General Information of the Protein
Protein ID
PT04894
Protein Name
5-hydroxytryptamine receptor 5A
Secondarily
Protein Name
REC17
Serotonin receptor 5A
Gene Name
HTR5A
Secondarily
Gene Name
5ht5a
Sequence
MDLPINLTSFSLSTPSTLEPNRSLDTEALRTSQSFLSAFRVLVLTLLGFLAAATFTWNLLVLATILRVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHLEYTLRARKRVSNVMILLTWALSAVISLAPLLFGWGETYSELSEECQVSREPSYTVFSTVGAFYLPLCVVLFVYWKIYKAAKFRMGSRKTNSVSPIPEAVEVKDASQHPQMVFTVRHATVTFQTEGDTWREQKEQRAALMVGILIGVFVLCWFPFFVTELISPLCSWDIPALWKSIFLWLGYSNSFFNPLIYTAFNRSYSSAFKVFFSKQQ
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Organism
Rattus norvegicus, Rat
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Monoamine receptor
>
Serotonin receptor
Function
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins.
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Uniprot ID
P35364
Ensembl ID
ENSG00000157219
Subcellular Location
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000006 , HEK293
Compound ID Compound Name Compound Formula
CP0379189
2-(1-Benzenesulfonyl-1H-indol-4-yl)-ethylamine
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C16H16N2O2S
 1
1
Ki = 1200 nM
   TI
   LI
   LO
   TS
CP0418991
[1-(benzenesulfonyl)-4-[2-(dimethylamino)ethyl]indol-2-yl]-phenylmethanone
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C25H24N2O3S
 1
1
Ki = 1600 nM
   TI
   LI
   LO
   TS
CP0330654
2-[1-(benzenesulfonyl)indol-4-yl]-N,N-dimethylethanamine
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C18H20N2O2S
 1
1
Ki = 3400 nM
   TI
   LI
   LO
   TS
CP0255950
2-[1-(benzenesulfonyl)indol-3-yl]-N,N-dimethylethanamine
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C18H20N2O2S
 1
1
Ki = 4000 nM
   TI
   LI
   LO
   TS
CP0409092
[3-[2-(dimethylamino)ethyl]-5-hydroxyindol-1-yl]-phenylmethanone
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C19H20N2O2
 1
1
Ki = 4500 nM
   TI
   LI
   LO
   TS
CP0045069
2-[1-(benzenesulfonyl)-5-methoxyindol-3-yl]-N,N-dimethylethanamine
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C19H22N2O3S
 1
1
Ki > 5000 nM
   TI
   LI
   LO
   TS
CP0186950
(4S,5S)-4-Dimethylamino-1-(toluene-4-sulfonyl)-1,3,4,5-tetrahydro-benzo[cd]indol-5-ol
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C20H22N2O3S
 1
1
Ki > 6400 nM
   TI
   LI
   LO
   TS