General Information of the Protein
Protein ID
PT03078
Protein Name
Glutaminase kidney isoform, mitochondrial
Secondarily
Protein Name
K-glutaminase
L-glutamine amidohydrolase
Gene Name
GLS
Secondarily
Gene Name
GLS1
KIAA0838
Sequence
MMRLRGSGMLRDLLLRSPAGVSATLRRAQPLVTLCRRPRGGGRPAAGPAAAARLHPWWGGGGWPAEPLARGLSSSPSEILQELGKGSTHPQPGVSPPAAPAAPGPKDGPGETDAFGNSEGKELVASGENKIKQGLLPSLEDLLFYTIAEGQEKIPVHKFITALKSTGLRTSDPRLKECMDMLRLTLQTTSDGVMLDKDLFKKCVQSNIVLLTQAFRRKFVIPDFMSFTSHIDELYESAKKQSGGKVADYIPQLAKFSPDLWGVSVCTVDGQRHSTGDTKVPFCLQSCVKPLKYAIAVNDLGTEYVHRYVGKEPSGLRFNKLFLNEDDKPHNPMVNAGAIVVTSLIKQGVNNAEKFDYVMQFLNKMAGNEYVGFSNATFQSERESGDRNFAIGYYLKEKKCFPEGTDMVGILDFYFQLCSIEVTCESASVMAATLANGGFCPITGERVLSPEAVRNTLSLMHSCGMYDFSGQFAFHVGLPAKSGVAGGILLVVPNVMGMMCWSPPLDKMGNSVKGIHFCHDLVSLCNFHNYDNLRHFAKKLDPRREGGDQRVKSVINLLFAAYTGDVSALRRFALSAMDMEQRDYDSRTALHVAAAEGHVEVVKFLLEACKVNPFPKDRWNNTPMDEALHFGHHDVFKILQEYQVQYTPQGDSDNGKENQTVHKNLDGLL
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
>
Hydrolase
Function
Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate, the main excitatory neurotransmitter in the brain (PubMed:30575854, PubMed:30239721, PubMed:30970188).
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Uniprot ID
Primary ID:
O94925

Secondarily ID:
Q9UL05
Q9UL06
Q9UL07
Q9UN40
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Ensembl ID
ENSG00000115419
HGNC ID
HGNC:4331
Subcellular Location
Mitochondrion
Cytoplasm
Cytosol
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000048 , PC-3
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0534274
 Compound Info 
(2R)-2-methoxy-N-[5-[[(3R)-1-(1,2,4-triazin-6-yl)pyrrolidin-3-yl]amino]-1,3,4-thiadiazol-2-yl]-2-[3-(trifluoromethoxy)phenyl]acetamide
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C19H19F3N8O3S
  1
1
IC50 = 0.206 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0473506
 Compound Info 
(2S)-2-methoxy-2-phenyl-N-[5-[[(3R)-1-(1,2,4-triazin-6-yl)pyrrolidin-3-yl]amino]-1,3,4-thiadiazol-2-yl]acetamide
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C18H20N8O2S
  1
1
IC50 = 0.39 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0464247
 Compound Info 
(2S)-2-methoxy-2-(4-methoxyphenyl)-N-[5-[[(3R)-1-pyridazin-3-ylpyrrolidin-3-yl]amino]-1,3,4-thiadiazol-2-yl]acetamide
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C20H23N7O3S
  1
1
IC50 = 0.4006 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0252218
 Compound Info 
(2S)-2-methoxy-2-phenyl-N-[5-[[(3R)-1-(1,2,4-triazin-3-yl)pyrrolidin-3-yl]amino]-1,3,4-thiadiazol-2-yl]acetamide
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C18H20N8O2S
  1
1
IC50 = 3.9 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0534275
 Compound Info 
(2R)-2-(4-fluoro-3-methoxyphenyl)-2-methoxy-N-[5-[[(3R)-1-(1,2,4-triazin-6-yl)pyrrolidin-3-yl]amino]-1,3,4-thiadiazol-2-yl]acetamide
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C19H21FN8O3S
  1
1
IC50 = 4.99 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0380185
 Compound Info 
(2S)-2-(4-fluorophenyl)-2-methoxy-N-[5-[[(3R)-1-(1,2,4-triazin-3-yl)pyrrolidin-3-yl]amino]-1,3,4-thiadiazol-2-yl]acetamide
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C18H19FN8O2S
  1
1
IC50 = 175.1 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0266846
 Compound Info 
1-[(2R)-4-[6-[[2-[4-(3,3-difluorocyclobutyl)oxy-6-methylpyridin-2-yl]acetyl]amino]pyridazin-3-yl]-2-fluorobutyl]-N-methyltriazole-4-carboxamide
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C24H27F3N8O3
  1
1 IC50 = 31 nM
CP0252218
 Compound Info 
(2S)-2-methoxy-2-phenyl-N-[5-[[(3R)-1-(1,2,4-triazin-3-yl)pyrrolidin-3-yl]amino]-1,3,4-thiadiazol-2-yl]acetamide
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C18H20N8O2S
  1
1 IC50 = 60 nM