrochloride
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C18H18ClF4N3O3
  1
1
IC50 = 35000 nM
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CP0229574
 Compound Info 
4,6-dimethyl-2-phenyl-1H-pyrazolo[3,4-b]pyridin-3-one
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C14H13N3O
  1
1
IC50 = 35000 nM
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CP0237362
 Compound Info 
[3-[4-(aminomethyl)pyridin-2-yl]oxyphenyl]-[(3R,4R)-3-fluoro-4-hydroxypyrrolidin-1-yl]methanone;hydrochloride
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C17H19ClFN3O3
  1
1
IC50 = 45000 nM
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CP0415596
 Compound Info 
6-(2,5-dimethylfuran-3-yl)-2-phenyl-1H-pyrazolo[3,4-b]pyridin-3-one
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C18H15N3O2
  1
1
IC50 = 50000 nM
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CP0224605
 Compound Info 
[3-[4-(aminomethyl)pyridin-2-yl]oxyphenyl]-[(3S,4S)-3-fluoro-4-hydroxypyrrolidin-1-yl]methanone;hydrochloride
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C17H19ClFN3O3
  1
1
IC50 = 52000 nM
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CP0915195
 Compound Info 
4-(Aminomethyl)-2-(trifluoromethyl)pyridine Hydrochloride
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C7H8ClF3N2
  1
1
IC50 = 54000 nM
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CP0396641
 Compound Info 
5-tert-butyl-2-phenyl-4H-pyrazol-3-one
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C13H16N2O
  1
1
IC50 = 75000 nM
 Bioactivity Info 
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CP0903503
 Compound Info 
3-((4-(Aminomethyl)-6-(trifluoromethyl)pyridin-2-yl)oxy)-N-methoxybenzamide Hydrochloride
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C15H15ClF3N3O3
  1
1
IC50 = 83000 nM
 Bioactivity Info 
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CP0390003
 Compound Info 
6-(2-methoxyphenyl)-2-phenyl-1,7-dihydropyrazolo[3,4-b]pyridine-3,4-dione
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C19H15N3O3
  1
1
IC50 = 91000 nM
 Bioactivity Info 
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CP0520208
 Compound Info 
[2-(3-phenoxyphenoxy)-6-(trifluoromethyl)pyridin-4-yl]methanamine
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C19H15F3N2O2
  1
1
IC50 = 93000 nM
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CP0468820
 Compound Info 
(3R)-3-[4-(aminomethyl)-6-(trifluoromethyl)pyridin-2-yl]oxy-N-phenylpiperidine-1-carboxamide
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C19H21F3N4O2
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0196902
 Compound Info 
3-phenyl-2-sulfanylidene-1H-pyrido[2,3-d]pyrimidin-4-one
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C13H9N3OS
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0396642
 Compound Info 
2-phenyl-6-thiophen-2-yl-1H-pyrazolo[3,4-b]pyridin-3-one
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C16H11N3OS
  1
1
IC50 > 100000 nM
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Cell Line ID: CL000411 , IMR-90
 Cell Line Info 
Clinical Information about the Protein
Target 1 ( Lysyl oxidase (LOX) )
Target Type Literature-reported Target
Target 2 ( HUMAN lysyl oxidase (LOX) )
Target Type Unknown Type Target