Protein Information

General Information of the Protein

Protein ID	PT03737
Protein Name	Interleukin-5
Secondarily Protein Name	B-cell growth factor II Cytotoxic T-lymphocyte inducer Eosinophil differentiation factor T-cell replacing factor
Gene Name	IL5
Secondarily Gene Name	Il-5
Sequence	MRRMLLHLSVLTLSCVWATAMEIPMSTVVKETLTQLSAHRALLTSNETMRLPVPTHKNHQLCIGEIFQGLDILKNQTVRGGTVEMLFQNLSLIKKYIDRQKEKCGEERRRTRQFLDYLQEFLGVMSTEWAMEG Show/Hide
Organism	Mus musculus, Mouse
Protein Classification	Secreted protein
Function	Homodimeric cytokine expressed predominantly by T-lymphocytes and NK cells that plays an important role in the survival, differentiation, and chemotaxis of eosinophils (PubMed:10444455, PubMed:1873482). Acts also on activated and resting B-cells to induce immunoglobulin production, growth, and differentiation (PubMed:3128631). Mechanistically, exerts its biological effects through a receptor composed of IL5RA subunit and the cytokine receptor common subunit beta/CSF2RB. Binding to the receptor leads to activation of various kinases including LYN, SYK and JAK2 and thereby propagates signals through the RAS-MAPK and JAK-STAT5 pathways respectively (By similarity). Show/Hide
Uniprot ID	P04401
Ensembl ID	ENSG00000113525
Subcellular Location	Secreted

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000500 , Y16

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0070217 Compound Info	5,7-dihydroxy-3-[4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]chromen-4-one Show/Hide	C21H20O10	2
1	IC50 = 1400 nM Bioactivity Info	TI LI LO TS
2	IC50 = 10600 nM Bioactivity Info	TI LI LO TS
CP0411833 Compound Info	2-cyclohexyl-5-(cyclohexylmethyl)-3-(3-hydroxypropoxy)chromen-4-one Show/Hide	C25H34O4	1
1	IC50 = 3000 nM Bioactivity Info	TI LI LO TS
CP0433513 Compound Info	5-(cyclohexylmethoxy)-3-[3-hydroxy-3-(4-hydroxyphenyl)propyl]chromen-4-one Show/Hide	C25H28O5	1
1	IC50 = 4000 nM Bioactivity Info	TI LI LO TS
CP0953936 Compound Info	7-(Cyclohexylmethoxy)-2-(4-hydroxybenzyl)-2,3-dihydro-1H-inden-1-one Show/Hide	C23H26O3	1
1	IC50 = 4000 nM Bioactivity Info	TI LI LO TS
CP0899059 Compound Info	3-benzylchromen-4-one Show/Hide	C23H24O4	1
1	IC50 = 5000 nM Bioactivity Info	TI LI LO TS
CP0493220 Compound Info	5-(cyclohexylmethyl)-3-(3-hydroxypropoxy)-2-propan-2-ylchromen-4-one Show/Hide	C22H30O4	1
1	IC50 = 5500 nM Bioactivity Info	TI LI LO TS
CP0417980 Compound Info	5-(cyclohexylmethoxy)-3-(4-hydroxyphenyl)-4H-chromen-4-one Show/Hide	C22H22O4	1
1	IC50 = 5800 nM Bioactivity Info	TI LI LO TS
CP0873076 Compound Info	7-(Cyclohexylmethoxy)-2-(3-hydroxybenzyl)-2,3-dihydro-1H-inden-1-one Show/Hide	C23H26O3	1
1	IC50 = 6000 nM Bioactivity Info	TI LI LO TS
CP0491015 Compound Info	5-(Cyclohexylmethoxy)-3-(3,4,5-trimethoxyphenyl)-4Hchromen-4-one Show/Hide	C25H28O6	1
1	IC50 = 6100 nM Bioactivity Info	TI LI LO TS
CP0460504 Compound Info	5-(cyclohexylmethoxy)-3-[(E)-3-(4-fluorophenyl)-3-hydroxyprop-1-enyl]chromen-4-one Show/Hide	C25H25FO4	1
1	IC50 = 6400 nM Bioactivity Info	TI LI LO TS
CP0509997 Compound Info	5-(cyclohexylmethoxy)-3-[3-hydroxy-3-(4-methoxyphenyl)propyl]chromen-4-one Show/Hide	C26H30O5	1
1	IC50 = 6500 nM Bioactivity Info	TI LI LO TS
CP0481467 Compound Info	4-[(E)-3-[5-(cyclohexylmethoxy)-4-oxochromen-3-yl]-1-hydroxyprop-2-enyl]benzonitrile Show/Hide	C26H25NO4	1
1	IC50 = 6700 nM Bioactivity Info	TI LI LO TS
CP0449160 Compound Info	3-[(E)-3-(4-chlorophenyl)-3-hydroxyprop-1-enyl]-5-(cyclohexylmethoxy)chromen-4-one Show/Hide	C25H25ClO4	1
1	IC50 = 7000 nM Bioactivity Info	TI LI LO TS
CP0481447 Compound Info	5-(cyclohexylmethoxy)-3-[(E)-3-hydroxy-3-(4-nitrophenyl)prop-1-enyl]chromen-4-one Show/Hide	C25H25NO6	1
1	IC50 = 7000 nM Bioactivity Info	TI LI LO TS
CP0411839 Compound Info	5-(cyclohexylmethyl)-3-(3-hydroxypropoxy)-2-methylchromen-4-one Show/Hide	C20H26O4	1
1	IC50 = 7500 nM Bioactivity Info	TI LI LO TS
CP0385604 Compound Info	5-(cyclohexylmethoxy)-3-[3-(3,4-dichlorophenyl)-3-hydroxypropyl]chromen-4-one Show/Hide	C25H26Cl2O4	1
1	IC50 = 7900 nM Bioactivity Info	TI LI LO TS
CP0449492 Compound Info	3-[[cyclohexyl(2-hydroxyethyl)amino]methyl]-5-(cyclohexylmethoxy)chromen-4-one Show/Hide	C25H35NO4	1
1	IC50 = 9000 nM Bioactivity Info	TI LI LO TS
CP0453328 Compound Info	5-(cyclohexylmethoxy)-3-[[2-hydroxyethyl-[(4-methoxyphenyl)methyl]amino]methyl]chromen-4-one Show/Hide	C27H33NO5	1
1	IC50 = 9000 nM Bioactivity Info	TI LI LO TS
CP0433511 Compound Info	5-(cyclohexylmethoxy)-3-[3-(4-fluorophenyl)-3-hydroxypropyl]chromen-4-one Show/Hide	C25H27FO4	1
1	IC50 = 9000 nM Bioactivity Info	TI LI LO TS
CP0468682 Compound Info	3-[3-(4-chlorophenyl)-3-hydroxypropyl]-5-(cyclohexylmethoxy)chromen-4-one Show/Hide	C25H27ClO4	1
1	IC50 = 9000 nM Bioactivity Info	TI LI LO TS
CP0495457 Compound Info	5-(cyclohexylmethoxy)-3-[[2-hydroxyethyl-[(4-hydroxyphenyl)methyl]amino]methyl]chromen-4-one Show/Hide	C26H31NO5	1
1	IC50 = 9100 nM Bioactivity Info	TI LI LO TS
CP0381047 Compound Info	3-[[butyl(2-hydroxyethyl)amino]methyl]-5-(cyclohexylmethoxy)chromen-4-one Show/Hide	C23H33NO4	1
1	IC50 = 9200 nM Bioactivity Info	TI LI LO TS
CP0453387 Compound Info	5-(cyclohexylmethoxy)-3-[[2-hydroxyethyl-[(4-methylphenyl)methyl]amino]methyl]chromen-4-one Show/Hide	C27H33NO4	1
1	IC50 = 9400 nM Bioactivity Info	TI LI LO TS
CP0540872 Compound Info	N-[[5-(cyclohexylmethoxy)-4-oxochromen-3-yl]methyl]-N-(2-hydroxyethyl)-2-phenylacetamide Show/Hide	C27H31NO5	1
1	IC50 = 10000 nM Bioactivity Info	TI LI LO TS
CP0536096 Compound Info	5-(cyclohexylmethyl)-3-(3-hydroxypropoxy)chromen-4-one Show/Hide	C19H24O4	1
1	IC50 = 10000 nM Bioactivity Info	TI LI LO TS
CP0408535 Compound Info	5-(cyclohexylmethoxy)-3-[[2-hydroxyethyl(propan-2-yl)amino]methyl]chromen-4-one Show/Hide	C22H31NO4	1
1	IC50 = 10200 nM Bioactivity Info	TI LI LO TS
CP0381045 Compound Info	3-[[(4-chlorophenyl)methyl-(2-hydroxyethyl)amino]methyl]-5-(cyclohexylmethoxy)chromen-4-one Show/Hide	C26H30ClNO4	1
1	IC50 = 10300 nM Bioactivity Info	TI LI LO TS
CP0470435 Compound Info	5,7-dihydroxy-3-[4-[(2R,3S,4R,5R,6S)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]chromen-4-one Show/Hide	C21H20O10	1
1	IC50 = 10600 nM Bioactivity Info	TI LI LO TS
CP0469713 Compound Info	5-(cyclohexylmethyl)-3-[[4-(hydroxymethyl)phenyl]methoxy]chromen-4-one Show/Hide	C24H26O4	1
1	IC50 = 11000 nM Bioactivity Info	TI LI LO TS
CP0467075 Compound Info	5-(cyclohexylmethoxy)-3-(3-hydroxy-3-phenylpropyl)chromen-4-one Show/Hide	C25H28O4	1
1	IC50 = 12000 nM Bioactivity Info	TI LI LO TS
CP0499270 Compound Info	5-(cyclohexylmethoxy)-3-[[cyclohexylmethyl(2-hydroxyethyl)amino]methyl]chromen-4-one Show/Hide	C26H37NO4	1
1	IC50 = 12400 nM Bioactivity Info	TI LI LO TS
CP0419288 Compound Info	5-(cyclohexylmethoxy)-3-[(E)-3-hydroxy-3-(4-hydroxyphenyl)prop-1-enyl]chromen-4-one Show/Hide	C25H26O5	1
1	IC50 = 12500 nM Bioactivity Info	TI LI LO TS
CP0117491 Compound Info	(E)-3-[2-(cyclohexylmethoxy)-6-hydroxyphenyl]-1-(4-hydroxyphenyl)prop-2-en-1-one Show/Hide	C22H24O4	1
1	IC50 = 12600 nM Bioactivity Info	TI LI LO TS
CP0550379 Compound Info	5-(cyclohexylmethyl)-3-[(4-nitrophenyl)methoxy]chromen-4-one Show/Hide	C23H23NO5	1
1	IC50 = 13000 nM Bioactivity Info	TI LI LO TS
CP0440849 Compound Info	5-(cyclohexylmethoxy)-3-[(E)-3-hydroxy-3-[4-(trifluoromethyl)phenyl]prop-1-enyl]chromen-4-one Show/Hide	C26H25F3O4	1
1	IC50 = 13200 nM Bioactivity Info	TI LI LO TS
CP0491629 Compound Info	3-[3-(4-chlorophenyl)-3-oxopropyl]-5-(cyclohexylmethoxy)chromen-4-one Show/Hide	C25H25ClO4	1
1	IC50 = 14000 nM Bioactivity Info	TI LI LO TS
CP0389288 Compound Info	3-(3-hydroxypropoxy)-5-(3-methylbutyl)chromen-4-one Show/Hide	C17H22O4	1
1	IC50 = 14000 nM Bioactivity Info	TI LI LO TS
CP0547868 Compound Info	5-(cyclohexylmethyl)-3-(3-hydroxypropoxy)-2-propylchromen-4-one Show/Hide	C22H30O4	1
1	IC50 = 14000 nM Bioactivity Info	TI LI LO TS
CP0514193 Compound Info	5-(cyclohexylmethoxy)-3-[[2-hydroxyethyl(pyridin-4-ylmethyl)amino]methyl]chromen-4-one Show/Hide	C25H30N2O4	1
1	IC50 = 14200 nM Bioactivity Info	TI LI LO TS
CP0404921 Compound Info	5-(cyclohexylmethoxy)-3-[[N-(2-hydroxyethyl)anilino]methyl]chromen-4-one Show/Hide	C25H29NO4	1
1	IC50 = 14300 nM Bioactivity Info	TI LI LO TS
CP0427212 Compound Info	5-(cyclohexylmethoxy)-3-[(E)-3-hydroxy-3-phenylprop-1-enyl]chromen-4-one Show/Hide	C25H26O4	1
1	IC50 = 15000 nM Bioactivity Info	TI LI LO TS
CP0476774 Compound Info	5-(cyclohexylmethoxy)-3-[(E)-3-hydroxy-3-(4-methylphenyl)prop-1-enyl]chromen-4-one Show/Hide	C26H28O4	1
1	IC50 = 15000 nM Bioactivity Info	TI LI LO TS
CP0404124 Compound Info	4-[3-[5-(cyclohexylmethoxy)-4-oxochromen-3-yl]-1-hydroxypropyl]benzonitrile Show/Hide	C26H27NO4	1
1	IC50 = 15000 nM Bioactivity Info	TI LI LO TS
CP0449659 Compound Info	5-(cyclohexylmethoxy)-3-[3-(4-hydroxyphenyl)-3-oxopropyl]chromen-4-one Show/Hide	C25H26O5	1
1	IC50 = 15000 nM Bioactivity Info	TI LI LO TS
CP0560452 Compound Info	1-[[5-(cyclohexylmethoxy)-4-oxochromen-3-yl]methyl]-1-(2-hydroxyethyl)-3-(3-phenylpropyl)urea Show/Hide	C29H36N2O5	1
1	IC50 = 15000 nM Bioactivity Info	TI LI LO TS
CP0393303 Compound Info	5-(cyclohexylmethoxy)-3-[[2-hydroxyethyl(propyl)amino]methyl]chromen-4-one Show/Hide	C22H31NO4	1
1	IC50 = 15400 nM Bioactivity Info	TI LI LO TS
CP0460376 Compound Info	5-(cyclohexylmethoxy)-3-[(E)-3-hydroxy-3-(4-methoxyphenyl)prop-1-enyl]chromen-4-one Show/Hide	C26H28O5	1
1	IC50 = 16000 nM Bioactivity Info	TI LI LO TS
CP0433508 Compound Info	5-(cyclohexylmethoxy)-3-[3-(4-methoxyphenyl)-3-oxopropyl]chromen-4-one Show/Hide	C26H28O5	1
1	IC50 = 16000 nM Bioactivity Info	TI LI LO TS
CP0396479 Compound Info	5-(cyclohexylmethyl)-3-hydroxychromen-4-one Show/Hide	C16H18O3	1
1	IC50 = 16000 nM Bioactivity Info	TI LI LO TS
CP0536094 Compound Info	3-hydroxy-5-(3-methylbutyl)chromen-4-one Show/Hide	C14H16O3	1
1	IC50 = 16000 nM Bioactivity Info	TI LI LO TS
CP0566360 Compound Info	methyl 4-[[5-(cyclohexylmethyl)-4-oxochromen-3-yl]oxymethyl]benzoate Show/Hide	C25H26O5	1
1	IC50 = 16000 nM Bioactivity Info	TI LI LO TS
CP0381046 Compound Info	3-[[benzyl(2-hydroxyethyl)amino]methyl]-5-(cyclohexylmethoxy)chromen-4-one Show/Hide	C26H31NO4	1
1	IC50 = 16100 nM Bioactivity Info	TI LI LO TS
CP0481446 Compound Info	5-(cyclohexylmethoxy)-3-[(E)-3-(4-hydroxyphenyl)-3-oxoprop-1-enyl]chromen-4-one Show/Hide	C25H24O5	1
1	IC50 = 16200 nM Bioactivity Info	TI LI LO TS
CP0432192 Compound Info	4-[3-[5-(cyclohexylmethoxy)-4-oxochromen-3-yl]propanoyl]benzonitrile Show/Hide	C26H25NO4	1
1	IC50 = 17000 nM Bioactivity Info	TI LI LO TS
CP0433509 Compound Info	5-(cyclohexylmethoxy)-3-(3-hydroxy-3-naphthalen-2-ylpropyl)chromen-4-one Show/Hide	C29H30O4	1
1	IC50 = 17000 nM Bioactivity Info	TI LI LO TS
CP0408633 Compound Info	3-cyclohexyl-1-[[5-(cyclohexylmethoxy)-4-oxochromen-3-yl]methyl]-1-(2-hydroxyethyl)urea Show/Hide	C26H36N2O5	1
1	IC50 = 17000 nM Bioactivity Info	TI LI LO TS
CP0463436 Compound Info	1-[[5-(cyclohexylmethoxy)-4-oxochromen-3-yl]methyl]-1-(2-hydroxyethyl)-3-phenylurea Show/Hide	C26H30N2O5	1
1	IC50 = 17000 nM Bioactivity Info	TI LI LO TS
CP0552505 Compound Info	4-[[5-(cyclohexylmethyl)-4-oxochromen-3-yl]oxymethyl]benzoic acid Show/Hide	C24H24O5	1
1	IC50 = 17000 nM Bioactivity Info	TI LI LO TS
CP0555850 Compound Info	5-(cyclohexylmethyl)-3-(2-hydroxyethoxy)chromen-4-one Show/Hide	C18H22O4	1
1	IC50 = 17000 nM Bioactivity Info	TI LI LO TS
CP0959419 Compound Info	7-(Cyclohexylmethoxy)-2-(4-(methoxymethoxy)benzyl)-2,3-dihydro-1H-inden-1-one Show/Hide	C25H30O4	1
1	IC50 = 17000 nM Bioactivity Info	TI LI LO TS
CP0400318 Compound Info	3-((1-Cyclohexyl-3-hydroxypropan-2-ylamino)methyl)-5-(cyclohexylmethoxy)-4H-chromen-4-one Show/Hide	C26H37NO4	1
1	IC50 = 17300 nM Bioactivity Info	TI LI LO TS
CP0504195 Compound Info	3-(4-(Benzyloxy)-3-methoxyphenyl)-5-(cyclohexylmethoxy)-4H-chromen-4-one Show/Hide	C30H30O5	1
1	IC50 = 17400 nM Bioactivity Info	TI LI LO TS
CP0408638 Compound Info	N-[[5-(cyclohexylmethoxy)-4-oxochromen-3-yl]methyl]-N-(2-hydroxyethyl)-2-(4-methoxyphenyl)acetamide Show/Hide	C28H33NO6	1
1	IC50 = 17900 nM Bioactivity Info	TI LI LO TS
CP0470840 Compound Info	1-[[5-(cyclohexylmethoxy)-4-oxochromen-3-yl]methyl]-1-(2-hydroxyethyl)-3-(4-methoxyphenyl)urea Show/Hide	C27H32N2O6	1
1	IC50 = 18000 nM Bioactivity Info	TI LI LO TS
CP0541528 Compound Info	3-benzyl-1-[[5-(cyclohexylmethoxy)-4-oxochromen-3-yl]methyl]-1-(2-hydroxyethyl)urea Show/Hide	C27H32N2O5	1
1	IC50 = 18000 nM Bioactivity Info	TI LI LO TS
CP0943134 Compound Info	7-(2-Cyclohexylethoxy)-2-(4-hydroxybenzyl)-2,3-dihydro-1H-inden-1-one Show/Hide	C24H28O3	1
1	IC50 = 18000 nM Bioactivity Info	TI LI LO TS
CP0425862 Compound Info	3-[(E)-3-(4-tert-butylphenyl)-3-oxoprop-1-enyl]-5-(cyclohexylmethoxy)chromen-4-one Show/Hide	C29H32O4	1
1	IC50 = 18100 nM Bioactivity Info	TI LI LO TS
CP0400316 Compound Info	5-(Cyclohexylmethoxy)-3-((2-hydroxy-1-phenylethylamino)methyl)-4H-chromen-4-one Show/Hide	C25H29NO4	1
1	IC50 = 18500 nM Bioactivity Info	TI LI LO TS
CP0449159 Compound Info	3-[(E)-3-(4-hydroxyphenyl)-3-oxoprop-1-enyl]-5-(2-methylpropoxy)chromen-4-one Show/Hide	C22H20O5	1
1	IC50 = 19100 nM Bioactivity Info	TI LI LO TS
CP0455240 Compound Info	5-(cyclohexylmethoxy)-3-[[ethyl(2-hydroxyethyl)amino]methyl]chromen-4-one Show/Hide	C21H29NO4	1
1	IC50 = 19500 nM Bioactivity Info	TI LI LO TS
CP0525703 Compound Info	5-(cyclohexylmethoxy)-3-[3-(4-fluorophenyl)-3-oxopropyl]chromen-4-one Show/Hide	C25H25FO4	1
1	IC50 = 20000 nM Bioactivity Info	TI LI LO TS
CP0411837 Compound Info	5-(cyclohexylmethyl)-3-[(4-methoxyphenyl)methoxy]chromen-4-one Show/Hide	C24H26O4	1
1	IC50 = 20000 nM Bioactivity Info	TI LI LO TS
CP0411838 Compound Info	3-hydroxy-6-(3-methylbutyl)chromen-4-one Show/Hide	C14H16O3	1
1	IC50 = 20000 nM Bioactivity Info	TI LI LO TS
CP0408635 Compound Info	ethyl N-[[5-(cyclohexylmethoxy)-4-oxochromen-3-yl]methyl]-N-(2-hydroxyethyl)carbamate Show/Hide	C22H29NO6	1
1	IC50 = 20200 nM Bioactivity Info	TI LI LO TS
CP0873081 Compound Info	2-(4-Chlorobenzyl)-7-(cyclohexylmethoxy)-2,3-dihydro-1H-inden-1-one Show/Hide	C23H25ClO2	1
1	IC50 = 20500 nM Bioactivity Info	TI LI LO TS
CP0952307 Compound Info	7-(Benzyloxy)-2-(4-hydroxybenzyl)-2,3-dihydro-1H-inden-1-one Show/Hide	C23H20O3	1
1	IC50 = 21000 nM Bioactivity Info	TI LI LO TS
CP0375460 Compound Info	5-(cyclohexylmethoxy)-3-[3-(3,4-dichlorophenyl)-3-oxopropyl]chromen-4-one Show/Hide	C25H24Cl2O4	1
1	IC50 = 22000 nM Bioactivity Info	TI LI LO TS
CP0465029 Compound Info	5-(cyclohexylmethyl)-3-(pyridin-4-ylmethoxy)chromen-4-one Show/Hide	C22H23NO3	1
1	IC50 = 24000 nM Bioactivity Info	TI LI LO TS
CP0957779 Compound Info	7-(Cyclohexylmethoxy)-2-(4-methylbenzyl)-2,3-dihydro-1H-inden-1-one Show/Hide	C24H28O2	1
1	IC50 = 24500 nM Bioactivity Info	TI LI LO TS
CP0408636 Compound Info	phenyl N-[[5-(cyclohexylmethoxy)-4-oxochromen-3-yl]methyl]-N-(2-hydroxyethyl)carbamate Show/Hide	C26H29NO6	1
1	IC50 = 25000 nM Bioactivity Info	TI LI LO TS
CP0465032 Compound Info	3-(2-hydroxyethoxy)-5-(3-methylbutyl)chromen-4-one Show/Hide	C16H20O4	1
1	IC50 = 25000 nM Bioactivity Info	TI LI LO TS
CP0447791 Compound Info	5-(cyclohexylmethoxy)-3-[(E)-3-(4-methylphenyl)-3-oxoprop-1-enyl]chromen-4-one Show/Hide	C26H26O4	1
1	IC50 = 25100 nM Bioactivity Info	TI LI LO TS
CP0408637 Compound Info	N-[[5-(cyclohexylmethoxy)-4-oxochromen-3-yl]methyl]-N-(2-hydroxyethyl)propanamide Show/Hide	C22H29NO5	1
1	IC50 = 25200 nM Bioactivity Info	TI LI LO TS
CP0541508 Compound Info	N-[[5-(cyclohexylmethoxy)-4-oxochromen-3-yl]methyl]-N-(2-hydroxyethyl)butanamide Show/Hide	C23H31NO5	1
1	IC50 = 25300 nM Bioactivity Info	TI LI LO TS
CP0400392 Compound Info	5-(Cyclohexylmethoxy)-3-((1-hydroxy-3-phenylpropan-2-ylamino)methyl)-4H-chromen-4-one Show/Hide	C26H31NO4	1
1	IC50 = 25700 nM Bioactivity Info	TI LI LO TS
CP0906643 Compound Info	2-(4-Hydroxybenzyl)-7-phenethoxy-2,3-dihydro-1H-inden-1-one Show/Hide	C24H22O3	1
1	IC50 = 26000 nM Bioactivity Info	TI LI LO TS
CP0084476 Compound Info	BUDESONIDE Show/Hide	C25H34O6	2
1	IC50 = 26200 nM Bioactivity Info	TI LI LO TS
2	IC50 = 27100 nM Bioactivity Info	TI LI LO TS
CP0427732 Compound Info	5-(Cyclohexylmethoxy)-3-((1-hydroxy-3,3-dimethylbutan-2-ylamino)methyl)-4H- chromen-4-one Show/Hide	C23H33NO4	1
1	IC50 = 26200 nM Bioactivity Info	TI LI LO TS
CP0930615 Compound Info	Budesonide Show/Hide	C25H34O6	1
1	IC50 = 26200 nM Bioactivity Info	TI LI LO TS
CP0492824 Compound Info	5-(Cyclohexylmethoxy)-3-((1-hydroxy-2-methylpropan-2-ylamino)methyl)-4H-chromen-4-one Show/Hide	C21H29NO4	1
1	IC50 = 26400 nM Bioactivity Info	TI LI LO TS
CP0389289 Compound Info	5-(cyclohexylmethyl)-3-phenylmethoxychromen-4-one Show/Hide	C23H24O3	1
1	IC50 = 27000 nM Bioactivity Info	TI LI LO TS
CP0401888 Compound Info	5-(Cyclohexylmethoxy)-3-((4-hydroxyphenylamino)-methyl)-4H-chromen-4-one Show/Hide	C23H25NO4	1
1	IC50 = 27300 nM Bioactivity Info	TI LI LO TS
CP0944941 Compound Info	2-(3-Hydroxybenzyl)-7-phenethoxy-2,3-dihydro-1H-inden-1-one Show/Hide	C24H22O3	1
1	IC50 = 28000 nM Bioactivity Info	TI LI LO TS
CP0493515 Compound Info	5-(Cyclohexylmethoxy)-3-((4-hydroxybenzylamino)methyl)-4H-chromen-4-one Show/Hide	C24H27NO4	1
1	IC50 = 28500 nM Bioactivity Info	TI LI LO TS
CP0465031 Compound Info	6-(cyclohexylmethyl)-3-hydroxychromen-4-one Show/Hide	C16H18O3	1
1	IC50 = 29000 nM Bioactivity Info	TI LI LO TS
CP0416316 Compound Info	(Z)-2-(Benzylidene)-4-(cyclohexylmethoxy)benzofuran-3(2H)-one Show/Hide	C22H22O3	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0416317 Compound Info	(Z)-2-(4-Chlorobenzylidene)-4-(cyclohexylmethoxy)benzofuran-3(2H)-one Show/Hide	C22H21ClO3	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0416318 Compound Info	(Z)-4-(Cyclohexylmethoxy)-2-(4-nitrobenzylidene)benzofuran-3(2H)-one Show/Hide	C22H21NO5	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0416319 Compound Info	5-(Cyclohexylmethoxy)-3-(4-methoxyphenyl)-4H-chromen-4-one Show/Hide	C23H24O4	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0417986 Compound Info	5-(Cyclohexylmethoxy)-3-(4-ethylphenyl)-4H-chromen-4-one Show/Hide	C24H26O3	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0438818 Compound Info	methyl 4-[(Z)-[4-(cyclohexylmethoxy)-3-oxo-1-benzofuran-2-ylidene]methyl]benzoate Show/Hide	C24H24O5	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0452167 Compound Info	(Z)-4-{[4-(Cyclohexylmethoxy)-3-oxobenzofuran-2(3H)-ylidene]methyl}benzaldehyde Show/Hide	C23H22O4	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0467483 Compound Info	5-(Cyclohexylmethoxy)-3-(3,4-dimethoxyphenyl)-4Hchromen-4-one Show/Hide	C24H26O5	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0475336 Compound Info	5-(Cyclohexylmethoxy)-3-(2,5-dimethoxyphenyl)-4Hchromen-4-one Show/Hide	C24H26O5	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0475337 Compound Info	5-(Cyclohexylmethoxy)-3-(4-hydroxy-3-methoxyphenyl)-4H-chromen-4-one Show/Hide	C23H24O5	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0491016 Compound Info	5-(Cyclohexylmethoxy)-3-[4-(methoxymethoxy)phenyl]-4H-chromen-4-one Show/Hide	C24H26O5	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0496168 Compound Info	(Z)-4-(cyclohexylmethoxy)-2-(4-ethylbenzylidene)benzofuran-3(2H)-one Show/Hide	C24H26O3	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0469758 Compound Info	5-(Cyclohexylmethoxy)-3-((4-methoxybenzylamino)-methyl)-4H-chromen-4-one Show/Hide	C25H29NO4	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0425861 Compound Info	3-[(E)-3-(4-chlorophenyl)-3-oxoprop-1-enyl]-5-(cyclohexylmethoxy)chromen-4-one Show/Hide	C25H23ClO4	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0427213 Compound Info	5-(cyclohexylmethoxy)-3-[(E)-3-(4-fluorophenyl)-3-oxoprop-1-enyl]chromen-4-one Show/Hide	C25H23FO4	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0433385 Compound Info	3-[(E)-3-hydroxy-3-(4-hydroxyphenyl)prop-1-enyl]-5-methoxychromen-4-one Show/Hide	C19H16O5	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0440848 Compound Info	4-[(E)-3-[5-(cyclohexylmethoxy)-4-oxochromen-3-yl]prop-2-enoyl]benzonitrile Show/Hide	C26H23NO4	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0449719 Compound Info	5-(cyclohexylmethoxy)-3-[(E)-3-(4-nitrophenyl)-3-oxoprop-1-enyl]chromen-4-one Show/Hide	C25H23NO6	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0460513 Compound Info	5-(cyclohexylmethoxy)-3-[(E)-3-(4-methoxyphenyl)-3-oxoprop-1-enyl]chromen-4-one Show/Hide	C26H26O5	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0464091 Compound Info	5-(cyclohexylmethoxy)-3-[(E)-3-oxo-3-phenylprop-1-enyl]chromen-4-one Show/Hide	C25H24O4	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0471237 Compound Info	5-(cyclohexylmethoxy)-3-[(E)-3-oxo-3-[4-(trifluoromethyl)phenyl]prop-1-enyl]chromen-4-one Show/Hide	C26H23F3O4	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0471238 Compound Info	3-[(E)-3-(4-hydroxyphenyl)-3-oxoprop-1-enyl]-5-methoxychromen-4-one Show/Hide	C19H14O5	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0477045 Compound Info	3-[(E)-3-(4-tert-butylphenyl)-3-hydroxyprop-1-enyl]-5-(cyclohexylmethoxy)chromen-4-one Show/Hide	C29H34O4	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0489052 Compound Info	3-[(E)-3-hydroxy-3-(4-hydroxyphenyl)prop-1-enyl]-5-(2-methylpropoxy)chromen-4-one Show/Hide	C22H22O5	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0385603 Compound Info	5-(cyclohexylmethoxy)-3-(3-oxo-3-phenylpropyl)chromen-4-one Show/Hide	C25H26O4	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0407582 Compound Info	5-(cyclohexylmethoxy)-3-[3-hydroxy-3-[4-(trifluoromethyl)phenyl]propyl]chromen-4-one Show/Hide	C26H27F3O4	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0432190 Compound Info	5-(cyclohexylmethoxy)-3-[3-oxo-3-[4-(trifluoromethyl)phenyl]propyl]chromen-4-one Show/Hide	C26H25F3O4	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0432193 Compound Info	5-(cyclohexylmethoxy)-3-[3-hydroxy-3-(4-methylphenyl)propyl]chromen-4-one Show/Hide	C26H30O4	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0433510 Compound Info	5-(cyclohexylmethoxy)-3-[3-(4-methoxyphenyl)-3-oxopropyl]-2,3-dihydrochromen-4-one Show/Hide	C26H30O5	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0449660 Compound Info	3-[3-(4-tert-butylphenyl)-3-hydroxypropyl]-5-(cyclohexylmethoxy)chromen-4-one Show/Hide	C29H36O4	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0468681 Compound Info	5-(cyclohexylmethoxy)-3-[3-(4-methylphenyl)-3-oxopropyl]chromen-4-one Show/Hide	C26H28O4	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0509998 Compound Info	3-[3-(4-tert-butylphenyl)-3-oxopropyl]-5-(cyclohexylmethoxy)chromen-4-one Show/Hide	C29H34O4	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0525302 Compound Info	5-(cyclohexylmethoxy)-3-[3-(3,4-dichlorophenyl)-3-oxopropyl]-2,3-dihydrochromen-4-one Show/Hide	C25H26Cl2O4	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0525303 Compound Info	5-(cyclohexylmethoxy)-3-(3-naphthalen-2-yl-3-oxopropyl)chromen-4-one Show/Hide	C29H28O4	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0408634 Compound Info	1-[[5-(3,3-dimethylbutoxy)-4-oxochromen-3-yl]methyl]-1-(2-hydroxyethyl)-3-phenylurea Show/Hide	C25H30N2O5	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0408639 Compound Info	N-[[5-(3,3-dimethylbutoxy)-4-oxochromen-3-yl]methyl]-N-(2-hydroxyethyl)-2-phenylacetamide Show/Hide	C26H31NO5	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0408640 Compound Info	N-(2-hydroxyethyl)-N-[[5-(3-methylbutoxy)-4-oxochromen-3-yl]methyl]-2-phenylacetamide Show/Hide	C25H29NO5	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0463437 Compound Info	phenyl N-[[5-(3,3-dimethylbutoxy)-4-oxochromen-3-yl]methyl]-N-(2-hydroxyethyl)carbamate Show/Hide	C25H29NO6	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0468857 Compound Info	1-[[5-(cyclohexylmethoxy)-4-oxochromen-3-yl]methyl]-1-(2-hydroxyethyl)-3-propan-2-ylurea Show/Hide	C23H32N2O5	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0475209 Compound Info	1-[[5-(cyclohexylmethoxy)-4-oxochromen-3-yl]methyl]-1-(2-hydroxyethyl)-3-propylurea Show/Hide	C23H32N2O5	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0495696 Compound Info	phenyl N-(2-hydroxyethyl)-N-[[5-(3-methylbutoxy)-4-oxochromen-3-yl]methyl]carbamate Show/Hide	C24H27NO6	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0540871 Compound Info	1-[[5-(cyclohexylmethoxy)-4-oxochromen-3-yl]methyl]-3-ethyl-1-(2-hydroxyethyl)urea Show/Hide	C22H30N2O5	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0562775 Compound Info	3-(4-chlorophenyl)-1-[[5-(cyclohexylmethoxy)-4-oxochromen-3-yl]methyl]-1-(2-hydroxyethyl)urea Show/Hide	C26H29ClN2O5	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0562777 Compound Info	1-(2-hydroxyethyl)-1-[[5-(3-methylbutoxy)-4-oxochromen-3-yl]methyl]-3-phenylurea Show/Hide	C24H28N2O5	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0389290 Compound Info	3-[(4-chlorophenyl)methoxy]-5-(cyclohexylmethyl)chromen-4-one Show/Hide	C23H23ClO3	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0411835 Compound Info	6-(cyclohexylmethyl)-3-(3-hydroxypropoxy)chromen-4-one Show/Hide	C19H24O4	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0465030 Compound Info	5-(cyclohexylmethyl)-3-[[4-(methoxymethoxy)phenyl]methoxy]chromen-4-one Show/Hide	C25H28O5	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0536093 Compound Info	5-(cyclohexylmethyl)-3-(4-hydroxybutoxy)chromen-4-one Show/Hide	C20H26O4	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0555851 Compound Info	3-(3-hydroxypropoxy)-6-(3-methylbutyl)chromen-4-one Show/Hide	C17H22O4	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0563363 Compound Info	5-(cyclohexylmethyl)-3-(5-hydroxypentoxy)chromen-4-one Show/Hide	C21H28O4	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0854293 Compound Info	2-(2-Hydroxybenzyl)-7-phenethoxy-2,3-dihydro-1H-inden-1-one Show/Hide	C24H22O3	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0865041 Compound Info	7-(Cyclohexylmethoxy)-2-(2-hydroxybenzyl)-2,3-dihydro-1H-inden-1-one Show/Hide	C23H26O3	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0873079 Compound Info	2-(4-Chlorobenzylidene)-7-((4-methoxybenzyl)oxy)-2,3-dihydro-1H-inden-1-one Show/Hide	C24H19ClO3	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0873080 Compound Info	7-Hydroxy-2-(4-methoxybenzylidene)-2,3-dihydro-1H-inden-1-one Show/Hide	C17H14O3	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0902464 Compound Info	2-(4-Hydroxybenzylidene)-7-((4-methoxybenzyl)oxy)-2,3-dihydro-1H-inden-1-one Show/Hide	C24H20O4	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0903492 Compound Info	7-(Cyclohexylmethoxy)-2-(4-(methoxymethoxy)benzylidene)-2,3-dihydro-1H-inden-1-one Show/Hide	C25H28O4	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0953922 Compound Info	7-((4-Methoxybenzyl)oxy)-2-(4-methylbenzylidene)-2,3-dihydro-1H-inden-1-one Show/Hide	C25H22O3	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0953932 Compound Info	7-(Cyclohexylmethoxy)-2-(4-hydroxybenzylidene)-2,3-dihydro-1H-inden-1-one Show/Hide	C23H24O3	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0953933 Compound Info	(E)-7-hydroxy-2-(4-hydroxybenzylidene)-2,3-dihydro-1H-inden-1-one Show/Hide	C16H12O3	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0953934 Compound Info	2-Benzylidene-7-hydroxy-2,3-dihydro-1H-inden-1-one Show/Hide	C16H12O2	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0953935 Compound Info	7-(Cyclohexylmethoxy)-2-(4-methoxybenzylidene)-2,3-dihydro-1H-inden-1-one Show/Hide	C24H26O3	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0953937 Compound Info	2-Benzylidene-7-((4-methoxybenzyl)oxy)-2,3-dihydro-1H-inden-1-one Show/Hide	C24H20O3	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0953938 Compound Info	2-(4-Hydroxybenzylidene)-7-((4-nitrobenzyl)oxy)-2,3-dihydro-1H-inden-1-one Show/Hide	C23H17NO5	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0957135 Compound Info	7-((4-Methoxybenzyl)oxy)-2-(4-methoxybenzylidene)-2,3-dihydro-1H-inden-1-one Show/Hide	C25H22O4	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0962264 Compound Info	7-(Cyclohexylmethoxy)-2-(4-methoxybenzyl)-2,3-dihydro-1H-inden-1-one Show/Hide	C24H28O3	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0963790 Compound Info	7-Hydroxy-2-(4-hydroxybenzyl)-2,3-dihydro-1H-inden-1-one Show/Hide	C16H14O3	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0453329 Compound Info	5-(cyclohexylmethoxy)-3-[[2-hydroxyethyl(methyl)amino]methyl]chromen-4-one Show/Hide	C20H27NO4	1
1	IC50 = 30300 nM Bioactivity Info	TI LI LO TS
CP0372730 Compound Info	5-(Cyclohexylmethoxy)-3-((4-methoxyphenylamino)-methyl)-4H-chromen-4-one Show/Hide	C24H27NO4	1
1	IC50 > 50000 nM Bioactivity Info	TI LI LO TS
CP0401886 Compound Info	5-(Cyclohexylmethoxy)-3-((3-hydroxypropylamino)-methyl)-4H-chromen-4-one Show/Hide	C20H27NO4	1
1	IC50 > 50000 nM Bioactivity Info	TI LI LO TS
CP0401889 Compound Info	5-(Cyclohexylmethoxy)-3-((1-hydroxypentan-2-ylamino)methyl)-4H-chromen-4-one Show/Hide	C22H31NO4	1
1	IC50 > 50000 nM Bioactivity Info	TI LI LO TS
CP0410127 Compound Info	5-(Cyclohexylmethoxy)-3-((phenylamino)methyl)-4Hchromen-4-one Show/Hide	C23H25NO3	1
1	IC50 > 50000 nM Bioactivity Info	TI LI LO TS
CP0421883 Compound Info	5-(Cyclohexylmethoxy)-3-((3-hydroxy-1-phenylpropylamino)methyl)-4H-chromen-4-one Show/Hide	C26H31NO4	1
1	IC50 > 50000 nM Bioactivity Info	TI LI LO TS
CP0421884 Compound Info	3-((Benzylamino)methyl)-5-(cyclohexylmethoxy)-4Hchromen-4-one Show/Hide	C24H27NO3	1
1	IC50 > 50000 nM Bioactivity Info	TI LI LO TS
CP0428885 Compound Info	5-(Cyclohexylmethoxy)-3-((5-hydroxypentylamino)-methyl)-4H-chromen-4-one Show/Hide	C22H31NO4	1
1	IC50 > 50000 nM Bioactivity Info	TI LI LO TS
CP0500630 Compound Info	5-(Cyclohexylmethoxy)-3-((2-hydroxyethylamino)-methyl)-4H-chromen-4-one Show/Hide	C19H25NO4	1
1	IC50 > 50000 nM Bioactivity Info	TI LI LO TS

Biochemical Assays

Compound ID	Compound Name	Compound Formula
CP0070217 Compound Info	5,7-dihydroxy-3-[4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]chromen-4-one Show/Hide	C21H20O10	1
1	IC50 = 10600 nM
CP0117491 Compound Info	(E)-3-[2-(cyclohexylmethoxy)-6-hydroxyphenyl]-1-(4-hydroxyphenyl)prop-2-en-1-one Show/Hide	C22H24O4	1
1	IC50 = 12600 nM
CP0084476 Compound Info	BUDESONIDE Show/Hide	C25H34O6	1
1	IC50 = 26200 nM

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han