Protein Information

General Information of the Protein

Protein ID	PT03414
Protein Name	Hematopoietic prostaglandin D synthase
Secondarily Protein Name	GST class-sigma Glutathione S-transferase Glutathione-dependent PGD synthase Glutathione-requiring prostaglandin D synthase Prostaglandin-H2 D-isomerase
Gene Name	HPGDS
Secondarily Gene Name	GSTS PGDS PTGDS2
Sequence	MPNYKLTYFNMRGRAEIIRYIFAYLDIQYEDHRIEQADWPEIKSTLPFGKIPILEVDGLTLHQSLAIARYLTKNTDLAGNTEMEQCHVDAIVDTLDDFMSCFPWAEKKQDVKEQMFNELLTYNAPHLMQDLDTYLGGREWLIGNSVTWADFYWEICSTTLLVFKPDLLDNHPRLVTLRKKVQAIPAVANWIKRRPQTKL Show/Hide
Organism	Homo sapiens, Human
Protein Classification	Enzyme > Transferase
Function	Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide. Show/Hide
Uniprot ID	Primary ID: O60760 Secondarily ID: Q6FHT9 Show/Hide
Ensembl ID	ENSG00000163106
HGNC ID	HGNC:17890
Subcellular Location	Cytoplasm

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000606 , MEG-01

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0571258 Compound Info	6-(3-fluorophenyl)-N-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]pyridine-3-carboxamide Show/Hide	C19H19F4N3O	1
1	EC50 = 35 nM Bioactivity Info	TI LI LO TS
CP0450029 Compound Info	N-[[4-[5-(2-hydroxypropan-2-yl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]-2-pyridin-2-ylpyrimidine-5-carboxamide Show/Hide	C22H20N6O3	1
1	EC50 = 74 nM Bioactivity Info	TI LI LO TS
CP0238279 Compound Info	2-phenyl-5-(1H-pyrazol-3-yl)-1,3-thiazole Show/Hide	C12H9N3S	1
1	EC50 = 110 nM Bioactivity Info	TI LI LO TS
CP0560828 Compound Info	6-(3-methoxyphenyl)-N-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]pyridine-3-carboxamide Show/Hide	C20H22F3N3O2	1
1	EC50 = 130 nM Bioactivity Info	TI LI LO TS
CP0486857 Compound Info	3-(dimethylamino)-N-[5-(1H-indol-4-yl)pyridin-3-yl]propanamide Show/Hide	C18H20N4O	1
1	EC50 = 350 nM Bioactivity Info	TI LI LO TS

Biochemical Assays

Compound ID	Compound Name	Compound Formula
CP0663326 Compound Info	N-cyclopentyl-3-(3-cyclopropyl-1H-pyrazol-4-yl)-5H-pyrrolo[3,4-b]pyridine-6(7H)-carboxamide Show/Hide	C19H23N5O	2
1	IC50 < 10 nM
2	IC50 = 40 nM
CP0238279 Compound Info	2-phenyl-5-(1H-pyrazol-3-yl)-1,3-thiazole Show/Hide	C12H9N3S	1
1	IC50 = 21 nM
CP0843339 Compound Info	3-(3-cyclopropyl-1H-pyrazol-4-yl)-N-ethyl-5H-pyrrolo[3,4-b]pyridine-6(7H)-carboxamide Show/Hide	C16H19N5O	2
1	IC50 = 40 nM
2	IC50 = 501 nM

Clinical Information about the Protein

Target 1 ( Glutathione-dependent PGD synthase (HPGDS) )