General Information of the Protein
Protein ID
PT05246
Protein Name
Plasmepsin X
Secondarily
Protein Name
Plasmepsin 10
Gene Name
PMX
Secondarily
Gene Name
PF3D7_0808200
Sequence
MKRISPLNTLFYLSLFFSYTFKGLKCTRIYKIGTKALPCSECHDVFDCTGCLFEEKESSHVIPLKLNKKNPNDHKKLQKHHESLKLGDVKYYVNRGEGISGSLGTSSGNTLDDMDLINEEINKKRTNAQLDEKNFLDFTTYNKNKAQDISDHLSDIQKHVYEQDAQKGNKNFTNNENNSDNENNSDNENNSDNENNLDNENNLDNENNSDNSSIEKNFIALENKNATVEQTKENIFLVPLKHLRDSQFVGELLVGTPPQTVYPIFDTGSTNVWVVTTACEEESCKKVRRYDPNKSKTFRRSFIEKNLHIVFGSGSISGSVGTDTFMLGKHLVRNQTFGLVESESNNNKNGGDNIFDYISFEGIVGLGFPGMLSAGNIPFFDNLLKQNPNVDPQFSFYISPYDGKSTLIIGGISKSFYEGDIYMLPVLKESYWEVKLDELYIGKERICCDEESYVIFDTGTSYNTMPSSQMKTFLNLIHSTACTEQNYKDILKSYPIIKYVFGELIIELHPEEYMILNDDVCMPAYMQIDVPSERNHAYLLGSLSFMRNFFTVFVRGTESRPSMVGVARAKSKN
    Show/Hide
Organism
Plasmodium falciparum (isolate 3D7)
Protein Classification
Enzyme
>
Hydrolase
Function
During the asexual blood stage, processes key proteins essential for merozoite egress and invasion of host erythrocytes (PubMed:29074775, PubMed:32109369). Cleaves and activates proteases SUB1 and SUB2 (PubMed:29074775, PubMed:32109369). May process members of the EBL and Rh protein families (PubMed:32109369). Also cleaves apical membrane protein AMA1 (PubMed:29074775). During the mosquito vector stage and probably in ookinetes, cleaves CelTOS (PubMed:29074775).
    Show/Hide
Uniprot ID
Q8IAS0
Subcellular Location
Cytoplasmic vesicle
Secretory vesicle
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000625 , Expi293F GnTI-
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0343849
 Compound Info 
N-[3-[(4S)-2-amino-4-methyl-1-[(2S,4S)-2-methyloxan-4-yl]-6-oxo-5H-pyrimidin-4-yl]-2-chlorophenyl]-3-cyanobenzamide
   Show/Hide
C25H26ClN5O3
  1
1
IC50 = 7 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0577222
 Compound Info 
(6S)-2-amino-6-[2-chloro-3-[(6-cyclopropylpyridin-3-yl)amino]phenyl]-6-methyl-3-[(2S,4S)-2-methyloxan-4-yl]-5H-pyrimidin-4-one
   Show/Hide
C25H30ClN5O2
  1
1
IC50 = 7 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0577058
 Compound Info 
(6S)-2-amino-6-[2-chloro-3-[(2-cyclopropylpyrimidin-5-yl)amino]phenyl]-6-methyl-3-[(2S,4S)-2-methyloxan-4-yl]-5H-pyrimidin-4-one
   Show/Hide
C24H29ClN6O2
  1
1
IC50 = 9 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0569942
 Compound Info 
(6S)-2-amino-6-(3-anilino-2-chlorophenyl)-6-methyl-3-(oxan-4-yl)-5H-pyrimidin-4-one
   Show/Hide
C22H25ClN4O2
  1
1
IC50 = 15 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0577223
 Compound Info 
N-[3-[(4S)-2-amino-4-methyl-1-(oxan-4-yl)-6-oxo-5H-pyrimidin-4-yl]-2-chlorophenyl]benzamide
   Show/Hide
C23H25ClN4O3
  1
1
IC50 = 32 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0532469
 Compound Info 
(6S)-2-amino-6-[2-chloro-3-[(6-cyclopropylpyridin-3-yl)amino]phenyl]-6-methyl-3-(oxan-4-yl)-5H-pyrimidin-4-one
   Show/Hide
C24H28ClN5O2
  1
1
IC50 = 37 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0343849
 Compound Info 
N-[3-[(4S)-2-amino-4-methyl-1-[(2S,4S)-2-methyloxan-4-yl]-6-oxo-5H-pyrimidin-4-yl]-2-chlorophenyl]-3-cyanobenzamide
   Show/Hide
C25H26ClN5O3
  1
1 IC50 = 7 nM