General Information of the Protein
Protein ID
PT03199
Protein Name
Hepatocyte nuclear factor 4-alpha
Secondarily
Protein Name
Nuclear receptor subfamily 2 group A member 1
Transcription factor 14
Transcription factor HNF-4
Gene Name
HNF4A
Secondarily
Gene Name
HNF4
NR2A1
TCF14
Sequence
MRLSKTLVDMDMADYSAALDPAYTTLEFENVQVLTMGNDTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDAPHAHHPLHPHLMQEHMGTNVIVANTMPTHLSNGQMCEWPRPRGQAATPETPQPSPPGGSGSEPYKLLPGAVATIVKPLSAIPQPTITKQEVI
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Organism
Homo sapiens, Human
Protein Classification
Unclassified protein
Function
Transcriptional regulator which controls the expression of hepatic genes during the transition of endodermal cells to hepatic progenitor cells, facilitating the recruitment of RNA pol II to the promoters of target genes (PubMed:30597922). Activates the transcription of CYP2C38 (By similarity). Represses the CLOCK-BMAL1 transcriptional activity and is essential for circadian rhythm maintenance and period regulation in the liver and colon cells (PubMed:30530698).
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Uniprot ID
Primary ID:
P41235

Secondarily ID:
A5JW41
B2RPP8
O00659
O00723
Q14540
Q5QPB8
Q6B4V5
Q6B4V6
Q6B4V7
Q92653
Q92654
Q92655
Q99864
Q9NQH0
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Ensembl ID
ENSG00000101076
HGNC ID
HGNC:5024
Subcellular Location
Nucleus
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000199 , Hep-G2/C3A
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0453127
 Compound Info 
2-(2-Nitro-naphtho[2,1-b]furan-1-yl)-ethanol
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C14H11NO4
  1
1
EC50 = 1220 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0463379
 Compound Info 
1-Methyl-2-nitro-naphtho[2,1-b]furan
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C13H9NO3
  1
1
EC50 = 1280 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0490966
 Compound Info 
7-methoxy-4-nitro-5-oxatricyclo[7.4.0.0^{2,6}]trideca-1(13),2(6),3,7,9,11-hexaene
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C13H9NO4
  1
1
EC50 = 1470 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0265280
 Compound Info 
2-Nitro-naphtho[2,1-b]furan-7-ol
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C12H7NO4
  1
1
EC50 = 1950 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0439082
 Compound Info 
2-Nitro-naphtho[2,1-b]furan
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C12H7NO3
  1
1
EC50 = 2090 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0453128
 Compound Info 
8-Methoxy-2-nitro-naphtho[2,1-b]furan
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C13H9NO4
  1
1
EC50 = 2330 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0463378
 Compound Info 
7-Methoxy-2-nitro-naphtho[2,1-b]furan
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C13H9NO4
  1
1
EC50 = 2570 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0452982
 Compound Info 
benzo[e][1]benzofuran-2-carboxamide
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C13H9NO2
  1
1
EC50 > 100000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Clinical Information about the Protein
Target 1 ( Hepatocyte nuclear factor 4-alpha (HNF4A) )
Target Type Literature-reported Target
Similar Protein(s) and Bioactivity Statistics
50% Identity
Protein ID Protein Name Protein Organism
PT06268 Hepatocyte nuclear factor 4-alpha Rattus norvegicus, Rat
 Protein Info