Protein Information

General Information of the Protein

Protein ID	PT04413
Protein Name	Vitamin K epoxide reductase complex subunit 1
Secondarily Protein Name	Vitamin K1 2,3-epoxide reductase subunit 1
Gene Name	VKORC1
Secondarily Gene Name	VKOR MSTP134 MSTP576 UNQ308/PRO351
Sequence	MGSTWGSPGWVRLALCLTGLVLSLYALHVKAARARDRDYRALCDVGTAISCSRVFSSRWGRGFGLVEHVLGQDSILNQSNSIFGCIFYTLQLLLGCLRTRWASVLMLLSSLVSLAGSVYLAWILFFVLYDFCIVCITTYAINVSLMWLSFRKVQEPQGKAKRH Show/Hide
Organism	Homo sapiens, Human
Protein Classification	Enzyme > Oxidoreductase
Function	Involved in vitamin K metabolism. Catalytic subunit of the vitamin K epoxide reductase (VKOR) complex which reduces inactive vitamin K 2,3-epoxide to active vitamin K. Vitamin K is required for the gamma-carboxylation of various proteins, including clotting factors, and is required for normal blood coagulation, but also for normal bone development. Show/Hide
Uniprot ID	Primary ID: Q9BQB6 Secondarily ID: A6NIQ6 B2R4Z6 Q6UX90 Q7Z2R4 Show/Hide
Ensembl ID	ENSG00000167397
HGNC ID	HGNC:23663
Subcellular Location	Endoplasmic reticulum membrane

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000006 , HEK293

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0944442 Compound Info	rac-4-(cycloocta-1,3,5,7-tetraenyl)-2-hydroxy-2-methyl-3,4-dihydropyrano[3,2-c]chromen-5(2H)-one Show/Hide	C21H18O4	1
1	IC50 = 4.5 nM Bioactivity Info	TI LI LO TS
CP0062501 Compound Info	2-hydroxy-3-(3-oxo-1-phenylbutyl)-4H-chromen-4-one Show/Hide	C19H16O4	1
1	IC50 = 8.8 nM Bioactivity Info	TI LI LO TS
CP0956189 Compound Info	(3'R,6R,8S)-6-(cycloocta-1,3,5,7-tetraenyl)-8-hydroxy-8-methyl-2-phenyl-7,8-dihydrospiro[[1,2,4]triazolo[1,2-a]pyridazine-5,3'-chroman]-1,3,4'(2H,6H)-trione Show/Hide	C29H25N3O5	1
1	IC50 = 58.2 nM Bioactivity Info	TI LI LO TS
CP0468886 Compound Info	3-(1-cyclooctyl-3-oxobutyl)-4-hydroxychromen-2-one Show/Hide	C21H26O4	1
1	IC50 = 59 nM Bioactivity Info	TI LI LO TS
CP0468887 Compound Info	3-(1-cyclohexyl-3-oxobutyl)-4-hydroxychromen-2-one Show/Hide	C19H22O4	1
1	IC50 = 90.2 nM Bioactivity Info	TI LI LO TS
CP0954385 Compound Info	rac-4-(1-(4-hydroxy-2-oxo-2H-chromen-3-yl)-3-oxobutyl)cycloocta-1,3,5,7-tetraenecarboxylic acid Show/Hide	C22H18O6	1
1	IC50 = 1929 nM Bioactivity Info	TI LI LO TS

Clinical Information about the Protein

Target 1 ( Vitamin K epoxide reductase complex 1 (VKORC1) )