General Information of the Protein
Protein ID
PT05652
Protein Name
Phospholipase A2
Secondarily
Protein Name
Group IB phospholipase A2
Phosphatidylcholine 2-acylhydrolase 1B
Gene Name
PLA2G1B
Sequence
MKLLLLAALLTAGVTAHSISTRAVWQFRNMIKCTIPGSDPLREYNNYGCYCGLGGSGTPVDDLDRCCQTHDHCYNQAKKLESCKFLIDNPYTNTYSYKCSGNVITCSDKNNDCESFICNCDRQAAICFSKVPYNKEYKDLDTKKHC
    Show/Hide
Organism
Rattus norvegicus, Rat
Protein Classification
Enzyme
>
Hydrolase
Function
Secretory calcium-dependent phospholipase A2 that primarily targets dietary phospholipids in the intestinal tract (PubMed:1420353, PubMed:17158102). Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) with preference for phosphatidylethanolamines and phosphatidylglycerols over phosphatidylcholines (PubMed:1420353, PubMed:17158102). May play a role in the biosynthesis of N-acyl ethanolamines that regulate energy metabolism and inflammation in the intestinal tract (PubMed:14998370). Hydrolyzes N-acyl phosphatidylethanolamines to N-acyl lysophosphatidylethanolamines, which are further cleaved by a lysophospholipase D to release N-acyl ethanolamines (PubMed:14998370). May act in an autocrine and paracrine manner (By similarity). Has anti-helminth activity in a process regulated by gut microbiota. Upon helminth infection of intestinal epithelia, directly affects phosphatidylethanolamine contents in the membrane of helminth larvae, likely controlling an array of phospholipid-mediated cellular processes such as membrane fusion and cell division while providing for better immune recognition, ultimately reducing larvae integrity and infectivity (By similarity).
    Show/Hide
Uniprot ID
P04055
Ensembl ID
ENSG00000170890
Subcellular Location
Secreted
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000006 , HEK293
Compound ID Compound Name Compound Formula
CP0012462
acs.jmedchem.1c00409_ST.480
   Show/Hide
C30H18O10
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0381515
3-(4-(4-oxo-4H-chromen-2-yl)phenyl)-2-phenyl-4H-chromen-4-one
   Show/Hide
C30H18O4
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0390962
2,2'-Diphenyl-[6,6']bichromenyl-4,4'-dione
   Show/Hide
C30H18O4
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0394409
6-[4-(4-Oxo-4H-chromen-2-yl)-phenyl]-2-phenyl-chromen-4-one
   Show/Hide
C30H18O4
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0440729
2-{4-[3-(4-oxo-4H-chromen-2-yl)phenyl]phenyl}-4H-chromen-4-one
   Show/Hide
C30H18O4
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0453270
6-[3-(4-Oxo-4H-chromen-2-yl)-phenyl]-2-phenyl-chromen-4-one
   Show/Hide
C30H18O4
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0464803
2-{4-[4-(4-oxo-4H-chromen-2-yl)phenyl]phenyl}-4H-chromen-4-one
   Show/Hide
C30H18O4
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0847707
Ochnaflavone
   Show/Hide
C30H18O10
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS