General Information of the Protein
Protein ID
PT03113
Protein Name
D-amino-acid oxidase
Gene Name
DAO
Secondarily
Gene Name
Dao1
Sequence
MRVAVIGAGVIGLSTALCIHERYHPAQPLHMKIYADRFTPFTTSDVAAGLWQPYLSDPSNPQEAEWNQQTFDHLQSCLHSPNAEKMGLALISGYNLFRDEVPDPFWKSTVLGFRKLTPSELDMFPDYSYGWFNTSLLLEGKSYLSWLTERLTERGVKFIHRKVASFEEVVRGGVDVIINCTGVWAGALQADASLQPGRGQIIQVEAPWIKHFILTHDPSLGIYNSPYIIPGSKTVTLGGVFQLGNWSELNSVHDHNTIWKSCCQLEPTLKNARIMGELTGFRPVRPQVRLERERLRFGSSSAEVIHNYGHGGYGLTIHWGCAMEAANLFGKILEEKNLSRMPPSHL
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Organism
Rattus norvegicus, Rat
Protein Classification
Enzyme
>
Oxidoreductase
Function
Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids.
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Uniprot ID
O35078
Ensembl ID
ENSG00000110887
Subcellular Location
Peroxisome
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0137017
 Compound Info 
6-[2-(4-fluorophenyl)ethyl]-1,2-dihydropyridazine-3,4-dione
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C12H11FN2O2
  1
1
IC50 = 2.2 nM
 Bioactivity Info 
   TI
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CP0265142
 Compound Info 
6-[2-[3-(trifluoromethyl)phenyl]ethyl]-1,2-dihydropyridazine-3,4-dione
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C13H11F3N2O2
  1
1
IC50 = 2.2 nM
 Bioactivity Info 
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CP0137019
 Compound Info 
6-[2-(4-chlorophenyl)ethyl]-1,2-dihydropyridazine-3,4-dione
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C12H11ClN2O2
  1
1
IC50 = 2.4 nM
 Bioactivity Info 
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CP0205967
 Compound Info 
6-[2-(3-fluorophenyl)ethyl]-1,2-dihydropyridazine-3,4-dione
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C12H11FN2O2
  1
1
IC50 = 2.6 nM
 Bioactivity Info 
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CP0121086
 Compound Info 
6-(1-phenylethyl)-1,2-dihydropyridazine-3,4-dione
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C12H12N2O2
  1
1
IC50 = 3.1 nM
 Bioactivity Info 
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CP0186475
 Compound Info 
6-[2-(4-methoxyphenyl)ethyl]-1,2-dihydropyridazine-3,4-dione
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C13H14N2O3
  1
1
IC50 = 3.8 nM
 Bioactivity Info 
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CP0231655
 Compound Info 
6-(2-phenylethyl)-1,2-dihydropyridazine-3,4-dione
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C12H12N2O2
  1
1
IC50 = 4.6 nM
 Bioactivity Info 
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CP0137018
 Compound Info 
6-[2-(2-fluorophenyl)ethyl]-1,2-dihydropyridazine-3,4-dione
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C12H11FN2O2
  1
1
IC50 = 4.9 nM
 Bioactivity Info 
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CP0184745
 Compound Info 
6-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,2-dihydropyridazine-3,4-dione
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C13H11F3N2O2
  1
1
IC50 = 5 nM
 Bioactivity Info 
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CP0265140
 Compound Info 
6-[2-(3-methoxyphenyl)ethyl]-1,2-dihydropyridazine-3,4-dione
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C13H14N2O3
  1
1
IC50 = 5.6 nM
 Bioactivity Info 
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CP0174406
 Compound Info 
US10202399, Example 237
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C11H10N2O3
  1
1
IC50 = 6.5 nM
 Bioactivity Info 
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CP0205973
 Compound Info 
US9212147, 40
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C12H18N2O2
  1
1
IC50 = 8.2 nM
 Bioactivity Info 
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CP0367093
 Compound Info 
6-[2-(3,5-difluorophenyl)ethyl]-1,2-dihydropyridazine-3,4-dione
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C12H10F2N2O2
  1
1
IC50 = 16 nM
 Bioactivity Info 
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CP0231654
 Compound Info 
6-[2-(3,5-dimethoxyphenyl)ethyl]-1,2-dihydropyridazine-3,4-dione
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C14H16N2O4
  1
1
IC50 = 19 nM
 Bioactivity Info 
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CP0129275
 Compound Info 
6-[2-[2-(trifluoromethyl)phenyl]ethyl]-1,2-dihydropyridazine-3,4-dione
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C13H11F3N2O2
  1
1
IC50 = 41 nM
 Bioactivity Info 
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CP0717824
 Compound Info 
(E)-6-(4-chlorostyryl)-4-hydroxypyridazin-3(2H)-one
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C12H9ClN2O2
  1
1
IC50 = 470 nM
 Bioactivity Info 
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CP0164978
 Compound Info 
6-(3-phenylpropyl)-1,2-dihydropyridazine-3,4-dione
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C13H14N2O2
  1
1
IC50 = 1217 nM
 Bioactivity Info 
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CP0121087
 Compound Info 
6-[2-[3,5-bis(trifluoromethyl)phenyl]ethyl]-1,2-dihydropyridazine-3,4-dione
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C14H10F6N2O2
  1
1
IC50 = 1900 nM
 Bioactivity Info 
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CP0164975
 Compound Info 
6-Cyclohexyl-4-hydroxypyridazin-3(2H)-one
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C10H14N2O2
  1
1
IC50 > 1000 nM
 Bioactivity Info 
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CP0443179
 Compound Info 
6-(3,3-dimethylbutyl)-1,2-dihydropyridazine-3,4-dione
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C10H16N2O2
  1
1
IC50 > 1000 nM
 Bioactivity Info 
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Cell Line ID: CL000013 , Sf9
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0176014
 Compound Info 
3-hydroxyquinolin-2(1H)-one, 2
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C9H7NO2
  1
1 IC50 = 94 nM
Similar Protein(s) and Bioactivity Statistics
90% Identity
Protein ID Protein Name Protein Organism
PT06971 D-amino-acid oxidase Mus musculus, Mouse
 Protein Info