General Information of the Protein
Protein ID
PT05455
Protein Name
Transforming growth factor beta-1 proprotein
Gene Name
TGFB1
Secondarily
Gene Name
TGFB
Sequence
MPPSGLRLLPLLLPLLWLLVLTPGRPAAGLSTCKTIDMELVKRKRIEAIRGQILSKLRLASPPSQGEVPPGPLPEAVLALYNSTRDRVAGESAEPEPEPEADYYAKEVTRVLMVETHNEIYDKFKQSTHSIYMFFNTSELREAVPEPVLLSRAELRLLRLKLKVEQHVELYQKYSNNSWRYLSNRLLAPSDSPEWLSFDVTGVVRQWLSRGGEIEGFRLSAHCSCDSRDNTLQVDINGFTTGRRGDLATIHGMNRPFLLLMATPLERAQHLQSSRHRRALDTNYCFSSTEKNCCVRQLYIDFRKDLGWKWIHEPKGYHANFCLGPCPYIWSLDTQYSKVLALYNQHNPGASAAPCCVPQALEPLPIVYYVGRKPKVEQLSNMIVRSCKCS
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Organism
Homo sapiens, Human
Protein Classification
Secreted protein
Function
Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively.
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Uniprot ID
Primary ID:
P01137

Secondarily ID:
A8K792
Q9UCG4
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Ensembl ID
ENSG00000105329
HGNC ID
HGNC:11766
Subcellular Location
Secreted
Extracellular space
Extracellular matrix
Clinical Information about the Protein
Target 1 ( Transforming growth factor beta 1 (TGFB1) )
Target Type Successful Target
Disease 2 Target-related Diseases  2
1 Idiopathic pulmonary fibrosis [ICD-11: CB03.4]
2 Arteriosclerosis [ICD-11: BD40]
Approved Drug(s) 1 Approved Drug  1
1 Pirfenidone
 Drug Info 
Approved
Idiopathic pulmonary fibrosis
Clinical Trial Drug(s) 1 Clinical Trial Drug  1
1 LY2157299
 Drug Info 
Phase 2/3
Arteriosclerosis
Target 2 ( TGFB1 messenger RNA (TGFB1 mRNA) )
Target Type Literature-reported Target