General Information of the Protein
Protein ID
PT04268
Protein Name
Ubiquitin-like modifier-activating enzyme ATG7
Secondarily
Protein Name
ATG12-activating enzyme E1 ATG7
Autophagy-related protein 7
Ubiquitin-activating enzyme E1-like protein
Gene Name
ATG7
Secondarily
Gene Name
APG7L
Sequence
MAAATGDPGLSKLQFAPFSSALDVGFWHELTQKKLNEYRLDEAPKDIKGYYYNGDSAGLPARLTLEFSAFDMSAPTPARCCPAIGTLYNTNTLESFKTADKKLLLEQAANEIWESIKSGTALENPVLLNKFLLLTFADLKKYHFYYWFCYPALCLPESLPLIQGPVGLDQRFSLKQIEALECAYDNLCQTEGVTALPYFLIKYDENMVLVSLLKHYSDFFQGQRTKITIGVYDPCNLAQYPGWPLRNFLVLAAHRWSSSFQSVEVVCFRDRTMQGARDVAHSIIFEVKLPEMAFSPDCPKAVGWEKNQKGGMGPRMVNLSECMDPKRLAESSVDLNLKLMCWRLVPTLDLDKVVSVKCLLLGAGTLGCNVARTLMGWGVRHITFVDNAKISYSNPVRQPLYEFEDCLGGGKPKALAAADRLQKIFPGVNARGFNMSIPMPGHPVNFSSVTLEQARRDVEQLEQLIESHDVVFLLMDTRESRWLPAVIAASKRKLVINAALGFDTFVVMRHGLKKPKQQGAGDLCPNHPVASADLLGSSLFANIPGYKLGCYFCNDVVAPGDSTRDRTLDQQCTVSRPGLAVIAGALAVELMVSVLQHPEGGYAIASSSDDRMNEPPTSLGLVPHQIRGFLSRFDNVLPVSLAFDKCTACSSKVLDQYEREGFNFLAKVFNSSHSFLEDLTGLTLLHQETQAAEIWDMSDDETI
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
Function
E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Facilitates LC3-I lipidation with phosphatidylethanolamine to form LC3-II which is found on autophagosomal membranes (PubMed:34161705). Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress. Also plays a key role in the maintenance of axonal homeostasis, the prevention of axonal degeneration, the maintenance of hematopoietic stem cells, the formation of Paneth cell granules, as well as in adipose differentiation. Plays a role in regulating the liver clock and glucose metabolism by mediating the autophagic degradation of CRY1 (clock repressor) in a time-dependent manner (By similarity).
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Uniprot ID
Primary ID:
O95352

Secondarily ID:
B4E170
E9PB95
Q7L8L0
Q9BWP2
Q9UFH4
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Ensembl ID
ENSG00000197548
HGNC ID
HGNC:16935
Subcellular Location
Cytoplasm
Preautophagosomal structure
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000006 , HEK293
Compound ID Compound Name Compound Formula
CP0126502
US10865208, Compound I-115
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C11H15FN6O5S2
 1
1
IC50 = 47 nM
   TI
   LI
   LO
   TS
CP0571688
US10865208, Compound I-141
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C17H19FN6O5S2
 2
1
IC50 = 51 nM
   TI
   LI
   LO
   TS
2
IC50 = 140 nM
   TI
   LI
   LO
   TS
CP0126501
US10865208, Compound I-106
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C16H16ClFN6O5S2
 2
1
IC50 = 56 nM
   TI
   LI
   LO
   TS
2
IC50 = 198 nM
   TI
   LI
   LO
   TS
CP0126513
US10865208, Compound I-139
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C13H19FN6O5S2
 2
1
IC50 = 56 nM
   TI
   LI
   LO
   TS
2
IC50 = 199 nM
   TI
   LI
   LO
   TS
CP0142433
US10865208, Compound I-42
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C11H16N6O6S2
 2
1
IC50 = 83 nM
   TI
   LI
   LO
   TS
2
IC50 = 431 nM
   TI
   LI
   LO
   TS
CP0343953
US10865208, Compound I-200
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C11H16N6O5S2
 2
1
IC50 = 86 nM
   TI
   LI
   LO
   TS
2
IC50 = 280 nM
   TI
   LI
   LO
   TS
CP0422146
US10865208, Compound I-181
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C13H20N6O5S2
 2
1
IC50 = 150 nM
   TI
   LI
   LO
   TS
2
IC50 = 438 nM
   TI
   LI
   LO
   TS
CP0136720
US10865208, Compound I-51
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C12H18N6O6S2
 1
1
IC50 = 160 nM
   TI
   LI
   LO
   TS
CP0343947
US10865208, Compound I-27
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C11H14F2N6O7S
 2
1
IC50 = 162 nM
   TI
   LI
   LO
   TS
2
IC50 = 479 nM
   TI
   LI
   LO
   TS
CP0571799
US10865208, Compound I-69
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C17H20N6O6S2
 1
1
IC50 = 178 nM
   TI
   LI
   LO
   TS
CP0232840
US10865208, Compound I-82
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C16H18N6O6S2
 1
1
IC50 = 201 nM
   TI
   LI
   LO
   TS
CP0098630
US10865208, Compound I-58
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C13H20N6O6S2
 2
1
IC50 = 284 nM
   TI
   LI
   LO
   TS
2
IC50 = 1250 nM
   TI
   LI
   LO
   TS
CP0098617
US10865208, Compound I-219
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C11H16N6O5S2
 1
1
IC50 = 295 nM
   TI
   LI
   LO
   TS
CP0219491
US10865208, Compound I-105
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C11H15FN6O6S
 1
1
IC50 = 317 nM
   TI
   LI
   LO
   TS
CP0098628
US10865208, Compound I-52
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C17H20N6O6S2
 2
1
IC50 = 322 nM
   TI
   LI
   LO
   TS
2
IC50 = 604 nM
   TI
   LI
   LO
   TS
CP0301792
US10865208, Compound I-1
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C11H16N6O7S
 1
1
IC50 = 335 nM
   TI
   LI
   LO
   TS
CP0126531
US10865208, Compound I-172
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C12H18N6O5S2
 1
1
IC50 = 367 nM
   TI
   LI
   LO
   TS
CP0422145
US10865208, Compound I-205
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C17H20N6O5S2
 1
1
IC50 = 422 nM
   TI
   LI
   LO
   TS
CP0126518
US10865208, Compound I-99
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C11H13F3N6O6S
 1
1
IC50 = 453 nM
   TI
   LI
   LO
   TS
CP0115955
US10865208, Compound I-220
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C13H20N6O5S2
 1
1
IC50 = 468 nM
   TI
   LI
   LO
   TS
CP0239911
US10865208, Compound I-179
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C16H17ClN6O5S2
 1
1
IC50 = 499 nM
   TI
   LI
   LO
   TS
CP0343931
US10865208, Compound I-195
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C11H14F2N6O6S
 1
1
IC50 = 545 nM
   TI
   LI
   LO
   TS
CP0232854
US10865208, Compound I-95
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C13H20N6O6S2
 1
1
IC50 = 882 nM
   TI
   LI
   LO
   TS
CP0098595
US10865208, Compound I-76
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C17H20N6O7S
 1
1
IC50 = 1280 nM
   TI
   LI
   LO
   TS
CP0126503
US10865208, Compound I-94
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C11H16N6O6S2
 1
1
IC50 = 1280 nM
   TI
   LI
   LO
   TS
CP0678838
{(2R,3S,4R,5R)-5-[4-amino-3-(1H-pyrazol-4-ylsulfanyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-3,4-dihydroxytetrahydrofuran-2-yl}methyl sulfamate
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C13H16N8O6S2
 1
1
IC50 = 1280 nM
   TI
   LI
   LO
   TS
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0142433
US10865208, Compound I-42
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C11H16N6O6S2
 2
1 IC50 = 14 nM
2 IC50 < 20 nM
CP0678838
{(2R,3S,4R,5R)-5-[4-amino-3-(1H-pyrazol-4-ylsulfanyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-3,4-dihydroxytetrahydrofuran-2-yl}methyl sulfamate
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C13H16N8O6S2
 2
1 IC50 = 16 nM
2 IC50 < 20 nM
CP0098630
US10865208, Compound I-58
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C13H20N6O6S2
 2
1 IC50 = 17 nM
2 IC50 < 20 nM
CP0571799
US10865208, Compound I-69
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C17H20N6O6S2
 2
1 IC50 = 18 nM
2 IC50 < 20 nM
CP0098628
US10865208, Compound I-52
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C17H20N6O6S2
 2
1 IC50 = 20 nM
2 IC50 = 23 nM
CP0126501
US10865208, Compound I-106
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C16H16ClFN6O5S2
 2
1 IC50 = 20 nM
2 IC50 = 31 nM
CP0126502
US10865208, Compound I-115
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C11H15FN6O5S2
 2
1 IC50 = 20 nM
2 IC50 = 41 nM
CP0126513
US10865208, Compound I-139
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C13H19FN6O5S2
 1
1 IC50 = 20 nM
CP0126518
US10865208, Compound I-99
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C11H13F3N6O6S
 2
1 IC50 = 20 nM
2 IC50 = 43 nM
CP0136720
US10865208, Compound I-51
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C12H18N6O6S2
 2
1 IC50 = 20 nM
2 IC50 = 22 nM
CP0232840
US10865208, Compound I-82
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C16H18N6O6S2
 2
1 IC50 = 20 nM
2 IC50 = 29 nM
CP0343947
US10865208, Compound I-27
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C11H14F2N6O7S
 2
1 IC50 = 20 nM
2 IC50 = 29 nM
CP0343953
US10865208, Compound I-200
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C11H16N6O5S2
 2
1 IC50 = 20 nM
2 IC50 = 48 nM
CP0422146
US10865208, Compound I-181
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C13H20N6O5S2
 2
1 IC50 = 20 nM
2 IC50 = 27 nM
CP0571688
US10865208, Compound I-141
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C17H19FN6O5S2
 2
1 IC50 = 20 nM
2 IC50 = 35 nM
CP0115955
US10865208, Compound I-220
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C13H20N6O5S2
 2
1 IC50 = 50 nM
2 IC50 = 57 nM
CP0126531
US10865208, Compound I-172
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C12H18N6O5S2
 2
1 IC50 = 50 nM
2 IC50 = 52 nM
CP0301792
US10865208, Compound I-1
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C11H16N6O7S
 2
1 IC50 = 50 nM
2 IC50 = 89 nM
CP0343931
US10865208, Compound I-195
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C11H14F2N6O6S
 2
1 IC50 = 50 nM
2 IC50 = 100 nM
CP0422145
US10865208, Compound I-205
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C17H20N6O5S2
 2
1 IC50 = 50 nM
2 IC50 = 95 nM
CP0098595
US10865208, Compound I-76
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C17H20N6O7S
 2
1 IC50 = 100 nM
2 IC50 = 264 nM
CP0098617
US10865208, Compound I-219
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C11H16N6O5S2
 2
1 IC50 = 100 nM
2 IC50 = 124 nM
CP0126503
US10865208, Compound I-94
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C11H16N6O6S2
 2
1 IC50 = 100 nM
2 IC50 = 325 nM
CP0219491
US10865208, Compound I-105
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C11H15FN6O6S
 2
1 IC50 = 100 nM
2 IC50 = 177 nM
CP0232854
US10865208, Compound I-95
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C13H20N6O6S2
 2
1 IC50 = 100 nM
2 IC50 = 129 nM
CP0239911
US10865208, Compound I-179
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C16H17ClN6O5S2
 2
1 IC50 = 100 nM
2 IC50 = 104 nM
CP0013833
MLN-4924
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C21H25N5O4S
 1
1 IC50 > 1000 nM
Clinical Information about the Protein
Target 1 ( Autophagy-related protein 7 (ATG7) )
Target Type Literature-reported Target