General Information of the Protein
Protein ID
PT04678
Protein Name
Serine hydrolase RBBP9
Secondarily
Protein Name
B5T-overexpressed gene protein
Retinoblastoma-binding protein 10
Retinoblastoma-binding protein 9
Gene Name
RBBP9
Secondarily
Gene Name
BOG
RBBP10
Sequence
MASPSKAVIVPGNGGGDVTTHGWYGWVKKELEKIPGFQCLAKNMPDPITARESIWLPFMETELHCDEKTIIIGHSSGAIAAMRYAETHRVYAIVLVSAYTSDLGDENERASGYFTRPWQWEKIKANCPYIVQFGSTDDPFLPWKEQQEVADRLETKLHKFTDCGHFQNTEFHELITVVKSLLKVPA
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
>
Hydrolase
Function
Serine hydrolase whose substrates have not been identified yet (PubMed:19329999, PubMed:20080647). May negatively regulate basal or autocrine TGF-beta signaling by suppressing SMAD2-SMAD3 phosphorylation (PubMed:20080647). May play a role in the transformation process due to its capacity to confer resistance to the growth-inhibitory effects of TGF-beta through interaction with RB1 and the subsequent displacement of E2F1 (PubMed:9697699).
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Uniprot ID
Primary ID:
O75884

Secondarily ID:
D3DW31
Q5JPH9
Q9H1D8
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Ensembl ID
ENSG00000089050
HGNC ID
HGNC:9892
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000025 , HEK-293T
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0452112
 Compound Info 
1-(thiazol-2-yl)ethanone O-cyclohexanecarbonyl oxime
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C12H16N2O2S
  1
1
IC50 = 640 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0059836
 Compound Info 
4-(cinnamoyloxyimino)-2,6-dimethylcyclohexa-2,5-dienone
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C17H15NO3
  1
1
IC50 = 1200 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0329045
 Compound Info 
4-(4-methoxybenzoyloxyimino)-2,6-dimethylcyclohexa-2,5-dienone
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C16H15NO4
  1
1
IC50 = 1500 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0290970
 Compound Info 
1-(thiazol-2-yl)ethanone O-4-chlorobenzoyl oxime
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C12H9ClN2O2S
  1
1
IC50 = 1900 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0430682
 Compound Info 
1-(thiazol-2-yl)ethanone O-4-fluorobenzoyl oxime
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C12H9FN2O2S
  1
1
IC50 = 5700 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0084994
 Compound Info 
(2S,3R,11bS)-2-[[(1R)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl]-3-ethyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-benzo[a]quinolizine;hydrochloride
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C29H40N2O4
  1
1
IC50 = 7800 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0485637
 Compound Info 
1-(thiazol-2-yl)ethanone O-4-methoxybenzoyl oxime
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C13H12N2O3S
  1
1
IC50 = 9200 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Clinical Information about the Protein
Target 1 ( Retinoblastoma-binding protein 9 (RBBP9) )
Target Type Literature-reported Target