General Information of the Protein
Protein ID
PT03564
Protein Name
Prostate-specific antigen
Secondarily
Protein Name
Gamma-seminoprotein
Kallikrein-3
P-30 antigen
Semenogelase
Gene Name
KLK3
Secondarily
Gene Name
APS
Sequence
MWVPVVFLTLSVTWIGAAPLILSRIVGGWECEKHSQPWQVLVASRGRAVCGGVLVHPQWVLTAAHCIRNKSVILLGRHSLFHPEDTGQVFQVSHSFPHPLYDMSLLKNRFLRPGDDSSHDLMLLRLSEPAELTDAVKVMDLPTQEPALGTTCYASGWGSIEPEEFLTPKKLQCVDLHVISNDVCAQVHPQKVTKFMLCAGRWTGGKSTCSGDSGGPLVCNGVLQGITSWGSEPCALPERPSLYTKVVHYRKWIKDTIVANP
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
>
Protease
>
Serine protease
>
Serine protease PA clan
>
Serine protease S1A subfamily
Function
Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum.
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Uniprot ID
Primary ID:
P07288

Secondarily ID:
C9JXH3
G3V0H4
G3XAE3
Q15096
Q16272
Q86TG8
Q8IXI4
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Ensembl ID
ENSG00000142515
HGNC ID
HGNC:6364
Subcellular Location
Secreted
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000141 , LNCaP
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0095953
 Compound Info 
ENZALUTAMIDE
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C21H16F4N4O2S
  1
1
IC50 = 130 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0274308
 Compound Info 
12-(4-bromophenyl)-11-azatetracyclo[8.7.0.02,7.013,17]heptadeca-1(10),2,4,6,8,15-hexaene
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C22H18BrN
  1
1
IC50 = 430 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0557355
 Compound Info 
12-(2-chlorophenyl)-11-azatetracyclo[8.7.0.02,7.013,17]heptadeca-1(10),2,4,6,8,15-hexaene
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C22H18ClN
  1
1
IC50 = 1400 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Clinical Information about the Protein
Target 1 ( Prostate specific antigen (KLK3) )
Target Type Clinical trial Target