General Information of the Protein
Protein ID
PT03938
Protein Name
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
Secondarily
Protein Name
Beta-1,2-N-acetylglucosaminyltransferase II
GlcNAc-T II
Mannoside acetylglucosaminyltransferase 2
N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II
Gene Name
MGAT2
Sequence
MRFRIYKRKVLILTLVVAACGFVLWSSNGRQRKNEALAPPLLDAEPARGAGGRGGDHPSVAVGIRRVSNVSAASLVPAVPQPEADNLTLRYRSLVYQLNFDQTLRNVDKAGTWAPRELVLVVQVHNRPEYLRLLLDSLRKAQGIDNVLVIFSHDFWSTEINQLIAGVNFCPVLQVFFPFSIQLYPNEFPGSDPRDCPRDLPKNAALKLGCINAEYPDSFGHYREAKFSQTKHHWWWKLHFVWERVKILRDYAGLILFLEEDHYLAPDFYHVFKKMWKLKQQECPECDVLSLGTYSASRSFYGMADKVDVKTWKSTEHNMGLALTRNAYQKLIECTDTFCTYDDYNWDWTLQYLTVSCLPKFWKVLVPQIPRIFHAGDCGMHHKKTCRPSTQSAQIESLLNNNKQYMFPETLTISEKFTVVAISPPRKNGGWGDIRDHELCKSYRRLQ
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
>
Transferase
Function
Plays an essential role in protein N-glycosylation. Catalyzes the transfer of N-acetylglucosamine (GlcNAc) onto the free terminal mannose moiety in the core structure of the nascent N-linked glycan chain, giving rise to the second branch in complex glycans.
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Uniprot ID
Primary ID:
Q10469

Secondarily ID:
B3KPC5
B3KQM0
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Ensembl ID
ENSG00000168282
HGNC ID
HGNC:7045
Subcellular Location
Golgi apparatus membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000742 , FreeStyle 293-F
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0385499
 Compound Info 
N-[5-[(2,4-difluorophenyl)sulfamoyl]-1-(2-phenylethyl)-2,3-dihydroindol-7-yl]acetamide
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C24H23F2N3O3S
  1
1
IC50 = 1 nM
 Bioactivity Info 
   TI
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CP0434818
 Compound Info 
N-[5-[(2,4-difluorophenyl)sulfamoyl]-1-[2-(4-fluorophenyl)ethyl]-2,3-dihydroindol-7-yl]acetamide
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C24H22F3N3O3S
  1
1
IC50 = 1.2 nM
 Bioactivity Info 
   TI
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CP0415109
 Compound Info 
N-[5-[(2,4-difluorophenyl)sulfamoyl]-1-(2-phenylethyl)indol-7-yl]acetamide
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C24H21F2N3O3S
  1
1
IC50 = 2.1 nM
 Bioactivity Info 
   TI
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CP0495220
 Compound Info 
benzyl 5-[(2,4-difluorophenyl)sulfamoyl]-7-(2-oxo-1,3-diazinan-1-yl)-2,3-dihydroindole-1-carboxylate
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C26H24F2N4O5S
  1
1
IC50 = 2.2 nM
 Bioactivity Info 
   TI
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CP0868923
 Compound Info 
N-{5-[(4-Methoxyphenyl)sulfamoyl]-1-(2-phenylethyl)-2,3-dihydro-1H-indol-7-yl}acetamide
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C25H27N3O4S
  1
1
IC50 = 2.2 nM
 Bioactivity Info 
   TI
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CP0488292
 Compound Info 
5-[(2,4-difluorophenyl)sulfamoyl]-7-(2-oxoimidazolidin-1-yl)-N-[4-(trifluoromethyl)phenyl]-2,3-dihydroindole-1-carboxamide
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C25H20F5N5O4S
  1
1
IC50 = 2.5 nM
 Bioactivity Info 
   TI
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CP0413379
 Compound Info 
5-[(2,4-difluorophenyl)sulfamoyl]-7-(2-oxopyrrolidin-1-yl)-N-[4-(trifluoromethyl)phenyl]-2,3-dihydroindole-1-carboxamide
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C26H21F5N4O4S
  1
1
IC50 = 3.1 nM
 Bioactivity Info 
   TI
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CP0420178
 Compound Info 
benzyl 5-[(2,4-difluorophenyl)sulfamoyl]-7-(2-oxoimidazolidin-1-yl)-2,3-dihydroindole-1-carboxylate
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C25H22F2N4O5S
  1
1
IC50 = 3.4 nM
 Bioactivity Info 
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CP0420177
 Compound Info 
N-(4-tert-butylphenyl)-5-[(2,4-difluorophenyl)sulfamoyl]-7-(2-oxopyrrolidin-1-yl)-2,3-dihydroindole-1-carboxamide
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C29H30F2N4O4S
  1
1
IC50 = 3.6 nM
 Bioactivity Info 
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CP0882903
 Compound Info 
N-(5-(N-(2,4-difluorophenyl)sulfamoyl)-1-(3-phenylpropyl)indolin-7-yl)acetamide
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C25H25F2N3O3S
  1
1
IC50 = 3.7 nM
 Bioactivity Info 
   TI
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CP0420137
 Compound Info 
N-(2,4-difluorophenyl)-7-(2-oxopyrrolidin-1-yl)-1-(2-phenylethyl)-2,3-dihydroindole-5-sulfonamide
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C26H25F2N3O3S
  1
1
IC50 = 6.7 nM
 Bioactivity Info 
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CP0434817
 Compound Info 
N-(2,4-difluorophenyl)-7-(2-oxopiperidin-1-yl)-1-(2-phenylethyl)-2,3-dihydroindole-5-sulfonamide
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C27H27F2N3O3S
  1
1
IC50 = 7.3 nM
 Bioactivity Info 
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CP0420136
 Compound Info 
benzyl 5-[(2,4-difluorophenyl)sulfamoyl]-7-(2-oxopiperidin-1-yl)-2,3-dihydroindole-1-carboxylate
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C27H25F2N3O5S
  1
1
IC50 = 10 nM
 Bioactivity Info 
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CP0415107
 Compound Info 
benzyl N-[4-[(2,4-difluorophenyl)sulfamoyl]-2-(2-oxopyrrolidin-1-yl)phenyl]carbamate
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C24H21F2N3O5S
  1
1
IC50 = 14 nM
 Bioactivity Info 
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CP0415108
 Compound Info 
N-[1-benzyl-5-[(2,4-difluorophenyl)sulfamoyl]-2,3-dihydroindol-7-yl]acetamide
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C23H21F2N3O3S
  1
1
IC50 = 23 nM
 Bioactivity Info 
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CP0445211
 Compound Info 
5-[(2,4-difluorophenyl)sulfamoyl]-N-(4-fluorophenyl)-7-(2-oxopyrrolidin-1-yl)-2,3-dihydroindole-1-carboxamide
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C25H21F3N4O4S
  1
1
IC50 = 28 nM
 Bioactivity Info 
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CP0445212
 Compound Info 
N-[5-[(2,4-difluorophenyl)sulfamoyl]-1-[2-(4-fluorophenyl)ethyl]indazol-7-yl]acetamide
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C23H19F3N4O3S
  1
1
IC50 = 41 nM
 Bioactivity Info 
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CP0445209
 Compound Info 
benzyl 5-[(2,4-difluorophenyl)sulfamoyl]-7-(2-oxo-1,3-oxazolidin-3-yl)-2,3-dihydroindole-1-carboxylate
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C25H21F2N3O6S
  1
1
IC50 = 43 nM
 Bioactivity Info 
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CP0415106
 Compound Info 
N-[5-[(4-methoxyphenyl)sulfamoyl]-2-methylphenyl]-2-phenoxyacetamide
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C22H22N2O5S
  1
1
IC50 = 130 nM
 Bioactivity Info 
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CP0445210
 Compound Info 
N-[5-[(4-methoxyphenyl)sulfamoyl]-2-(2-phenylethoxy)phenyl]acetamide
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C23H24N2O5S
  1
1
IC50 = 130 nM
 Bioactivity Info 
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CP0529454
 Compound Info 
N-(2,4-difluorophenyl)-7-(methylamino)-1-(2-phenylethyl)-2,3-dihydroindole-5-sulfonamide
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C23H23F2N3O2S
  1
1
IC50 = 130 nM
 Bioactivity Info 
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CP0882904
 Compound Info 
N-{5-[(2,4-Difluomphenyl)sulfamoyl]-1-[2-(4-fluorophenyl)ethyl]-1H-benzimidazol-7-yl}acetamide
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C23H19F3N4O3S
  1
1
IC50 = 170 nM
 Bioactivity Info 
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CP0431742
 Compound Info 
N-(2,4-difluorophenyl)-1-(2-phenylethyl)-2,3-dihydroindole-5-sulfonamide
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C22H20F2N2O2S
  1
1
IC50 = 270 nM
 Bioactivity Info 
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CP0875415
 Compound Info 
N-{6-[(2,4-Difluorophenyl)sulfamoyl]-2-oxo-3-(2-phenylethyl)-2,3-dihydro-1,3-benzoxazol-4-yl}acetamide
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C23H19F2N3O5S
  1
1
IC50 = 2100 nM
 Bioactivity Info 
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CP0456598
 Compound Info 
N-[6-[(2,4-difluorophenyl)sulfamoyl]-3-[2-(4-fluorophenyl)ethyl]-2-methylbenzimidazol-4-yl]acetamide
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C24H21F3N4O3S
  1
1
IC50 = 3300 nM
 Bioactivity Info 
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Cell Line ID: CL000013 , Sf9
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0519913
 Compound Info 
US9365558, 67
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C27H25F9N2O5S
  1
1 IC50 = 1 nM
Clinical Information about the Protein
Target 1 ( Mannoside acetylglucosaminyltransferase 2 (MGAT2) )
Target Type Patented-recorded Target