General Information of the Protein
| Protein ID |
PT04053
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| Protein Name |
Protein mono-ADP-ribosyltransferase PARP11
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| Secondarily Protein Name |
ADP-ribosyltransferase diphtheria toxin-like 11
Poly [ADP-ribose] polymerase 11
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| Gene Name |
PARP11
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| Secondarily Gene Name |
C12orf6
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| Sequence |
MWEANPEMFHKAEELFSKTTNNEVDDMDTSDTQWGWFYLAECGKWHMFQPDTNSQCSVSSEDIEKSFKTNPCGSISFTTSKFSYKIDFAEMKQMNLTTGKQRLIKRAPFSISAFSYICENEAIPMPPHWENVNTQVPYQLIPLHNQTHEYNEVANLFGKTMDRNRIKRIQRIQNLDLWEFFCRKKAQLKKKRGVPQINEQMLFHGTSSEFVEAICIHNFDWRINGIHGAVFGKGTYFARDAAYSSRFCKDDIKHGNTFQIHGVSLQQRHLFRTYKSMFLARVLIGDYINGDSKYMRPPSKDGSYVNLYDSCVDDTWNPKIFVVFDANQIYPEYLIDFH
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| Organism |
Homo sapiens, Human
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| Protein Classification |
Enzyme
>
Transferase
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| Function |
Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins (PubMed:25043379, PubMed:25673562). Plays a role in nuclear envelope stability and nuclear remodeling during spermiogenesis (By similarity).
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| Uniprot ID |
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| Ensembl ID | |||||
| HGNC ID | |||||
| Subcellular Location |
Nucleus
Nuclear pore complex
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Map of Molecular Bioactivity Related to the Protein
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Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity |
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Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000013 , Sf9
| Compound ID | Compound Name | Compound Formula | |
| CP0346125 |
6,8-difluoro-2-[4-(2-hydroxypropan-2-yl)phenyl]-3H-quinazolin-4-one
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C17H14F2N2O2
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1 |
| 1 |
IC50 > 10000 nM
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TI
LI
LO
TS
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Biochemical Assays
| Compound ID | Compound Name | Compound Formula | |
| CP0544630 |
8-methyl-7-prop-1-ynyl-2-(pyrimidin-2-ylsulfanylmethyl)-3H-quinazolin-4-one
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C17H14N4OS
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1 |
| 1 | IC50 = 14 nM | ||
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