General Information of the Protein
| Protein ID |
PT04790
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| Protein Name |
Sodium- and chloride-dependent betaine transporter
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| Secondarily Protein Name |
BGT-1
Na(+)/Cl(-) betaine/GABA transporter
Sodium- and chloride-dependent GABA transporter 2
Solute carrier family 6 member 12
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| Gene Name |
SLC6A12
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| Secondarily Gene Name |
Bgt1
Gabt2
Gat-2
Gat2
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| Sequence |
MDRKVAVHEDGYPVVSWVPEEGEMMDQKGKDQVKDRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFFSCGIPVFFLEVALGQYSSQGSVTAWRKICPLLQGIGMASVVIESYLNIYYIIILAWALFYLFSSFTWELPWTTCTNSWNTEHCVDFLNHSSARGVSSSENFTSPVMEFWERRVLGITSGIHDLGSLRWELALCLLLAWIICYFCIWKGVKSTGKVVYFTATFPYLMLIILLIRGVTLPGAYQGIVFYLKPDLLRLKDPQVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYRDSIALCFLNSATSFVAGFVVFSILGFMSQEQGIPISEVAESGPGLAFIAFPKAVTMMPLSQLWSCLFFIMLLFLGLDSQFVCMECLVTASMDMFPQQLRKSGRRDVLILAISVLCYLMGLLLVTEGGMYIFQLFDYYASSGICLLFLSLFEVICIGWVYGADRFYDNVEDMIGYRPWPLVKISWLFLTPGLCLATFFFSLSKYTPLKYNNVYMYPSWGYSIGWLLAFSSMACVPLFIIITFLKTQGSFKKRLRRLITPDPSLPQPGRRPPQDGSSAQNCSSSPAKQELIAWEKETHL
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| Organism |
Mus musculus, Mouse
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| Protein Classification |
Transporter
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Electrochemical transporter
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SLC superfamily of solute carriers
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SLC06 neurotransmitter transporter family
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| Function |
Transporter that mediates cellular uptake of betaine and GABA in a sodium- and chloride-dependent process (By similarity). May have a role in regulation of GABAergic transmission in the brain through the reuptake of GABA into presynaptic terminals, as well as in osmotic regulation (Probable). Probably also involved in renal and hepatic osmotic regulation (PubMed:22071246).
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| Uniprot ID | |||||
| Ensembl ID | |||||
| Subcellular Location |
Basolateral cell membrane
Cell membrane
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Map of Molecular Bioactivity Related to the Protein
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Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity |
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Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000051 , BHK-21
| Compound ID | Compound Name | Compound Formula | |
| CP0390468 |
1-(3-carbazol-9-ylpropyl)-4-(2-methoxyphenyl)piperidin-4-ol
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C27H30N2O2
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1 |
| 1 |
Ki = 1400 nM
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TI
LI
LO
TS
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Cell Line ID: CL000006 , HEK293
Biochemical Assays