General Information of the Protein
Protein ID
PT04304
Protein Name
Acidic mammalian chitinase
Secondarily
Protein Name
YNL
Gene Name
CHIA
Secondarily
Gene Name
Chia1
Sequence
MAKLLLVTGLALLLNAQLGSAYNLICYFTNWAQYRPGLGSFKPDDINPCLCTHLIYAFAGMQNNEITTIEWNDVTLYKAFNDLKNRNSKLKTLLAIGGWNFGTAPFTTMVSTSQNRQTFITSVIKFLRQYGFDGLDLDWEYPGSRGSPPQDKHLFTVLVKEMREAFEQEAIESNRPRLMVTAAVAGGISNIQAGYEIPELSKYLDFIHVMTYDLHGSWEGYTGENSPLYKYPTETGSNAYLNVDYVMNYWKNNGAPAEKLIVGFPEYGHTFILRNPSDNGIGAPTSGDGPAGPYTRQAGFWAYYEICTFLRSGATEVWDASQEVPYAYKANEWLGYDNIKSFSVKAQWLKQNNFGGAMIWAIDLDDFTGSFCDQGKFPLTSTLNKALGISTEGCTAPDVPSEPVTTPPGSGSGGGSSGGSSGGSGFCADKADGLYPVADDRNAFWQCINGITYQQHCQAGLVFDTSCNCCNWP
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Organism
Mus musculus, Mouse
Protein Classification
Enzyme
>
Hydrolase
Function
Degrades chitin and chitotriose. May participate in the defense against nematodes, fungi and other pathogens. Plays a role in T-helper cell type 2 (Th2) immune response. Contributes to the response to IL-13 and inflammation in response to IL-13. Stimulates chemokine production by pulmonary epithelial cells. Protects lung epithelial cells against apoptosis and promotes phosphorylation of AKT1. Its function in the inflammatory response and in protecting cells against apoptosis is inhibited by allosamidin, suggesting that the function of this protein depends on carbohydrate binding. Presence in saliva and gastric juice suggests a function as a digestive enzyme.
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Uniprot ID
Primary ID:
Q91XA9

Secondarily ID:
A0T468
B8K282
Q3TVE7
Q99PH2
Q9D803
Q9JLN1
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Ensembl ID
ENSG00000134216
Subcellular Location
Secreted
Cytoplasm
Cytoplasmic granule
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000026 , CHO-K1
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0839360
 Compound Info 
5-(4-((2S,5S)-5-(4-Chlorobenzyl)-2-isobutylmorpholino)-piperidin-1-yl)-4H-1,2,4-triazol-3-amine
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C22H33ClN6O
  1
1
IC50 = 1 nM
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CP0946120
 Compound Info 
5-(4-((2S,5S)-5-(4-Chlorobenzyl)-2-ethylmorpholino)-piperidin-1-yl)-4H-1,2,4-triazol-3-amine
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C20H29ClN6O
  1
1
IC50 = 1.3 nM
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CP0719096
 Compound Info 
5-(4-((2S,5S)-5-(4-Chlorobenzyl)-2-isopropylmorpholino)-piperidin-1-yl)-4H-1,2,4-triazol-3-amine
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C21H31ClN6O
  1
1
IC50 = 2.1 nM
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CP0719097
 Compound Info 
2-((2R,5S)-4-(1-(5-Amino-4H-1,2,4-triazol-3-yl)piperidin-4-yl)-5-(4-chlorobenzyl)morpholin-2-yl)propan-2-ol
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C21H31ClN6O2
  1
1
IC50 = 5.5 nM
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CP0456481
 Compound Info 
1-(5-amino-1H-1,2,4-triazol-3-yl)-N-[2-(4-chlorophenyl)ethyl]-N-(naphthalen-1-ylmethyl)piperidin-4-amine
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C26H29ClN6
  1
1
IC50 = 6.2 nM
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CP0957936
 Compound Info 
((2R,5S)-4-(1-(5-Amino-4H-1,2,4-triazol-3-yl)piperidin-4-yl)-5-(4-chlorobenzyl)morpholin-2-yl)methanol
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C19H27ClN6O2
  1
1
IC50 = 6.7 nM
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CP0946531
 Compound Info 
5-(4-((2R,5S)-5-(4-Chlorobenzyl)-2-(methoxymethyl)-morpholino)piperidin-1-yl)-4H-1,2,4-triazol-3-amine
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C20H29ClN6O2
  1
1
IC50 = 7.7 nM
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CP0719098
 Compound Info 
5-(4-((2S,5S)-5-(4-Chlorobenzyl)-2-methylmorpholino)-piperidin-1-yl)-4H-1,2,4-triazol-3-amine
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C19H27ClN6O
  2
1
IC50 = 7.8 nM
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2
Ki = 5.7 nM
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CP0956391
 Compound Info 
(2R,5S)-4-(1-(5-Amino-4H-1,2,4-triazol-3-yl)piperidin-4-yl)-5-(4-chlorobenzyl)-N-methylmorpholine-2-carboxamide
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C20H28ClN7O2
  1
1
IC50 = 7.8 nM
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CP0437217
 Compound Info 
1-(5-amino-1H-1,2,4-triazol-3-yl)-N-[2-(4-chlorophenyl)ethyl]-N-(cyclohexylmethyl)piperidin-4-amine
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C22H33ClN6
  1
1
IC50 = 8 nM
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CP0447368
 Compound Info 
1-(5-amino-1H-1,2,4-triazol-3-yl)-N-[2-(4-bromophenyl)ethyl]-N-(2-methylpropyl)piperidin-4-amine
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C19H29BrN6
  1
1
IC50 = 8 nM
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CP0368213
 Compound Info 
1-(5-amino-1H-1,2,4-triazol-3-yl)-N-[2-(4-chlorophenyl)ethyl]-N-[(2-chlorophenyl)methyl]piperidin-4-amine
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C22H26Cl2N6
  1
1
IC50 = 9.7 nM
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CP0409606
 Compound Info 
1-(5-amino-1H-1,2,4-triazol-3-yl)-N-benzyl-N-[2-(4-chlorophenyl)ethyl]piperidin-4-amine
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C22H27ClN6
  1
1
IC50 = 11.2 nM
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CP0390143
 Compound Info 
1-(5-amino-1H-1,2,4-triazol-3-yl)-N-[2-(4-chlorophenyl)ethyl]-N-(oxolan-2-ylmethyl)piperidin-4-amine
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C20H29ClN6O
  1
1
IC50 = 17 nM
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CP0323379
 Compound Info 
1-(5-amino-1H-1,2,4-triazol-3-yl)-N-[2-(4-chlorophenyl)ethyl]-N-(2-methylpropyl)piperidin-4-amine
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C19H29ClN6
  2
1
IC50 = 18.8 nM
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2
Ki = 10.5 nM
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CP0161810
 Compound Info 
2-[[1-(5-amino-1H-1,2,4-triazol-3-yl)piperidin-4-yl]-[2-(4-chlorophenyl)ethyl]amino]-N-methylethanesulfonamide
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C18H28ClN7O2S
  1
1
IC50 = 21 nM
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CP0220464
 Compound Info 
3-[4-[(2S,4R)-2-[(4-chlorophenyl)methyl]-4-methoxypyrrolidin-1-yl]piperidin-1-yl]-1H-1,2,4-triazol-5-amine
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C19H27ClN6O
  1
1
IC50 = 21 nM
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CP0157956
 Compound Info 
N-[2-[[1-(5-amino-1H-1,2,4-triazol-3-yl)piperidin-4-yl]-[2-(4-chlorophenyl)ethyl]amino]ethyl]methanesulfonamide
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C18H28ClN7O2S
  1
1
IC50 = 22 nM
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CP0220471
 Compound Info 
1-(5-amino-1H-1,2,4-triazol-3-yl)-N-[2-(4-chlorophenyl)ethyl]-N-(oxetan-3-yl)piperidin-4-amine
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C18H25ClN6O
  1
1
IC50 = 27 nM
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CP0363328
 Compound Info 
1-(5-amino-1H-1,2,4-triazol-3-yl)-N-[2-(4-chlorophenyl)ethyl]-N-(2-methoxy-2-methylpropyl)piperidin-4-amine
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C20H31ClN6O
  1
1
IC50 = 28 nM
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CP0230989
 Compound Info 
3-[4-[(3S)-3-[(4-chlorophenyl)methyl]morpholin-4-yl]piperidin-1-yl]-1H-1,2,4-triazol-5-amine
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C18H25ClN6O
  1
1
IC50 = 30 nM
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CP0262463
 Compound Info 
N-[2-[[1-(5-amino-1H-1,2,4-triazol-3-yl)piperidin-4-yl]-[2-(4-chlorophenyl)ethyl]amino]ethyl]acetamide
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C19H28ClN7O
  1
1
IC50 = 35 nM
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CP0458641
 Compound Info 
1-(5-amino-1H-1,2,4-triazol-3-yl)-N-[2-(4-bromophenyl)ethyl]-N-ethylpiperidin-4-amine
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C17H25BrN6
  1
1
IC50 = 36 nM
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CP0262465
 Compound Info 
1-(5-amino-1H-1,2,4-triazol-3-yl)-N-[2-(4-chlorophenyl)ethyl]-N-[(2S)-2-methoxypropyl]piperidin-4-amine
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C19H29ClN6O
  1
1
IC50 = 53 nM
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CP0352216
 Compound Info 
1-(5-amino-1H-1,2,4-triazol-3-yl)-N-[2-(4-chlorophenyl)ethyl]-N-(2-methoxyethyl)piperidin-4-amine
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C18H27ClN6O
  1
1
IC50 = 55 nM
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CP0157955
 Compound Info 
1-(5-amino-1H-1,2,4-triazol-3-yl)-N-[2-(4-chlorophenyl)ethyl]-N-(oxan-2-ylmethyl)piperidin-4-amine
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C21H31ClN6O
  1
1
IC50 = 56 nM
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CP0686385
 Compound Info 
(S)-3-(4-(3-(4-chlorobenzyl)-2,3-dihydrobenzo[f][1,4]oxazepin-4(5H)-yl)piperidin-1-yl)-1H-1,2,4-triazol-5-amine
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C23H27ClN6O
  1
1
IC50 = 59 nM
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CP0220465
 Compound Info 
3-[4-[(2S,4S)-2-[(4-chlorophenyl)methyl]-4-methoxypyrrolidin-1-yl]piperidin-1-yl]-1H-1,2,4-triazol-5-amine
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C19H27ClN6O
  1
1
IC50 = 65 nM
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CP0109502
 Compound Info 
(2R)-1-[[1-(5-amino-1H-1,2,4-triazol-3-yl)piperidin-4-yl]-[2-(4-chlorophenyl)ethyl]amino]propan-2-ol
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C18H27ClN6O
  1
1
IC50 = 66 nM
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CP0075840
 Compound Info 
(3R,5S)-1-[1-(5-amino-1H-1,2,4-triazol-3-yl)piperidin-4-yl]-5-[(4-chlorophenyl)methyl]pyrrolidin-3-ol
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C18H25ClN6O
  1
1
IC50 = 68 nM
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CP0075800
 Compound Info 
1-[[1-(5-amino-1H-1,2,4-triazol-3-yl)piperidin-4-yl]-[2-(4-chlorophenyl)ethyl]amino]-2-methylpropan-2-ol
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C19H29ClN6O
  1
1
IC50 = 73 nM
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CP0175801
 Compound Info 
3-[4-[(2R)-2-[(4-chlorophenyl)methyl]piperidin-1-yl]piperidin-1-yl]-1H-1,2,4-triazol-5-amine
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C19H27ClN6
  1
1
IC50 = 81 nM
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CP0417516
 Compound Info 
1-(5-amino-1H-1,2,4-triazol-3-yl)-N-[2-(4-chlorophenyl)ethyl]-N-ethylpiperidin-4-amine
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C17H25ClN6
  1
1
IC50 = 95 nM
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CP0476153
 Compound Info 
1-(5-amino-1H-1,2,4-triazol-3-yl)-N-[2-(4-bromophenyl)ethyl]-N-methylpiperidin-4-amine
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C16H23BrN6
  1
1
IC50 = 108 nM
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CP0238580
 Compound Info 
1-(5-amino-1H-1,2,4-triazol-3-yl)-N-[2-(4-chlorophenyl)ethyl]-N-[(2R)-2-methoxypropyl]piperidin-4-amine
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C19H29ClN6O
  1
1
IC50 = 110 nM
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CP0369392
 Compound Info 
3-[4-[(2R)-2-[(4-chlorophenyl)methyl]pyrrolidin-1-yl]piperidin-1-yl]-1H-1,2,4-triazol-5-amine
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C18H25ClN6
  1
1
IC50 = 120 nM
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CP0220469
 Compound Info 
1-[2-[[1-(5-amino-1H-1,2,4-triazol-3-yl)piperidin-4-yl]-[2-(4-chlorophenyl)ethyl]amino]ethyl]-3-methylurea
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C19H29ClN8O
  1
1
IC50 = 130 nM
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CP0238581
 Compound Info 
2-[[1-(5-amino-1H-1,2,4-triazol-3-yl)piperidin-4-yl]-[2-(4-chlorophenyl)ethyl]amino]ethanol
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C17H25ClN6O
  1
1
IC50 = 135 nM
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CP0220467
 Compound Info 
(3S,5S)-1-[1-(5-amino-1H-1,2,4-triazol-3-yl)piperidin-4-yl]-5-[(4-chlorophenyl)methyl]pyrrolidin-3-ol
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C18H25ClN6O
  1
1
IC50 = 170 nM
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CP0434613
 Compound Info 
(2S)-1-[[1-(5-amino-1H-1,2,4-triazol-3-yl)piperidin-4-yl]-[2-(4-chlorophenyl)ethyl]amino]propan-2-ol
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C18H27ClN6O
  1
1
IC50 = 180 nM
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CP0452090
 Compound Info 
1-(5-amino-1H-1,2,4-triazol-3-yl)-N-[2-(4-chlorophenyl)ethyl]-N-propan-2-ylpiperidin-4-amine
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C18H27ClN6
  1
1
IC50 = 185 nM
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CP0417514
 Compound Info 
1-(5-amino-1H-1,2,4-triazol-3-yl)-N-[2-(4-chlorophenyl)ethyl]-N-methylpiperidin-4-amine
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C16H23ClN6
  1
1
IC50 = 245 nM
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CP0447331
 Compound Info 
1-(5-amino-1H-1,2,4-triazol-3-yl)-N-[2-(2,4-dichlorophenyl)ethyl]-N-methylpiperidin-4-amine
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C16H22Cl2N6
  1
1
IC50 = 333 nM
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CP0220468
 Compound Info 
3-[4-[3-(4-chlorophenyl)piperidin-1-yl]piperidin-1-yl]-1H-1,2,4-triazol-5-amine
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C18H25ClN6
  1
1
IC50 = 335 nM
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CP0220472
 Compound Info 
2-[[1-(5-amino-1H-1,2,4-triazol-3-yl)piperidin-4-yl]-[2-(4-chlorophenyl)ethyl]amino]acetic acid
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C17H23ClN6O2
  1
1
IC50 = 395 nM
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CP0365402
 Compound Info 
3-[4-[(2S,3S)-2-[(4-chlorophenyl)methyl]-3-methoxyazetidin-1-yl]piperidin-1-yl]-1H-1,2,4-triazol-5-amine
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C18H25ClN6O
  1
1
IC50 = 485 nM
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CP0417517
 Compound Info 
1-(5-amino-1H-1,2,4-triazol-3-yl)-N-methyl-N-[2-(4-methylphenyl)ethyl]piperidin-4-amine
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C17H26N6
  1
1
IC50 = 544 nM
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CP0458649
 Compound Info 
N-[1-(5-amino-1H-1,2,4-triazol-3-yl)piperidin-4-yl]-1-(4-bromophenyl)methanesulfonamide
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C14H19BrN6O2S
  1
1
IC50 = 573 nM
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CP0957172
 Compound Info 
(S)-4-(1-(5-Amino-4H-1,2,4-triazol-3-yl)piperidin-4-yl)-5-(4-chlorobenzyl)piperazin-2-one
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C18H24ClN7O
  1
1
IC50 = 660 nM
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CP0719095
 Compound Info 
5-(4-((2R,5S)-5-(4-Chlorobenzyl)-2-methylmorpholino)-piperidin-1-yl)-4H-1,2,4-triazol-3-amine
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C19H27ClN6O
  1
1
IC50 = 1000 nM
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CP0352217
 Compound Info 
2-[[1-(5-amino-1H-1,2,4-triazol-3-yl)piperidin-4-yl]-[2-(4-chlorophenyl)ethyl]amino]-N-methylacetamide
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C18H26ClN7O
  1
1
IC50 = 1150 nM
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CP0447329
 Compound Info 
1-(5-amino-1H-1,2,4-triazol-3-yl)-N-methyl-N-[2-(4-propan-2-ylphenyl)ethyl]piperidin-4-amine
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C19H30N6
  1
1
IC50 = 1288 nM
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CP0478236
 Compound Info 
1-[4-(5-amino-1H-1,2,4-triazol-3-yl)piperazin-1-yl]-2-(4-bromophenoxy)ethanone
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C14H17BrN6O2
  1
1
IC50 = 1355 nM
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CP0437222
 Compound Info 
1-(5-amino-1H-1,2,4-triazol-3-yl)-N-[2-(4-ethylphenyl)ethyl]-N-methylpiperidin-4-amine
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C18H28N6
  1
1
IC50 = 1430 nM
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CP0437223
 Compound Info 
1-(5-amino-1H-1,2,4-triazol-3-yl)-N-[2-(4-cyclopropylphenyl)ethyl]-N-methylpiperidin-4-amine
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C19H28N6
  1
1
IC50 = 1735 nM
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CP0041008
 Compound Info 
3-[4-[2-(4-bromophenoxy)ethyl]piperazin-1-yl]-1H-1,2,4-triazol-5-amine
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C14H19BrN6O
  1
1
IC50 = 2095 nM
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CP0157970
 Compound Info 
3-[4-[3-(4-chlorophenyl)pyrrolidin-1-yl]piperidin-1-yl]-1H-1,2,4-triazol-5-amine
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C17H23ClN6
  1
1
IC50 = 2600 nM
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CP0955868
 Compound Info 
(S)-4-(1-(5-Amino-4H-1,2,4-triazol-3-yl)piperidin-4-yl)-3-(4-chlorobenzyl)thiomorpholine-1,1-Dioxide
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C18H25ClN6O2S
  1
1
IC50 = 3000 nM
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CP0370214
 Compound Info 
3-[4-[(2S,5S)-2-[(4-chlorophenyl)methyl]-5-methyl-4-(2-methylpropyl)piperazin-1-yl]piperidin-1-yl]-1H-1,2,4-triazol-5-amine
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C23H36ClN7
  1
1
IC50 = 4170 nM
 Bioactivity Info 
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CP0437221
 Compound Info 
1-(5-amino-1H-1,2,4-triazol-3-yl)-N-[2-(4-tert-butylphenyl)ethyl]-N-methylpiperidin-4-amine
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C20H32N6
  1
1
IC50 = 7330 nM
 Bioactivity Info 
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CP0311092
 Compound Info 
3-[4-[(2S)-2-[(4-chlorophenyl)methyl]-4-methylpiperazin-1-yl]piperidin-1-yl]-1H-1,2,4-triazol-5-amine
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C19H28ClN7
  1
1
IC50 = 7600 nM
 Bioactivity Info 
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CP0882792
 Compound Info 
(S)-4-(1-(5-Amino-4H-1,2,4-triazol-3-yl)piperidin-4-yl)-3-(4-chlorobenzyl)piperazin-2-one
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C18H24ClN7O
  1
1
IC50 = 22000 nM
 Bioactivity Info 
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CP0478235
 Compound Info 
1-(5-amino-1H-1,2,4-triazol-3-yl)-N-methyl-N-(2-phenylethyl)piperidin-4-amine
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C16H24N6
  1
1
IC50 = 24400 nM
 Bioactivity Info 
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CP0417510
 Compound Info 
N-[[1-(5-amino-1H-1,2,4-triazol-3-yl)piperidin-4-yl]methyl]-4-bromobenzamide
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C15H19BrN6O
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0417513
 Compound Info 
N-[1-(5-amino-1H-1,2,4-triazol-3-yl)piperidin-4-yl]-1-(4-bromophenyl)-N-methylmethanesulfonamide
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C15H21BrN6O2S
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0437218
 Compound Info 
1-(5-amino-1H-1,2,4-triazol-3-yl)-N-[(4-bromophenyl)methyl]piperidine-4-carboxamide
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C15H19BrN6O
  1
1
IC50 > 100000 nM
 Bioactivity Info 
   TI
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CP0437220
 Compound Info 
1-[1-(5-amino-1H-1,2,4-triazol-3-yl)piperidin-4-yl]-3-(4-bromophenyl)urea
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C14H18BrN7O
  1
1
IC50 > 100000 nM
 Bioactivity Info 
   TI
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CP0447367
 Compound Info 
N-[1-(5-amino-1H-1,2,4-triazol-3-yl)piperidin-4-yl]-2-(4-bromophenyl)acetamide
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C15H19BrN6O
  1
1
IC50 > 100000 nM
 Bioactivity Info 
   TI
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CP0458642
 Compound Info 
3-[4-[[(4-bromophenyl)methyl-methylamino]methyl]piperidin-1-yl]-1H-1,2,4-triazol-5-amine
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C16H23BrN6
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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   TS
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0370214
 Compound Info 
3-[4-[(2S,5S)-2-[(4-chlorophenyl)methyl]-5-methyl-4-(2-methylpropyl)piperazin-1-yl]piperidin-1-yl]-1H-1,2,4-triazol-5-amine
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C23H36ClN7
  1
1 IC50 = 4170 nM
CP0311092
 Compound Info 
3-[4-[(2S)-2-[(4-chlorophenyl)methyl]-4-methylpiperazin-1-yl]piperidin-1-yl]-1H-1,2,4-triazol-5-amine
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C19H28ClN7
  1
1 IC50 = 7600 nM