General Information of the Protein
Protein ID
PT04445
Protein Name
Oxoeicosanoid receptor 1
Secondarily
Protein Name
5-oxo-ETE G-protein coupled receptor
G-protein coupled receptor 170
G-protein coupled receptor R527
G-protein coupled receptor TG1019
Gene Name
OXER1
Secondarily
Gene Name
GPR170
TG1019
Sequence
MELHNLSSPSPSLSSSVLPPSFSPSPSSAPSAFTTVGGSSGGPCHPTSSSLVSAFLAPILALEFVLGLVGNSLALFIFCIHTRPWTSNTVFLVSLVAADFLLISNLPLRVDYYLLHETWRFGAAACKVNLFMLSTNRTASVVFLTAIALNRYLKVVQPHHVLSRASVGAAARVAGGLWVGILLLNGHLLLSTFSGPSCLSYRVGTKPSASLRWHQALYLLEFFLPLALILFAIVSIGLTIRNRGLGGQAGPQRAMRVLAMVVAVYTICFLPSIIFGMASMVAFWLSACRSLDLCTQLFHGSLAFTYLNSVLDPVLYCFSSPNFLHQSRALLGLTRGRQGPVSDESSYQPSRQWRYREASRKAEAIGKLKVQGEVSLEKEGSSQG
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Organism
Homo sapiens, Human
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Lipid-like ligand receptor (family A GPCR)
>
Leukotriene receptor
Function
Receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. Seems to be coupled to the G(i)/G(o), families of heteromeric G proteins.
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Uniprot ID
Primary ID:
Q8TDS5

Secondarily ID:
Q86WP7
Q8NGW4
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Ensembl ID
ENSG00000162881
HGNC ID
HGNC:24884
Subcellular Location
Membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000026 , CHO-K1
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0659028
 Compound Info 
(6E,8Z,11Z,14Z)-5-oxoicosa-6,8,11,14-tetraenoic acid
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C20H30O3
  1
1
EC50 = 220 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0556212
 Compound Info 
(6E,8Z,11Z,14Z,17Z)-5-oxoicosa-6,8,11,14,17-pentaenoic acid
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C20H28O3
  1
1
EC50 = 380 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0741469
 Compound Info 
Methyl (6E,8Z,11Z,14Z)-5-oxo-6,8,11,14-eicosatetraenoate
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C21H32O3
  1
1
EC50 = 1540 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0393157
 Compound Info 
methyl (6E,8Z,11Z,14Z,17Z)-5-oxoicosa-6,8,11,14,17-pentaenoate
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C21H30O3
  1
1
EC50 = 2080 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0465041
 Compound Info 
(5E,7Z,10Z,13Z,16Z,19Z)-4-oxodocosa-5,7,10,13,16,19-hexaenoic acid
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C22H30O3
  1
1
EC50 > 100000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0558929
 Compound Info 
methyl (5E,7Z,10Z,13Z,16Z,19Z)-4-oxodocosa-5,7,10,13,16,19-hexaenoate
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C23H32O3
  1
1
EC50 > 100000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Clinical Information about the Protein
Target 1 ( Oxoeicosanoid receptor 1 (OXER1) )
Target Type Literature-reported Target