General Information of the Protein
Protein ID
PT03099
Protein Name
Acetylcholinesterase
Gene Name
ACE
Secondarily
Gene Name
ACE1
ACHE1
AGAP001356
Sequence
MEIRGLLMGRLRLGRRMVPLGLLGVTALLLILPPFALVQGRHHELNNGAAIGSHQLSAAAGVGLASQSAQSGSLASGVMSSVPAAGASSSSSSSLLSSSAEDDVARITLSKDADAFFTPYIGHGESVRIIDAELGTLEHVHSGATPRRRGLTRRESNSDANDNDPLVVNTDKGRIRGITVDAPSGKKVDVWLGIPYAQPPVGPLRFRHPRPAEKWTGVLNTTTPPNSCVQIVDTVFGDFPGATMWNPNTPLSEDCLYINVVAPRPRPKNAAVMLWIFGGGFYSGTATLDVYDHRALASEENVIVVSLQYRVASLGFLFLGTPEAPGNAGLFDQNLALRWVRDNIHRFGGDPSRVTLFGESAGAVSVSLHLLSALSRDLFQRAILQSGSPTAPWALVSREEATLRALRLAEAVGCPHEPSKLSDAVECLRGKDPHVLVNNEWGTLGICEFPFVPVVDGAFLDETPQRSLASGRFKKTEILTGSNTEEGYYFIIYYLTELLRKEEGVTVTREEFLQAVRELNPYVNGAARQAIVFEYTDWTEPDNPNSNRDALDKMVGDYHFTCNVNEFAQRYAEEGNNVYMYLYTHRSKGNPWPRWTGVMHGDEINYVFGEPLNPTLGYTEDEKDFSRKIMRYWSNFAKTGNPNPNTASSEFPEWPKHTAHGRHYLELGLNTSFVGRGPRLRQCAFWKKYLPQLVAATSNLPGPAPPSEPCESSAFFYRPDLIVLLVSLLTATVRFIQ
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Organism
Anopheles gambiae, African malaria mosquito
Protein Classification
Enzyme
>
Hydrolase
Function
Rapidly hydrolyzes choline released into the synapse.
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Uniprot ID
Primary ID:
Q869C3

Secondarily ID:
Q7PUR2
Q7RTM0
Q86GC7
Q8ISM4
Q8ISM7
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Ensembl ID
ENSG00000159640
Subcellular Location
Synapse
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000013 , Sf9
Compound ID Compound Name Compound Formula
CP0238744
1-[4-(4-ethylpiperazin-1-yl)piperidin-1-yl]-2-[4-(4-nitrophenyl)phenoxy]ethanone
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C25H32N4O4
 2
1
IC50 = 80 nM
   TI
   LI
   LO
   TS
2
IC50 = 130 nM
   TI
   LI
   LO
   TS
CP0241917
1-(3-chloro-4-methoxyphenyl)-3-(2-morpholin-4-ylethyl)thiourea
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C14H20ClN3O2S
 2
1
IC50 = 120 nM
   TI
   LI
   LO
   TS
2
IC50 = 84000 nM
   TI
   LI
   LO
   TS
CP0085212
1-[4-(4-ethylpiperazin-1-yl)piperidin-1-yl]-2-(4-phenylphenoxy)ethanone
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C25H33N3O2
 2
1
IC50 = 210 nM
   TI
   LI
   LO
   TS
2
IC50 = 1300 nM
   TI
   LI
   LO
   TS
CP0198070
1-[4-(4-ethylpiperazin-1-yl)piperidin-1-yl]-2-[4-(2-fluorophenyl)phenoxy]ethanone
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C25H32FN3O2
 2
1
IC50 = 240 nM
   TI
   LI
   LO
   TS
2
IC50 = 710 nM
   TI
   LI
   LO
   TS
CP0338326
1-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]-2-(4-phenylphenoxy)ethanone
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C24H31N3O2
 2
1
IC50 = 240 nM
   TI
   LI
   LO
   TS
2
IC50 = 540 nM
   TI
   LI
   LO
   TS
CP0066576
2-(2,4-dichlorophenoxy)-N-[4-(1-piperidinylmethyl)phenyl]acetamide
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C20H22Cl2N2O2
 1
1
IC50 = 260 nM
   TI
   LI
   LO
   TS
CP0338327
5-[2-[4-(4-ethylpiperazin-1-yl)piperidin-1-yl]-2-oxoethoxy]-2,3-dihydroinden-1-one
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C22H31N3O3
 2
1
IC50 = 290 nM
   TI
   LI
   LO
   TS
2
IC50 = 380 nM
   TI
   LI
   LO
   TS
CP0153432
1-[4-(4-ethylpiperazin-1-yl)piperidin-1-yl]-2-[4-(4-methoxyphenyl)phenoxy]ethanone
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C26H35N3O3
 2
1
IC50 = 400 nM
   TI
   LI
   LO
   TS
2
IC50 = 960 nM
   TI
   LI
   LO
   TS
CP0510814
1-(3-chloranyl-4-methoxy-phenyl)-3-[2-(4-methylpiperidin-1-yl)ethyl]thiourea
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C16H24ClN3OS
 2
1
IC50 = 960 nM
   TI
   LI
   LO
   TS
2
IC50 = 24000 nM
   TI
   LI
   LO
   TS
CP0254917
2-[(4-phenylmethoxyphenyl)methyl]-3,4-dihydro-1H-isoquinoline
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C23H23NO
 1
1
IC50 = 2900 nM
   TI
   LI
   LO
   TS
CP0303269
N-[3-(4-ethylpiperazin-1-yl)propyl]-2-(4-phenylphenoxy)acetamide
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C23H31N3O2
 2
1
IC50 = 3500 nM
   TI
   LI
   LO
   TS
2
IC50 = 16000 nM
   TI
   LI
   LO
   TS
CP0265435
1-[4-(4-ethylpiperazin-1-yl)piperidin-1-yl]-2-(4-iodophenoxy)ethanone
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C19H28IN3O2
 2
1
IC50 = 3600 nM
   TI
   LI
   LO
   TS
2
IC50 = 6200 nM
   TI
   LI
   LO
   TS
CP0117214
2-(4-phenylphenoxy)-1-(4-piperidin-1-ylpiperidin-1-yl)ethanone
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C24H30N2O2
 2
1
IC50 = 3800 nM
   TI
   LI
   LO
   TS
2
IC50 = 4200 nM
   TI
   LI
   LO
   TS
CP0537426
2-[4-(4-methoxyphenyl)phenoxy]-N-(3-piperidin-1-ylpropyl)acetamide
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C23H30N2O3
 2
1
IC50 = 4500 nM
   TI
   LI
   LO
   TS
2
IC50 = 5200 nM
   TI
   LI
   LO
   TS
CP0153433
N-[3-(4-ethylpiperazin-1-yl)propyl]-2-[4-(4-methoxyphenyl)phenoxy]acetamide
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C24H33N3O3
 2
1
IC50 = 5800 nM
   TI
   LI
   LO
   TS
2
IC50 = 20000 nM
   TI
   LI
   LO
   TS
CP0330017
1-[2-(dimethylamino)ethyl]-3-(2-methoxyphenyl)thiourea
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C12H19N3OS
 2
1
IC50 = 7100 nM
   TI
   LI
   LO
   TS
2
IC50 = 50000 nM
   TI
   LI
   LO
   TS
CP0465976
1-(2-piperidin-1-ylethyl)-3-(4-sulfamoylphenyl)thiourea
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C14H22N4O2S2
 2
1
IC50 = 7800 nM
   TI
   LI
   LO
   TS
2
IC50 = 33000 nM
   TI
   LI
   LO
   TS
CP0140083
11-benzyl-5-ethylsulfanyl-4-phenyl-8-thia-4,6,11-triazatricyclo[7.4.0.02,7]trideca-1(9),2(7),5-trien-3-one
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C24H23N3OS2
 1
1
IC50 = 8300 nM
   TI
   LI
   LO
   TS
CP0392566
2-(4-phenylphenoxy)-N-(3-piperidin-1-ylpropyl)acetamide
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C22H28N2O2
 2
1
IC50 = 10000 nM
   TI
   LI
   LO
   TS
2
IC50 = 23000 nM
   TI
   LI
   LO
   TS
CP0436801
1-(4-methoxyphenyl)-3-(2-morpholin-4-ylethyl)thiourea
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C14H21N3O2S
 1
1
IC50 = 11000 nM
   TI
   LI
   LO
   TS
CP0346141
N-[3-(4-methylpiperazin-1-yl)propyl]-2-(4-phenylphenoxy)acetamide
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C22H29N3O2
 2
1
IC50 = 13000 nM
   TI
   LI
   LO
   TS
2
IC50 = 39000 nM
   TI
   LI
   LO
   TS
CP0240461
[4-(1-benzylpiperidin-4-yl)piperazin-1-yl]-(2-fluorophenyl)methanone
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C23H28FN3O
 1
1
IC50 = 17000 nM
   TI
   LI
   LO
   TS
CP0892603
1-(2-Chlorophenyl)-3-(2-(dimethylamino)ethyl)thiourea sulfate
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C11H18ClN3O4S2
 1
1
IC50 = 17000 nM
   TI
   LI
   LO
   TS
CP0465928
1-(3-chloro-4-methoxyphenyl)-3-[2-(dimethylamino)ethyl]thiourea
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C12H18ClN3OS
 2
1
IC50 = 17000 nM
   TI
   LI
   LO
   TS
2
IC50 = 18000 nM
   TI
   LI
   LO
   TS
CP0240852
1-[4-(1-benzylpiperidin-4-yl)piperazin-1-yl]-2-phenoxyethanone
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C24H31N3O2
 1
1
IC50 = 21000 nM
   TI
   LI
   LO
   TS
CP0510813
1-(3-chlorophenyl)-3-(2-piperidin-1-ylethyl)thiourea
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C14H20ClN3S
 1
1
IC50 = 22000 nM
   TI
   LI
   LO
   TS
CP0265437
2-[4-(4-methoxyphenyl)phenoxy]-N-[3-(4-methylpiperazin-1-yl)propyl]acetamide
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C23H31N3O3
 2
1
IC50 = 25000 nM
   TI
   LI
   LO
   TS
2
IC50 = 33000 nM
   TI
   LI
   LO
   TS
CP0436790
1-(4-methoxyphenyl)-3-(2-piperidin-1-ylethyl)thiourea
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C15H23N3OS
 2
1
IC50 = 29000 nM
   TI
   LI
   LO
   TS
2
IC50 = 94000 nM
   TI
   LI
   LO
   TS
CP0906485
1-(2-Methoxyphenyl)-3-(2-(piperidin-1-yl)ethyl)thiourea hydrochloride
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C15H24ClN3OS
 2
1
IC50 = 29000 nM
   TI
   LI
   LO
   TS
2
IC50 = 66000 nM
   TI
   LI
   LO
   TS
CP0078818
2-(4-iodophenoxy)-N-(3-piperidin-1-ylpropyl)acetamide
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C16H23IN2O2
 2
1
IC50 = 31000 nM
   TI
   LI
   LO
   TS
2
IC50 = 44000 nM
   TI
   LI
   LO
   TS
CP0116804
N-[3-(4-ethylpiperazin-1-yl)propyl]-2-(4-iodophenoxy)acetamide
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C17H26IN3O2
 2
1
IC50 = 43000 nM
   TI
   LI
   LO
   TS
2
IC50 = 95000 nM
   TI
   LI
   LO
   TS
CP0454626
1-(3-chlorophenyl)-3-(2-morpholin-4-ylethyl)thiourea
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C13H18ClN3OS
 1
1
IC50 = 68000 nM
   TI
   LI
   LO
   TS
CP0082292
4-[3-(2-Dimethylamino-ethyl)-thioureido]-benzenesulfonamide
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C11H18N4O2S2
 1
1
IC50 = 74000 nM
   TI
   LI
   LO
   TS
CP0510815
1-(3-chlorophenyl)-3-[2-(dimethylamino)ethyl]thiourea
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C11H16ClN3S
 1
1
IC50 = 96000 nM
   TI
   LI
   LO
   TS
CP0046252
4-(4-fluorophenyl)-1-[(4-methoxy-3-phenylmethoxyphenyl)methyl]-3,6-dihydro-2H-pyridine
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C26H26FNO2
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0241917
1-(3-chloro-4-methoxyphenyl)-3-(2-morpholin-4-ylethyl)thiourea
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C14H20ClN3O2S
 2
1 IC50 = 150 nM
2 IC50 = 190 nM
CP0330017
1-[2-(dimethylamino)ethyl]-3-(2-methoxyphenyl)thiourea
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C12H19N3OS
 2
1 IC50 = 7100 nM
2 IC50 = 7600 nM