Protein Information

General Information of the Protein

Protein ID	PT03697
Protein Name	5-hydroxytryptamine receptor 3A
Secondarily Protein Name	5-hydroxytryptamine receptor 3 Serotonin receptor 3A Serotonin-gated ion channel receptor
Gene Name	HTR3A
Secondarily Gene Name	5ht3 Htr3
Sequence	MRLCIPQVLLALFLSMLTAPGEGSRRRATQARDTTQPALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQRPVPDWLRHLVLDRIAWILCLGEQPMAHRPPATFQANKTDDCSGSDLLPAMGNHCSHVGGPQDLEKTPRGRGSPLPPPREASLAVRGLLQELSSIRHFLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIWHYS Show/Hide
Organism	Mus musculus, Mouse
Protein Classification	Ion channel > Ligand-gated ion channel > 5HT3 receptor
Function	Forms serotonin (5-hydroxytryptamine/5-HT3)-activated cation-selective channel complexes, which when activated cause fast, depolarizing responses in neurons. Show/Hide
Uniprot ID	Primary ID: P23979 Secondarily ID: E9QLC0 Q61225 Q61226 Show/Hide
Ensembl ID	ENSG00000166736
Subcellular Location	Postsynaptic cell membrane Cell membrane

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000006 , HEK293

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0056636 Compound Info	10-[(3S)-1-azabicyclo[2.2.2]octan-3-yl]-6-fluoro-1,2,10-triazatricyclo[6.4.1.04,13]trideca-2,4(13),5,7-tetraen-9-one Show/Hide	C17H19FN4O	1
1	EC50 = 178 nM Bioactivity Info	TI LI LO TS
CP0056637 Compound Info	10-[(3S)-1-azabicyclo[2.2.2]octan-3-yl]-6-chloro-1,2,10-triazatricyclo[6.4.1.04,13]trideca-2,4(13),5,7-tetraen-9-one Show/Hide	C17H19ClN4O	1
1	EC50 = 178 nM Bioactivity Info	TI LI LO TS
CP0120281 Compound Info	10-[(3S)-1-azabicyclo[2.2.2]octan-3-yl]-6-methoxy-1,2,10-triazatricyclo[6.4.1.04,13]trideca-2,4(13),5,7-tetraen-9-one Show/Hide	C18H22N4O2	1
1	EC50 = 178 nM Bioactivity Info	TI LI LO TS
CP0120282 Compound Info	10-[(3S)-1-azabicyclo[2.2.2]octan-3-yl]-1,2,10-triazatricyclo[6.4.1.04,13]trideca-2,4(13),5,7-tetraen-9-one Show/Hide	C17H20N4O	1
1	EC50 = 178 nM Bioactivity Info	TI LI LO TS
CP0447804 Compound Info	4-(5-Chlorobenzoxazol-2-yl)-1,4-diazabicyclo[3.2.2]nonane Show/Hide	C14H16ClN3O	1
1	Ki = 1.2 nM Bioactivity Info	TI LI LO TS
CP0376721 Compound Info	4-(5-Methylbenzoxazol-2-yl)-1,4-diazabicyclo[3.2.2]nonane Show/Hide	C15H19N3O	1
1	Ki = 3.4 nM Bioactivity Info	TI LI LO TS
CP0421782 Compound Info	4-(5-Fluorobenzoxazol-2-yl)-1,4-diazabicyclo[3.2.2]nonane Show/Hide	C14H16FN3O	1
1	Ki = 3.9 nM Bioactivity Info	TI LI LO TS
CP0197608 Compound Info	4-Benzoxazo-2-yl-1,4-diazabicyclo[3.2.2]nonane Show/Hide	C14H17N3O	1
1	Ki = 13 nM Bioactivity Info	TI LI LO TS
CP0371836 Compound Info	4-(5-Bromobenzoxazol-2-yl)-1,4-diazabicyclo[3.2.2]nonane Show/Hide	C14H16BrN3O	1
1	Ki < 17 nM Bioactivity Info	TI LI LO TS
CP0421783 Compound Info	4-(6-Methylbenzoxazol-2-yl)-1,4-diazabicyclo[3.2.2]nonane Show/Hide	C15H19N3O	1
1	Ki < 17 nM Bioactivity Info	TI LI LO TS
CP0459024 Compound Info	4-Oxazolo[5,4-b]pyridin-2-yl-1,4-diazabicyclo[3.2.2]nonane Show/Hide	C13H16N4O	1
1	Ki = 92 nM Bioactivity Info	TI LI LO TS
CP0459020 Compound Info	2-(5-Methyloxazolo[5,4-b]pyridin-2-yl)-2,5-diazabicyclo[3.2.2]-nonane Show/Hide	C14H18N4O	1
1	Ki = 126 nM Bioactivity Info	TI LI LO TS
CP0382768 Compound Info	2-(5-Methoxyoxazolo[4,5-b]pyridin-2-yl)-2,5-diazabicyclo[3.2.2]-nonane Show/Hide	C14H18N4O2	1
1	Ki = 141 nM Bioactivity Info	TI LI LO TS
CP0382769 Compound Info	4-Oxazolo[5,4-c]pyridin-2-yl-1,4-diazabicyclo[3.2.2]nonane Show/Hide	C13H16N4O	1
1	Ki = 162 nM Bioactivity Info	TI LI LO TS
CP0080669 Compound Info	4-(6-Chloro-5-methyloxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo-[3.2.2]nonane Show/Hide	C14H17ClN4O	1
1	Ki = 244 nM Bioactivity Info	TI LI LO TS
CP0007707 Compound Info	4-(5-Methyloxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]-nonane Show/Hide	C14H18N4O	1
1	Ki = 269 nM Bioactivity Info	TI LI LO TS
CP0371831 Compound Info	4-(6-Fluoro-5-methyloxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]nonane Show/Hide	C14H17FN4O	1
1	Ki = 547 nM Bioactivity Info	TI LI LO TS
CP0191832 Compound Info	4-Oxazolo[4,5-b]pyridin-2-yl-1,4-diazabicyclo[3.2.2]nonane Show/Hide	C13H16N4O	1
1	Ki = 579 nM Bioactivity Info	TI LI LO TS
CP0060566 Compound Info	4-(6-Bromooxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]-nonane Show/Hide	C13H15BrN4O	1
1	Ki = 926 nM Bioactivity Info	TI LI LO TS
CP0488652 Compound Info	2-(5-(Piperidin-1-yl)oxazolo[4,5-b]pyridin-2-yl)-2,5-diazabicyclo-[3.2.2]nonane Show/Hide	C18H25N5O	1
1	Ki = 1140 nM Bioactivity Info	TI LI LO TS
CP0237924 Compound Info	4-(6-Chlorooxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]-nonane Show/Hide	C13H15ClN4O	1
1	Ki = 1370 nM Bioactivity Info	TI LI LO TS
CP0447806 Compound Info	2-(6-Phenoxyoxazolo[4,5-b]pyridin-2-yl)-2,5-diazabicyclo[3.2.2]-nonane Show/Hide	C19H20N4O2	1
1	Ki = 1960 nM Bioactivity Info	TI LI LO TS
CP0447805 Compound Info	4-(6-Phenyloxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]-nonane Show/Hide	C19H20N4O	1
1	Ki = 2117 nM Bioactivity Info	TI LI LO TS
CP0421784 Compound Info	4-Oxazolo[4,5-c]pyridin-2-yl-1,4-diazabicyclo[3.2.2]nonane Show/Hide	C13H16N4O	1
1	Ki = 2120 nM Bioactivity Info	TI LI LO TS
CP0481485 Compound Info	4-(6-Methyloxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]-nonane Show/Hide	C14H18N4O	1
1	Ki = 3390 nM Bioactivity Info	TI LI LO TS
CP0371827 Compound Info	4-(6-Phenyloxazolo[5,4-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]-nonane Show/Hide	C19H20N4O	1
1	Ki = 3673 nM Bioactivity Info	TI LI LO TS
CP0080659 Compound Info	phenyl 1,4-diazabicyclo[3.2.2]nonane-4-carboxylate Show/Hide	C14H18N2O2	1
1	Ki = 3993 nM Bioactivity Info	TI LI LO TS
CP0237925 Compound Info	4-(6-Fluorooxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]-nonane Show/Hide	C13H15FN4O	1
1	Ki = 6200 nM Bioactivity Info	TI LI LO TS
CP0476149 Compound Info	2-(1,4-Diazabicyclo[3.2.2]nonan-4-yl)-5-(pyrrolidin-1-yl)oxazolo-[4,5-b]pyridine Show/Hide	C17H23N5O	1
1	Ki = 6340 nM Bioactivity Info	TI LI LO TS
CP0371835 Compound Info	2-(5-Phenoxyoxazolo[4,5-b]pyridin-2-yl)-2,5-diazabicyclo[3.2.2]-nonane Show/Hide	C19H20N4O2	1
1	Ki = 6830 nM Bioactivity Info	TI LI LO TS
CP0371832 Compound Info	2-(5-Phenyloxazolo[4,5-b]pyridin-2-yl)-2,5-diazabicyclo[3.2.2]-nonane Show/Hide	C19H20N4O	1
1	Ki > 3580 nM Bioactivity Info	TI LI LO TS
CP0034957 Compound Info	2-(5-(2-Fluorophenyl)oxazolo[4,5-b]pyridin-2-yl)-2,5-diazabicyclo[3.2.2]nonane Show/Hide	C19H19FN4O	1
1	Ki > 3770 nM Bioactivity Info	TI LI LO TS
CP0135869 Compound Info	2-(5-Ethyloxazolo[4,5-b]pyridin-2-yl)-2,5-diazabicyclo[3.2.2]-nonane Show/Hide	C15H20N4O	1
1	Ki > 5260 nM Bioactivity Info	TI LI LO TS
CP0459021 Compound Info	2-(6-(1H-Pyrazol-3-yl)oxazolo[4,5-b]pyridin-2-yl)-2,5-diazabicyclo[3.2.2]nonane Show/Hide	C16H18N6O	1
1	Ki > 5260 nM Bioactivity Info	TI LI LO TS
CP0488651 Compound Info	4-(6-Ethyloxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]-nonane Show/Hide	C15H20N4O	1
1	Ki > 5260 nM Bioactivity Info	TI LI LO TS
CP0387208 Compound Info	2-(5-Cyclopentyloxazolo[4,5-b]pyridin-2-yl)-2,5-diazabicyclo-[3.2.2]nonane Show/Hide	C18H24N4O	1
1	Ki > 5290 nM Bioactivity Info	TI LI LO TS
CP0459022 Compound Info	2-(5-Isopropyloxazolo[4,5-b]pyridin-2-yl)-2,5-diazabicyclo[3.2.2]-nonane Show/Hide	C16H22N4O	1
1	Ki > 5290 nM Bioactivity Info	TI LI LO TS
CP0476148 Compound Info	4-(6-Cyanooxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]-nonane Show/Hide	C14H15N5O	1
1	Ki > 5290 nM Bioactivity Info	TI LI LO TS
CP0371829 Compound Info	2-(6-(Pyridin-3-yl)oxazolo[4,5-b]pyridin-2-yl)-2,5-diazabicyclo-[3.2.2]nonane Show/Hide	C18H19N5O	1
1	Ki > 5350 nM Bioactivity Info	TI LI LO TS
CP0371830 Compound Info	2-(6-(Pyrimidine-5-yl)oxazolo[4,5-b]pyridin-2-yl)-2,5-diazabicyclo[3.2.2]nonane Show/Hide	C17H18N6O	1
1	Ki > 7140 nM Bioactivity Info	TI LI LO TS

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han