General Information of the Protein
Protein ID
PT04197
Protein Name
Ornithine decarboxylase
Gene Name
ODC1
Sequence
MNNFGNEEFDCHFLDEGFTAKDILDQKINEVSSSDDKDAFYVADLGDILKKHLRWLKALPRVTPFYAVKCNDSKAIVKTLAATGTGFDCASKTEIQLVQSLGVPPERIIYANPCKQVSQIKYAANNGVQMMTFDSEVELMKVARAHPKAKLVLRIATDDSKAVCRLSVKFGATLRTSRLLLERAKELNIDVVGVSFHVGSGCTDPETFVQAISDARCVFDMGAEVGFSMYLLDIGGGFPGSEDVKLKFEEITGVINPALDKYFPSDSGVRIIAEPGRYYVASAFTLAVNIIAKKIVLKEQTGSDDEDESSEQTFMYYVNDGVYGSFNCILYDHAHVKPLLQKRPKPDEKYYSSSIWGPTCDGLDRIVERCDLPEMHVGDWMLFENMGAYTVAAASTFNGFQRPTIYYVMSGPAWQLMQQFQNPDFPPEVEEQDASTLPVSCAWESGMKRHRAACASASINV
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
>
Lyase
Function
Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.
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Uniprot ID
Primary ID:
P11926

Secondarily ID:
Q53TU3
Q6LDS9
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Ensembl ID
ENSG00000115758
HGNC ID
HGNC:8109
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000083 , MCF-7
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0462629
 Compound Info 
(2S)-6-(gamma,gamma-dimethylallyl)-5,4'-dihydroxy-3'-methoxy-6'',6''-dimethylpyran[2'',3'':7,8]flavanone
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C26H28O6
  1
1
IC50 = 1100 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0493772
 Compound Info 
(2S)-6-(gamma,gamma-dimethylallyl)-5-3'-dihydroxy-4'-methoxy-6'',6''dimethylpyran[2'',3''7,8]flavanone
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C26H28O6
  1
1
IC50 = 2100 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0508030
 Compound Info 
(2S)-6-(gamma,gamma-dimethylallyl)-5-hydroxy-3',4'-dimethoxy-6'',6''-dimethylpyran[2'',3'':7,8]flavanone
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C27H30O6
  1
1
IC50 = 2200 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0493667
 Compound Info 
(2S)-6-(gamma,gamma-dimethylallyl)-3',4'-dimethoxy-6'',6''-dimethylpyran[2'',3'':7,8]flavanone
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C27H30O5
  1
1
IC50 = 2300 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0422862
 Compound Info 
8,8-dimethyl-3-(2,4,5-trimethoxyphenyl)-2,3-dihydropyrano[2,3-f]chromen-4-one
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C23H24O6
  1
1
IC50 = 2600 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0493773
 Compound Info 
3-methoxy-4-hydroxylonchocarpin
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C21H20O5
  1
1
IC50 = 3600 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0437921
 Compound Info 
3,4,5-trimethoxy-6'',6''-dimethylpyran[2'',3'':3',4']stilbene
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C22H24O4
  1
1
IC50 = 3900 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0082336
 Compound Info 
(E)-1-(5-hydroxy-2,2-dimethyl-2H-chromen-6-yl)-3-(4-hydroxyphenyl)prop-2-en-1-one
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C20H18O4
  1
1
IC50 = 4700 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0498664
 Compound Info 
4-hydroxy-5'-methoxy-6'',6''-dimethyl-pyran[2'',3'',3',4']stilbene
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C20H20O3
  1
1
IC50 = 5200 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0514714
 Compound Info 
3,5'-dimethoxy-4-hydroxy-6'',6''-dimethylpyran[2'',3'':3',4']stilbene
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C21H22O4
  1
1
IC50 = 7400 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0041805
 Compound Info 
(E)-resveratrol
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C14H12O3
  1
1
IC50 = 19000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0012708
 Compound Info 
5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one
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C15H10O5
  1
1
IC50 = 26000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0473732
 Compound Info 
(9S,10S)-9,10-dihydroxy-8,8-dimethyl-3-(2,4,5-trimethoxyphenyl)-2,3,9,10-tetrahydropyrano[2,3-f]chromen-4-one
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C23H26O8
  1
1
IC50 > 30000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Clinical Information about the Protein
Target 1 ( Ornithine decarboxylase (ODC1) )
Target Type Successful Target
Disease 2 Target-related Diseases  2
1 African trypanosomiasis [ICD-11: 1F51]
2 Burn and burn infection [ICD-11: ND90-NE2Z]
Approved Drug(s) 1 Approved Drug  1
1 Eflornithine
 Drug Info 
Approved
African trypanosomiasis
Discontinued Drug(s) 1 Discontinued Drug  1
1 Putrescine
 Drug Info 
Discontinued in Phase 2
Burn and burn infection