General Information of the Protein
Protein ID
PT04001
Protein Name
Integrin-linked protein kinase
Secondarily
Protein Name
59 kDa serine/threonine-protein kinase
Beta-integrin-linked kinase
ILK-1
ILK-2
p59ILK
Gene Name
ILK
Secondarily
Gene Name
ILK1
ILK2
Sequence
MDDIFTQCREGNAVAVRLWLDNTENDLNQGDDHGFSPLHWACREGRSAVVEMLIMRGARINVMNRGDDTPLHLAASHGHRDIVQKLLQYKADINAVNEHGNVPLHYACFWGQDQVAEDLVANGALVSICNKYGEMPVDKAKAPLRELLRERAEKMGQNLNRIPYKDTFWKGTTRTRPRNGTLNKHSGIDFKQLNFLTKLNENHSGELWKGRWQGNDIVVKVLKVRDWSTRKSRDFNEECPRLRIFSHPNVLPVLGACQSPPAPHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMARGMAFLHTLEPLIPRHALNSRSVMIDEDMTARISMADVKFSFQCPGRMYAPAWVAPEALQKKPEDTNRRSADMWSFAVLLWELVTREVPFADLSNMEIGMKVALEGLRPTIPPGISPHVCKLMKICMNEDPAKRPKFDMIVPILEKMQDK
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TKL protein kinase group
>
TKL protein kinase MLK family
>
TKL protein kinase ILK subfamily
Function
Receptor-proximal protein kinase regulating integrin-mediated signal transduction (PubMed:8538749, PubMed:9736715). May act as a mediator of inside-out integrin signaling (PubMed:10712922). Focal adhesion protein part of the complex ILK-PINCH (PubMed:10712922). This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway (PubMed:10712922). Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells (PubMed:10712922). Regulates cell motility by forming a complex with PARVB (PubMed:32528174). Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B (PubMed:8538749, PubMed:9736715).
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Uniprot ID
Primary ID:
Q13418

Secondarily ID:
B7Z1I0
B7Z418
D3DQU0
P57043
Q68DZ3
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Ensembl ID
ENSG00000166333
HGNC ID
HGNC:6040
Subcellular Location
Cell junction
Focal adhesion
Cell membrane
Cell projection
Lamellipodium
Cytoplasm
Myofibril
Sarcomere
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000023 , BTI-Tn-5B1-4
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0382558
 Compound Info 
US8754233, 2-(5-Amino-3-methyl-1H-pyrazol-4-yl)-5-fluoro-benzothiazole-6-sulfonic acid amide
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C11H10FN5O2S2
  1
1
IC50 = 7 nM
 Bioactivity Info 
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CP0538425
 Compound Info 
US8754233, 5-(3-Amino-propyl)-4-benzothiazol-2-yl-2H-pyrazol-3-ylamine
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C13H15N5S
  1
1
IC50 = 10 nM
 Bioactivity Info 
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CP0573513
 Compound Info 
US8754233, 2-(5-Amino-3-methyl-1H-pyrazol-4-yl)-benzothiazole-6-sulfonic acid amide
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C11H11N5O2S2
  1
1
IC50 = 10 nM
 Bioactivity Info 
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CP0391497
 Compound Info 
US8754233, 2-(3-Amino-1H-pyrazol-4-yl)-5-fluoro-benzothiazole-6-sulfonic acid amide
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C10H8FN5O2S2
  1
1
IC50 = 20 nM
 Bioactivity Info 
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CP0538428
 Compound Info 
US8754233, N3-(2-Amino-ethyl)-4-benzothiazol-2-yl-1H-pyrazole-3,5-diamine
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C12H14N6S
  1
1
IC50 = 20 nM
 Bioactivity Info 
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CP0566659
 Compound Info 
US8754233, 4-Benzothiazol-2-yl-5-(3-methylamino-propyl)-2H-pyrazol-3-ylamine
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C14H17N5S
  1
1
IC50 = 20 nM
 Bioactivity Info 
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CP0951312
 Compound Info 
2-(5-Amino-3-methyl-1H-pyrazol-4-yl)-benzothiazole-6-sulfonic acid(acetic hydrazido)amide
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C13H14N6O3S2
  1
1
IC50 = 30 nM
 Bioactivity Info 
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CP0403644
 Compound Info 
US8754233, 2-(3-Amino-5-methyl-1H-pyrazol-4-yl)-5-fluoro-benzothiazole-6-sulfonic acid methylamide
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C12H12FN5O2S2
  1
1
IC50 = 40 nM
 Bioactivity Info 
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CP0524256
 Compound Info 
US8754233, 4-(5-Fluoro-benzothiazol-2-yl)-5-methyl-2H-pyrazol-3-ylamine
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C11H9FN4S
  1
1
IC50 = 40 nM
 Bioactivity Info 
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CP0544481
 Compound Info 
US8754233, 2-(5-Amino-3-methyl-1H-pyrazol-4-yl)-benzothiazole-6-sulfonic acid(pyridin-4-ylmethyl)-amide
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C17H16N6O2S2
  1
1
IC50 = 40 nM
 Bioactivity Info 
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CP0549372
 Compound Info 
US8754233, 2-(5-Amino-3-methyl-1H-pyrazol-4-yl)-4-fluorobenzothiazole-6-sulfonic acid amide
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C11H10FN5O2S2
  1
1
IC50 = 40 nM
 Bioactivity Info 
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CP0566366
 Compound Info 
US8754233, 4-(5-Fluoro-6-methoxy-benzothiazol-2-yl)-5-furan-2-yl-2H-pyrazol-3-ylamine
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C15H11FN4O2S
  1
1
IC50 = 40 nM
 Bioactivity Info 
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CP0391494
 Compound Info 
US8754233, 4-(5-Fluoro-6-methyl-benzothiazol-2-yl)-2H-pyrazol-3-ylamine
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C11H9FN4S
  1
1
IC50 = 50 nM
 Bioactivity Info 
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CP0524283
 Compound Info 
US8754233, 2-(5-Amino-3-methyl-1H-pyrazol-4-yl)-5-fluoro-benzothiazole-6-sulfonicacid (2-hydroxy-ethyl)-amide
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C13H14FN5O3S2
  1
1
IC50 = 50 nM
 Bioactivity Info 
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CP0538638
 Compound Info 
US8754233, 2-(5-Amino-3-pyridin-4-yl-1H-pyrazol-4-yl)-benzothiazole-6-sulfonic acidamide
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C15H12N6O2S2
  1
1
IC50 = 50 nM
 Bioactivity Info 
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CP0389337
 Compound Info 
US8754233, 2-(3-Amino-5-methyl-1H-pyrazol-4-yl)-5-fluoro-benzothiazole-6-carboxylic acid methyl ester
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C13H11FN4O2S
  1
1
IC50 = 60 nM
 Bioactivity Info 
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CP0524258
 Compound Info 
US8754233, 4-(5-Fluoro-6-methoxy-benzothiazol-2-yl)-5-methyl-1H-pyrazol-3-ylamine
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C12H11FN4OS
  1
1
IC50 = 60 nM
 Bioactivity Info 
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CP0573514
 Compound Info 
US8754233, 2-(5-Amino-1H-pyrazol-4-yl)-benzothiazole-6-sulfonic acid methylamide
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C11H11N5O2S2
  1
1
IC50 = 60 nM
 Bioactivity Info 
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CP0574147
 Compound Info 
US8754233, 4-Benzothiazol-2-yl-5-piperidin-4-yl-2H-pyrazol-3-ylamine
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C15H17N5S
  1
1
IC50 = 60 nM
 Bioactivity Info 
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CP0540606
 Compound Info 
US8754233, 4-(5-Fluoro-6-methoxy-benzothiazol-2-yl)-5-piperazin-1-yl-2H-pyrazol-3-ylamine
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C15H17FN6OS
  1
1
IC50 = 70 nM
 Bioactivity Info 
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CP0545229
 Compound Info 
US8754233, 2-(3-Amino-5-methyl-1H-pyrazol-4-yl)-benzothiazole-6-sulfonic acid methyl amide
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C12H13N5O2S2
  1
1
IC50 = 70 nM
 Bioactivity Info 
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CP0566368
 Compound Info 
US8754233, 2-(3-Amino-5-methyl-1H-pyrazol-4-yl)-4,5,6-trifluoro-benzothiazole-7-sulfonic acid amide
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C11H8F3N5O2S2
  1
1
IC50 = 70 nM
 Bioactivity Info 
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CP0544482
 Compound Info 
US8754233, 2-(5-Amino-3-methyl-1H-pyrazol-4-yl)-benzothiazole-6-sulfonic acid(2,2,2-trifluoro-ethyl)-amide
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C13H12F3N5O2S2
  1
1
IC50 = 90 nM
 Bioactivity Info 
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CP0382556
 Compound Info 
US8754233, 2-{[2-(5-Amino-3-methyl-1H-pyrazol-4-yl)-benzothiazol-6-ylmethyl]-amino}-ethanol
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C14H17N5OS
  1
1
IC50 = 100 nM
 Bioactivity Info 
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CP0391496
 Compound Info 
US8754233, 5-(4-Amino-phenyl)-4-benzothiazol-2-yl-2H-pyrazol-3-ylamine
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C16H13N5S
  1
1
IC50 = 100 nM
 Bioactivity Info 
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CP0414078
 Compound Info 
US8754233, 4-(5-Fluoro-6-methoxy-benzothiazol-2-yl)-5-isoxazol-5-yl-2H-pyrazol-3-ylamine
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C14H10FN5O2S
  1
1
IC50 = 100 nM
 Bioactivity Info 
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CP0419802
 Compound Info 
US8754233, [2-(3-Amino-5-methyl-1H-pyrazol-4-yl)-5-fluoro-benzothiazol-6-yl]-methanol
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C12H11FN4OS
  1
1
IC50 = 100 nM
 Bioactivity Info 
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CP0527448
 Compound Info 
US8754233, 4-Benzothiazol-2-yl-5-(4-methylamino-butyl)-2H-pyrazol-3-ylamine
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C15H19N5S
  1
1
IC50 = 100 nM
 Bioactivity Info 
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CP0527450
 Compound Info 
US8754233, 4-Benzothiazol-2-yl-5-pyridin-4-yl-2H-pyrazol-3-ylamine
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C15H11N5S
  1
1
IC50 = 100 nM
 Bioactivity Info 
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CP0566661
 Compound Info 
US8754233, 4-Benzothiazol-2-yl-5-furan-2-yl-2H-pyrazol-3-ylamine
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C14H10N4OS
  1
1
IC50 = 100 nM
 Bioactivity Info 
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CP0545228
 Compound Info 
US8754233, 2-(5-Amino-3-methyl-1H-pyrazol-4-yl)-5-fluoro-benzothiazole-6-sulfonic acid (pyridin-4-ylmethyl)-amide
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C17H15FN6O2S2
  1
1
IC50 = 130 nM
 Bioactivity Info 
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CP0407710
 Compound Info 
US8754233, 2-(5-Amino-3-methyl-1H-pyrazol-4-yl)-5-fluoro-benzothiazole-4-sulfonicacid (2-hydroxy-ethyl)-amide
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C13H14FN5O3S2
  1
1
IC50 = 150 nM
 Bioactivity Info 
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CP0468184
 Compound Info 
US8754233, 4-Benzothiazol-2-yl-N3-(2-ethylamino-ethyl)-1H-pyrazole-3,5-diamine
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C14H18N6S
  1
1
IC50 = 150 nM
 Bioactivity Info 
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CP0470056
 Compound Info 
US8754233, 4-Benzothiazol-2-yl-5-piperazin-1-yl-2H-pyrazol-3-ylamine
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C14H16N6S
  1
1
IC50 = 190 nM
 Bioactivity Info 
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CP0382557
 Compound Info 
US8754233, 2-(5-Amino-3-methyl-1H-pyrazol-4-yl)-benzothiazole-6-sulfonic acid [2-(3H-imidazol-4-yl)-ethyl]-amide
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C16H17N7O2S2
  1
1
IC50 = 200 nM
 Bioactivity Info 
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CP0389333
 Compound Info 
US8754233, 4-(6-Bromo-5-fluoro-benzothiazol-2-yl)-5-methyl-1H-pyrazol-3-ylamine
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C11H8BrFN4S
  1
1
IC50 = 200 nM
 Bioactivity Info 
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CP0409755
 Compound Info 
US8754233, 4-(6-Fluoro-benzothiazol-2-yl)-1H-pyrazol-3-ylamine
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C10H7FN4S
  1
1
IC50 = 200 nM
 Bioactivity Info 
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CP0414061
 Compound Info 
US8754233, 4-(6-Methoxy-benzothiazol-2-yl)-5-piperazin-1-yl-2H-pyrazol-3-ylamine
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C15H18N6OS
  1
1
IC50 = 200 nM
 Bioactivity Info 
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CP0524261
 Compound Info 
US8754233, N3-(3-Dimethylamino-propyl)-4-(5-fluoro-6-methoxy-benzothiazol-2-yl)-1H-pyrazole-3,5-diamine
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C16H21FN6OS
  1
1
IC50 = 200 nM
 Bioactivity Info 
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CP0546107
 Compound Info 
US8754233, (4-Benzothiazol-2-yl-1H-pyrazol-3-yl)-[2-(1H-imidazol-4-yl)-ethyl]-amine
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C15H14N6S
  1
1
IC50 = 200 nM
 Bioactivity Info 
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CP0546568
 Compound Info 
US8754233, 4-(5-Fluoro-6-methoxy-benzothiazol-2-yl)-N3-[2-(3H-imidazol-4-yl)-ethyl]-1H-pyrazole-3,5-diamine
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C16H16FN7OS
  1
1
IC50 = 200 nM
 Bioactivity Info 
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CP0546569
 Compound Info 
US8754233, 4-(5-Fluoro-6-methoxy-benzothiazol-2-yl)-5-pyridin-4-yl-2H-pyrazol-3-ylamine
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C16H12FN5OS
  1
1
IC50 = 200 nM
 Bioactivity Info 
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CP0547948
 Compound Info 
US8754233, 2-(5-Amino-3-methyl-1H-pyrazol-4-yl)-benzothiazol-5-ol
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C11H10N4OS
  1
1
IC50 = 200 nM
 Bioactivity Info 
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CP0549369
 Compound Info 
US8754233, 2-(5-Amino-3-methyl-1H-pyrazol-4-yl)-benzothiazole-6-sulfonic acid [2-(4-amino-phenyl)-ethyl]-amide
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C19H20N6O2S2
  1
1
IC50 = 200 nM
 Bioactivity Info 
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CP0560325
 Compound Info 
US8754233, 4-(6-Dimethylaminomethyl-benzothiazol-2-yl)-5-methyl-2H-pyrazol-3-ylamine
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C14H17N5S
  1
1
IC50 = 200 nM
 Bioactivity Info 
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CP0560328
 Compound Info 
US8754233, 5-Methyl-4-(4,5,6-trifluoro-benzothiazol-2-yl)-1H-pyrazol-3-ylamine
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C11H7F3N4S
  1
1
IC50 = 200 nM
 Bioactivity Info 
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CP0566656
 Compound Info 
US8754233, 2-(5-Amino-3-methyl-1H-pyrazol-4-yl)-benzothiazole-6-sulfonic acid (2-hydroxy-ethyl)-amide
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C13H15N5O3S2
  1
1
IC50 = 200 nM
 Bioactivity Info 
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CP0566658
 Compound Info 
US8754233, 4-Benzothiazol-2-yl-5-(3-dimethylamino-propyl)-2H-pyrazol-3-ylamine
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C15H19N5S
  1
1
IC50 = 200 nM
 Bioactivity Info 
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CP0574141
 Compound Info 
US8754233, 3-(5-Amino-4-benzothiazol-2-yl-1H-pyrazol-3-yl)-propan-1-ol
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C13H14N4OS
  1
1
IC50 = 200 nM
 Bioactivity Info 
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CP0463184
 Compound Info 
US8754233, 2-(3-Amino-5-methyl-1H-pyrazol-4-yl)-benzothiazole-6-carboxylic acid methyl ester
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C13H12N4O2S
  1
1
IC50 = 300 nM
 Bioactivity Info 
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CP0474733
 Compound Info 
US8754233, 4-(5-Fluoro-6-methyl-benzothiazol-2-yl)-5-methyl-2H-pyrazol-3-ylamine
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C12H11FN4S
  1
1
IC50 = 300 nM
 Bioactivity Info 
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CP0524260
 Compound Info 
US8754233, N3-(2-Dimethylamino-ethyl)-4-(5-fluoro-6-methoxy-benzothiazol-2-yl)-1H-pyrazole-3,5-diamine
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C15H19FN6OS
  1
1
IC50 = 300 nM
 Bioactivity Info 
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CP0538910
 Compound Info 
US8754233, 4-Benzothiazol-2-yl-5-methyl-1H-pyrazol-3-ylamine
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C11H10N4S
  1
1
IC50 = 300 nM
 Bioactivity Info 
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CP0540607
 Compound Info 
US8754233, 4-(5-Fluoro-6-methoxy-benzothiazol-2-yl)-5-(5-nitro-furan-2-yl)-2H-pyrazol-3-ylamine
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C15H10FN5O4S
  1
1
IC50 = 300 nM
 Bioactivity Info 
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CP0545230
 Compound Info 
US8754233, 4-Benzothiazol-2-yl-1H-pyrazol-3-ylamine
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C10H8N4S
  1
1
IC50 = 300 nM
 Bioactivity Info 
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CP0549371
 Compound Info 
US8754233, 2-(5-Amino-3-methyl-1H-pyrazol-4-yl)-benzothiazole-6-carboxylic acid amide
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C12H11N5OS
  1
1
IC50 = 300 nM
 Bioactivity Info 
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CP0559970
 Compound Info 
US8754233, 4-Benzothiazol-2-yl-N3-(3-dimethylamino-propyl)-1H-pyrazole-3,5-diamine
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C15H20N6S
  1
1
IC50 = 300 nM
 Bioactivity Info 
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CP0560326
 Compound Info 
US8754233, 4-(6-Chlorobenzothiazol-2-yl)-5-methyl-2H-pyrazol-3-ylamine
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C11H9ClN4S
  1
1
IC50 = 300 nM
 Bioactivity Info 
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CP0573512
 Compound Info 
US8754233, 2-(5-Amino-3-methyl-1H-pyrazol-4-yl)-benzothiazole-6-sulfonic acid (2-dimethylamino-ethyl)-amide
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C15H20N6O2S2
  1
1
IC50 = 300 nM
 Bioactivity Info 
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CP0544737
 Compound Info 
US8754233, 4-(6-Methoxy-benzothiazol-2-yl)-5-methyl-1H-pyrazol-3-ylamine
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C12H12N4OS
  1
1
IC50 = 340 nM
 Bioactivity Info 
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CP0409768
 Compound Info 
US8754233, 4-(6-Fluoro-benzothiazol-2-yl)-5-methyl-1H-pyrazol-3-ylamine
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C11H9FN4S
  1
1
IC50 = 400 nM
 Bioactivity Info 
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CP0409769
 Compound Info 
US8754233, 4-(6-Bromo-benzothiazol-2-yl)-5-methyl-1H-pyrazol-3-ylamine
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C11H9BrN4S
  1
1
IC50 = 400 nM
 Bioactivity Info 
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CP0416415
 Compound Info 
US8754233, 4-(4-fluorobenzothiazol-2-yl)-5-methyl-2H-pyrazol-3-ylamine
   Show/Hide
C11H9FN4S
  1
1
IC50 = 400 nM
 Bioactivity Info 
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CP0524254
 Compound Info 
US8754233, 4-(7-Chloro-5-fluoro-6-methoxy-benzothiazol-2-yl)-5-methyl-1H-pyrazol-3-ylamine
   Show/Hide
C12H10ClFN4OS
  1
1
IC50 = 400 nM
 Bioactivity Info 
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CP0527447
 Compound Info 
US8754233, 4-Benzothiazol-2-yl-5-(4-dimethylamino-butyl)-2H-pyrazol-3-ylamine
   Show/Hide
C16H21N5S
  1
1
IC50 = 400 nM
 Bioactivity Info 
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CP0538099
 Compound Info 
US8754233, N-[2-(5-Amino-3-methyl-1H-pyrazol-4-yl)-benzothiazol-6-yl]-acetamide
   Show/Hide
C13H13N5OS
  1
1
IC50 = 400 nM
 Bioactivity Info 
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CP0544426
 Compound Info 
US8754233, 2-(5-Amino-4-benzothiazol-2-yl-1H-pyrazol-3-ylamino)-ethanol
   Show/Hide
C12H13N5OS
  1
1
IC50 = 400 nM
 Bioactivity Info 
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CP0546836
 Compound Info 
US8754233, 3-(5-Amino-4-benzothiazol-2-yl-1H-pyrazol-3-ylamino)-propan-1-ol
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C13H15N5OS
  1
1
IC50 = 400 nM
 Bioactivity Info 
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CP0389334
 Compound Info 
US8754233, 5-Methyl-4-(6-morpholin-4-ylmethyl-benzothiazol-2-yl)-2H-pyrazol-3-ylamine
   Show/Hide
C16H19N5OS
  1
1
IC50 = 500 nM
 Bioactivity Info 
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CP0456476
 Compound Info 
US8754233, 4-(6-Methanesulfonyl-benzothiazol-2-yl)-5-methyl-2H-pyrazol-3-ylamine
   Show/Hide
C12H12N4O2S2
  1
1
IC50 = 500 nM
 Bioactivity Info 
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CP0474456
 Compound Info 
US8754233, 3-[5-Amino-4-(5-fluoro-6-methoxy-benzothiazol-2-yl)-1H-pyrazol-3-ylamino]-propan-1-ol
   Show/Hide
C14H16FN5O2S
  1
1
IC50 = 500 nM
 Bioactivity Info 
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CP0538429
 Compound Info 
US8754233, 2-(1H-Pyrazol-4-yl)-benzothiazole-6-sulfonic acid amide
   Show/Hide
C10H8N4O2S2
  1
1
IC50 = 500 nM
 Bioactivity Info 
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CP0538908
 Compound Info 
US8754233, 2-(5-Amino-1H-pyrazol-4-yl)-benzothiazol-6-ylamine
   Show/Hide
C10H9N5S
  1
1
IC50 = 500 nM
 Bioactivity Info 
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CP0538911
 Compound Info 
US8754233, 4-Benzothiazol-2-yl-N3-(2-dimethylamino-ethyl)-1H-pyrazole-3,5-diamine
   Show/Hide
C14H18N6S
  1
1
IC50 = 500 nM
 Bioactivity Info 
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CP0540608
 Compound Info 
US8754233, 5-Methyl-4-(6-methylaminomethyl-benzothiazol-2-yl)-2H-pyrazol-3-ylamine
   Show/Hide
C13H15N5S
  1
1
IC50 = 500 nM
 Bioactivity Info 
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CP0547950
 Compound Info 
US8754233, 4-Benzothiazol-2-yl-N3-(3-imidazol-1-yl-propyl)-1H-pyrazole-3,5-diamine
   Show/Hide
C16H17N7S
  1
1
IC50 = 500 nM
 Bioactivity Info 
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CP0462798
 Compound Info 
US8754233, 2-(5-Amino-3-methyl-1H-pyrazol-4-yl)-benzothiazole-6-sulfonic acid (2-methoxy-ethyl)-amide
   Show/Hide
C14H17N5O3S2
  1
1
IC50 = 600 nM
 Bioactivity Info 
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CP0527449
 Compound Info 
US8754233, 4-Benzothiazol-2-yl-5-cyclopropyl-2H-pyrazol-3-ylamine
   Show/Hide
C13H12N4S
  1
1
IC50 = 600 nM
 Bioactivity Info 
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CP0538639
 Compound Info 
US8754233, 2-(5-Amino-3-methyl-1H-pyrazol-4-yl)-benzothiazole-6-sulfonic acid 4-amino-benzylamide
   Show/Hide
C18H18N6O2S2
  1
1
IC50 = 600 nM
 Bioactivity Info 
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CP0538904
 Compound Info 
US8754233, N3-[2-(3H-Imidazol-4-yl)-ethyl]-4-(6-methoxy-benzothiazol-2-yl)-1H-pyrazole-3,5-diamine
   Show/Hide
C16H17N7OS
  1
1
IC50 = 600 nM
 Bioactivity Info 
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CP0540593
 Compound Info 
US8754233, 4-(6-Dimethylaminomethyl-5-fluoro-benzothiazol-2-yl)-5-methyl-1H-pyrazol-3-ylamine
   Show/Hide
C14H16FN5S
  1
1
IC50 = 600 nM
 Bioactivity Info 
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CP0547949
 Compound Info 
US8754233, 4-Benzothiazol-2-yl-5-pyridin-3-yl-2H-pyrazol-3-ylamine
   Show/Hide
C15H11N5S
  1
1
IC50 = 600 nM
 Bioactivity Info 
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CP0541471
 Compound Info 
US8754233, N-{2-[2-(5-Amino-3-methyl-1H-pyrazol-4-yl)-benzothiazole-6-sulfonylamino]-ethyl}-acetamide
   Show/Hide
C15H18N6O3S2
  1
1
IC50 = 700 nM
 Bioactivity Info 
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CP0548111
 Compound Info 
US8754233, 4-Benzothiazol-2-yl-N3-(2-methoxy-ethyl)-1H-pyrazole-3,5-diamine
   Show/Hide
C13H15N5OS
  1
1
IC50 = 700 nM
 Bioactivity Info 
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CP0549233
 Compound Info 
US8754233, 4-(5-Fluoro-6-methoxy-benzothiazol-2-yl)-5-thiophen-2-yl-2H-pyrazol-3-ylamine
   Show/Hide
C15H11FN4OS2
  1
1
IC50 = 700 nM
 Bioactivity Info 
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CP0549368
 Compound Info 
US8754233, 2-(5-Amino-3-methyl-1H-pyrazol-4-yl)-benzothiazole-6-sulfonic acid cyclopropylmethyl-amide
   Show/Hide
C15H17N5O2S2
  1
1
IC50 = 700 nM
 Bioactivity Info 
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CP0566657
 Compound Info 
US8754233, 2-(3-Amino-5-methyl-1H-pyrazol-4-yl)-benzothiazole-7-carboxylic acid methyl ester
   Show/Hide
C13H12N4O2S
  1
1
IC50 = 700 nM
 Bioactivity Info 
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CP0573515
 Compound Info 
US8754233, 4-Benzothiazol-2-yl-1H-pyrazole-3,5-diamine
   Show/Hide
C10H9N5S
  1
1
IC50 = 700 nM
 Bioactivity Info 
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CP0407708
 Compound Info 
US8754233, 2-(5-Amino-3-methyl-1H-pyrazol-4-yl)-benzothiazole-6-sulfonic acidphenethyl-amide
   Show/Hide
C19H19N5O2S2
  1
1
IC50 = 800 nM
 Bioactivity Info 
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CP0416416
 Compound Info 
US8754233, 3-{[2-(5-Amino-3-methyl-1H-pyrazol-4-yl)-benzothiazol-6-ylmethyl]-amino}-benzenesulfonamide
   Show/Hide
C18H18N6O2S2
  1
1
IC50 = 800 nM
 Bioactivity Info 
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CP0470055
 Compound Info 
US8754233, 4-Benzothiazol-2-yl-5-ethyl-1H-pyrazol-3-ylamine
   Show/Hide
C12H12N4S
  1
1
IC50 = 800 nM
 Bioactivity Info 
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CP0538615
 Compound Info 
US8754233, 2-(5-Amino-3-methyl-1H-pyrazol-4-yl)-benzothiazole-6-sulfonic acidbenzylamide
   Show/Hide
C18H17N5O2S2
  1
1
IC50 = 800 nM
 Bioactivity Info 
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CP0419744
 Compound Info 
US8754233, 4-Benzothiazol-2-yl-5-phenyl-1H-pyrazol-3-ylamine
   Show/Hide
C16H12N4S
  1
1
IC50 = 900 nM
 Bioactivity Info 
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CP0538426
 Compound Info 
US8754233, 5-Methyl-4-(6-pyrrolidin-1-ylmethyl-benzothiazol-2-yl)-2H-pyrazol-3-ylamine
   Show/Hide
C16H19N5S
  1
1
IC50 = 900 nM
 Bioactivity Info 
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CP0538905
 Compound Info 
US8754233, 4-(5-Fluoro-6-methoxy-benzothiazol-2-yl)-5-(3-nitro-phenyl)-2H-pyrazol-3-ylamine
   Show/Hide
C17H12FN5O3S
  1
1
IC50 = 900 nM
 Bioactivity Info 
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CP0546571
 Compound Info 
US8754233, [2-(5-Amino-3-methyl-1H-pyrazol-4-yl)-benzothiazol-6-yl]-methanol
   Show/Hide
C12H12N4OS
  1
1
IC50 = 900 nM
 Bioactivity Info 
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CP0549370
 Compound Info 
US8754233, 2-(5-Amino-3-methyl-1H-pyrazol-4-yl)-benzothiazole-6-sulfonic acid 4-chloro-benzylamide
   Show/Hide
C18H16ClN5O2S2
  1
1
IC50 = 900 nM
 Bioactivity Info 
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CP0549373
 Compound Info 
US8754233, 2-(3-Methyl-1H-pyrazol-4-yl)-benzothiazole
   Show/Hide
C11H9N3S
  1
1
IC50 = 900 nM
 Bioactivity Info 
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CP0574180
 Compound Info 
US8754233, 4-Benzothiazol-2-yl-5-thiophen-2-yl-2H-pyrazol-3-ylamine
   Show/Hide
C14H10N4S2
  1
1
IC50 = 900 nM
 Bioactivity Info 
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CP0946752
 Compound Info 
2-(5-Amino-3-methyl-1H-pyrazol-4-yl)-benzothiazole-6-sulfonic acid(phenylhydrazino)amide
   Show/Hide
C17H16N6O2S2
  1
1
IC50 = 900 nM
 Bioactivity Info 
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CP0472425
 Compound Info 
US8754233, 4-(5-Amino-4-benzothiazol-2-yl-1H-pyrazol-3-yl)-butan-1-ol
   Show/Hide
C14H16N4OS
  1
1
IC50 = 1000 nM
 Bioactivity Info 
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CP0524259
 Compound Info 
US8754233, 5-Cyclopropyl-4-(5-fluoro-6-methoxy-benzothiazol-2-yl)-2H-pyrazol-3-ylamine
   Show/Hide
C14H13FN4OS
  1
1
IC50 = 1000 nM
 Bioactivity Info 
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CP0538907
 Compound Info 
US8754233, 2-(5-Amino-3-methyl-1H-pyrazol-4-yl)-benzothiazole-6-sulfonic acid 4-methoxy-benzylamide
   Show/Hide
C19H19N5O3S2
  1
1
IC50 = 1000 nM
 Bioactivity Info 
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CP0566365
 Compound Info 
US8754233, 4-(7-chloro-4-methoxy-benzothiazol-2-yl)-5-methyl-2H-pyrazol-3-ylamine
   Show/Hide
C12H11ClN4OS
  1
1
IC50 = 1000 nM
 Bioactivity Info 
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CP0967549
 Compound Info 
US8754233, 4-Benzothiazol-2-yl-N3-(1H-imidazol-2-ylmethylene)-1H-pyrazole-3,5-diamine
   Show/Hide
C14H11N7S
  1
1
IC50 = 1000 nM
 Bioactivity Info 
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CP0389335
 Compound Info 
US8754233, N-[2-(5-Amino-4-benzothiazol-2-yl-1H-pyrazol-3-ylamino)-ethyl]-acetamide
   Show/Hide
C14H16N6OS
  1
1
IC50 = 1100 nM
 Bioactivity Info 
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CP0474735
 Compound Info 
US8754233, 2-(3-Amino-5-methyl-1H-pyrazol-4-yl)-benzothiazole-6-carboxylic acid
   Show/Hide
C12H10N4O2S
  1
1
IC50 = 1100 nM
 Bioactivity Info 
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CP0545231
 Compound Info 
US8754233, 4-Benzothiazol-2-yl-5-methylsulfanyl-1H-pyrazol-3-ylamine
   Show/Hide
C11H10N4S2
  1
1
IC50 = 1100 nM
 Bioactivity Info 
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CP0560327
 Compound Info 
US8754233, 4-(5-Trifluoromethyl-benzothiazol-2-yl)-1H-pyrazol-3-ylamine
   Show/Hide
C11H7F3N4S
  1
1
IC50 = 1100 nM
 Bioactivity Info 
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CP0954256
 Compound Info 
4-Benzothiazol-2-yl-N5-(2-morpholin-4-yl-ethyl)-1H-pyrazole-3,5-diamine
   Show/Hide
C16H20N6OS
  1
1
IC50 = 1500 nM
 Bioactivity Info 
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CP0409770
 Compound Info 
US8754233, 2-(1H-Pyrazol-4-yl)-benzothiazole
   Show/Hide
C10H7N3S
  1
1
IC50 = 1600 nM
 Bioactivity Info 
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CP0474734
 Compound Info 
US8754233, N-[4-(5-Amino-4-benzothiazol-2-yl-1H-pyrazol-3-yl)-phenyl]-hydroxylamine
   Show/Hide
C16H13N5OS
  1
1
IC50 = 1600 nM
 Bioactivity Info 
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CP0462796
 Compound Info 
US8754233, 4-(5-Amino-4-benzothiazol-2-yl-1H-pyrazol-3-ylamino)-butan-1-ol
   Show/Hide
C14H17N5OS
  1
1
IC50 = 1700 nM
 Bioactivity Info 
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CP0550851
 Compound Info 
US8754233, 2-(5-Amino-3-methyl-1H-pyrazol-4-yl)-benzothiazole-6-sulfonic acid (2-thiophen-2-yl-ethyl)-amide
   Show/Hide
C17H17N5O2S3
  1
1
IC50 = 1700 nM
 Bioactivity Info 
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CP0861444
 Compound Info 
4-Benzothiazol-2-yl-N5-ethyl-1H-pyrazole-3,5-diamine
   Show/Hide
C12H13N5S
  1
1
IC50 = 1700 nM
 Bioactivity Info 
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CP0935553
 Compound Info 
(4-Benzothiazol-2-yl-2H-pyrazol-3-yl)-methyl-amine
   Show/Hide
C11H10N4S
  1
1
IC50 = 1700 nM
 Bioactivity Info 
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CP0546570
 Compound Info 
US8754233, N-{2-[5-Amino-4-(5-fluoro-6-methoxy-benzothiazol-2-yl)-1H-pyrazol-3-ylamino]-ethyl}-acetamide
   Show/Hide
C15H17FN6O2S
  1
1
IC50 = 1800 nM
 Bioactivity Info 
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CP0407707
 Compound Info 
US8754233, 4-(4-Benzothiazol-2-yl-1H-pyrazol-3-yl)-6-ethyl-benzene-1,3-diol
   Show/Hide
C18H15N3O2S
  1
1
IC50 = 1900 nM
 Bioactivity Info 
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CP0407709
 Compound Info 
US8754233, 2-(5-Amino-3-methyl-1H-pyrazol-4-yl)-benzothiazole-5-sulfonic acid methyl amide
   Show/Hide
C12H13N5O2S2
  1
1
IC50 = 1900 nM
 Bioactivity Info 
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CP0538912
 Compound Info 
US8754233, 4-Benzothiazol-2-yl-N3-(2-pyrrolidin-1-yl-ethyl)-1H-pyrazole-3,5-diamine
   Show/Hide
C16H20N6S
  1
1
IC50 = 1900 nM
 Bioactivity Info 
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CP0403645
 Compound Info 
US8754233, 4-(5-Fluoro-6-methoxy-benzothiazol-2-yl)-5-(4-methoxy-phenyl)-2H-pyrazol-3-ylamine
   Show/Hide
C18H15FN4O2S
  1
1
IC50 = 2000 nM
 Bioactivity Info 
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CP0573510
 Compound Info 
US8754233, 4-(5-Fluoro-6-methoxy-benzothiazol-2-yl)-5-(2-phenyl-cyclopropyl)-2H-pyrazol-3-ylamine
   Show/Hide
C20H17FN4OS
  1
1
IC50 = 2100 nM
 Bioactivity Info 
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CP0524257
 Compound Info 
US8754233, 4-(5-Fluoro-6-methoxy-benzothiazol-2-yl)-5-phenyl-2H-pyrazol-3-ylamine
   Show/Hide
C17H13FN4OS
  1
1
IC50 = 2300 nM
 Bioactivity Info 
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CP0538906
 Compound Info 
US8754233, 4-(5-Fluoro-6-methoxy-benzothiazol-2-yl)-5-(3-fluoro-phenyl)-2H-pyrazol-3-ylamine
   Show/Hide
C17H12F2N4OS
  1
1
IC50 = 2300 nM
 Bioactivity Info 
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CP0572565
 Compound Info 
US8754233, 4-(5-Fluoro-6-methoxy-benzothiazol-2-yl)-5-(4-fluoro-phenyl)-2H-pyrazol-3-ylamine
   Show/Hide
C17H12F2N4OS
  1
1
IC50 = 2400 nM
 Bioactivity Info 
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CP0470057
 Compound Info 
US8754233, 4-Benzothiazol-2-yl-N3-(1H-imidazol-2-ylmethyl)-1H-pyrazole-3,5-diamine
   Show/Hide
C14H13N7S
  1
1
IC50 = 2500 nM
 Bioactivity Info 
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CP0558185
 Compound Info 
US8754233, 2-(3-Amino-5-methyl-1H-pyrazol-4-yl)-benzothiazole-6-sulfonic acid (2,6-dimethyl-pyrimidin-4-yl)-amide
   Show/Hide
C17H17N7O2S2
  1
1
IC50 = 2600 nM
 Bioactivity Info 
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CP0574181
 Compound Info 
US8754233, 4-Benzothiazol-2-yl-N3-piperidin-4-ylmethyl-1H-pyrazole-3,5-diamine
   Show/Hide
C16H20N6S
  1
1
IC50 = 2700 nM
 Bioactivity Info 
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CP0456477
 Compound Info 
US8754233, 5-Methyl-4-(5-trifluoromethylbenzothiazol-2-yl)-1H-pyrazol-3-ylamine
   Show/Hide
C12H9F3N4S
  1
1
IC50 = 2800 nM
 Bioactivity Info 
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CP0414060
 Compound Info 
US8754233, 4-[2-(5-Amino-4-benzothiazol-2-yl-1H-pyrazol-3-ylamino)-ethyl]-phenol
   Show/Hide
C18H17N5OS
  1
1
IC50 = 2900 nM
 Bioactivity Info 
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CP0566364
 Compound Info 
US8754233, 4-[(5-Amino-4-benzothiazol-2-yl-1H-pyrazol-3-ylamino)-methyl]-benzenesulfonamide
   Show/Hide
C17H16N6O2S2
  1
1
IC50 = 2900 nM
 Bioactivity Info 
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CP0849217
 Compound Info 
4-Benzothiazol-2-yl-N5-pyridin-3-ylmethyl-1H-pyrazole-3,5-diamine
   Show/Hide
C16H14N6S
  1
1
IC50 = 2900 nM
 Bioactivity Info 
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CP0547946
 Compound Info 
US8754233, 2-(5-Amino-3-methyl-1H-pyrazol-4-yl)-benzothiazole-6-sulfonic acid (2-morpholin-4-yl-ethyl)-amide
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C17H22N6O3S2
  1
1
IC50 = 3000 nM
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CP0547945
 Compound Info 
US8754233, 2-(5-Amino-3-methyl-1H-pyrazol-4-yl)-benzothiazole-6-sulfonic acid (3-dimethylamino-propyl)-amide
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C16H22N6O2S2
  1
1
IC50 = 3200 nM
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CP0419745
 Compound Info 
US8754233, 4-Benzothiazol-2-yl-N3-[2-(1H-indol-3-yl)-ethyl]-1H-pyrazole-3,5-diamine
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C20H18N6S
  1
1
IC50 = 3300 nM
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CP0463446
 Compound Info 
(4E)-4-[4-(1,3-benzothiazol-2-yl)-1,2-dihydropyrazol-3-ylidene]-3-hydroxy-1-cyclohexa-2,5-dienone
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C16H11N3O2S
  1
1
IC50 = 3300 nM
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CP0402866
 Compound Info 
US8754233, 4-(6-Nitro-benzothiazol-2-yl)-2H-pyrazol-3-ylamine
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C10H7N5O2S
  1
1
IC50 = 3400 nM
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CP0546835
 Compound Info 
US8754233, 4-(4-Benzothiazol-2-yl-1H-pyrazol-3-yl)-phenol
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C16H11N3OS
  1
1
IC50 = 3400 nM
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CP0560324
 Compound Info 
US8754233, 5-(2-Chloro-pyridin-3-yl)-4-(5-fluoro-6-methoxy-benzothiazol-2-yl)-2H-pyrazol-3-ylamine
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C16H11ClFN5OS
  1
1
IC50 = 3400 nM
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CP0572566
 Compound Info 
US8754233, 2-(5-Amino-4-benzothiazol-2-yl-2H-pyrazol-3-ylamino)-cyclopentanol
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C15H17N5OS
  1
1
IC50 = 3500 nM
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CP0867463
 Compound Info 
4-(5-Amino-4-benzothiazol-2-yl-2H-pyrazol-3-ylamino)-N-thiazol-2-yl-benzenesulfonamide
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C19H15N7S3
  1
1
IC50 = 3500 nM
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CP0524255
 Compound Info 
US8754233, 4-(5-Methoxy-benzothiazol-2-yl)-5-methyl-2H-pyrazol-3-ylamine
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C12H12N4OS
  1
1
IC50 = 3700 nM
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CP0524263
 Compound Info 
US8754233, [2-(5-Amino-3-methyl-1H-pyrazol-4-yl)-benzothiazol-5-yl]-methanol
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C12H12N4OS
  1
1
IC50 = 3700 nM
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CP0544775
 Compound Info 
US8754233, 4-Benzothiazol-2-yl-5-pyrrolidin-1-yl-1H-pyrazol-3-ylamine
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C14H15N5S
  1
1
IC50 = 3700 nM
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CP0549339
 Compound Info 
US8754233, 4-(5-Fluoro-6-methoxy-benzothiazol-2-yl)-5-(2-fluoro-phenyl)-2H-pyrazol-3-ylamine
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C17H12F2N4OS
  1
1
IC50 = 4000 nM
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CP0566660
 Compound Info 
US8754233, 4-Benzothiazol-2-yl-5-(4-nitro-phenyl)-2H-pyrazol-3-ylamine
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C16H11N5O2S
  1
1
IC50 = 4000 nM
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CP0462721
 Compound Info 
US8754233, 4-(5-Amino-4-benzothiazol-2-yl-1H-pyrazol-3-ylamino)-butyric acid
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C14H15N5O2S
  1
1
IC50 = 4300 nM
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CP0538909
 Compound Info 
US8754233, 2-(4-Benzothiazol-2-yl-1H-pyrazol-3-yl)-phenol
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C16H11N3OS
  1
1
IC50 = 4600 nM
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CP0538616
 Compound Info 
US8754233, 2-(5-Amino-3-methyl-1H-pyrazol-4-yl)-benzothiazole-6-sulfonic acid 4-fluoro-benzylamide
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C18H16FN5O2S2
  1
1
IC50 = 4800 nM
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CP0391641
 Compound Info 
US8754233, 5-Methyl-4-[6-(4-methyl-piperazine-1-sulfonyl)-benzothiazol-2-yl]-2H-pyrazol-3-ylamine
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C16H20N6O2S2
  1
1
IC50 = 4900 nM
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CP0385571
 Compound Info 
US8754233, 5-Methyl-4-[6-(4-methyl-piperazin-1-ylmethyl)-benzothiazol-2-yl]-2H-pyrazol-3-ylamine
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C17H22N6S
  1
1
IC50 = 5000 nM
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CP0566367
 Compound Info 
US8754233, N3-(4-Amino-phenyl)-4-benzothiazol-2-yl-1H-pyrazole-3,5-diamine
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C16H14N6S
  1
1
IC50 = 5000 nM
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Cell Line ID: CL000013 , Sf9
 Cell Line Info 
Clinical Information about the Protein
Target 1 ( Integrin-linked protein kinase 1 (ILK) )
Target Type Patented-recorded Target