Protein Information

General Information of the Protein

Protein ID	PT03476
Protein Name	Polymerase basic protein 2
Secondarily Protein Name	RNA-directed RNA polymerase subunit P3
Gene Name	PB2
Sequence	MERIKELRNLMSQSRTREILTKTTVDHMAIIKKYTSGRQEKNPALRMKWMMAMKYPITADKRITEMIPERNEQGQTLWSKMNDAGSDRVMVSPLAVTWWNRNGPITNTVHYPKIYKTYFERVERLKHGTFGPVHFRNQVKIRRRVDINPGHADLSAKEAQDVIMEVVFPNEVGARILTSESQLTITKEKKEELQDCKISPLMVAYMLERELVRKTRFLPVAGGTSSVYIEVLHLTQGTCWEQMYTPGGEVRNDDVDQSLIIAARNIVRRAAVSADPLASLLEMCHSTQIGGIRMVDILRQNPTEEQAVDICKAAMGLRISSSFSFGGFTFKRTSGSSVKREEEVLTGNLQTLKIRVHEGYEEFTMVGRRATAILRKATRRLIQLIVSGRDEQSIAEAIIVAMVFSQEDCMIKAVRGDLNFVNRANQRLNPMHQLLRHFQKDAKVLFQNWGVEPIDNVMGMIGILPDMTPSIEMSMRGVRISKMGVDEYSSTERVVVSIDRFLRIRDQRGNVLLSPEEVSETQGTEKLTITYSSSMMWEINGPESVLVNTYQWIIRNWETVKIQWSQNPTMLYNKMEFEPFQSLVPKAIRGQYSGFVRTLFQQMRDVLGTFDTAQIIKLLPFAAAPPKQSRMQFSSFTVNVRGSGMRILVRGNSPVFNYNKATKRLTVLGKDAGTLTEDPDEGTAGVESAVLRGFLILGKEDKRYGPALSINELSNLAKGEKANVLIGQGDVVLVMKRKRDSSILTDSQTATKRIRMAIN Show/Hide
Organism	Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)
Protein Classification	Unclassified protein
Function	Plays an essential role in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNAs are used to generate primers for viral transcription. Recognizes and binds the 7-methylguanosine-containing cap of the target pre-RNA which is subsequently cleaved after 10-13 nucleotides by the viral protein PA. Plays a role in the initiation of the viral genome replication and modulates the activity of the ribonucleoprotein (RNP) complex. In addition, participates in the inhibition of type I interferon induction through interaction with and inhibition of the host mitochondrial antiviral signaling protein MAVS. Show/Hide
Uniprot ID	Primary ID: P03428 Secondarily ID: A4GXH0 Q20N28 Q8JUU8 Show/Hide
Subcellular Location	Virion Host nucleus Host mitochondrion

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000031 , MDCK

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0468624 Compound Info	(2S,3S)-3-[[2-(5-fluoro-2H-pyrazolo[3,4-b]pyridin-3-yl)thieno[2,3-d]pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid Show/Hide	C21H19FN6O2S	1
1	EC50 = 0.06 nM Bioactivity Info	TI LI LO TS
CP0429621 Compound Info	(2S,3S)-3-[[2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)thieno[2,3-d]pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid Show/Hide	C22H20FN5O2S	1
1	EC50 = 0.2 nM Bioactivity Info	TI LI LO TS
CP0482034 Compound Info	(2S,3S)-3-[[2-(5-fluoro-2H-pyrazolo[3,4-b]pyridin-3-yl)-6,7-dihydrothieno[3,2-d]pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid Show/Hide	C21H21FN6O2S	1
1	EC50 = 0.2 nM Bioactivity Info	TI LI LO TS
CP0567305 Compound Info	(2S,3S)-3-[[2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)-6,7-dihydrothieno[3,2-d]pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid Show/Hide	C22H22FN5O2S	1
1	EC50 = 0.4 nM Bioactivity Info	TI LI LO TS
CP0458025 Compound Info	(2S,3S)-3-[[2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)thieno[3,2-d]pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid Show/Hide	C22H20FN5O2S	1
1	EC50 = 0.5 nM Bioactivity Info	TI LI LO TS
CP0519460 Compound Info	(2S,3S)-3-[[2-(5-fluoro-2H-pyrazolo[3,4-b]pyridin-3-yl)thieno[3,2-d]pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid Show/Hide	C21H19FN6O2S	1
1	EC50 = 0.5 nM Bioactivity Info	TI LI LO TS
CP0100388 Compound Info	(2S,3S)-3-[[5-fluoro-2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid Show/Hide	C20H19F2N5O2	1
1	EC50 = 0.6 nM Bioactivity Info	TI LI LO TS
CP0549184 Compound Info	(2S,3S)-3-[[2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)thieno[3,4-d]pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid Show/Hide	C22H20FN5O2S	1
1	EC50 = 1.4 nM Bioactivity Info	TI LI LO TS
CP0519459 Compound Info	(2S,3S)-3-[[2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid Show/Hide	C22H22FN5O2S	1
1	EC50 = 2.6 nM Bioactivity Info	TI LI LO TS
CP0549186 Compound Info	(2S,3S)-3-[[2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)-5,6-dihydrothieno[2,3-d]pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid Show/Hide	C22H22FN5O2S	1
1	EC50 = 2.8 nM Bioactivity Info	TI LI LO TS
CP0446068 Compound Info	(2S,3S)-3-[[5-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)-[1,3]thiazolo[5,4-d]pyrimidin-7-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid Show/Hide	C21H19FN6O2S	1
1	EC50 = 3 nM Bioactivity Info	TI LI LO TS
CP0549183 Compound Info	(2S,3S)-3-[[7-cyano-2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)thieno[3,2-d]pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid Show/Hide	C23H19FN6O2S	1
1	EC50 = 4 nM Bioactivity Info	TI LI LO TS
CP0954106 Compound Info	(2S,3S)-3-((2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)bicyclo[2.2.2]octane-2-carboxylic acid Show/Hide	C22H21FN6O2	1
1	EC50 = 4.5 nM Bioactivity Info	TI LI LO TS
CP0567304 Compound Info	(2S,3S)-3-[[2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)furo[3,2-d]pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid Show/Hide	C22H20FN5O3	1
1	EC50 = 5.3 nM Bioactivity Info	TI LI LO TS
CP0557238 Compound Info	(2S,3S)-3-[[2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid Show/Hide	C23H24FN5O2	1
1	EC50 = 5.5 nM Bioactivity Info	TI LI LO TS
CP0554943 Compound Info	(2S,3S)-3-[[5-fluoro-2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)-7-methylpyrrolo[2,3-d]pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid Show/Hide	C23H22F2N6O2	1
1	EC50 = 9.6 nM Bioactivity Info	TI LI LO TS
CP0482032 Compound Info	(2S,3S)-3-[[6-(difluoromethyl)-2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)thieno[3,2-d]pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid Show/Hide	C23H20F3N5O2S	1
1	EC50 = 10 nM Bioactivity Info	TI LI LO TS
CP0549176 Compound Info	(2S,3S)-3-[[7-fluoro-2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrido[3,2-d]pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid Show/Hide	C23H20F2N6O2	1
1	EC50 = 10 nM Bioactivity Info	TI LI LO TS
CP0446067 Compound Info	(2S,3S)-3-[[2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)-7-methylpyrido[3,2-d]pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid Show/Hide	C24H23FN6O2	1
1	EC50 = 11 nM Bioactivity Info	TI LI LO TS
CP0554942 Compound Info	(2S,3S)-3-[[2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-methylquinazolin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid Show/Hide	C25H24FN5O2	1
1	EC50 = 11 nM Bioactivity Info	TI LI LO TS
CP0458024 Compound Info	(2S,3S)-3-[[2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)-5,6,7,8-tetrahydroquinazolin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid Show/Hide	C24H26FN5O2	1
1	EC50 = 12 nM Bioactivity Info	TI LI LO TS
CP0473817 Compound Info	(2S,3S)-3-[2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrrolo[2,3-d]pyrimidin-7-yl]bicyclo[2.2.2]octane-2-carboxylic acid Show/Hide	C22H20FN5O2	1
1	EC50 = 12 nM Bioactivity Info	TI LI LO TS
CP0468623 Compound Info	(2S,3S)-3-[[2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)pteridin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid Show/Hide	C22H20FN7O2	1
1	EC50 = 13 nM Bioactivity Info	TI LI LO TS
CP0458023 Compound Info	(2S,3S)-3-[[2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrido[3,2-d]pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid Show/Hide	C23H21FN6O2	1
1	EC50 = 14 nM Bioactivity Info	TI LI LO TS
CP0567303 Compound Info	(2S,3S)-3-[[5-fluoro-2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)quinazolin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid Show/Hide	C24H21F2N5O2	1
1	EC50 = 20 nM Bioactivity Info	TI LI LO TS
CP0554941 Compound Info	(2S,3S)-3-[2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)-6,7-dihydropyrimido[5,4-b][1,4]oxazin-8-yl]bicyclo[2.2.2]octane-2-carboxylic acid Show/Hide	C22H22FN5O3	1
1	EC50 = 24 nM Bioactivity Info	TI LI LO TS
CP0563552 Compound Info	(2S,3S)-3-[5-cyano-2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrrolo[2,3-d]pyrimidin-7-yl]bicyclo[2.2.2]octane-2-carboxylic acid Show/Hide	C23H19FN6O2	1
1	EC50 = 70 nM Bioactivity Info	TI LI LO TS
CP0559670 Compound Info	(2S,3S)-3-[[2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)-5,5-dioxo-6,7-dihydrothieno[3,2-d]pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid Show/Hide	C22H22FN5O4S	1
1	EC50 = 110 nM Bioactivity Info	TI LI LO TS
CP0446066 Compound Info	(2S,3S)-3-[2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)purin-9-yl]bicyclo[2.2.2]octane-2-carboxylic acid Show/Hide	C21H19FN6O2	1
1	EC50 = 190 nM Bioactivity Info	TI LI LO TS
CP0519462 Compound Info	(2S,3S)-3-[[5-fluoro-2-(5-fluoro-1H-indol-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid Show/Hide	C21H20F2N4O2	1
1	EC50 = 220 nM Bioactivity Info	TI LI LO TS
CP0559671 Compound Info	(2S,3S)-3-[[5-fluoro-2-(6-fluoropyrrolo[3,2-b]pyridin-1-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid Show/Hide	C20H19F2N5O2	1
1	EC50 = 230 nM Bioactivity Info	TI LI LO TS
CP0559672 Compound Info	(2S,3S)-3-[[4-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-methylquinazolin-2-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid Show/Hide	C25H24FN5O2	1
1	EC50 = 450 nM Bioactivity Info	TI LI LO TS
CP0482033 Compound Info	(2S,3S)-3-[[2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)-6,6-dioxo-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid Show/Hide	C22H22FN5O4S	1
1	EC50 = 2000 nM Bioactivity Info	TI LI LO TS

Clinical Information about the Protein

Target 1 ( Influenza Polymerase basic protein 2 (Influ PB2) )

Target Type	Clinical trial Target
Disease	1 Target-related Disease				1
1	Influenza A virus infection [ICD-11: 1E30]
Clinical Trial Drug(s)	1 Clinical Trial Drug				1
1	VX-787	Drug Info	Phase 3	Influenza A virus infection

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han