General Information of the Protein
Protein ID
PT05756
Protein Name
Leukotriene B4 receptor 2
Secondarily
Protein Name
LTB4 receptor JULF2
Leukotriene B4 receptor BLT2
Seven transmembrane receptor BLTR2
Gene Name
LTB4R2
Secondarily
Gene Name
BLT2R
BLTR2
Sequence
MSVCYRPPGNETLLSWKTSRATGTAFLLLAALLGLPGNGFVVWSLAGWRPARGRPLAATLVLHLALADGAVLLLTPLFVAFLTRQAWPLGQAGCKAVYYVCALSMYASVLLTGLLSLQRCLAVTRPFLAPRLRSPALARRLLLAVWLAALLLAVPAAVYRHLWRDRVCQLCHPSPVHAAAHLSLETLTAFVLPFGLMLGCYSVTLARLRGARWGSGRHGARVGRLVSAIVLAFGLLWAPYHAVNLLQAVAALAPPEGALAKLGGAGQAARAGTTALAFFSSSVNPVLYVFTAGDLLPRAGPRFLTRLFEGSGEARGGGRSREGTMELRTTPQLKVVGQGRGNGDPGGGMEKDGPEWDL
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Organism
Homo sapiens, Human
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Lipid-like ligand receptor (family A GPCR)
>
Leukotriene receptor
Function
Low-affinity receptor for leukotrienes including leukotriene B4. Mediates chemotaxis of granulocytes and macrophages. The response is mediated via G-proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTB4 > 12-epi-LTB4 > LTB5 > LTB3.
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Uniprot ID
Primary ID:
Q9NPC1

Secondarily ID:
Q5KU28
Q9NPE5
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Ensembl ID
ENSG00000213906
HGNC ID
HGNC:19260
Subcellular Location
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000026 , CHO-K1
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0486154
 Compound Info 
4-fluoro-2-[4-[(N-pentanoylanilino)methyl]phenyl]benzoic acid
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C25H24FNO3
  1
1
EC50 = 22.1 nM
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CP0466285
 Compound Info 
N-phenyl-N-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]pentanamide
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C25H25N5O
  1
1
EC50 = 23.2 nM
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CP0487537
 Compound Info 
N-(4-fluorophenyl)-N-[[4-[5-fluoro-2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-3-methylbutanamide
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C25H23F2N5O
  1
1
EC50 = 25 nM
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CP0466287
 Compound Info 
2-[4-[(4-methyl-N-pentanoylanilino)methyl]phenyl]benzoic acid
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C26H27NO3
  1
1
EC50 = 26 nM
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CP0517356
 Compound Info 
2-[4-[(4-fluoro-N-pentanoylanilino)methyl]phenyl]benzoic acid
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C25H24FNO3
  1
1
EC50 = 27.3 nM
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CP0548825
 Compound Info 
2-[4-[(N-pentanoylanilino)methyl]phenyl]benzoic acid
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C25H25NO3
  1
1
EC50 = 28.9 nM
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CP0466286
 Compound Info 
2-[4-[[N-(3-methylbutanoyl)anilino]methyl]phenyl]benzoic acid
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C25H25NO3
  1
1
EC50 = 36.3 nM
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CP0551684
 Compound Info 
2-[4-[(N-(2-phenylacetyl)anilino)methyl]phenyl]benzoic acid
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C28H23NO3
  1
1
EC50 = 38.3 nM
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CP0517358
 Compound Info 
2-[4-[(N-butanoylanilino)methyl]phenyl]benzoic acid
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C24H23NO3
  1
1
EC50 = 42.2 nM
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CP0486141
 Compound Info 
2-[4-[(4-chloro-N-pentanoylanilino)methyl]phenyl]benzoic acid
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C25H24ClNO3
  1
1
EC50 = 47.5 nM
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CP0486146
 Compound Info 
N-[[4-[2-(5-oxo-4H-1,2,4-oxadiazol-3-yl)phenyl]phenyl]methyl]-N-phenylpentanamide
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C26H25N3O3
  1
1
EC50 = 48.2 nM
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CP0554586
 Compound Info 
2-[3-fluoro-4-[(N-pentanoylanilino)methyl]phenyl]benzoic acid
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C25H24FNO3
  1
1
EC50 = 48.4 nM
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CP0517342
 Compound Info 
2-[4-[(3,4-difluoro-N-pentanoylanilino)methyl]phenyl]benzoic acid
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C25H23F2NO3
  1
1
EC50 = 48.8 nM
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CP0486152
 Compound Info 
2-[4-[(3-fluoro-N-pentanoylanilino)methyl]phenyl]benzoic acid
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C25H24FNO3
  1
1
EC50 = 51.8 nM
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CP0486151
 Compound Info 
2-[4-[(N-benzoylanilino)methyl]phenyl]benzoic acid
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C27H21NO3
  1
1
EC50 = 52 nM
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CP0548138
 Compound Info 
5-fluoro-2-[4-[(N-pentanoylanilino)methyl]phenyl]benzoic acid
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C25H24FNO3
  1
1
EC50 = 60.7 nM
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CP0870106
 Compound Info 
1-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-2-butyl-4-isopropyl-4-methyl-1H-imidazol-5(4H)-one
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C25H30N6O
  1
1
EC50 = 67.6 nM
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CP0571836
 Compound Info 
2-[4-[(4-hydroxy-N-pentanoylanilino)methyl]phenyl]benzoic acid
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C25H25NO4
  1
1
EC50 = 75 nM
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CP0486153
 Compound Info 
2-[4-[[N-(butylcarbamoyl)anilino]methyl]phenyl]benzoic acid
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C25H26N2O3
  1
1
EC50 = 96 nM
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CP0548191
 Compound Info 
2-[4-[(N-(2-cyclopropylacetyl)anilino)methyl]phenyl]benzoic acid
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C25H23NO3
  1
1
EC50 = 103 nM
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CP0551686
 Compound Info 
2-[4-[(4-cyano-N-pentanoylanilino)methyl]phenyl]benzoic acid
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C26H24N2O3
  1
1
EC50 = 134 nM
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CP0487538
 Compound Info 
2-[4-[[pentanoyl(pyridin-4-yl)amino]methyl]phenyl]benzoic acid
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C24H24N2O3
  1
1
EC50 = 167 nM
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CP0554607
 Compound Info 
2-[4-[[benzoyl(butyl)amino]methyl]phenyl]benzoic acid
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C25H25NO3
  1
1
EC50 = 216 nM
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CP0486140
 Compound Info 
2-[4-[(4-methoxy-N-pentanoylanilino)methyl]phenyl]benzoic acid
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C26H27NO4
  1
1
EC50 = 229 nM
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CP0545781
 Compound Info 
3-[4-[(N-pentanoylanilino)methyl]phenyl]pyridine-4-carboxylic acid
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C24H24N2O3
  1
1
EC50 = 357 nM
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CP0486143
 Compound Info 
2-[4-[(N-propanoylanilino)methyl]phenyl]benzoic acid
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C23H21NO3
  1
1
EC50 = 390 nM
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CP0551685
 Compound Info 
2-[4-[[N-(2-methylpropanoyl)anilino]methyl]phenyl]benzoic acid
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C24H23NO3
  1
1
EC50 = 398 nM
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CP0486149
 Compound Info 
2-[4-[[butyl(3-phenylpropanoyl)amino]methyl]phenyl]benzoic acid
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C27H29NO3
  1
1
EC50 = 404 nM
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CP0041261
 Compound Info 
2-butyl-3-{[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl}-1,3-diazaspiro[4.4]non-1-en-4-one
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C25H28N6O
  1
1
EC50 = 410 nM
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CP0558006
 Compound Info 
5-chloro-2-[4-[(N-pentanoylanilino)methyl]phenyl]benzoic acid
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C25H24ClNO3
  1
1
EC50 = 428 nM
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CP0887676
 Compound Info 
1-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-2-butyl-4-methyl-4-phenyl-1H-imidazol-5(4H)-one
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C28H28N6O
  1
1
EC50 = 550 nM
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CP0517357
 Compound Info 
methyl 2-[4-[(N-pentanoylanilino)methyl]phenyl]benzoate
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C26H27NO3
  1
1
EC50 = 570 nM
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CP0540411
 Compound Info 
2-[4-[(pentanoylamino)methyl]phenyl]benzoic acid
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C19H21NO3
  1
1
EC50 = 658 nM
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CP0564132
 Compound Info 
2-[4-[(3-chloro-N-pentanoylanilino)methyl]phenyl]benzoic acid
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C25H24ClNO3
  1
1
EC50 = 720 nM
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CP0517354
 Compound Info 
2-[4-[[butyl-(2-phenylacetyl)amino]methyl]phenyl]benzoic acid
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C26H27NO3
  1
1
EC50 = 789 nM
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CP0547232
 Compound Info 
4'-(2-Butyl-4-oxo-1,3-diaza-spiro[4.5]dec-1-en-3-ylmethyl)-biphenyl-2-carboxylic acid
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C26H30N2O3
  1
1
EC50 = 860 nM
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CP0547228
 Compound Info 
4'-(2-Butyl-4-oxo-1,3-diaza-spiro[4.4]non-1-en-3-ylmethyl)-biphenyl-2-carboxylic acid
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C25H28N2O3
  1
1
EC50 = 1490 nM
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CP0486145
 Compound Info 
2-[4-[(N-pentanoylanilino)methyl]phenyl]benzamide
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C25H26N2O2
  1
1
EC50 = 1730 nM
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CP0486148
 Compound Info 
N-methylsulfonyl-2-[4-[(N-pentanoylanilino)methyl]phenyl]benzamide
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C26H28N2O4S
  1
1
EC50 = 2060 nM
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CP0549514
 Compound Info 
2-[4-[(N-acetylanilino)methyl]phenyl]benzoic acid
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C22H19NO3
  1
1
EC50 = 2400 nM
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CP0486147
 Compound Info 
2-[4-[[benzyl(pentanoyl)amino]methyl]phenyl]benzoic acid
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C26H27NO3
  1
1
EC50 = 2650 nM
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CP0517355
 Compound Info 
2-[4-[[cyclohexyl(pentanoyl)amino]methyl]phenyl]benzoic acid
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C25H31NO3
  1
1
EC50 = 2960 nM
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CP0486142
 Compound Info 
2-[4-[[N-(3-methoxypropanoyl)anilino]methyl]phenyl]benzoic acid
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C24H23NO4
  1
1
EC50 = 3060 nM
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CP0538751
 Compound Info 
N-[[4-[2-(hydroxymethyl)phenyl]phenyl]methyl]-N-phenylpentanamide
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C25H27NO2
  1
1
EC50 = 4260 nM
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CP0887677
 Compound Info 
3-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-2-butyl-5,5-dimethylimidazolidin-4-one
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C23H28N6O
  1
1
EC50 = 6390 nM
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CP0549515
 Compound Info 
2-[4-[[pentanoyl(propan-2-yl)amino]methyl]phenyl]benzoic acid
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C22H27NO3
  1
1
EC50 = 6460 nM
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CP0451134
 Compound Info 
4'-(2-Benzyl-4-oxo-1,3-diaza-spiro[4.4]non-1-en-3-ylmethyl)-biphenyl-2-carboxylic acid
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C28H26N2O3
  1
1
EC50 = 6580 nM
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CP0870107
 Compound Info 
(3R,7aR)-2-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-3-butylhexahydro-1H-pyrrolo[1,2-c]imidazol-1-one
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C24H28N6O
  1
1
EC50 = 7500 nM
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CP0451135
 Compound Info 
2-butyl-5,5-dimethyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-one
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C23H26N6O
  1
1
EC50 = 8140 nM
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CP0114119
 Compound Info 
2-Ethoxy-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-benzoimidazole-4-carboxylic acid(CV-11974)
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C24H20N6O3
  1
1
EC50 = 15000 nM
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CP0041674
 Compound Info 
(S)-3-Methyl-2-{pentanoyl-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-amino}-butyric acid
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C24H29N5O3
  1
1
EC50 = 16000 nM
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CP0471071
 Compound Info 
4'-(2-Butyl-4-oxo-1,3-diaza-spiro[4.4]non-1-ylmethyl)-biphenyl-2-carboxylic acid
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C25H30N2O3
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1
EC50 = 24200 nM
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CP0507541
 Compound Info 
2-[4-[[methyl(pentanoyl)amino]methyl]phenyl]benzoic acid
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C20H23NO3
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1
EC50 > 7600 nM
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Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Clinical Information about the Protein
Target 1 ( Leukotriene B4 receptor 2 (LTB4R2) )
Target Type Clinical trial Target
Disease 4 Target-related Diseases  4
1 Human immunodeficiency virus infection [ICD-11: 1C62]
2 Inflammatory bowel disease [ICD-11: DD72]
3 Kidney cancer [ICD-11: 2C90.0]
4 Asthma [ICD-11: CA23]
Clinical Trial Drug(s) 2 Clinical Trial Drugs  2
1 LTB4
 Drug Info 
Phase 2
Human immunodeficiency virus infection
2 Biomed 101
 Drug Info 
Phase 1
Kidney cancer
Discontinued Drug(s) 3 Discontinued Drugs  3
1 ONO-4057
 Drug Info 
Discontinued in Phase 2
Inflammatory bowel disease
2 CP-105696
 Drug Info 
Discontinued in Phase 1
Inflammatory bowel disease
3 LY-255283
 Drug Info 
Terminated
Asthma