General Information of the Protein
| Protein ID |
PT03522
|
||||
|---|---|---|---|---|---|
| Protein Name |
Gamma-aminobutyric acid receptor subunit rho-1
|
||||
| Secondarily Protein Name |
GABA(A) receptor subunit rho-1
GABA(C) receptor
|
||||
| Gene Name |
GABRR1
|
||||
| Sequence |
MLAVPNMRFGIFLLWWGWVLATESRMHWPGREVHEMSKKGRPQRQRREVHEDAHKQVSPILRRSPDITKSPLTKSEQLLRIDDHDFSMRPGFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLSFPSTNNLSMTFDGRLVKKIWVPDMFFVHSKRSFIHDTTTDNVMLRVQPDGKVLYSLRVTVTAMCNMDFSRFPLDTQTCSLEIESYAYTEDDLMLYWKKGNDSLKTDERISLSQFLIQEFHTTTKLAFYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVPLGITTVLTMSTIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQERKEQKLREKLPCTSGLPPPRTAMLDGNYSDGEVNDLDNYMPENGEKPDRMMVQLTLASERSSPQRKSQRSSYVSMRIDTHAIDKYSRIIFPAAYILFNLIYWSIFS
Show/Hide
|
||||
| Organism |
Homo sapiens, Human
|
||||
| Protein Classification |
Ion channel
>
Ligand-gated ion channel
>
GABA-A receptor
|
||||
| Function |
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-1 GABA receptor could play a role in retinal neurotransmission.
Show/Hide
|
||||
| Uniprot ID |
Show/Hide
|
||||
| HGNC ID | |||||
| Subcellular Location |
Postsynaptic cell membrane
Cell membrane
|
||||
Map of Molecular Bioactivity Related to the Protein
|
Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity |
|
|---|
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000027 , tsA201
| Compound ID | Compound Name | Compound Formula | |
| CP0001373 |
2-[(4R,5S)-2-amino-5-methyl-4,5-dihydro-1,3-thiazol-4-yl]acetic acid
Show/Hide
|
C6H10N2O2S
|
1 |
| 1 |
IC50 = 100000 nM
|
TI
LI
LO
TS
|
|
|---|---|---|---|
Biochemical Assays
| Compound ID | Compound Name | Compound Formula | |
| CP0000066 |
4-amino-n-[2,3-3H]butyric acid
Show/Hide
|
C4H9NO2
|
1 |
| 1 | EC50 = 1000 nM | ||
|---|---|---|---|
Clinical Information about the Protein
Target 1 ( GABA(A) receptor rho1 (GABRR1) )
| Target Type | Literature-reported Target | ||||
|---|---|---|---|---|---|