General Information of the Protein
Protein ID
PT03247
Protein Name
Glycogen [starch] synthase, muscle
Secondarily
Protein Name
Glycogen synthase 1
Gene Name
GYS1
Secondarily
Gene Name
GYS
Sequence
MPLNRTLSMSSLPGLEDWEDEFDLENAVLFEVAWEVANKVGGIYTVLQTKAKVTGDEWGDNYFLVGPYTEQGVRTQVELLEAPTPALKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDREANDAVLFGFLTTWFLGEFLAQSEEKPHVVAHFHEWLAGVGLCLCRARRLPVATIFTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQITAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFYGHLDFNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNVETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQRQSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRFRSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALSKAFPEHFTYEPNEADAAQGYRYPRPASVPPSPSLSRHSSPHQSEDEEDPRNGPLEEDGERYDEDEEAAKDRRNIRAPEWPRRASCTSSTSGSKRNSVDTATSSSLSTPSEPLSPTSSLGEERN
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
Function
Glycogen synthase participates in the glycogen biosynthetic process along with glycogenin and glycogen branching enzyme. Extends the primer composed of a few glucose units formed by glycogenin by adding new glucose units to it. In this context, glycogen synthase transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.
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Uniprot ID
Primary ID:
P13807

Secondarily ID:
Q9BTT9
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Ensembl ID
ENSG00000104812
HGNC ID
HGNC:4706
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000013 , Sf9
Compound ID Compound Name Compound Formula
CP0401287
2-[[3-[[4-(4,5-difluoro-2-methoxyphenyl)phenoxy]methyl]benzoyl]-methylamino]acetic acid
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C24H21F2NO5
 1
1
EC50 = 100 nM
   TI
   LI
   LO
   TS
CP0058044
(2S)-1-[3-[[4-(4,5-difluoro-2-methoxyphenyl)phenoxy]methyl]benzoyl]pyrrolidine-2-carboxylic acid
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C26H23F2NO5
 1
1
EC50 = 140 nM
   TI
   LI
   LO
   TS
CP0432215
2-[7-[[4-(4,5-difluoro-2-methoxyphenyl)phenoxy]methyl]-3-oxo-1H-indazol-2-yl]acetic acid
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C23H18F2N2O5
 1
1
EC50 = 200 nM
   TI
   LI
   LO
   TS
CP0439088
7-[[4-(4,5-difluoro-2-methylphenyl)phenoxy]methyl]-2-[(2R)-2,3-dihydroxypropyl]-1H-indazol-3-one
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C24H22F2N2O4
 1
1
EC50 = 230 nM
   TI
   LI
   LO
   TS
CP0401560
7-[[4-(4,5-difluoro-2-methylphenyl)phenoxy]methyl]-2-methyl-1H-indazol-3-one
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C22H18F2N2O2
 1
1
EC50 = 240 nM
   TI
   LI
   LO
   TS
CP0466798
7-[[4-(4,5-difluoro-2-methoxyphenyl)phenoxy]methyl]-2-[(2S)-2,3-dihydroxypropyl]-1H-indazol-3-one
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C24H22F2N2O5
 1
1
EC50 = 250 nM
   TI
   LI
   LO
   TS
CP0432218
7-[[4-(2-chloro-4,5-difluorophenyl)phenoxy]methyl]-2-[(2R)-2,3-dihydroxypropyl]-1H-indazol-3-one
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C23H19ClF2N2O4
 1
1
EC50 = 260 nM
   TI
   LI
   LO
   TS
CP0432217
7-[[4-(4,5-difluoro-2-methoxyphenyl)phenoxy]methyl]-2-[(2R)-2,3-dihydroxypropyl]-1H-indazol-3-one
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C24H22F2N2O5
 1
1
EC50 = 270 nM
   TI
   LI
   LO
   TS
CP0386182
7-[[4-(2-chloro-4,5-difluorophenyl)phenoxy]methyl]-2-[(2S)-2,3-dihydroxypropyl]-1H-indazol-3-one
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C23H19ClF2N2O4
 1
1
EC50 = 300 nM
   TI
   LI
   LO
   TS
CP0449883
7-[[4-(4,5-difluoro-2-methoxyphenyl)phenoxy]methyl]-2-methyl-1H-indazol-3-one
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C22H18F2N2O3
 1
1
EC50 = 320 nM
   TI
   LI
   LO
   TS
CP0468451
7-[[4-(4,5-difluoro-2-methylphenyl)phenoxy]methyl]-2-[(2S)-2,3-dihydroxypropyl]-1H-indazol-3-one
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C24H22F2N2O4
 1
1
EC50 = 340 nM
   TI
   LI
   LO
   TS
CP0524038
7-[[4-(4,5-difluoro-2-methoxyphenyl)phenoxy]methyl]-2-(2-methoxyethyl)-1H-indazol-3-one
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C24H22F2N2O4
 1
1
EC50 = 370 nM
   TI
   LI
   LO
   TS
CP0420242
2-[7-[[4-(4,5-difluoro-2-methylphenyl)phenoxy]methyl]-3-oxo-1H-indazol-2-yl]acetic acid
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C23H18F2N2O4
 1
1
EC50 = 420 nM
   TI
   LI
   LO
   TS
CP0386183
2-[(2S)-2,3-dihydroxypropyl]-7-[[4-(2,4,5-trifluorophenyl)phenoxy]methyl]-1H-indazol-3-one
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C23H19F3N2O4
 1
1
EC50 = 580 nM
   TI
   LI
   LO
   TS
CP0404120
2-[(2R)-2,3-dihydroxypropyl]-7-[[4-(2,4,5-trifluorophenyl)phenoxy]methyl]-1H-indazol-3-one
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C23H19F3N2O4
 1
1
EC50 = 680 nM
   TI
   LI
   LO
   TS
CP0404122
2-(2-hydroxyethyl)-7-[[4-(2,4,5-trifluorophenyl)phenoxy]methyl]-1H-indazol-3-one
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C22H17F3N2O3
 1
1
EC50 = 770 nM
   TI
   LI
   LO
   TS
CP0401288
2-(2-methoxyethyl)-7-[[4-(2,4,5-trifluorophenyl)phenoxy]methyl]-1H-indazol-3-one
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C23H19F3N2O3
 1
1
EC50 = 790 nM
   TI
   LI
   LO
   TS
CP0401561
7-[[4-(2,4,5-trifluorophenyl)phenoxy]methyl]-1H-2,1-benzoxazol-3-one
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C20H12F3NO3
 1
1
EC50 = 1000 nM
   TI
   LI
   LO
   TS
CP0449882
2-[3-oxo-7-[[4-(2,4,5-trifluorophenyl)phenoxy]methyl]-1H-indazol-2-yl]acetic acid
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C22H15F3N2O4
 1
1
EC50 = 1200 nM
   TI
   LI
   LO
   TS
CP0375458
7-[[4-(4,5-difluoro-2-methoxyphenyl)phenoxy]methyl]-2-(4-fluorophenyl)-1H-indazol-3-one
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C27H19F3N2O3
 1
1
EC50 = 1370 nM
   TI
   LI
   LO
   TS
CP0395827
7-[[4-(4,5-difluoro-2-methylphenyl)phenoxy]methyl]-2-(4-fluorophenyl)-1H-indazol-3-one
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C27H19F3N2O2
 1
1
EC50 = 1470 nM
   TI
   LI
   LO
   TS
CP0491638
2-methyl-7-[[4-(2,4,5-trifluorophenyl)phenoxy]methyl]-1H-indazol-3-one
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C21H15F3N2O2
 1
1
EC50 = 1780 nM
   TI
   LI
   LO
   TS
CP0432216
7-[[4-(2-chloro-4,5-difluorophenyl)phenoxy]methyl]-2-pyridin-3-yl-1H-indazol-3-one
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C25H16ClF2N3O2
 1
1
EC50 = 1860 nM
   TI
   LI
   LO
   TS
CP0491639
2-pyridin-3-yl-7-[[4-(2,4,5-trifluorophenyl)phenoxy]methyl]-1H-indazol-3-one
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C25H16F3N3O2
 1
1
EC50 = 4010 nM
   TI
   LI
   LO
   TS
CP0521866
3-[[4-(4,5-difluoro-2-methoxyphenyl)phenoxy]methyl]-N-(2-hydroxyethyl)-N-methylbenzamide
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C24H23F2NO4
 1
1
EC50 = 4100 nM
   TI
   LI
   LO
   TS
CP0510955
3-[[4-(4,5-difluoro-2-methoxyphenyl)phenoxy]methyl]-N-(2,2-dihydroxyethyl)-N-methylbenzamide
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C24H23F2NO5
 1
1
EC50 = 10300 nM
   TI
   LI
   LO
   TS
CP0314303
(2S)-1-[5-[(4-phenylphenoxy)methyl]furan-2-carbonyl]pyrrolidine-2-carboxylic acid
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C23H21NO5
 1
1
EC50 = 15100 nM
   TI
   LI
   LO
   TS
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0058044
(2S)-1-[3-[[4-(4,5-difluoro-2-methoxyphenyl)phenoxy]methyl]benzoyl]pyrrolidine-2-carboxylic acid
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C26H23F2NO5
 2
1 EC50 = 10 nM
2 EC50 = 140 nM
CP0314303
(2S)-1-[5-[(4-phenylphenoxy)methyl]furan-2-carbonyl]pyrrolidine-2-carboxylic acid
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C23H21NO5
 1
1 EC50 = 15100 nM