General Information of the Protein
Protein ID
PT03201
Protein Name
Sialidase-1
Secondarily
Protein Name
Acetylneuraminyl hydrolase
G9 sialidase
Lysosomal sialidase
N-acetyl-alpha-neuraminidase 1
Gene Name
NEU1
Secondarily
Gene Name
NANH
Sequence
MTGERPSTALPDRRWGPRILGFWGGCRVWVFAAIFLLLSLAASWSKAENDFGLVQPLVTMEQLLWVSGRQIGSVDTFRIPLITATPRGTLLAFAEARKMSSSDEGAKFIALRRSMDQGSTWSPTAFIVNDGDVPDGLNLGAVVSDVETGVVFLFYSLCAHKAGCQVASTMLVWSKDDGVSWSTPRNLSLDIGTEVFAPGPGSGIQKQREPRKGRLIVCGHGTLERDGVFCLLSDDHGASWRYGSGVSGIPYGQPKQENDFNPDECQPYELPDGSVVINARNQNNYHCHCRIVLRSYDACDTLRPRDVTFDPELVDPVVAAGAVVTSSGIVFFSNPAHPEFRVNLTLRWSFSNGTSWRKETVQLWPGPSGYSSLATLEGSMDGEEQAPQLYVLYEKGRNHYTESISVAKISVYGTL
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
>
Hydrolase
Function
Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moieties from glycoproteins and glycolipids. To be active, it is strictly dependent on its presence in the multienzyme complex. Appears to have a preference for alpha 2-3 and alpha 2-6 sialyl linkage.
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Uniprot ID
Q99519
Ensembl ID
ENSG00000204386
HGNC ID
HGNC:7758
Subcellular Location
Lysosome membrane
Lysosome lumen
Cell membrane
Cytoplasmic vesicle
Lysosome
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0389217
 Compound Info 
(2R,3R,4S)-2-[(1R,2R)-3-acetamido-1,2-dihydroxypropyl]-3-(hexanoylamino)-4-hydroxy-3,4-dihydro-2H-pyran-6-carboxylic acid
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C17H28N2O8
  1
1
IC50 = 140 nM
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CP0475517
 Compound Info 
(2R,3R,4S)-2-[(1R,2R)-3-acetamido-1,2-dihydroxypropyl]-4-hydroxy-3-(pentanoylamino)-3,4-dihydro-2H-pyran-6-carboxylic acid
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C16H26N2O8
  1
1
IC50 = 350 nM
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CP0490887
 Compound Info 
(2R,3R,4S)-2-[(1R,2R)-1,2-dihydroxy-3-(propanoylamino)propyl]-3-(hexanoylamino)-4-hydroxy-3,4-dihydro-2H-pyran-6-carboxylic acid
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C18H30N2O8
  1
1
IC50 = 400 nM
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CP0455401
 Compound Info 
(2R,3R,4S)-3-(hexanoylamino)-4-hydroxy-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid
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C15H25NO8
  2
1
IC50 = 420 nM
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2
Ki = 180 nM
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CP0955517
 Compound Info 
5-(2-Methyl)hexanamido(S/R)-9-acetanamido-2,6-anhydro-3,5-dideoxy-D-glycero-D-galactonon-2-enonic acid
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C18H30N2O8
  1
1
IC50 = 420 nM
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CP0964588
 Compound Info 
5-(2-Methyl)hexanamido(S/R)-2,6-anhydro-3,5-dideoxy-D-glycero-D-galacto-non-2-enonic acid
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C16H27NO8
  1
1
IC50 = 550 nM
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CP0954501
 Compound Info 
5-(2-Ethyl)hexanamido(S/R)-2,6-anhydro-3,5-dideoxy-D-glycero-D-galacto-non-2-enonic acid
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C17H29NO8
  1
1
IC50 = 580 nM
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CP0490888
 Compound Info 
(2R,3R,4S)-4-hydroxy-3-(pentanoylamino)-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid
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C14H23NO8
  2
1
IC50 = 990 nM
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2
Ki = 240 nM
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CP0962534
 Compound Info 
5-Pentanamido-9-(4-biphenyl)-2,6-anhydro-3,5-dideoxy-D-glycero-D-galacto-non-2-enonic acid
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C26H31NO7
  1
1
IC50 = 990 nM
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CP0394777
 Compound Info 
(2R,3R,4S)-2-[(1R,2R)-3-(butanoylamino)-1,2-dihydroxypropyl]-3-(hexanoylamino)-4-hydroxy-3,4-dihydro-2H-pyran-6-carboxylic acid
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C19H32N2O8
  1
1
IC50 = 1200 nM
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CP0478940
 Compound Info 
(2R,3R,4S)-2-[(1R,2R)-3-(hexanoylamino)-1,2-dihydroxypropyl]-4-hydroxy-3-(propanoylamino)-3,4-dihydro-2H-pyran-6-carboxylic acid
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C18H30N2O8
  1
1
IC50 = 1400 nM
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CP0536335
 Compound Info 
(2R,3R,4S)-2-[(1R,2R)-1,2-dihydroxy-3-(pentanoylamino)propyl]-4-hydroxy-3-(pentanoylamino)-3,4-dihydro-2H-pyran-6-carboxylic acid
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C19H32N2O8
  1
1
IC50 = 1500 nM
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CP0482392
 Compound Info 
(2R,3R,4S)-2-[(1R,2R)-1,2-dihydroxy-3-(pentanoylamino)propyl]-4-hydroxy-3-(propanoylamino)-3,4-dihydro-2H-pyran-6-carboxylic acid
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C17H28N2O8
  1
1
IC50 = 1600 nM
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CP0534609
 Compound Info 
(2R,3R,4S)-4-hydroxy-3-(4-methylpentanoylamino)-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid
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C15H25NO8
  1
1
IC50 = 1700 nM
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CP0956726
 Compound Info 
5-(2-Ethyl)hexanamido(S/R)-9-acetanamido-2,6-anhydro-3,5-dideoxy-D-glycero-D-galacto-non-2-enonic acid
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C19H32N2O8
  1
1
IC50 = 1800 nM
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CP0536337
 Compound Info 
(2R,3R,4S)-3-acetamido-2-[(1R,2R)-3-[(4-acetamidobenzoyl)amino]-1,2-dihydroxypropyl]-4-hydroxy-3,4-dihydro-2H-pyran-6-carboxylic acid
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C20H25N3O9
  1
1
IC50 = 1900 nM
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CP0482938
 Compound Info 
(2R,3R,4S)-3-(heptanoylamino)-4-hydroxy-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid
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C16H27NO8
  1
1
IC50 = 2100 nM
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CP0290417
 Compound Info 
(2R,3R,4S)-3-acetamido-2-((1R,2R)-3-benzamido-1,2-dihydroxypropyl)-4-hydroxy-3,4-dihydro-2H-pyran-6-carboxylate
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C18H22N2O8
  1
1
IC50 = 2500 nM
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CP0567260
 Compound Info 
(2R,3R,4S)-3-acetamido-2-[(1R,2R)-1,2-dihydroxy-3-(3-methylbutanoylamino)propyl]-4-hydroxy-3,4-dihydro-2H-pyran-6-carboxylic acid
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C16H26N2O8
  1
1
IC50 = 2500 nM
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CP0552045
 Compound Info 
(2R,3R,4S)-3-acetamido-2-[(1R,2R)-3-(hexanoylamino)-1,2-dihydroxypropyl]-4-hydroxy-3,4-dihydro-2H-pyran-6-carboxylic acid
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C17H28N2O8
  1
1
IC50 = 2900 nM
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CP0546594
 Compound Info 
(2R,3R,4S)-3-acetamido-2-[(1R,2R)-1,2-dihydroxy-3-(4-methylpentanoylamino)propyl]-4-hydroxy-3,4-dihydro-2H-pyran-6-carboxylic acid
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C17H28N2O8
  1
1
IC50 = 3200 nM
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CP0466365
 Compound Info 
(2R,3R,4S)-3-acetamido-2-[(1R,2R)-1,2-dihydroxy-3-(pentanoylamino)propyl]-4-hydroxy-3,4-dihydro-2H-pyran-6-carboxylic acid
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C16H26N2O8
  2
1
IC50 = 3400 nM
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2
Ki = 830 nM
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CP0546595
 Compound Info 
(2R,3R,4S)-3-acetamido-2-[(1R,2R)-3-(butanoylamino)-1,2-dihydroxypropyl]-4-hydroxy-3,4-dihydro-2H-pyran-6-carboxylic acid
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C15H24N2O8
  1
1
IC50 = 4000 nM
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CP0415064
 Compound Info 
(2R,3R,4S)-3-(hexanoylamino)-2-[(1R,2R)-3-(hexanoylamino)-1,2-dihydroxypropyl]-4-hydroxy-3,4-dihydro-2H-pyran-6-carboxylic acid
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C21H36N2O8
  1
1
IC50 = 4300 nM
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CP0478942
 Compound Info 
(2R,3R,4S)-4-hydroxy-3-(2-methylpropanoylamino)-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid
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C13H21NO8
  1
1
IC50 = 5300 nM
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CP0393977
 Compound Info 
(2R,3R,4S)-3-acetamido-2-[(1R,2R)-3-[(3-aminobenzoyl)amino]-1,2-dihydroxypropyl]-4-hydroxy-3,4-dihydro-2H-pyran-6-carboxylic acid
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C18H23N3O8
  1
1
IC50 = 6500 nM
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CP0415065
 Compound Info 
(2R,3R,4S)-3-acetamido-2-[(1R,2R)-3-[(3-acetamidobenzoyl)amino]-1,2-dihydroxypropyl]-4-hydroxy-3,4-dihydro-2H-pyran-6-carboxylic acid
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C20H25N3O9
  2
1
IC50 = 6500 nM
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2
IC50 = 7500 nM
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CP0493554
 Compound Info 
(2R,3R,4S)-3-(cyclopropanecarbonylamino)-4-hydroxy-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid
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C13H19NO8
  1
1
IC50 = 6900 nM
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CP0538046
 Compound Info 
(2R,3R,4S)-3-(butanoylamino)-4-hydroxy-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid
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C13H21NO8
  1
1
IC50 = 8400 nM
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CP0387378
 Compound Info 
(2R,3R,4S)-3-acetamido-2-[(1R,2R)-3-(heptanoylamino)-1,2-dihydroxypropyl]-4-hydroxy-3,4-dihydro-2H-pyran-6-carboxylic acid
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C18H30N2O8
  1
1
IC50 = 9900 nM
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CP0388435
 Compound Info 
(4S,5R,6R)-5-acetamido-6-((1S,2S)-1,2-dihydroxy-3-pentanamidopropyl)-4-hydroxy-5,6-dihydro-4H-pyran-2-carboxylic acid
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C16H26N2O8
  1
1
IC50 = 10000 nM
 Bioactivity Info 
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CP0446403
 Compound Info 
(2R,3R,4S)-3-benzamido-4-hydroxy-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid
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C16H19NO8
  1
1
IC50 = 11000 nM
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CP0493553
 Compound Info 
(2R,3R,4S)-3-(cyclobutanecarbonylamino)-4-hydroxy-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid
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C14H21NO8
  1
1
IC50 = 12000 nM
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CP0445048
 Compound Info 
(4S,5R,6R)-5-acetamido-6-((1S,2S)-3-benzamido-1,2-dihydroxypropyl)-4-hydroxy-5,6-dihydro-4H-pyran-2-carboxylic acid
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C18H22N2O8
  1
1
IC50 = 13000 nM
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CP0475518
 Compound Info 
(2R,3R,4S)-4-(diaminomethylideneamino)-3-(4-methylpentanoylamino)-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid
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C16H28N4O7
  1
1
IC50 = 14000 nM
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CP0405653
 Compound Info 
(2R,3R,4S)-4-hydroxy-3-(propanoylamino)-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid
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C12H19NO8
  1
1
IC50 = 18000 nM
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CP0108317
 Compound Info 
(2R,3R,4S)-3-(2-azidoacetamido)-4-hydroxy-2-((1R,2R)-1,2,3-trihydroxypropyl)-3,4-dihydro-2H-pyran-6-carboxylate
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C11H16N4O8
  1
1
IC50 = 24000 nM
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CP0909770
 Compound Info 
5-(N-2-azidoacetyl)-2,3,5-trideoxy-D-glycero-D-galacto-2-nonulopyranosonic acid
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C10H14N4O8
  1
1
IC50 = 24000 nM
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CP0451102
 Compound Info 
(2R,3R,4S)-3-acetamido-2-[(1R,2R)-3-[(4-aminobenzoyl)amino]-1,2-dihydroxypropyl]-4-hydroxy-3,4-dihydro-2H-pyran-6-carboxylic acid
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C18H23N3O8
  1
1
IC50 = 29000 nM
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CP0467214
 Compound Info 
(4S,5R,6R)-5-acetamido-6-((1S,2S)-3-butyramido-1,2-dihydroxypropyl)-4-hydroxy-5,6-dihydro-4H-pyran-2-carboxylic acid
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C15H24N2O8
  1
1
IC50 = 32000 nM
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CP0393979
 Compound Info 
(2R,3R,4S)-4-hydroxy-3-(3-methylbutanoylamino)-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid
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C14H23NO8
  1
1
IC50 = 32000 nM
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CP0495663
 Compound Info 
(2R,3R,4S)-3-acetamido-2-[(1R,2R)-1,2-dihydroxy-3-[4-(4-methoxyphenyl)triazol-1-yl]propyl]-4-hydroxy-3,4-dihydro-2H-pyran-6-carboxylic acid
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C20H24N4O8
  1
1
IC50 = 47000 nM
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CP0056939
 Compound Info 
(2R,3R,4S)-3-acetamido-4-hydroxy-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid
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C11H17NO8
  2
1
IC50 = 49000 nM
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2
Ki = 12000 nM
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CP0482936
 Compound Info 
(2R,3R,4S)-3-acetamido-2-[(1R,2R)-1,2-dihydroxy-3-[4-(4-methylphenyl)triazol-1-yl]propyl]-4-hydroxy-3,4-dihydro-2H-pyran-6-carboxylic acid
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C20H24N4O7
  1
1
IC50 = 51000 nM
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CP0467213
 Compound Info 
(4S,5R,6R)-5-acetamido-6-((1S,2S)-3-acetamido-1,2-dihydroxypropyl)-4-hydroxy-5,6-dihydro-4H-pyran-2-carboxylic acid
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C13H20N2O8
  1
1
IC50 = 58000 nM
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CP0566497
 Compound Info 
(2R,3R,4S)-3-acetamido-2-[(1R,2R)-3-[4-(4-acetamidophenyl)triazol-1-yl]-1,2-dihydroxypropyl]-4-hydroxy-3,4-dihydro-2H-pyran-6-carboxylic acid
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C21H25N5O8
  1
1
IC50 = 59000 nM
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CP0482935
 Compound Info 
(2R,3R,4S)-3-acetamido-2-[(1R,2R)-3-[4-(4-aminophenyl)triazol-1-yl]-1,2-dihydroxypropyl]-4-hydroxy-3,4-dihydro-2H-pyran-6-carboxylic acid
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C19H23N5O7
  1
1
IC50 = 76000 nM
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CP0405650
 Compound Info 
(2R,3R,4S)-3-acetamido-2-[(1R,2R)-1,2-dihydroxy-3-(4-pentyltriazol-1-yl)propyl]-4-hydroxy-3,4-dihydro-2H-pyran-6-carboxylic acid
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C18H28N4O7
  1
1
IC50 = 77000 nM
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CP0482937
 Compound Info 
(2R,3R,4S)-3-acetamido-2-[(1R,2R)-3-[4-(4-fluorophenyl)triazol-1-yl]-1,2-dihydroxypropyl]-4-hydroxy-3,4-dihydro-2H-pyran-6-carboxylic acid
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C19H21FN4O7
  1
1
IC50 = 100000 nM
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CP0415071
 Compound Info 
(2R,3R,4S)-3-[[2-[4-(4-aminophenyl)triazol-1-yl]acetyl]amino]-4-hydroxy-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid
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C19H23N5O8
  1
1
Ki = 53 nM
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Cell Line ID: CL000025 , HEK-293T
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0108317
 Compound Info 
(2R,3R,4S)-3-(2-azidoacetamido)-4-hydroxy-2-((1R,2R)-1,2,3-trihydroxypropyl)-3,4-dihydro-2H-pyran-6-carboxylate
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C11H16N4O8
  1
1 IC50 = 29000 nM
CP0056939
 Compound Info 
(2R,3R,4S)-3-acetamido-4-hydroxy-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid
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C11H17NO8
  3
1 IC50 = 49000 nM
2 IC50 = 76000 nM
3 IC50 = 80000 nM