General Information of the Protein
Protein ID
PT04545
Protein Name
Delta(24)-sterol reductase
Secondarily
Protein Name
24-dehydrocholesterol reductase
3-beta-hydroxysterol Delta-24-reductase
Diminuto/dwarf1 homolog
Seladin-1
Gene Name
DHCR24
Secondarily
Gene Name
KIAA0018
Sequence
MEPAVSLAVCALLFLLWVRLKGLEFVLIHQRWVFVCLFLLPLSLIFDIYYYVRAWVVFKLSSAPRLHEQRVRDIQKQVREWKEQGSKTFMCTGRPGWLTVSLRVGKYKKTHKNIMINLMDILEVDTKKQIVRVEPLVTMGQVTALLTSIGWTLPVLPELDDLTVGGLIMGTGIESSSHKYGLFQHICTAYELVLADGSFVRCTPSENSDLFYAVPWSCGTLGFLVAAEIRIIPAKKYVKLRFEPVRGLEAICAKFTHESQRQENHFVEGLLYSLDEAVIMTGVMTDEAEPSKLNSIGNYYKPWFFKHVENYLKTNREGLEYIPLRHYYHRHTRSIFWELQDIIPFGNNPIFRYLFGWMVPPKISLLKLTQGETLRKLYEQHHVVQDMLVPMKCLQQALHTFQNDIHVYPIWLCPFILPSQPGLVHPKGNEAELYIDIGAYGEPRVKHFEARSCMRQLEKFVRSVHGFQMLYADCYMNREEFWEMFDGSLYHKLREKLGCQDAFPEVYDKICKAARH
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
>
Oxidoreductase
Function
Catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis (PubMed:11519011, PubMed:21671375, PubMed:25637936, PubMed:22178193). In addition to its cholesterol-synthesizing activity, can protect cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress (PubMed:11007892, PubMed:22010141). Also protects against amyloid-beta peptide-induced apoptosis (PubMed:11007892).
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Uniprot ID
Primary ID:
Q15392

Secondarily ID:
B7Z817
D3DQ51
Q9HBA8
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Ensembl ID
ENSG00000116133
HGNC ID
HGNC:2859
Subcellular Location
Endoplasmic reticulum membrane
Golgi apparatus membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000018 , HL-60
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0494086
 Compound Info 
(3S,5S,9R,10S,13R,14R,17R)-17-[(2S)-1-hydroxypropan-2-yl]-10,13-dimethyl-2,3,4,5,6,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol
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C22H36O2
  1
1
IC50 = 0.1 nM
 Bioactivity Info 
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CP0252873
 Compound Info 
(4R)-4-[(1S,2R,5S,10S,11S,14R,15R)-5-hydroxy-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-7-en-14-yl]-N,N-dimethylpentanamide
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C26H43NO2
  1
1
IC50 = 0.7 nM
 Bioactivity Info 
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CP0538753
 Compound Info 
(3S,8S,9S,10R,13S,14S,17R)-17-[(2S)-1-hydroxypropan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol
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C22H36O2
  1
1
IC50 = 2.5 nM
 Bioactivity Info 
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CP0538752
 Compound Info 
(3S,5S,9R,10S,13R,14R,17R)-10,13-dimethyl-17-[(E,2R)-4-(1-methylpyridin-1-ium-4-yl)but-3-en-2-yl]-2,3,4,5,6,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol;iodide
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C29H42INO
  1
1
IC50 = 2.9 nM
 Bioactivity Info 
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CP0390331
 Compound Info 
[(3S,5S,9R,10S,13R,14R,17R)-17-[(2S)-1-hydroxypropan-2-yl]-10,13-dimethyl-2,3,4,5,6,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate
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C24H38O3
  1
1
IC50 = 3.3 nM
 Bioactivity Info 
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CP0520003
 Compound Info 
[(3S,5S,9R,10S,13R,14R,17R)-17-[(2S)-1-formyloxypropan-2-yl]-10,13-dimethyl-2,3,4,5,6,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate
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C25H38O4
  1
1
IC50 = 4.2 nM
 Bioactivity Info 
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CP0415322
 Compound Info 
[(2S)-2-[(3S,5S,9R,10S,13R,14R,17R)-3-acetyloxy-10,13-dimethyl-2,3,4,5,6,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]propyl] 2-(dimethylamino)acetate
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C28H45NO4
  1
1
IC50 = 5.5 nM
 Bioactivity Info 
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CP0386783
 Compound Info 
[(2S)-2-[(3S,5S,9R,10S,13R,14R,17R)-3-acetyloxy-10,13-dimethyl-2,3,4,5,6,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]propyl] (E)-but-2-enoate
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C28H42O4
  1
1
IC50 = 6.3 nM
 Bioactivity Info 
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CP0494085
 Compound Info 
[(3S,5S,9R,10S,13R,14R,17R)-17-[(2S)-1-aminopropan-2-yl]-10,13-dimethyl-2,3,4,5,6,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate
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C24H39NO2
  1
1
IC50 = 198 nM
 Bioactivity Info 
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CP0393648
 Compound Info 
[(2S)-2-[(3S,5S,9R,10S,13R,14R,17R)-3-acetyloxy-10,13-dimethyl-2,3,4,5,6,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]propyl] (E)-2-methylbut-2-enoate
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C29H44O4
  1
1
IC50 = 203 nM
 Bioactivity Info 
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CP0520004
 Compound Info 
[(3S,5S,9R,10S,13R,14R,17R)-17-[(2S)-1-(methoxyamino)-1-oxopropan-2-yl]-10,13-dimethyl-2,3,4,5,6,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate
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C25H39NO4
  1
1
IC50 = 805 nM
 Bioactivity Info 
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CP0480900
 Compound Info 
[(3S,5S,9R,10S,13R,14R,17R)-10,13-dimethyl-17-[(2S)-1-(methylamino)-1-oxopropan-2-yl]-2,3,4,5,6,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate
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C25H39NO3
  1
1
IC50 = 823 nM
 Bioactivity Info 
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CP0562675
 Compound Info 
[(3S,5S,9R,10S,13R,14R,17R)-10,13-dimethyl-17-[(2S)-1-(propanoylamino)propan-2-yl]-2,3,4,5,6,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate
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C27H43NO3
  1
1
IC50 = 16900 nM
 Bioactivity Info 
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Clinical Information about the Protein
Target 1 ( Delta(24)-sterol reductase (DHCR24) )
Target Type Literature-reported Target
Disease 1 Target-related Disease  1
1 Obesity [ICD-11: 5B81]
Preclinical Drug(s) 1 Preclinical Drug  1
1 T-226293
 Drug Info 
Preclinical
Obesity