General Information of the Protein
Protein ID
PT04673
Protein Name
B-cell receptor CD22
Secondarily
Protein Name
B-lymphocyte cell adhesion molecule
Sialic acid-binding Ig-like lectin 2
T-cell surface antigen Leu-14
Gene Name
CD22
Secondarily
Gene Name
SIGLEC2
Sequence
MHLLGPWLLLLVLEYLAFSDSSKWVFEHPETLYAWEGACVWIPCTYRALDGDLESFILFHNPEYNKNTSKFDGTRLYESTKDGKVPSEQKRVQFLGDKNKNCTLSIHPVHLNDSGQLGLRMESKTEKWMERIHLNVSERPFPPHIQLPPEIQESQEVTLTCLLNFSCYGYPIQLQWLLEGVPMRQAAVTSTSLTIKSVFTRSELKFSPQWSHHGKIVTCQLQDADGKFLSNDTVQLNVKHTPKLEIKVTPSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKKQNTFTLNLREVTKDQSGKYCCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHSPAVEGSQVEFLCMSLANPLPTNYTWYHNGKEMQGRTEEKVHIPKILPWHAGTYSCVAENILGTGQRGPGAELDVQYPPKKVTTVIQNPMPIREGDTVTLSCNYNSSNPSVTRYEWKPHGAWEEPSLGVLKIQNVGWDNTTIACAACNSWCSWASPVALNVQYAPRDVRVRKIKPLSEIHSGNSVSLQCDFSSSHPKEVQFFWEKNGRLLGKESQLNFDSISPEDAGSYSCWVNNSIGQTASKAWTLEVLYAPRRLRVSMSPGDQVMEGKSATLTCESDANPPVSHYTWFDWNNQSLPYHSQKLRLEPVKVQHSGAYWCQGTNSVGKGRSPLSTLTVYYSPETIGRRVAVGLGSCLAILILAICGLKLQRRWKRTQSQQGLQENSSGQSFFVRNKKVRRAPLSEGPHSLGCYNPMMEDGISYTTLRFPEMNIPRTGDAESSEMQRPPPDCDDTVTYSALHKRQVGDYENVIPDFPEDEGIHYSELIQFGVGERPQAQENVDYVILKH
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Organism
Homo sapiens, Human
Protein Classification
Membrane receptor
Function
Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.
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Uniprot ID
Primary ID:
P20273

Secondarily ID:
F5GYU4
F5H7U3
O95699
O95701
O95702
O95703
Q01665
Q32M46
Q92872
Q92873
Q9UQA6
Q9UQA7
Q9UQA8
Q9UQA9
Q9UQB0
Q9Y2A6
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Ensembl ID
ENSG00000012124
HGNC ID
HGNC:1643
Subcellular Location
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000025 , HEK-293T
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0574503
 Compound Info 
sodium;(2R,4S,5R,6R)-6-[(1R,2R)-1,2-dihydroxy-3-[[2-[4-(4-hydroxyphenyl)phenyl]acetyl]amino]propyl]-4-hydroxy-5-[(2-hydroxyacetyl)amino]-2-(4-phenyltriazol-1-yl)oxane-2-carboxylate
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C33H34N5NaO10
  1
1
Kd = 335 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0557055
 Compound Info 
sodium;(2R,4S,5R,6R)-6-[(1R,2R)-1,2-dihydroxy-3-[[2-[4-(4-hydroxyphenyl)phenyl]acetyl]amino]propyl]-4-hydroxy-5-[(2-hydroxyacetyl)amino]-2-phenylmethoxyoxane-2-carboxylate
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C32H35N2NaO11
  1
1
Kd = 458 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0560082
 Compound Info 
sodium;(2R,4S,5R,6R)-6-[(1R,2R)-1,2-dihydroxy-3-[[2-[4-(4-hydroxyphenyl)phenyl]acetyl]amino]propyl]-4-hydroxy-5-[(2-hydroxyacetyl)amino]-2-[4-(4-phenylphenyl)triazol-1-yl]oxane-2-carboxylate
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C39H38N5NaO10
  1
1
Kd = 620 nM
 Bioactivity Info 
   TI
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   LO
   TS
CP0557056
 Compound Info 
sodium;(2R,4S,5R,6R)-6-[(1R,2R)-1,2-dihydroxy-3-[[2-[4-(4-hydroxyphenyl)phenyl]acetyl]amino]propyl]-2-[(4-ethynylphenyl)methoxy]-4-hydroxy-5-[(2-hydroxyacetyl)amino]oxane-2-carboxylate
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C34H35N2NaO11
  1
1
Kd = 628 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0574505
 Compound Info 
sodium;(2R,4S,5R,6R)-2-[[4-[1-[2-[2-[2-[2-[5-[(3aR,4R,6aS)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]ethoxy]ethoxy]ethoxy]ethyl]triazol-4-yl]phenyl]methoxy]-6-[(1R,2R)-1,2-dihydroxy-3-[[2-[4-(4-hydroxyphenyl)phenyl]acetyl]amino]propyl]-4-hydroxy-5-[(2-hydroxyacetyl)amino]oxane-2-carboxylate
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C52H67N8NaO16S
  1
1
Kd = 740 nM
 Bioactivity Info 
   TI
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CP0538734
 Compound Info 
sodium;(2R,4S,5R,6R)-2-[4-(cyclohexylmethyl)triazol-1-yl]-6-[(1R,2R)-1,2-dihydroxy-3-[[2-[4-(4-hydroxyphenyl)phenyl]acetyl]amino]propyl]-4-hydroxy-5-[(2-hydroxyacetyl)amino]oxane-2-carboxylate
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C34H42N5NaO10
  1
1
Kd = 766 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0557182
 Compound Info 
sodium;(2R,4S,5R,6R)-2-[4-(cyclohexylmethoxy)triazol-1-yl]-6-[(1R,2R)-1,2-dihydroxy-3-[[2-[4-(4-hydroxyphenyl)phenyl]acetyl]amino]propyl]-4-hydroxy-5-[(2-hydroxyacetyl)amino]oxane-2-carboxylate
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C34H42N5NaO11
  1
1
Kd = 860 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0574504
 Compound Info 
sodium;(2R,4S,5R,6R)-2-(4-benzyltriazol-1-yl)-6-[(1R,2R)-1,2-dihydroxy-3-[[2-[4-(4-hydroxyphenyl)phenyl]acetyl]amino]propyl]-4-hydroxy-5-[(2-hydroxyacetyl)amino]oxane-2-carboxylate
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C34H36N5NaO10
  1
1
Kd = 952 nM
 Bioactivity Info 
   TI
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   LO
   TS
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0543559
 Compound Info 
disodium;(2R,4S,5R,6R)-5-acetamido-2-[3-[2-[[4-[2-[3-[(2R,4S,5R,6R)-5-acetamido-2-carboxylato-6-[(1R,2R)-1,2-dihydroxy-3-[(4-phenylbenzoyl)amino]propyl]-4-hydroxyoxan-2-yl]oxypropylsulfanyl]ethylcarbamoyl]benzoyl]amino]ethylsulfanyl]propoxy]-6-[(1R,2R)-1,2-dihydroxy-3-[(4-phenylbenzoyl)amino]propyl]-4-hydroxyoxane-2-carboxylate
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C66H78N6Na2O20S2
  1
1 IC50 = 0.41 nM
Clinical Information about the Protein
Target 1 ( B-cell receptor CD22 (CD22) )
Target Type Successful Target