General Information of the Protein
Protein ID
PT04206
Protein Name
DNA (cytosine-5)-methyltransferase 3B
Secondarily
Protein Name
DNA methyltransferase HsaIIIB
Gene Name
DNMT3B
Sequence
MKGDTRHLNGEEDAGGREDSILVNGACSDQSSDSPPILEAIRTPEIRGRRSSSRLSKREVSSLLSYTQDLTGDGDGEDGDGSDTPVMPKLFRETRTRSESPAVRTRNNNSVSSRERHRPSPRSTRGRQGRNHVDESPVEFPATRSLRRRATASAGTPWPSPPSSYLTIDLTDDTEDTHGTPQSSSTPYARLAQDSQQGGMESPQVEADSGDGDSSEYQDGKEFGIGDLVWGKIKGFSWWPAMVVSWKATSKRQAMSGMRWVQWFGDGKFSEVSADKLVALGLFSQHFNLATFNKLVSYRKAMYHALEKARVRAGKTFPSSPGDSLEDQLKPMLEWAHGGFKPTGIEGLKPNNTQPVVNKSKVRRAGSRKLESRKYENKTRRRTADDSATSDYCPAPKRLKTNCYNNGKDRGDEDQSREQMASDVANNKSSLEDGCLSCGRKNPVSFHPLFEGGLCQTCRDRFLELFYMYDDDGYQSYCTVCCEGRELLLCSNTSCCRCFCVECLEVLVGTGTAAEAKLQEPWSCYMCLPQRCHGVLRRRKDWNVRLQAFFTSDTGLEYEAPKLYPAIPAARRRPIRVLSLFDGIATGYLVLKELGIKVGKYVASEVCEESIAVGTVKHEGNIKYVNDVRNITKKNIEEWGPFDLVIGGSPCNDLSNVNPARKGLYEGTGRLFFEFYHLLNYSRPKEGDDRPFFWMFENVVAMKVGDKRDISRFLECNPVMIDAIKVSAAHRARYFWGNLPGMNRPVIASKNDKLELQDCLEYNRIAKLKKVQTITTKSNSIKQGKNQLFPVVMNGKEDVLWCTELERIFGFPVHYTDVSNMGRGARQKLLGRSWSVPVIRHLFAPLKDYFACE
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Organism
Homo sapiens, Human
Protein Classification
Epigenetic regulator
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Writer
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DNA methyltransferase
Function
Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing (By similarity). In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Isoforms 4 and 5 are probably not functional due to the deletion of two conserved methyltransferase motifs. Functions as a transcriptional corepressor by associating with ZHX1. Required for DUX4 silencing in somatic cells (PubMed:27153398).
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Uniprot ID
Primary ID:
Q9UBC3

Secondarily ID:
A2A2E2
B4DSM8
B4DSU1
E1P5M6
E1P5M7
E7EN63
E9PBF2
Q9UBD4
Q9UJQ5
Q9UKA6
Q9UNE5
Q9Y5R9
Q9Y5S0
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Ensembl ID
ENSG00000088305
HGNC ID
HGNC:2979
Subcellular Location
Nucleus
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000023 , BTI-Tn-5B1-4
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0011023
 Compound Info 
AdoHcy
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C14H20N6O5S
  1
1
IC50 = 300 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0429609
 Compound Info 
(2S)-2-amino-4-[[(2S,3S,4R,5R)-5-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxyoxolan-2-yl]methylsulfanyl]butanoic acid
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C15H21N5O5S
  1
1
IC50 = 300 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0281849
 Compound Info 
(2-amino-4-(((2S,3S,4R,5R)-5-(6-(2-(biphenyl-4-yl)ethylamino)-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methylthio)butanoic acid)
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C28H32N6O5S
  1
1
IC50 = 600 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0498808
 Compound Info 
2-amino-4-(((2S,3S,4R,5R)-3,4-dihydroxy-5-(6-(3-phenylpropylamino)-9H-purin-9-yl)-tetrahydrofuran-2-yl)methylthio)butanoic acid
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C23H30N6O5S
  1
1
IC50 = 600 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0475851
 Compound Info 
4-(((2S,3S,4R,5R)-5-(6-(3,5-dimethoxybenzylamino)-9H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl)methylthio)-2-aminobutanoic acid
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C23H30N6O7S
  1
1
IC50 = 900 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0397034
 Compound Info 
2-amino-4-(((2S,3S,4R,5R)-5-(6-(benzylamino)-9H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl)methylthio)butanoic acid
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C21H26N6O5S
  1
1
IC50 = 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0429610
 Compound Info 
2-amino-4-(((2S,3S,4R,5R)-5-(6-amino-2-methyl-9H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl)methylthio)butanoic acid
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C15H22N6O5S
  1
1
IC50 = 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0429615
 Compound Info 
2-amino-4-(((2S,3S,4R,5R)-3,4-dihydroxy-5-(6-(phenylamino)-9H-purin-9-yl)-tetrahydrofuran-2-yl)methylthio)butanoic acid
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C20H24N6O5S
  1
1
IC50 = 2000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0457502
 Compound Info 
2-amino-4-(((2S,3S,4R,5R)-3,4-dihydroxy-5-(6-(phenethylamino)-9H-purin-9-yl)-tetrahydrofuran-2-yl)methylthio)butanoic acid
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C22H28N6O5S
  1
1
IC50 = 2000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0429613
 Compound Info 
2-amino-4-(((2S,3S,4R,5R)-5-(7-amino-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl)methylthio)butanoic acid
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C13H19N7O5S
  1
1
IC50 = 3000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0455272
 Compound Info 
2-amino-4-(((2S,3S,4R,5R)-3,4-dihydroxy-5-(6-(pyridin-4-ylmethylamino)-9H-purin-9-yl)-tetrahydrofuran-2-yl)methylthio)butanoic acid
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C20H25N7O5S
  1
1
IC50 = 3600 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0338078
 Compound Info 
2-amino-4-(((2S,3S,4R,5R)-5-(6-amino-2-fluoro-9H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl)methylthio)butanoic acid
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C14H19FN6O5S
  1
1
IC50 = 6800 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0457501
 Compound Info 
2-amino-4-(((2S,3S,4R,5R)-5-(4-amino-1H-imidazo[4,5-c]pyridin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl)methylthio)butanoic acid
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C15H21N5O5S
  1
1
IC50 = 6800 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0429611
 Compound Info 
(2S)-2-amino-4-[[(2S,3S,4R,5R)-3,4-dihydroxy-5-purin-9-yloxolan-2-yl]methylsulfanyl]butanoic acid
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C14H19N5O5S
  1
1
IC50 = 28000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0455274
 Compound Info 
2-Amino-4-{(2S,3S,4R,5R)-5-[6-(2-biphenyl-4-yl-ethylamino)-2-chloro-purin-9-yl]-3,4-dihydroxy-tetrahydro-furan-2-ylmethylsulfanyl}-butyric acid
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C28H31ClN6O5S
  1
1
IC50 = 29000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0492257
 Compound Info 
2-amino-4-(((2S,3S,4R,5R)-5-(7-amino-3H-imidazo[4,5-b]pyridin-3-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl)methylthio)butanoic acid
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C15H21N5O5S
  1
1
IC50 = 45000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0302399
 Compound Info 
2-amino-4-(((2S,3S,4R,5R)-5-(6-amino-2-chloro-9H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl)methylthio)butanoic acid
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C14H19ClN6O5S
  1
1
IC50 = 57200 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0011023
 Compound Info 
AdoHcy
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C14H20N6O5S
  1
1 IC50 = 200 nM
CP0395509
 Compound Info 
CHEBI:48202
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C16H14O6
  1
1 IC50 = 500 nM
CP0281849
 Compound Info 
(2-amino-4-(((2S,3S,4R,5R)-5-(6-(2-(biphenyl-4-yl)ethylamino)-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methylthio)butanoic acid)
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C28H32N6O5S
  1
1 IC50 = 600 nM
Clinical Information about the Protein
Target 1 ( DNA [cytosine-5]-methyltransferase 3B (DNMT3B) )
Target Type Clinical trial Target
Disease 1 Target-related Disease  1
1 Solid tumour/cancer [ICD-11: 2A00-2F9Z]
Clinical Trial Drug(s) 1 Clinical Trial Drug  1
1 Curcumin
 Drug Info 
Phase 3
Solid tumour/cancer