General Information of the Protein
Protein ID
PT05165
Protein Name
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
Secondarily
Protein Name
Brain cyclic nucleotide-gated channel 1
Gene Name
HCN1
Secondarily
Gene Name
BCNG1
Sequence
MEGGGKPNSSSNSRDDGNSVFPAKASATGAGPAAAEKRLGTPPGGGGAGAKEHGNSVCFKVDGGGGGGGGGGGGEEPAGGFEDAEGPRRQYGFMQRQFTSMLQPGVNKFSLRMFGSQKAVEKEQERVKTAGFWIIHPYSDFRFYWDLIMLIMMVGNLVIIPVGITFFTEQTTTPWIIFNVASDTVFLLDLIMNFRTGTVNEDSSEIILDPKVIKMNYLKSWFVVDFISSIPVDYIFLIVEKGMDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCHWDGCLQFLVPLLQDFPPDCWVSLNEMVNDSWGKQYSYALFKAMSHMLCIGYGAQAPVSMSDLWITMLSMIVGATCYAMFVGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADMRQKIHDYYEHRYQGKIFDEENILNELNDPLREEIVNFNCRKLVATMPLFANADPNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVAGVITKSSKEMKLTDGSYFGEICLLTKGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILLQKFQKDLNTGVFNNQENEILKQIVKHDREMVQAIAPINYPQMTTLNSTSSTTTPTSRMRTQSPPVYTATSLSHSNLHSPSPSTQTPQPSAILSPCSYTTAVCSPPVQSPLAARTFHYASPTASQLSLMQQQPQQQVQQSQPPQTQPQQPSPQPQTPGSSTPKNEVHKSTQALHNTNLTREVRPLSASQPSLPHEVSTLISRPHPTVGESLASIPQPVTAVPGTGLQAGGRSTVPQRVTLFRQMSSGAIPPNRGVPPAPPPPAAALPRESSSVLNTDPDAEKPRFASNL
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Organism
Homo sapiens, Human
Protein Classification
Ion channel
>
Voltage-gated ion channel
>
Cyclic nucleotide-regulated channel
Function
Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions (PubMed:28086084). Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). May mediate responses to sour stimuli.
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Uniprot ID
O60741
Ensembl ID
ENSG00000164588
HGNC ID
HGNC:4845
Subcellular Location
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0389054
 Compound Info 
2-ethoxy-N-[[1-(4-propan-2-ylpiperazin-1-yl)cyclohexyl]methyl]benzamide
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C23H37N3O2
  1
1
IC50 = 15.85 nM
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CP0452466
 Compound Info 
2-methoxy-N-[[1-(4-propan-2-ylpiperazin-1-yl)cyclohexyl]methyl]benzamide
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C22H35N3O2
  1
1
IC50 = 31.62 nM
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CP0490002
 Compound Info 
2-ethoxy-N-[[1-(4-ethylpiperazin-1-yl)cyclohexyl]methyl]benzamide
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C22H35N3O2
  1
1
IC50 = 31.62 nM
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CP0505841
 Compound Info 
N-[[1-(4-cyclopropylpiperazin-1-yl)cyclohexyl]methyl]-2-ethoxybenzamide
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C23H35N3O2
  1
1
IC50 = 50.12 nM
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CP0505471
 Compound Info 
N-[[1-(4-cyclobutylpiperazin-1-yl)cyclohexyl]methyl]-2-ethoxybenzamide
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C24H37N3O2
  1
1
IC50 = 79.43 nM
 Bioactivity Info 
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CP0512573
 Compound Info 
2-ethoxy-N-[[1-(4-methylpiperazin-1-yl)cyclohexyl]methyl]benzamide
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C21H33N3O2
  1
1
IC50 = 125.89 nM
 Bioactivity Info 
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CP0888597
 Compound Info 
N-ethyl-1,2-dimethyl-6-(methylimino)-N-phenyl-1,6-dihydropyrimidin-4-amine hydrochloride
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C15H21ClN4
  1
1
IC50 = 158.49 nM
 Bioactivity Info 
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CP0397889
 Compound Info 
N-[[1-(4-cyclopentylpiperazin-1-yl)cyclohexyl]methyl]-2-ethoxybenzamide
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C25H39N3O2
  1
1
IC50 = 199.53 nM
 Bioactivity Info 
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CP0505470
 Compound Info 
2-propan-2-yloxy-N-[[1-(4-propan-2-ylpiperazin-1-yl)cyclohexyl]methyl]benzamide
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C24H39N3O2
  1
1
IC50 = 251.19 nM
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CP0452497
 Compound Info 
2-ethoxy-N-[[4-(4-propan-2-ylpiperazin-1-yl)oxan-4-yl]methyl]benzamide
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C22H35N3O3
  1
1
IC50 = 316.23 nM
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CP0431255
 Compound Info 
2-methoxy-N-[[1-(4-methylpiperazin-1-yl)cyclohexyl]methyl]benzamide
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C20H31N3O2
  1
1
IC50 = 398.11 nM
 Bioactivity Info 
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CP0452462
 Compound Info 
2-ethoxy-N-[[2-(4-methylpiperazin-1-yl)-1,3-dihydroinden-2-yl]methyl]benzamide
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C24H31N3O2
  1
1
IC50 = 398.11 nM
 Bioactivity Info 
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CP0456075
 Compound Info 
2-ethoxy-N-[(1-piperazin-1-ylcyclohexyl)methyl]benzamide
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C20H31N3O2
  1
1
IC50 = 398.11 nM
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CP0505468
 Compound Info 
2-ethoxy-N-[[1-(4-methylpiperazin-1-yl)cyclopentyl]methyl]benzamide
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C20H31N3O2
  1
1
IC50 = 398.11 nM
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CP0426126
 Compound Info 
2-methoxy-N-[[1-phenyl-4-(4-propan-2-ylpiperazin-1-yl)piperidin-4-yl]methyl]benzamide
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C27H38N4O2
  1
1
IC50 = 630.96 nM
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CP0494247
 Compound Info 
N-[[2-(4-methylpiperazin-1-yl)-1,3-dihydroinden-2-yl]methyl]-2-phenylmethoxybenzamide
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C29H33N3O2
  1
1
IC50 = 630.96 nM
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CP0512571
 Compound Info 
2-ethoxy-N-[[2-(4-propan-2-ylpiperazin-1-yl)-1,3-dihydroinden-2-yl]methyl]benzamide
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C26H35N3O2
  1
1
IC50 = 630.96 nM
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CP0389055
 Compound Info 
2-methoxy-N-[[2-(4-methylpiperazin-1-yl)-1,3-dihydroinden-2-yl]methyl]benzamide
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C23H29N3O2
  1
1
IC50 = 1258.93 nM
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CP0429849
 Compound Info 
2-methoxy-N-[[2-(4-methylpiperazin-1-yl)-3,4-dihydro-1H-naphthalen-2-yl]methyl]benzamide
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C24H31N3O2
  1
1
IC50 = 1584.89 nM
 Bioactivity Info 
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CP0505469
 Compound Info 
2-methoxy-N-[2-(4-methylphenyl)-2-(4-methylpiperazin-1-yl)ethyl]benzamide
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C22H29N3O2
  1
1
IC50 = 2511.89 nM
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CP0431254
 Compound Info 
2-ethoxy-N-[(2-piperidin-1-yl-1,3-dihydroinden-2-yl)methyl]benzamide
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C24H30N2O2
  1
1
IC50 = 15848.93 nM
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CP0490003
 Compound Info 
2-ethoxy-N-[(1-piperidin-1-ylcyclohexyl)methyl]benzamide
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C21H32N2O2
  1
1
IC50 = 15848.93 nM
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CP0389053
 Compound Info 
2-chloro-N-[[2-(4-methylpiperazin-1-yl)-1,3-dihydroinden-2-yl]methyl]benzamide
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C22H26ClN3O
  1
1
IC50 = 19952.62 nM
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CP0452463
 Compound Info 
N-[[2-(4-methylpiperazin-1-yl)-1,3-dihydroinden-2-yl]methyl]-2-(trifluoromethoxy)benzamide
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C23H26F3N3O2
  1
1
IC50 = 25118.86 nM
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CP0512570
 Compound Info 
2-fluoro-N-[[2-(4-methylpiperazin-1-yl)-1,3-dihydroinden-2-yl]methyl]benzamide
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C22H26FN3O
  1
1
IC50 = 25118.86 nM
 Bioactivity Info 
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CP0494554
 Compound Info 
2-methoxy-N-[(2-piperidin-1-yl-1,3-dihydroinden-2-yl)methyl]benzamide
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C23H28N2O2
  1
1
IC50 = 50118.72 nM
 Bioactivity Info 
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CP0431253
 Compound Info 
3-methoxy-N-[[2-(4-methylpiperazin-1-yl)-1,3-dihydroinden-2-yl]methyl]benzamide
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C23H29N3O2
  1
1
IC50 = 63095.73 nM
 Bioactivity Info 
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CP0431256
 Compound Info 
2-methyl-N-[[1-(4-methylpiperazin-1-yl)cyclohexyl]methyl]benzamide
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C20H31N3O
  1
1
IC50 = 63095.73 nM
 Bioactivity Info 
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CP0452464
 Compound Info 
4-methoxy-N-[[2-(4-methylpiperazin-1-yl)-1,3-dihydroinden-2-yl]methyl]benzamide
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C23H29N3O2
  1
1
IC50 = 100000 nM
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Clinical Information about the Protein
Target 1 ( Hyperpolarization cyclic nucleotide-gated channel 1 (HCN1) )
Target Type Literature-reported Target