General Information of the Protein
Protein ID
PT03085
Protein Name
P2X purinoceptor 4
Secondarily
Protein Name
ATP receptor
Purinergic receptor
Gene Name
P2RX4
Secondarily
Gene Name
P2x4
Sequence
MAGCCSVLGSFLFEYDTPRIVLIRSRKVGLMNRVVQLLILAYVIGWVFVWEKGYQETDSVVSSVTTKAKGVAVTNTSQLGFRIWDVADYVVPAQEENSLFIMTNMIVTVNQTQGTCPEIPDKTSICDSDANCTLGSSDTHSSGIGTGRCVPFNASVKTCEVAAWCPVENDAGVPTPAFLKAAENFTLLVKNNIWYPKFNFSKRNILPNITTSYLKSCIYNARTDPFCPIFRLGQIVADAGHSFQEMAVEGGIMGIQIKWDCNLDRAASHCLPRYSFRRLDTRDLEHNVSPGYNFRFAKYYRDLAGNEQRTLTKAYGIRFDIIVFGKAGKFDIIPTMINVGSGLALLGVATVLCDVIVLYCMKKRYYYRDKKYKYVEDYEQGLSGEMNQ
    Show/Hide
Organism
Mus musculus, Mouse
Protein Classification
Ion channel
>
Ligand-gated ion channel
>
P2X receptor
Function
ATP-gated nonselective transmembrane cation channel permeable to potassium, sodium and calcium. Activated by extracellularly released ATP, it plays multiple role in immunity and central nervous system physiology (PubMed:26456657, PubMed:35119925). Plays a key role in initial steps of T-cell activation and Ca(2+) microdomain formation (PubMed:35119925). Participates also in basal T-cell activity without TCR/CD3 stimulation (PubMed:35119925). Promotes the differentiation and activation of Th17 cells via expression of retinoic acid-related orphan receptor C/RORC (By similarity). Upon activation, drives microglia motility via the PI3K/Akt pathway (PubMed:17299767). Could also function as an ATP-gated cation channel of lysosomal membranes (PubMed:27477609).
    Show/Hide
Uniprot ID
Primary ID:
Q9JJX6

Secondarily ID:
Q9JJX3
Q9JJX4
Q9JJX5
    Show/Hide
Ensembl ID
ENSG00000135124
Subcellular Location
Cell membrane
Lysosome membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000094 , 1321N1
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0019161
 Compound Info 
N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-phenylacetamide
   Show/Hide
C20H17ClN2O4S
  1
1
IC50 = 112 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Similar Protein(s) and Bioactivity Statistics
90% Identity
Protein ID Protein Name Protein Organism
PT03084 P2X purinoceptor 4 Rattus norvegicus, Rat
 Protein Info