General Information of the Protein
| Protein ID |
PT05005
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| Protein Name |
Interleukin-1 receptor antagonist protein
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| Secondarily Protein Name |
ICIL-1RA
IL1 inhibitor
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| Gene Name |
IL1RN
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| Secondarily Gene Name |
IL1F3
IL1RA
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| Sequence |
MEICRGLRSHLITLLLFLFHSETICRPSGRKSSKMQAFRIWDVNQKTFYLRNNQLVAGYLQGPNVNLEEKIDVVPIEPHALFLGIHGGKMCLSCVKSGDETRLQLEAVNITDLSENRKQDKRFAFIRSDSGPTTSFESAACPGWFLCTAMEADQPVSLTNMPDEGVMVTKFYFQEDE
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| Organism |
Homo sapiens, Human
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| Protein Classification |
Unclassified protein
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| Function |
Anti-inflammatory antagonist of interleukin-1 family of proinflammatory cytokines such as interleukin-1beta/IL1B and interleukin-1alpha/IL1A. Protects from immune dysregulation and uncontrolled systemic inflammation triggered by IL1 for a range of innate stimulatory agents such as pathogens.
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| Uniprot ID |
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| Ensembl ID | |||||
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| Subcellular Location |
Secreted
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Map of Molecular Bioactivity Related to the Protein
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Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity |
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Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000025 , HEK-293T
Cell Line ID: CL000006 , HEK293
Cell Line ID: CL000107 , HEK293S
Cell Line ID: CL000013 , Sf9
Clinical Information about the Protein
Target 1 ( Interleukin-1 receptor antagonist protein (IL1RN) )
| Target Type | Clinical trial Target | ||||
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